메뉴 건너뛰기




Volumn 18, Issue 8, 2012, Pages 1194-1204

Epigenetic mechanisms in neurological disease

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; DNA METHYLTRANSFERASE 3B; DNA TOPOISOMERASE INHIBITOR; ETOPOSIDE; HISTONE; HISTONE DEACETYLASE INHIBITOR; IRINOTECAN; METHYL CPG BINDING PROTEIN 2; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; N PHTHALOYLTRYPTOPHAN; NICOTINAMIDE; RAZOXANE; TOPOTECAN; TRANSFERASE INHIBITOR; ZEBULARINE;

EID: 84864700183     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2828     Document Type: Review
Times cited : (351)

References (155)
  • 1
    • 84857062545 scopus 로고    scopus 로고
    • DNA methylation signatures in development and aging of the human prefrontal cortex
    • Numata, S. et al. DNA methylation signatures in development and aging of the human prefrontal cortex. Am. J. Hum. Genet. 90, 260-272 (2012).
    • (2012) Am. J. Hum. Genet. , vol.90 , pp. 260-272
    • Numata, S.1
  • 2
    • 41149090082 scopus 로고    scopus 로고
    • DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
    • Siegmund, K.D. et al. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One 2, e895 (2007).
    • (2007) PLoS One , vol.2
    • Siegmund, K.D.1
  • 3
    • 79952036163 scopus 로고    scopus 로고
    • Distinct DNA methylation changes highly correlated with chronological age in the human brain
    • Hernandez, D.G. et al. Distinct DNA methylation changes highly correlated with chronological age in the human brain. Hum. Mol. Genet. 20, 1164-1172 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 1164-1172
    • Hernandez, D.G.1
  • 4
    • 77952715009 scopus 로고    scopus 로고
    • Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex
    • Cheung, I. et al. Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex. Proc. Natl. Acad. Sci. USA 107, 8824-8829 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 8824-8829
    • Cheung, I.1
  • 5
    • 79957623760 scopus 로고    scopus 로고
    • Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
    • Klein, C.J. et al. Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat. Genet. 43, 595-600 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 595-600
    • Klein, C.J.1
  • 6
    • 84860491605 scopus 로고    scopus 로고
    • Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy
    • Winkelmann, J. et al. Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy. Hum. Mol. Genet. 21, 2205-2210 (2012).
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 2205-2210
    • Winkelmann, J.1
  • 7
    • 79960276209 scopus 로고    scopus 로고
    • Balancing histone methylation activities in psychiatric disorders
    • Peter, C.J. & Akbarian, S. Balancing histone methylation activities in psychiatric disorders. Trends Mol. Med. 17, 372-379 (2011).
    • (2011) Trends Mol. Med. , vol.17 , pp. 372-379
    • Peter, C.J.1    Akbarian, S.2
  • 8
    • 70350018325 scopus 로고    scopus 로고
    • Multiple roles of HDAC inhibition in neurodegenerative conditions
    • Chuang, D.M., Leng, Y., Marinova, Z., Kim, H.J. & Chiu, C.T. Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci. 32, 591-601 (2009).
    • (2009) Trends Neurosci , vol.32 , pp. 591-601
    • Chuang, D.M.1    Leng, Y.2    Marinova, Z.3    Kim, H.J.4    Chiu, C.T.5
  • 9
    • 79952759556 scopus 로고    scopus 로고
    • Histone deacety-lase inhibitors preserve white-matter structure and function during ischemia by conserving ATP and reducing excitotoxicity
    • Baltan, S., Murphy, S.P., Danilov, C.A., Bachleda, A. & Morrison, R.S. Histone deacety-lase inhibitors preserve white-matter structure and function during ischemia by conserving ATP and reducing excitotoxicity. J. Neurosci. 31, 3990-3999 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 3990-3999
    • Baltan, S.1    Murphy, S.P.2    Danilov, C.A.3    Bachleda, A.4    Morrison, R.S.5
  • 12
    • 77958580776 scopus 로고    scopus 로고
    • DNA methylation and memory formation
    • Day, J.J. & Sweatt, J.D. DNA methylation and memory formation. Nat. Neurosci. 13, 1319-1323 (2010).
    • (2010) Nat. Neurosci. , vol.13 , pp. 1319-1323
    • Day, J.J.1    Sweatt, J.D.2
  • 13
    • 14644394263 scopus 로고    scopus 로고
    • Molecular aging in human prefrontal cortex is selective and continuous throughout adult life
    • Erraji-Benchekroun, L. et al. Molecular aging in human prefrontal cortex is selective and continuous throughout adult life. Biol. Psychiatry 57, 549-558 (2005).
    • (2005) Biol. Psychiatry , vol.57 , pp. 549-558
    • Erraji-Benchekroun, L.1
  • 14
    • 66149180587 scopus 로고    scopus 로고
    • Normal human aging and early-stage schizophrenia share common molecular profiles
    • Tang, B. et al. Normal human aging and early-stage schizophrenia share common molecular profiles. Aging Cell 8, 339-342 (2009).
    • (2009) Aging Cell , vol.8 , pp. 339-342
    • Tang, B.1
  • 15
    • 3042631024 scopus 로고    scopus 로고
    • Gene regulation and DNA damage in the ageing human brain
    • Lu, T. et al. Gene regulation and DNA damage in the ageing human brain. Nature 429, 883-891 (2004).
    • (2004) Nature , vol.429 , pp. 883-891
    • Lu, T.1
  • 16
    • 82255192294 scopus 로고    scopus 로고
    • 5-hmC-mediated epigenetic dynamics during postnatal neuro-development and aging
    • Szulwach, K.E. et al. 5-hmC-mediated epigenetic dynamics during postnatal neuro-development and aging. Nat. Neurosci. 14, 1607-1616 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 1607-1616
    • Szulwach, K.E.1
  • 17
    • 22244460464 scopus 로고    scopus 로고
    • Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain
    • Stadler, F. et al. Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain. J. Neurochem. 94, 324-336 (2005).
    • (2005) J. Neurochem. , vol.94 , pp. 324-336
    • Stadler, F.1
  • 18
    • 73449105432 scopus 로고    scopus 로고
    • Identification of histone methylation multiplicities patterns in the brain of senescence-Accelerated prone mouse 8
    • Wang, C.M., Tsai, S.N., Yew, T.W., Kwan, Y.W. & Ngai, S.M. Identification of histone methylation multiplicities patterns in the brain of senescence-Accelerated prone mouse 8. Biogerontology 11, 87-102 (2010).
    • (2010) Biogerontology , vol.11 , pp. 87-102
    • Wang, C.M.1    Tsai, S.N.2    Yew, T.W.3    Kwan, Y.W.4    Ngai, S.M.5
  • 19
    • 77952168294 scopus 로고    scopus 로고
    • Altered histone acetylation is associated with age-dependent memory impairment in mice
    • Peleg, S. et al. Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328, 753-756 (2010).
