Involvement of HDAC1 and HDAC3 in the pathology of polyglutamine disorders: Therapeutic implications for selective HDAC1/HDAC3 inhibitors

Pharmaceuticals

Volumn 7, Issue 6, 2014, Pages 634-661

  Thomas, Elizabeth A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Chromatin; HDAC1; HDAC3; Histone; Histone deacetylase (HDAC); Mechanism; Neurodegenerative; Polyglutamine; Selective; Subtype

Indexed keywords

ATAXIN 1; BRAIN DERIVED NEUROTROPHIC FACTOR; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE INHIBITOR; HUNTINGTIN; POLYGLUTAMINE; VALPROIC ACID;

BDNF GENE; CEREBELLAR ATAXIA; CHROMATIN STRUCTURE; DISEASE ACTIVITY; DISEASE ASSOCIATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME ASSAY; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HISTONE UBIQUITINATION; HUMAN; HUNTINGTON CHOREA; MACHADO JOSEPH DISEASE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NEUROTOXICITY; NONHUMAN; POLYGLUTAMINE DISORDER; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; REVIEW; SPINOCEREBELLAR ATAXIA TYPE 1; SPINOCEREBELLAR ATAXIA TYPE 7; SYNDROME DELINEATION; TISSUE LEVEL;

EID: 84901505786     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph7060634     Document Type: Review

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