Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease

Journal of Biological Chemistry

Volumn 280, Issue 1, 2005, Pages 556-563

  Gardian, Gabriella ^a   Browne, Susan E ^a   Choi, Dong Kug ^a   Klivenyi, Peter ^a   Gregorio, Jason ^a   Kubilus, James K ^b,c   Ryu, Hoon ^b,c   Langley, Brett ^d   Ratan, Rajiv R ^a,d,e   Ferrante, Robert J ^b,c   Beal, M Flint ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e BURKE MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; BRAIN; ENZYMES; GENES; IMMUNOLOGY; MUTAGENESIS; NEUROLOGY; PROTEINS; RNA;

GENE ENCODING; HUNTINGTON'S DISEASE (HD); NEURONAL ATROPHY;

DISEASES;

ARYLBUTYRIC ACID DERIVATIVE; CASPASE 3; HISTONE DEACETYLASE INHIBITOR; MESSENGER RNA;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ATROPHY; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; HUNTINGTON CHOREA; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; METHYLATION; MOUSE; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; WESTERN BLOTTING;

ACETYLATION; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; HISTONE DEACETYLASES; HISTONES; HUNTINGTON DISEASE; MALE; METHYLATION; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; NUCLEAR PROTEINS; PHENYLBUTYRATES; TRINUCLEOTIDE REPEAT EXPANSION; UBIQUITIN;

ANIMALIA; MUS MUSCULUS;

EID: 19944431703     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410210200     Document Type: Article

References (51)