    • (2010) Science , vol.328 , pp. 753-756
    • Peleg, S.1
  • 20
    • 67649648237 scopus 로고    scopus 로고
    • Control of inducible gene expression by signal-dependent transcriptional elongation
    • Hargreaves, D.C., Horng, T. & Medzhitov, R. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell 138, 129-145 (2009).
    • (2009) Cell , vol.138 , pp. 129-145
    • Hargreaves, D.C.1    Horng, T.2    Medzhitov, R.3
  • 21
    • 70449650339 scopus 로고    scopus 로고
    • Epigenetic mechanisms facilitating oligodendrocyte development, maturation, and aging
    • Copray, S., Huynh, J.L., Sher, F., Casaccia-Bonnefil, P. & Boddeke, E. Epigenetic mechanisms facilitating oligodendrocyte development, maturation, and aging. Glia 57, 1579-1587 (2009).
    • (2009) Glia , vol.57 , pp. 1579-1587
    • Copray, S.1    Huynh, J.L.2    Sher, F.3    Casaccia-Bonnefil, P.4    Boddeke, E.5
  • 23
    • 75749101495 scopus 로고    scopus 로고
    • Chromatin remodelling during development
    • Ho, L. & Crabtree, G.R. Chromatin remodelling during development. Nature 463, 474-484 (2010).
    • (2010) Nature , vol.463 , pp. 474-484
    • Ho, L.1    Crabtree, G.R.2
  • 24
    • 84861537561 scopus 로고    scopus 로고
    • CoREST/LSD1 control the development of pyramidal cortical neurons
    • Fuentes, P., Canovas, J., Berndt, F.A., Noctor, S.C. & Kukuljan, M. CoREST/LSD1 control the development of pyramidal cortical neurons. Cereb. Cortex 22, 1431-1441 (2012).
    • (2012) Cereb. Cortex , vol.22 , pp. 1431-1441
    • Fuentes, P.1    Canovas, J.2    Berndt, F.A.3    Noctor, S.C.4    Kukuljan, M.5
  • 25
    • 0033435205 scopus 로고    scopus 로고
    • The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
    • Hansen, R.S. et al. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc. Natl. Acad. Sci. USA 96, 14412-14417 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14412-14417
    • Hansen, R.S.1
  • 26
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano, M., Bell, D.W., Haber, D.A. & Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257 (1999).
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 27
    • 39749152283 scopus 로고    scopus 로고
    • DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function
    • Jin, B. et al. DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. Hum. Mol. Genet. 17, 690-709 (2008).
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 690-709
    • Jin, B.1
  • 28
    • 79958846467 scopus 로고    scopus 로고
    • Mutations in ZBTB24 are associated with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2
    • de Greef, J.C. et al. Mutations in ZBTB24 are associated with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2. Am. J. Hum. Genet. 88, 796-804 (2011).
    • (2011) Am. J. Hum. Genet. , vol.88 , pp. 796-804
    • De Greef, J.C.1
  • 29
    • 84867592763 scopus 로고    scopus 로고
    • A novel deletion in ZBTB24 in a Lebanese family with immunodeficiency, centromeric instability and facial anomalies syndrome type 2
    • doi: 10.1111/j.1399-0004.2011.01783.x
    • Chouery, E. et al. A novel deletion in ZBTB24 in a Lebanese family with immunodeficiency, centromeric instability and facial anomalies syndrome type 2. Clin. Genet. doi: 10.1111/j.1399-0004.2011.01783.x (2011).
    • (2011) Clin. Genet
    • Chouery, E.1
  • 30
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein-2
    • Amir, R.E. et al. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein-2. Nat. Genet. 23, 185-188 (1999).
    • (1999) Nat. Genet. , vol.23 , pp. 185-188
    • Amir, R.E.1
  • 31
    • 66149139048 scopus 로고    scopus 로고
    • Autism and other neuropsychiatric symptoms are prevalent in individuals with MECP2 duplication syndrome
    • Ramocki, M.B. et al. Autism and other neuropsychiatric symptoms are prevalent in individuals with MECP2 duplication syndrome. Ann. Neurol. 66, 771-782 (2009).
    • (2009) Ann. Neurol. , vol.66 , pp. 771-782
    • Ramocki, M.B.1
  • 32
    • 80053997718 scopus 로고    scopus 로고
    • MeCP2 Rett mutations affect large-scale chromatin organization
    • Agarwal, N. et al. MeCP2 Rett mutations affect large-scale chromatin organization. Hum. Mol. Genet. 20, 4187-4195. (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 4187-4195
    • Agarwal, N.1
  • 33
    • 79955955059 scopus 로고    scopus 로고
    • MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation
    • Singleton, M.K. et al. MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation. Neurobiol. Dis. 43, 190-200 (2011).
    • (2011) Neurobiol. Dis. , vol.43 , pp. 190-200
    • Singleton, M.K.1
  • 34
    • 0035170550 scopus 로고    scopus 로고
    • Expression pattern of the Rett syndrome gene MeCP2 in primate prefrontal cortex
    • Akbarian, S. et al. Expression pattern of the Rett syndrome gene MeCP2 in primate prefrontal cortex. Neurobiol. Dis. 8, 784-791 (2001).
    • (2001) Neurobiol. Dis. , vol.8 , pp. 784-791
    • Akbarian, S.1
  • 35
    • 0035093830 scopus 로고    scopus 로고
    • Deficiency of methyl-CpG-binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
    • Chen, R.Z., Akbarian, S., Tudor, M. & Jaenisch, R. Deficiency of methyl-CpG-binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat. Genet. 27, 327-331 (2001).
    • (2001) Nat. Genet. , vol.27 , pp. 327-331
    • Chen, R.Z.1    Akbarian, S.2    Tudor, M.3    Jaenisch, R.4
  • 36
    • 76849094693 scopus 로고    scopus 로고
    • Neuronal MeCP2 is expressed at near-histone-octamer levels and globally alters the chromatin state
    • Skene, P.J. et al. Neuronal MeCP2 is expressed at near-histone-octamer levels and globally alters the chromatin state. Mol. Cell 37, 457-468 (2010).
    • (2010) Mol. Cell , vol.37 , pp. 457-468
    • Skene, P.J.1
  • 37
    • 0026439115 scopus 로고
    • A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei
    • Leonhardt, H., Page, A.W., Weier, H.U. & Bestor, T.H. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71, 865-873 (1992).
    • (1992) Cell , vol.71 , pp. 865-873
    • Leonhardt, H.1    Page, A.W.2    Weier, H.U.3    Bestor, T.H.4
  • 38
    • 12144255958 scopus 로고    scopus 로고
    • Replication-independent chromatin loading of Dnmt1 during G2 and M phases
    • Easwaran, H.P., Schermelleh, L., Leonhardt, H. & Cardoso, M.C. Replication-independent chromatin loading of Dnmt1 during G2 and M phases. EMBO Rep. 5, 1181-1186 (2004).
