Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation

NeuroReport

Volumn 14, Issue 4, 2003, Pages 565-568

  Igarashi, Shuichi ^a   Morita, Hokuto ^b   Bennett, Kyla M ^b   Tanaka, Yuji ^b   Engelender, Simone ^c   Peters, Matthew F ^b   Cooper, Jillian K ^b   Wood, Jonathan D ^b   Sawa, Akira ^b   Ross, Christopher A ^b  

^a NIIGATA UNIVERSITY   (Japan)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

CBP; Histone acetyltransferase; Huntingtin; Huntington's disease; PC12; Polyglutamine

Indexed keywords

DOXYCYCLINE; HISTONE; HISTONE ACETYLTRANSFERASE; HUNTINGTIN; POLYGLUTAMINE;

ACETYLATION; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN; CHROMATIN CONDENSATION; CYTOTOXICITY; ENZYME ACTIVITY; HUNTINGTON CHOREA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; TRANSCRIPTION REGULATION;

ACETYLATION; ACETYLTRANSFERASES; ANIMALS; BLOTTING, WESTERN; CELL DEATH; DOXYCYCLINE; HISTONE ACETYLTRANSFERASES; HISTONES; HUMANS; HUNTINGTON DISEASE; NERVE GROWTH FACTOR; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PC12 CELLS; PEPTIDE FRAGMENTS; PEPTIDES; RATS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0037961686     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200303240-00007     Document Type: Article

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