1. Cha, J. H. (2000) Trends Neurosci. 23, 387-392
2. La Spada, A. R., Fu, Y. H., Sopher, B. L., Libby, R. T., Wang, X., Li, L. Y., Einum, D. D., Huang, J., Possin, D. E., Smith, A. C., Martinez, R. A., Koszidin, K. L., Treuting, P. M., Ware, C. M., Hurley, J. B., Ptacek, L. J., and Chen, S. (2001) Neuron 31, 913-927
3. Lin, X., Antalffy, B., Kang, D., Orr, H. T., and Zoghbi, H. Y. (2000) Nat. Neurosci. 3, 157-163
4. Luthi-Carter, R., Strand, A., Peters, N. L., Solano, S. M., Hollingsworth, Z. R., Menon, A. S., Frey, A. S., Spektor, B. S., Penney, E. B., Schilling, G., Ross, C. A., Borchelt, D. R., Tapscott, S. J., Young, A. B., Cha, J. H., and Olson, J. M. (2000) Hum. Mol. Genet. 9, 1259-1271
5. Kazantsev, A., Preisinger, E., Dranovsky, A., Goldgaber, D., and Housman, D. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11404-11409
6. Steffan, J. S., Kazantsev, A., Spasic-Boskovic, O., Greenwald, M., Zhu, Y. Z., Gohler, H., Wanker, E. E., Bates, G. P., Housman, D. E., and Thompson, L. M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6763-6768
7. Nucifora, F. C., Jr., Sasaki, M., Peters, M. F., Huang, H., Cooper, J. K., Yamada, M., Takahashi, H., Tsuji, S., Troncoso, J., Dawson, V. L., Dawson, T. M., and Ross, C. A. (2001) Science 291, 2423-2428
8. Steffan, J. S., Bodai, L., Pallos J., Poelman, M., McCampbell, A., Apostol, B. L., Kazanstev, A., Schmidt, E., Zhu, Y. Z., Greenwald, M., Kurokawa, R., Housman, D. E., Jackson G. R., Marsh, J. L., and Thompson, L. M. (2001) Nature 413, 739-743
9. Obrietan, K., and Hoyt, K. R. (2004) J. Neurosci. 24, 791-796
10. Hughes, R. E., Lo, R. S., Davis, C., Strand, A. D., Neal, C. L., Olson, J. M., and Fields, S. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 13201-13206
11. McCampbell, A., Taye, A. A., Whitty, L., Penney, E., Staffan, J. S., and Fischbeck, K. H. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 15179-15184
12. Hockly, E. Richon, V. M., Woodman, B., Smith, D. L., Zhou, X., Rosa, E., Sathasivam, K., Ghazi-Noori, S., Mahal, A., Lowden, P. A., Steffan, J. S., Marsh, J. L., Thompson, L. M., Lewis, C. M., Marks, P. A., and Bates, G. P. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 2041-2046
13. Ferrante, R. J., Kubilus, J. K., Lee, J., Ryu, H., Beesen, A., Zucker, B., Smith, K., Kowall, N. W., Ratan, R. R., Luthi-Carter, R., and Hersch, S. M. (2003) J. Neurosci. 23, 9418-9427
14. Richon, V. M., Zhou, X., Rifkind, R. A., and Marks, P. A. (2001) Blood Cells Mol. Dis. 27, 260-264
15. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. (eds) (2000) Current Protocols in Molecular Biology, pp. 61-111, Wiley, New York
16. Warrell, R. P., Jr., He, L. Z., Richon, V., Calleja, E., and Pandolfi, P. P. (1998) J. Natl. Cancer Inst. 90, 1621-1625
17. Richon, V. M., Sandhoff, T. W., Rifkind, R. A., and Marks, P. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 10014-10019
18. Andreassen, O. A., Dedeoglu, A., Ferrante, R. J., Jenkins, B. G., Ferrante, K. L., Thomas, M., Friedlich, A., Browne, S. E., Schilling, G., Borchelt, D. R., Hersch, S. M., Ross, C. A., and Beal, M. F. (2001) Neurobiol. Dis. 8, 479-491
19. Kiechle, T., Dedeoglu, A., Kubilus, J., Kowall, N. W., Beal, M. F., Friedlander, R. M., Hersch, S. M., and Ferrante, R. J. (2002) Neuromol. Med. 1, 183-195
20. Schilling, G., Becher, M. W., Sharp, A. H., Jinnah, H. A., Duan, K., Kotzuk, J. A., Slunt, H. H., Ratovitski, T., Cooper, J. K., Jenkins, N. A., Copeland, N. G., Price, D. L., Ross, C. A., and Borchelt, D. R. (1999) Hum. Mol. Genet. 8, 397-407
21. Jenkins, B. G., Andreassen, O. A., Dedeoglu, A., Leavitt, B., Hayden, M., Borchelt, D., Ross, C. A., Detloff, P., Ferrante, R. J., and Beal, M. F. (2004) J. Neurochem., in press
22. Yu, Z. X., Li, S. H., Evans, J., Pillarisetti, A., Li, H., and Li, X. J. (2003) J. Neurosci. 23, 2193-2202
23. Schilling, G., Jinnah, H. A., Gonzales, V., Coonfield, M. L., Kim, Y., Wood, J. D., Price, D. L., Li, X. J., Jenkins, N., Copeland, N., Moran, T., Ross, C. A., and Borchelt, D.R. (2001) Neurobiol. Dis. 8, 405-418