    • (2004) EMBO Rep , vol.5 , pp. 1181-1186
    • Easwaran, H.P.1    Schermelleh, L.2    Leonhardt, H.3    Cardoso, M.C.4
  • 39
    • 0035109547 scopus 로고    scopus 로고
    • DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals
    • Fan, G. et al. DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J. Neurosci. 21, 788-797 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 788-797
    • Fan, G.1
  • 40
    • 14944359718 scopus 로고    scopus 로고
    • The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis
    • Bérubé, N.G. et al. The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. J. Clin. Invest. 115, 258-267 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 258-267
    • Bérubé, N.G.1
  • 41
    • 58149391969 scopus 로고    scopus 로고
    • Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53
    • Seah, C. et al. Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53. J. Neurosci. 28, 12570-12580 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 12570-12580
    • Seah, C.1
  • 42
    • 78650902751 scopus 로고    scopus 로고
    • Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain
    • Shioda, N. et al. Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain. J. Neurosci. 31, 346-358 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 346-358
    • Shioda, N.1
  • 43
    • 0033797735 scopus 로고    scopus 로고
    • Dendritic anomalies in disorders associated with mental retardation
    • Kaufmann, W.E. & Moser, H.W. Dendritic anomalies in disorders associated with mental retardation. Cereb. Cortex 10, 981-991 (2000).
    • (2000) Cereb. Cortex , vol.10 , pp. 981-991
    • Kaufmann, W.E.1    Moser, H.W.2
  • 44
    • 77958494782 scopus 로고    scopus 로고
    • ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner
    • Law, M.J. et al. ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner. Cell 143, 367-378 (2010).
    • (2010) Cell , vol.143 , pp. 367-378
    • Law, M.J.1
  • 45
    • 77956282773 scopus 로고    scopus 로고
    • Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
    • Lewis, P.W., Elsaesser, S.J., Noh, K.M., Stadler, S.C. & Allis, C.D. Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc. Natl. Acad. Sci. USA 107, 14075-14080 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 14075-14080
    • Lewis, P.W.1    Elsaesser, S.J.2    Noh, K.M.3    Stadler, S.C.4    Allis, C.D.5
  • 46
    • 79960063257 scopus 로고    scopus 로고
    • Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin
    • Eustermann, S. et al. Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin. Nat. Struct. Mol. Biol. 18, 777-782 (2011).
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 777-782
    • Eustermann, S.1
  • 47
    • 78049434700 scopus 로고    scopus 로고
    • Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and preimplantation embryo
    • Baumann, C., Viveiros, M.M. & De La Fuente, R. Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and preimplantation embryo. PLoS Genet. 6, e1001137 (2010).
    • (2010) PLoS Genet. , vol.6
    • Baumann, C.1    Viveiros, M.M.2    De La Fuente, R.3
  • 48
    • 0035909330 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
    • Steffan, J.S. et al. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413, 739-743 (2001).
    • (2001) Nature , vol.413 , pp. 739-743
    • Steffan, J.S.1
  • 49
    • 0142157600 scopus 로고    scopus 로고
    • Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice
    • Ferrante, R.J. et al. Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J. Neurosci. 23, 9418-9427 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 9418-9427
    • Ferrante, R.J.1
  • 50
    • 79953178935 scopus 로고    scopus 로고
    • A-synuclein sequesters Dnmt1 from the nucleus: A novel mechanism for epigenetic alterations in Lewy body diseases
    • Desplats, P. et al. a-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J. Biol. Chem. 286, 9031-9037 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 9031-9037
    • Desplats, P.1
  • 51
    • 81255143014 scopus 로고    scopus 로고
    • Epigenetic regulation of motor-neuron cell death through DNA methylation
    • Chestnut, B.A. et al. Epigenetic regulation of motor-neuron cell death through DNA methylation. J. Neurosci. 31, 16619-16636 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 16619-16636
    • Chestnut, B.A.1
  • 52
    • 79952749156 scopus 로고    scopus 로고
    • DNA methyl-transferase 1, cytosine methylation and cytosine hydroxymethylation in mammalian mitochondria
    • Shock, L.S., Thakkar, P.V., Peterson, E.J., Moran, R.G. & Taylor, S.M. DNA methyl-transferase 1, cytosine methylation and cytosine hydroxymethylation in mammalian mitochondria. Proc. Natl. Acad. Sci. USA 108, 3630-3635 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 3630-3635
    • Shock, L.S.1    Thakkar, P.V.2    Peterson, E.J.3    Moran, R.G.4    Taylor, S.M.5
  • 53
    • 0035937523 scopus 로고    scopus 로고
    • Interference by huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity
    • Nucifora, F.C. Jr. et al. Interference by huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity. Science 291, 2423-2428 (2001).
    • (2001) Science , vol.291 , pp. 2423-2428
    • Nucifora Jr., F.C.1
  • 54
    • 78651072485 scopus 로고    scopus 로고
    • CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease
    • Caccamo, A., Maldonado, M.A., Bokov, A.F., Majumder, S. & Oddo, S. CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 107, 22687-22692 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 22687-22692
    • Caccamo, A.1    Maldonado, M.A.2    Bokov, A.F.3    Majumder, S.4    Oddo, S.5
  • 55
    • 79955660764 scopus 로고    scopus 로고
    • An antisense CAG repeat transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice
    • Wilburn, B. et al. An antisense CAG repeat transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice. Neuron 70, 427-440 (2011).
    • (2011) Neuron , vol.70 , pp. 427-440
    • Wilburn, B.1
  • 56
    • 77956964442 scopus 로고    scopus 로고
    • Déjà vu with a twist: Transglutaminases in bioenergetics and transcriptional dysfunction in Huntington's disease
    • Kazemi-Esfarjani, P. & La Spada, A.R. Déjà vu with a twist: transglutaminases in bioenergetics and transcriptional dysfunction in Huntington's disease. EMBO Mol. Med. 2, 335-337 (2010).
    • (2010) EMBO Mol. Med. , vol.2 , pp. 335-337
    • Kazemi-Esfarjani, P.1    La Spada, A.R.2
  • 57
    • 79955456732 scopus 로고    scopus 로고
    • Mutant huntingtin causes defective actin remodeling during stress: Defining a new role for transglutaminase-2 in neurodegenerative disease
    • Munsie, L. et al. Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase-2 in neurodegenerative disease. Hum. Mol. Genet. 20, 1937-1951 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 1937-1951
    • Munsie, L.1
  • 58
    • 77956949459 scopus 로고    scopus 로고
    • Inhibition of transglutaminase-2 mitigates transcriptional dysregulation in models of Huntington disease
    • McConoughey, S.J. et al. Inhibition of transglutaminase-2 mitigates transcriptional dysregulation in models of Huntington disease. EMBO Mol. Med. 2, 349-370 (2010).
