Active genes are tri-methylated at K4 of histone H3

Nature

Volumn 419, Issue 6905, 2002, Pages 407-411

  Santos Rosa, Helena ^a   Schneider, Robert ^a   Bannister, Andrew J ^a   Sherriff, Julia ^b   Bernstein, Bradley E ^c   Emre, N C Tolga ^d   Schreiber, Stuart L ^c   Mellor, Jane ^b   Kouzarides, Tony ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HARVARD UNIVERSITY   (United States)

^d Wilstar Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; ANTIBODIES; CATALYSIS;

GENE EXPRESSIONS;

GENES;

HISTONE; HISTONE H3; LYSINE; PROTEIN; PROTEIN SET1; UNCLASSIFIED DRUG;

GENE;

ARTICLE; EUCHROMATIN; GENE ACTIVITY; GENE EXPRESSION; GENE INACTIVATION; HETEROCHROMATIN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; PROTEIN MODIFICATION; SACCHAROMYCES CEREVISIAE;

ANTIBODIES; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; HISTONES; INOSITOL; LYSINE; METHIONINE; METHYLATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0037179716     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01080     Document Type: Article

References (20)

1. Strahl, B. D., Ohba, R., Cook, R. G. & Allis, C. D. Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena. Proc. Natl Acad. Sci. USA 96, 14967-14972 (1999).
2. Noma, K., Allis, C. D. & Grewal, S. I. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries. Science 293, 1150-1155 (2001).
3. Cheung, P., Allis, C. D. & Sassone-Corsi, P. Signaling to chromatin through histone modifications. Cell 103, 263-271 (2000).
4. Strahl, B. D. & Allis, C. D. The language of covalent histone modifications. Nature 403, 41-45 (2000).
5. Rea, S. et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406, 579-580 (2000).
6. Bannister, A. J. et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120-124 (2001).
7. Lachner, M., O'Carroll, D., Rea, S., Mechtler, K. & Jenuwein, T. Methylation of histone H3 lysine 9 creates a binding site for HPI proteins. Nature 410, 116-120 (2001).
8. Roguev, A. et al. The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J. 20, 7137-7148 (2001).
9. Briggs, S.D. et al. Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev. 15, 3286-3295 (2001).
10. Nislow, C., Ray, E. & Pillus, L. SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol. Biol. Chem. 8, 2421-2436 (1997).
11. Krogan, N. J. et al. COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc. Natl Acad. Sci. 98, 12902-12907 (2001).
12. Bryk, M. et al. Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. Cerevisiae by a Sir2-independent mechanism. Curr. Biol. 12, 165-170 (2002).
13. Krogan, N. J. et al. COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J. Biol. Chem. 13, 10753-10755 (2002).
14. Litt, M. D., Simpson, M., Gaszner, M., Allis, C. D. & Felsenfeld, G. Correlation between histone lysine methylation and developmental changes at the chicken β-globin locus. Science 293, 2453-2455 (2001).
15. Bernstein, B. E. et al. Methylation of histone H3 Lys 4 in coding regions of active genes. Proc. Natl Acad. Sci. USA 99, 8695-8697 (2002).
16. Siniossoglou, S. et al. A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Cell 84, 265-275 (1996).
17. Carroll, A. S., Bishop, A. C., DeRisi, J. L., Shokat, K. M. & O'Shea, E. K. Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response. Proc. Natl Acad. Sci. USA 98, 12578-12583 (2001).
18. DeRisi, J. L., Iyer, V. R. & Brown, P. O. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278, 680-686 (1997).
19. Hughes, T. R. et al. Functional discovery via a compendium of expression profiles. Cell 102, 109-126 (2000).
20. Kent, N. A., Karabetsou, N., Politis, P. K. & Mellor, J. In vivo chromatin remodeling by yeast ISWI homologs Isw1p and Isw2p. Genes Dev. 15, 619-626 (2001).