24. Ferrante, R. J., Andreassen, O.A., Dedeoglu, A., Ferrante, K. L., Jenkins, B. G., Hersch, S. M., and Beal, M. F. (2002) J. Neurosci. 22, 1592-1599
25. Schilling, G., Coonfield, M. L., Ross, C. A., and Borchelt, D. R. (2001) Neurosci. Lett. 315, 149-153
26. Dedeoglu, A., Kubilus, J. K., Ferrante, K. L., Hersch, S. M., Beal, M. F., and Ferrante, R.J. (2003) J. Neurochem. 85, 1459-1471
27. Kang, H.-L., Benzer, S., and Min, K.-T. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 839-843
28. Dedeoglu, A., Kubilus, J. K., Jeitner, T. M., Matson, S. A., Bogdanov, M., Kowall, N. W., Matson, W. R., Cooper, A. J., Ratan, R. R., Beal, M. F., Hersch, S. M., and Ferrante, R. J., (2002) J. Neurosci. 22, 8942-8950
29. Chen, M., Ona, V. O., Li, M., Ferrante, R. J., Fink, K. B., Zhu, S., Bian, J., Guo, L., Farrell, L. A., Hersch, S. M., Hobbs, W., Vonsattel, J.-P., Cha, J.-H. J., and Friedlander, R. M. (2000) Nat. Med. 6, 797-801
30. Andreassen, O. A., Ferrante, R. J., Huang, H. M., Dedeoglu, A., Park, L., Ferrante, K. L., Kwon, J., Borchelt, D. R., Ross, C. A., Gibson, G. E., and Beal, M. F. (2001) Ann. Neurol. 50, 112-117
31. Zhang, Y., and Reinberg, D. (2001) Genes Dev. 15, 2343-2360
32. Pal, S., Yun, R., Datta, A., Lacomis, L., Erdjument-Bromage, H., Kumar, J., Tempst, P., and Sif, S. (2003) Mol. Cell. Biol. 23, 7475-7487
33. Gui, C. Y., Ngo, L., Xu, W. S., Richon, V. M., and Marks, P. A. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 1241-1246
34. Deplus, R., Brenner, C., Burgers, W. A., Putmans, P., Kouzarides, T., de Launoit, Y., and Fuks, F. (2002) Nucleic Acids Res. 30, 3831-3838
35. Sekimata, M., Takahashi, A., Murakami-Sekimata, A., and Homma, Y. (2001) J. Biol. Chem. 276, 42632-42638
36. Friedlander, R. M. (2003) N. Engl. J. Med. 348, 1365-1375
37. Jana, N. R., Zemskov, E. A., Wang, G. H., and Nukina, N. (2001) Hum. Mol. Genet. 10, 1049-1059
38. Taylor, J. P., Taye, A. A., Campbell, C., Kazemi-Esfarjani, P., Fischbeck, K. H., and Min, K-T. (2003) Genes Dev. 17, 1463-1468
39. Dunah, A. W., Jeong, H., Griffin, A., Kim, Y. M., Standaert, D. G., Hersch, S. M., Mouradian, M. M., Young, A. B., Tanese, N., and Krainc, D. (2002) Science 296, 2238-2243
40. Shimohata, T., Nakajima, T., Yamada, M., Uchida, C., Onodera, O., Naruse, S., Kimura, T., Koide, R., Nozaki, K., Sano, Y., Ishiguro, H., Sakoe, K., Ooshima, T., Sato, A., Ikeuchi, T., Oyake, M, Sato, T., Aoyagi, Y., Hozumi, I., Nagatsu, T., Takiyama, Y., Nishizawa, M., Goto, J., Kanazawa, I., Davidson, I., Ranese, N., Takahashi, H., and Tsuji, S. (2000) Nat. Genet. 26, 29-36
41. Ryu, H., Lee, J., Olofsson, B. A., Mwidau, A., Dedeoglu, A., Escudero, M., Flemington, E., Azizkhan-Clifford, J., Ferrante, R. J., and Ratan, R. R. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 4281-4286
42. Bogdanov, M. B., Andreassen, O. A., Dedeoglu, A., Ferrante, R. J., and Beal, M. F. (2001) J. Neurochem. 79, 1246-1249
43. Perez-Serviano, F., Rios, C., and Segovia, J. (2000) Brain Res. 862, 234-237
44. Tabrizi, S. J., Workman, J., Hart, P. E., Mangiarini, L., Mahal, A., Bates, G., Cooper, J. M., and Schapira, A. H. (2000) Ann. Neurol. 47, 80-86
45. Dover, G. J., Brusilow, S., and Charache, S. (1994) Blood 84, 339-343
46. Hoppe, C., Vichinsky, E., Lewis, B., Foote, D., and Styles, L. (1999) Am. J. Hematol. 62, 221-227
47. Rubenstein, R. C., and Zeitlin, P. L. (1998) Am. J. Respir. Crit. Care Med. 157, 484-490
48. Burlina, A. B., Ogier, H., Korall, H., and Trefz, F. K. (2001) Mol. Genet. Metab. 72, 351-355
49. Maestri, N. E., Brusilow, S. W., Clissold, D. B., and Bassett, S. S. (1996) N. Engl. J. Med. 335, 855-859
50. Carducci, M. A., Gilbert, J., Bowling, M. K., Noe, D., Eisenberger, M. A., Sinibaldi, V., Zabelina, Y., Chen, T. L., Grochow, L. B., and Donehower, R. C. (2001) Clin. Cancer Res. 7, 3047-3055
51. Gilbert, J., Baker, S. D., Bowling, M. K., Grochow, L., Figg, W. D., Zabelina, Y., Donehower, R. C., and Carducci, M. A. (2001) Clin. Cancer Res. 7, 2292-2300