    • (2010) EMBO Mol. Med. , vol.2 , pp. 349-370
    • McConoughey, S.J.1
  • 59
    • 34447312020 scopus 로고    scopus 로고
    • ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease
    • Ryu, H. et al. ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease. Proc. Natl. Acad. Sci. USA 103, 19176-19181 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 19176-19181
    • Ryu, H.1
  • 60
    • 80054742094 scopus 로고    scopus 로고
    • Transcriptional modulator H2A histone family, member y (H2AFY) marks Huntington disease activity in man and mouse
    • Hu, Y. et al. Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse. Proc. Natl. Acad. Sci. USA 108, 17141-17146 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 17141-17146
    • Hu, Y.1
  • 61
    • 34447302317 scopus 로고    scopus 로고
    • Modulation of nucleosome dynamics in Huntington's disease
    • Stack, E.C. et al. Modulation of nucleosome dynamics in Huntington's disease. Hum. Mol. Genet. 16, 1164-1175 (2007).
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 1164-1175
    • Stack, E.C.1
  • 62
    • 77955980364 scopus 로고    scopus 로고
    • Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain
    • Morris, M.J., Karra, A.S. & Monteggia, L.M. Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain. Behav. Pharmacol. 21, 409-419 (2010).
    • (2010) Behav. Pharmacol. , vol.21 , pp. 409-419
    • Morris, M.J.1    Karra, A.S.2    Monteggia, L.M.3
  • 63
    • 70349085803 scopus 로고    scopus 로고
    • Antidepressant actions of histone deacetylase inhibitors
    • Covington, H.E. III et al. Antidepressant actions of histone deacetylase inhibitors. J. Neurosci. 29, 11451-11460 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 11451-11460
    • Covington Iii, H.E.1
  • 64
    • 34250161829 scopus 로고    scopus 로고
    • Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse
    • Schroeder, F.A., Lin, C.L., Crusio, W.E. & Akbarian, S. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol. Psychiatry 62, 55-64 (2007).
    • (2007) Biol. Psychiatry , vol.62 , pp. 55-64
    • Schroeder, F.A.1    Lin, C.L.2    Crusio, W.E.3    Akbarian, S.4
  • 65
    • 38749132992 scopus 로고    scopus 로고
    • Negative regulation of the deacetylase SIRT1 by DBC1
    • Zhao, W. et al. Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451, 587-590 (2008).
    • (2008) Nature , vol.451 , pp. 587-590
    • Zhao, W.1
  • 66
    • 26444439216 scopus 로고    scopus 로고
    • Prospects: Histone deacetylase inhibitors
    • Dokmanovic, M. & Marks, P.A. Prospects: histone deacetylase inhibitors. J. Cell. Biochem. 96, 293-304 (2005).
    • (2005) J. Cell. Biochem. , vol.96 , pp. 293-304
    • Dokmanovic, M.1    Marks, P.A.2
  • 67
    • 84855563516 scopus 로고    scopus 로고
    • Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
    • Jeong, H. et al. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat. Med. 18, 159-165 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 159-165
    • Jeong, H.1
  • 68
    • 84455169414 scopus 로고    scopus 로고
    • SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive
    • Libert, S. et al. SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell 147, 1459-1472 (2011).
    • (2011) Cell , vol.147 , pp. 1459-1472
    • Libert, S.1
  • 69
    • 80052923233 scopus 로고    scopus 로고
    • Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration
    • Rohrer, J.D. et al. Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration. Brain 134, 2565-2581 (2011).
    • (2011) Brain , vol.134 , pp. 2565-2581
    • Rohrer, J.D.1
  • 70
    • 79955534069 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid (vorinostat) upregulates progranu-lin transcription: Rational therapeutic approach to frontotemporal dementia
    • Cenik, B. et al. Suberoylanilide hydroxamic acid (vorinostat) upregulates progranu-lin transcription: rational therapeutic approach to frontotemporal dementia. J. Biol. Chem. 286, 16101-16108 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 16101-16108
    • Cenik, B.1
  • 71
    • 77957001697 scopus 로고    scopus 로고
    • Acetylation of tau inhibits its degradation and contributes to tauopathy
    • Min, S.W. et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67, 953-966 (2010).
    • (2010) Neuron , vol.67 , pp. 953-966
    • Min, S.W.1
  • 72
    • 77955046461 scopus 로고    scopus 로고
    • SIRT1 suppresses b-Amyloid production by activating the a-secretase gene ADAM10
    • Donmez, G., Wang, D., Cohen, D.E. & Guarente, L. SIRT1 suppresses b-Amyloid production by activating the a-secretase gene ADAM10. Cell 142, 320-332 (2010).
    • (2010) Cell , vol.142 , pp. 320-332
    • Donmez, G.1    Wang, D.2    Cohen, D.E.3    Guarente, L.4
  • 73
    • 58149267462 scopus 로고    scopus 로고
    • Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
    • Green, K.N. et al. Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J. Neurosci. 28, 11500-11510 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 11500-11510
    • Green, K.N.1
  • 74
    • 34547599329 scopus 로고    scopus 로고
    • Sirtuin 2 inhibitors rescue a-synuclein-mediated toxicity in models of Parkinson's disease
    • Outeiro, T.F. et al. Sirtuin 2 inhibitors rescue a-synuclein-mediated toxicity in models of Parkinson's disease. Science 317, 516-519 (2007).
    • (2007) Science , vol.317 , pp. 516-519
    • Outeiro, T.F.1
  • 75
    • 9344252804 scopus 로고    scopus 로고
    • Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells
    • Hsieh, J., Nakashima, K., Kuwabara, T., Mejia, E. & Gage, F.H. Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc. Natl. Acad. Sci. USA 101, 16659-16664 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 16659-16664
    • Hsieh, J.1    Nakashima, K.2    Kuwabara, T.3    Mejia, E.4    Gage, F.H.5
  • 76
    • 79952272438 scopus 로고    scopus 로고
    • Changed histone acetylation patterns in normal-Appearing white matter and early multiple sclerosis lesions
    • Pedre, X. et al. Changed histone acetylation patterns in normal-Appearing white matter and early multiple sclerosis lesions. J. Neurosci. 31, 3435-3445 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 3435-3445
    • Pedre, X.1
  • 77
    • 77950867183 scopus 로고    scopus 로고
    • Epigenetic regulation of oligodendrocyte identity
    • Liu, J. & Casaccia, P. Epigenetic regulation of oligodendrocyte identity. Trends Neurosci. 33, 193-201 (2010).
    • (2010) Trends Neurosci , vol.33 , pp. 193-201
    • Liu, J.1    Casaccia, P.2
  • 78
    • 84855477961 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells
    • Coufal, N.G. et al. Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc. Natl. Acad. Sci. USA 108, 20382-20387 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 20382-20387
    • Coufal, N.G.1
  • 79
    • 79959483607 scopus 로고    scopus 로고
    • The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3
    • Rahman, S. et al. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol. Cell. Biol. 31, 2641-2652 (2011).
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 2641-2652
    • Rahman, S.1
  • 80
    • 80052955256 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a therapeutic strategy to target c-Myc
    • Delmore, J.E. et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146, 904-917 (2011).
    • (2011) Cell , vol.146 , pp. 904-917
    • Delmore, J.E.1
  • 81
    • 78650847770 scopus 로고    scopus 로고
    • Selective inhibition of BET bromodomains
    • Filippakopoulos, P. et al. Selective inhibition of BET bromodomains. Nature 468, 1067-1073 (2010).
    • (2010) Nature , vol.468 , pp. 1067-1073
    • Filippakopoulos, P.1
  • 82
    • 78650806593 scopus 로고    scopus 로고
    • Suppression of inflammation by a synthetic histone mimic
    • Nicodeme, E. et al. Suppression of inflammation by a synthetic histone mimic. Nature 468, 1119-1123 (2010).
    • (2010) Nature , vol.468 , pp. 1119-1123
    • Nicodeme, E.1
  • 83
    • 33846252240 scopus 로고    scopus 로고
    • Genome-wide atlas of gene expression in the adult mouse brain
    • Lein, E.S. et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168-176 (2007).
    • (2007) Nature , vol.445 , pp. 168-176
    • Lein, E.S.1
  • 84
    • 33846783261 scopus 로고    scopus 로고
    • Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase
    • Kubicek, S. et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol. Cell 25, 473-481 (2007).
    • (2007) Mol. Cell , vol.25 , pp. 473-481
    • Kubicek, S.1
  • 85
    • 74249105659 scopus 로고    scopus 로고
    • Essential role of the histone methyltransferase G9a in cocaine-induced plasticity
    • Maze, I. et al. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327, 213-216 (2010).
    • (2010) Science , vol.327 , pp. 213-216
    • Maze, I.1
  • 86
    • 77957937450 scopus 로고    scopus 로고
    • Epigenetic modifications as therapeutic targets
    • Kelly, T.K., De Carvalho, D.D. & Jones, P.A. Epigenetic modifications as therapeutic targets. Nat. Biotechnol. 28, 1069-1078 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1069-1078
    • Kelly, T.K.1    De Carvalho, D.D.2    Jones, P.A.3
  • 87
    • 33744920106 scopus 로고    scopus 로고
    • Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus
    • Levenson, J.M. et al. Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus. J. Biol. Chem. 281, 15763-15773 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 15763-15773
    • Levenson, J.M.1
  • 88
    • 77954624378 scopus 로고    scopus 로고
    • Effect of 5-Aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice
    • Han, J. et al. Effect of 5-Aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice. Eur. J. Pharmacol. 642, 93-98 (2010).
    • (2010) Eur. J. Pharmacol. , vol.642 , pp. 93-98
    • Han, J.1
  • 89
    • 33847614418 scopus 로고    scopus 로고
    • Covalent modification of DNA regulates memory formation
    • Miller, C.A. & Sweatt, J.D. Covalent modification of DNA regulates memory formation. Neuron 53, 857-869 (2007).
    • (2007) Neuron , vol.53 , pp. 857-869
    • Miller, C.A.1    Sweatt, J.D.2
  • 90
    • 77956139754 scopus 로고    scopus 로고
    • Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
    • LaPlant, Q. et al. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat. Neurosci. 13, 1137-1143 (2010).
    • (2010) Nat. Neurosci. , vol.13 , pp. 1137-1143
    • Laplant, Q.1
  • 91
    • 54849426071 scopus 로고    scopus 로고
    • Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory
    • Lubin, F.D., Roth, T.L. & Sweatt, J.D. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J. Neurosci. 28, 10576-10586 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 10576-10586
    • Lubin, F.D.1    Roth, T.L.2    Sweatt, J.D.3
  • 92
    • 77952886110 scopus 로고    scopus 로고
    • Cortical DNA methylation maintains remote memory
    • Miller, C.A. et al. Cortical DNA methylation maintains remote memory. Nat. Neurosci. 13, 664-666 (2010).
    • (2010) Nat. Neurosci. , vol.13 , pp. 664-666
    • Miller, C.A.1
  • 93
    • 0035807767 scopus 로고    scopus 로고
    • Effects of cerebral ischemia in mice lacking DNA methyltransferase-1 in postmitotic neurons
    • Endres, M., Fan, G., Meisel, A., Dirnagl, U. & Jaenisch, R. Effects of cerebral ischemia in mice lacking DNA methyltransferase-1 in postmitotic neurons. Neuroreport 12, 3763-3766 (2001).
    • (2001) Neuroreport , vol.12 , pp. 3763-3766
    • Endres, M.1    Fan, G.2    Meisel, A.3    Dirnagl, U.4    Jaenisch, R.5
  • 94
    • 0034193368 scopus 로고    scopus 로고
    • DNA methyltransferase contributes to delayed ischemic brain injury
    • Endres, M. et al. DNA methyltransferase contributes to delayed ischemic brain injury. J. Neurosci. 20, 3175-3181 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 3175-3181
    • Endres, M.1
  • 95
    • 78650670619 scopus 로고    scopus 로고
    • Recent advances in the development of dual topoisomerase i and II inhibitors as anticancer drugs
    • Salerno, S. et al. Recent advances in the development of dual topoisomerase I and II inhibitors as anticancer drugs. Curr. Med. Chem. 17, 4270-4290 (2010).
    • (2010) Curr. Med. Chem. , vol.17 , pp. 4270-4290
    • Salerno, S.1
  • 96
    • 84855807682 scopus 로고    scopus 로고
    • Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons
    • Huang, H.S. et al. Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature 481, 185-189 (2012).
    • (2012) Nature , vol.481 , pp. 185-189
    • Huang, H.S.1
  • 97
    • 0034931032 scopus 로고    scopus 로고
    • The SNRPN promoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice
    • Bressler, J. et al. The SNRPN promoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice. Nat. Genet. 28, 232-240 (2001).
    • (2001) Nat. Genet. , vol.28 , pp. 232-240
    • Bressler, J.1
  • 98
    • 34249279527 scopus 로고    scopus 로고
    • Stability and flexibility of epigenetic gene regulation in mammalian development
    • Reik, W. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447, 425-432 (2007).
    • (2007) Nature , vol.447 , pp. 425-432
    • Reik, W.1
  • 99
    • 0031012849 scopus 로고    scopus 로고
    • UBE3A/E6-AP mutations cause Angelman syndrome
    • Kishino, T., Lalande, M. & Wagstaff, J. UBE3A/E6-AP mutations cause Angelman syndrome. Nat. Genet. 15, 70-73 (1997).
    • (1997) Nat. Genet. , vol.15 , pp. 70-73
    • Kishino, T.1    Lalande, M.2    Wagstaff, J.3
  • 100
    • 0031031570 scopus 로고    scopus 로고
    • De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome
    • Matsuura, T. et al. De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. Nat. Genet. 15, 74-77 (1997).
    • (1997) Nat. Genet. , vol.15 , pp. 74-77
    • Matsuura, T.1
  • 101
    • 0030890115 scopus 로고    scopus 로고
    • The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region
    • Sutcliffe, J.S. et al. The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region. Genome Res. 7, 368-377 (1997).
    • (1997) Genome Res , vol.7 , pp. 368-377
    • Sutcliffe, J.S.1
  • 102
    • 0038523969 scopus 로고    scopus 로고
    • Chimeric nucleases stimulate gene targeting in human cells
    • Porteus, M.H. & Baltimore, D. Chimeric nucleases stimulate gene targeting in human cells. Science 300, 763 (2003).
    • (2003) Science , vol.300 , pp. 763
    • Porteus, M.H.1    Baltimore, D.2
  • 103
    • 80053343092 scopus 로고    scopus 로고
    • TAL effectors: Customizable proteins for DNA targeting
    • Bogdanove, A.J. & Voytas, D.F. TAL effectors: customizable proteins for DNA targeting. Science 333, 1843-1846 (2011).
    • (2011) Science , vol.333 , pp. 1843-1846
    • Bogdanove, A.J.1    Voytas, D.F.2
  • 104
    • 83355177262 scopus 로고    scopus 로고
    • ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot
    • MiSkiewicz, K. et al. ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot. Neuron 72, 776-788 (2011).
    • (2011) Neuron , vol.72 , pp. 776-788
    • Miskiewicz, K.1
  • 105
    • 35448932480 scopus 로고    scopus 로고
    • Rubinstein-Taybi syndrome: Clinical and molecular overview
    • Roelfsema, J.H. & Peters, D.J. Rubinstein-Taybi syndrome: clinical and molecular overview. Expert Rev. Mol. Med. 9, 1-16 (2007).
    • (2007) Expert Rev. Mol. Med. , vol.9 , pp. 1-16
    • Roelfsema, J.H.1    Peters, D.J.2
  • 106
    • 42649130058 scopus 로고    scopus 로고
    • ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies and gene dysregulation
    • Ehrlich, M. et al. ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies and gene dysregulation. Autoimmunity 41, 253-271 (2008).
    • (2008) Autoimmunity , vol.41 , pp. 253-271
    • Ehrlich, M.1
  • 107
    • 82955235679 scopus 로고    scopus 로고
    • Evidence report: Genetic and metabolic testing on children with global developmental delay: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society
    • Michelson, D.J. et al. Evidence report: genetic and metabolic testing on children with global developmental delay: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 77, 1629-1635 (2011).
    • (2011) Neurology , vol.77 , pp. 1629-1635
    • Michelson, D.J.1
  • 108
    • 38849159213 scopus 로고    scopus 로고
    • A novel mutation in JARID1C/SMCX in a patient with autism spectrum disorder (ASD)
    • Adegbola, A., Gao, H., Sommer, S. & Browning, M. A novel mutation in JARID1C/SMCX in a patient with autism spectrum disorder (ASD). Am. J. Med. Genet. A. 146A, 505-511 (2008).
    • (2008) Am. J. Med. Genet. A. , vol.146 A , pp. 505-511
    • Adegbola, A.1    Gao, H.2    Sommer, S.3    Browning, M.4
  • 109
    • 69749123793 scopus 로고    scopus 로고
    • Further clinical and molecular delineation of the 9q subtelomeric deletion syndrome supports a major contribution of EHMT1 haploinsufficiency to the core phenotype
    • Kleefstra, T. et al. Further clinical and molecular delineation of the 9q subtelomeric deletion syndrome supports a major contribution of EHMT1 haploinsufficiency to the core phenotype. J. Med. Genet. 46, 598-606 (2009).
    • (2009) J. Med. Genet. , vol.46 , pp. 598-606
    • Kleefstra, T.1
  • 110
    • 84856225986 scopus 로고    scopus 로고
    • De novo CNV analysis implicates specific abnormalities of postsynap-tic signalling complexes in the pathogenesis of schizophrenia
    • Kirov, G. et al. De novo CNV analysis implicates specific abnormalities of postsynap-tic signalling complexes in the pathogenesis of schizophrenia. Mol. Psychiatry 17, 142-153 (2012).
    • (2012) Mol. Psychiatry , vol.17 , pp. 142-153
    • Kirov, G.1
  • 111
    • 80053094981 scopus 로고    scopus 로고
    • Kleefstra syndrome in three adult patients: Further delineation of the behavioral and neurological phenotype shows aspects of a neurodegenerative course
    • Verhoeven, W.M., Egger, J.I., Vermeulen, K., van de Warrenburg, B.P. & Kleefstra, T. Kleefstra syndrome in three adult patients: further delineation of the behavioral and neurological phenotype shows aspects of a neurodegenerative course. Am. J. Med. Genet. A. 155, 2409-2415 (2011).
    • (2011) Am. J. Med. Genet. A. , vol.155 , pp. 2409-2415
    • Verhoeven, W.M.1    Egger, J.I.2    Vermeulen, K.3    Van De Warrenburg, B.P.4    Kleefstra, T.5
  • 112
    • 76049084596 scopus 로고    scopus 로고
    • Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma
    • Berdasco, M. et al. Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Proc. Natl. Acad. Sci. USA 106, 21830-21835 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 21830-21835
    • Berdasco, M.1
  • 113
    • 77950893589 scopus 로고    scopus 로고
    • A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation
    • Kleine-Kohlbrecher, D. et al. A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol. Cell 38, 165-178 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 165-178
    • Kleine-Kohlbrecher, D.1
  • 114
    • 77953449792 scopus 로고    scopus 로고
    • PHF8 targets histone methylation and RNA polymerase II to activate transcription
    • Fortschegger, K. et al. PHF8 targets histone methylation and RNA polymerase II to activate transcription. Mol. Cell. Biol. 30, 3286-3298 (2010).
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 3286-3298
    • Fortschegger, K.1
  • 116
    • 80051558111 scopus 로고    scopus 로고
    • Rett syndrome: Exploring the autism link
    • Percy, A.K. Rett syndrome: exploring the autism link. Arch. Neurol. 68, 985-989 (2011).
    • (2011) Arch. Neurol. , vol.68 , pp. 985-989
    • Percy, A.K.1
  • 117
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodríguez-Paredes, M. & Esteller, M. Cancer epigenetics reaches mainstream oncology. Nat. Med. 17, 330-339 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 330-339
    • Rodríguez-Paredes, M.1    Esteller, M.2
  • 118
    • 79953163378 scopus 로고    scopus 로고
    • Chromatin higher-order structures and gene regulation
    • Li, G. & Reinberg, D. Chromatin higher-order structures and gene regulation. Curr. Opin. Genet. Dev. 21, 175-186 (2011).
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 175-186
    • Li, G.1    Reinberg, D.2
  • 119
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis, S. & Heintz, N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324, 929-930 (2009).
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 120
    • 79960249232 scopus 로고    scopus 로고
    • Genomic mapping of 5-hydroxymethyl-cytosine in the human brain
    • Jin, S.G., Wu, X., Li, A.X. & Pfeifer, G.P. Genomic mapping of 5-hydroxymethyl-cytosine in the human brain. Nucleic Acids Res. 39, 5015-5024 (2011).
    • (2011) Nucleic Acids Res , vol.39 , pp. 5015-5024
    • Jin, S.G.1    Wu, X.2    Li, A.X.3    Pfeifer, G.P.4
  • 121
    • 78651280460 scopus 로고    scopus 로고
    • Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
    • Song, C.X. et al. Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat. Biotechnol. 29, 68-72 (2011).
    • (2011) Nat. Biotechnol. , vol.29 , pp. 68-72
    • Song, C.X.1
  • 122
    • 77954504873 scopus 로고    scopus 로고
    • Conserved role of intragenic DNA methylation in regulating alternative promoters
    • Maunakea, A.K. et al. Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature 466, 253-257 (2010).
    • (2010) Nature , vol.466 , pp. 253-257
    • Maunakea, A.K.1
  • 123
    • 80052942443 scopus 로고    scopus 로고
    • Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
    • Tan, M. et al. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 146, 1016-1028 (2011).
    • (2011) Cell , vol.146 , pp. 1016-1028
    • Tan, M.1
  • 124
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides, T. Chromatin modifications and their function. Cell 128, 693-705 (2007).
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 125
    • 35848961668 scopus 로고    scopus 로고
    • How chromatin-binding modules interpret histone modifications: Lessons from professional pocket pickers
    • Taverna, S.D., Li, H., Ruthenburg, A.J., Allis, C.D. & Patel, D.J. How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat. Struct. Mol. Biol. 14, 1025-1040 (2007).
    • (2007) Nat. Struct. Mol. Biol. , vol.14 , pp. 1025-1040
    • Taverna, S.D.1    Li, H.2    Ruthenburg, A.J.3    Allis, C.D.4    Patel, D.J.5
  • 126
    • 78650304236 scopus 로고    scopus 로고
    • Charting histone modifications and the functional organization of mammalian genomes
    • Zhou, V.W., Goren, A. & Bernstein, B.E. Charting histone modifications and the functional organization of mammalian genomes. Nat. Rev. Genet. 12, 7-18 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 7-18
    • Zhou, V.W.1    Goren, A.2    Bernstein, B.E.3
  • 128
    • 34250745886 scopus 로고    scopus 로고
    • Nucleosome stability mediated by histone variants H3.3 and H2A
    • Jin, C. & Felsenfeld, G. Nucleosome stability mediated by histone variants H3.3 and H2A.Z. Genes Dev. 21, 1519-1529 (2007).
    • (2007) Z. Genes Dev. , vol.21 , pp. 1519-1529
    • Jin, C.1    Felsenfeld, G.2
  • 129
    • 29244467484 scopus 로고    scopus 로고
    • Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length
    • Woodcock, C.L., Skoultchi, A.I. & Fan, Y. Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length. Chromosome Res. 14, 17-25 (2006).
    • (2006) Chromosome Res , vol.14 , pp. 17-25
    • Woodcock, C.L.1    Skoultchi, A.I.2    Fan, Y.3
  • 130
    • 0021134257 scopus 로고
    • Neuronal nuclei and glial nuclei from mammalian cerebral cortex. Nucleosome repeat lengths, DNA contents and H1 contents
    • Pearson, E.C., Bates, D.L., Prospero, T.D. & Thomas, J.O. Neuronal nuclei and glial nuclei from mammalian cerebral cortex. Nucleosome repeat lengths, DNA contents and H1 contents. Eur. J. Biochem. 144, 353-360 (1984).
    • (1984) Eur. J. Biochem. , vol.144 , pp. 353-360
    • Pearson, E.C.1    Bates, D.L.2    Prospero, T.D.3    Thomas, J.O.4
  • 131
    • 77956683757 scopus 로고    scopus 로고
    • MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites
    • Ghosh, R.P., Horowitz-Scherer, R.A., Nikitina, T., Shlyakhtenko, L.S. & Woodcock, C.L. MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites. Mol. Cell. Biol. 30, 4656-4670 (2010).
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 4656-4670
    • Ghosh, R.P.1    Horowitz-Scherer, R.A.2    Nikitina, T.3    Shlyakhtenko, L.S.4    Woodcock, C.L.5
  • 132
    • 80052805267 scopus 로고    scopus 로고
    • Histone modification: Cause or cog?
    • Henikoff, S. & Shilatifard, A. Histone modification: cause or cog? Trends Genet. 27, 389-396 (2011).
    • (2011) Trends Genet , vol.27 , pp. 389-396
    • Henikoff, S.1    Shilatifard, A.2
  • 133
    • 80054827869 scopus 로고    scopus 로고
    • Transcriptional and epigenetic mechanisms of addiction
    • Robison, A.J. & Nestler, E.J. Transcriptional and epigenetic mechanisms of addiction. Nat. Rev. Neurosci. 12, 623-637 (2011).
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 623-637
    • Robison, A.J.1    Nestler, E.J.2
  • 134
    • 79958038559 scopus 로고    scopus 로고
    • Epigenetic mechanisms in cognition
    • Day, J.J. & Sweatt, J.D. Epigenetic mechanisms in cognition. Neuron 70, 813-829 (2011).
    • (2011) Neuron , vol.70 , pp. 813-829
    • Day, J.J.1    Sweatt, J.D.2
  • 135
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcy-tosine by TET1 promotes active DNA demethylation in the adult brain
    • Guo, J.U., Su, Y., Zhong, C., Ming, G.L. & Song, H. Hydroxylation of 5-methylcy-tosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145, 423-434 (2011).
    • (2011) Cell , vol.145 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.L.4    Song, H.5
  • 136
    • 80052933429 scopus 로고    scopus 로고
    • DNA demethylation dynamics
    • Bhutani, N., Burns, D.M. & Blau, H.M. DNA demethylation dynamics. Cell 146, 866-872 (2011).
    • (2011) Cell , vol.146 , pp. 866-872
    • Bhutani, N.1    Burns, D.M.2    Blau, H.M.3
  • 137
    • 69949148388 scopus 로고    scopus 로고
    • Protein methyltransferases as a target class for drug discovery
    • Copeland, R.A., Solomon, M.E. & Richon, V.M. Protein methyltransferases as a target class for drug discovery. Nat. Rev. Drug Discov. 8, 724-732 (2009).
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 724-732
    • Copeland, R.A.1    Solomon, M.E.2    Richon, V.M.3
  • 138
    • 80054787805 scopus 로고    scopus 로고
    • Targeting histone demethylases: A new avenue for the fight against cancer
    • Rotili, D. & Mai, A. Targeting histone demethylases: a new avenue for the fight against cancer. Genes Canc. 2, 663-679 (2011).
    • (2011) Genes Canc , vol.2 , pp. 663-679
    • Rotili, D.1    Mai, A.2
  • 139
    • 77956643239 scopus 로고    scopus 로고
    • Quantitative-interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers
    • Vermeulen, M. et al. Quantitative-interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell 142, 967-980 (2010).
    • (2010) Cell , vol.142 , pp. 967-980
    • Vermeulen, M.1
  • 140
    • 84856252670 scopus 로고    scopus 로고
    • MeCP2: Only 100% will do
    • Chao, H.T. & Zoghbi, H.Y. MeCP2: only 100% will do. Nat. Neurosci. 15, 176-177 (2012).
    • (2012) Nat. Neurosci. , vol.15 , pp. 176-177
    • Chao, H.T.1    Zoghbi, H.Y.2
  • 141
    • 84856286525 scopus 로고    scopus 로고
    • Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome
    • Samaco, R.C. et al. Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome. Nat. Genet. 44, 206-211 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 206-211
    • Samaco, R.C.1
  • 142
    • 84856270235 scopus 로고    scopus 로고
    • Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses
    • Goffin, D. et al. Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses. Nat. Neurosci. 15, 274-283 (2012).
    • (2012) Nat. Neurosci. , vol.15 , pp. 274-283
    • Goffin, D.1
  • 143
    • 63849239275 scopus 로고    scopus 로고
    • Phosphorylation of MeCP2 at serine 80 regulates its chromatin association and neurological function
    • Tao, J. et al. Phosphorylation of MeCP2 at serine 80 regulates its chromatin association and neurological function. Proc. Natl. Acad. Sci. USA 106, 4882-4887 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 4882-4887
    • Tao, J.1
  • 144
    • 79960842090 scopus 로고    scopus 로고
    • Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory
    • Li, H., Zhong, X., Chau, K.F., Williams, E.C. & Chang, Q. Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory. Nat. Neurosci. 14, 1001-1008 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 1001-1008
    • Li, H.1    Zhong, X.2    Chau, K.F.3    Williams, E.C.4    Chang, Q.5
  • 145
    • 1542513556 scopus 로고    scopus 로고
    • Mobile elements: Drivers of genome evolution
    • Kazazian, H.H. Jr. Mobile elements: drivers of genome evolution. Science 303, 1626-1632 (2004).
    • (2004) Science , vol.303 , pp. 1626-1632
    • Kazazian Jr., H.H.1
  • 146
    • 70349318211 scopus 로고    scopus 로고
    • The impact of retrotransposons on human genome evolution
    • Cordaux, R. & Batzer, M.A. The impact of retrotransposons on human genome evolution. Nat. Rev. Genet. 10, 691-703 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 691-703
    • Cordaux, R.1    Batzer, M.A.2
  • 147
    • 81855178276 scopus 로고    scopus 로고
    • Somatic retrotransposition alters the genetic landscape of the human brain
    • Baillie, J.K. et al. Somatic retrotransposition alters the genetic landscape of the human brain. Nature 479, 534-537 (2011).
    • (2011) Nature , vol.479 , pp. 534-537
    • Baillie, J.K.1
  • 148
    • 69349096044 scopus 로고    scopus 로고
    • L1 retrotransposition in human neural progenitor cells
    • Coufal, N.G. et al. L1 retrotransposition in human neural progenitor cells. Nature 460, 1127-1131 (2009).
    • (2009) Nature , vol.460 , pp. 1127-1131
    • Coufal, N.G.1
  • 149
    • 77955271952 scopus 로고    scopus 로고
    • LINE-1 retrotransposons: Mediators of somatic variation in neuronal genomes?
    • Singer, T., McConnell, M.J., Marchetto, M.C., Coufal, N.G. & Gage, F.H. LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes? Trends Neurosci. 33, 345-354 (2010).
    • (2010) Trends Neurosci , vol.33 , pp. 345-354
    • Singer, T.1    McConnell, M.J.2    Marchetto, M.C.3    Coufal, N.G.4    Gage, F.H.5
  • 150
    • 70349448571 scopus 로고    scopus 로고
    • Environmental influence on L1 retrotransposons in the adult hippocampus
    • Muotri, A.R., Zhao, C., Marchetto, M.C. & Gage, F.H. Environmental influence on L1 retrotransposons in the adult hippocampus. Hippocampus 19, 1002-1007 (2009).
    • (2009) Hippocampus , vol.19 , pp. 1002-1007
    • Muotri, A.R.1    Zhao, C.2    Marchetto, M.C.3    Gage, F.H.4
  • 151
    • 79952582606 scopus 로고    scopus 로고
    • Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens
    • Maze, I. et al. Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Proc. Natl. Acad. Sci. USA 108, 3035-3040 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 3035-3040
    • Maze, I.1
  • 152
    • 33947303168 scopus 로고    scopus 로고
    • Transposable elements and the epigenetic regulation of the genome
    • Slotkin, R.K. & Martienssen, R. Transposable elements and the epigenetic regulation of the genome. Nat. Rev. Genet. 8, 272-285 (2007).
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 272-285
    • Slotkin, R.K.1    Martienssen, R.2
  • 153
    • 20544466648 scopus 로고    scopus 로고
    • Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
    • Muotri, A.R. et al. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature 435, 903-910 (2005).
    • (2005) Nature , vol.435 , pp. 903-910
    • Muotri, A.R.1
  • 154
    • 69449086642 scopus 로고    scopus 로고
    • Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis
    • Kuwabara, T. et al. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat. Neurosci. 12, 1097-1105 (2009).
    • (2009) Nat. Neurosci. , vol.12 , pp. 1097-1105
    • Kuwabara, T.1
  • 155
    • 78549247463 scopus 로고    scopus 로고
    • L1 retrotransposition in neurons is modulated by MeCP2
    • Muotri, A.R. et al. L1 retrotransposition in neurons is modulated by MeCP2. Nature 468, 443-446 (2010).
    • (2010) Nature , vol.468 , pp. 443-446
    • Muotri, A.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.