Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation

Human Molecular Genetics

Volumn 24, Issue 9, 2015, Pages 2442-2457

  Biagioli, Marta ^a,b   Ferrari, Francesco ^c   Mendenhall, Eric M ^d   Zhang, Yijing ^a   Erdin, Serkan ^a   Vijayvargia, Ravi ^a,b   Vallabh, Sonia M ^a   Solomos, Nicole ^a   Manavalan, Poornima ^a   Ragavendran, Ashok ^a   Ozsolak, Fatih ^e   Lee, Jong Min ^a,b   Talkowski, Michael E ^a,f   Gusella, James F ^a,b,f   Macdonald, Marcy E ^a,b   Park, Peter J ^c,g   Seong, Ihn Sik ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Center for Biomedical Informatics   (United States)

^d UNIVERSITY OF ALABAMA IN HUNTSVILLE   (United States)

^e Translate Bio Inc   (United States)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; HUNTINGTIN; POLYCOMB REPRESSIVE COMPLEX 2; CHROMATIN; HUNTINGTON PROTEIN, MOUSE; NERVE PROTEIN; NUCLEAR PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CAG REPEAT; CHROMATIN; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; GENE; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; HISTONE MODIFICATION; HTT GENE; MOUSE; NEURAL STEM CELL; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA SEQUENCE; ALLELE; ANIMAL; CHEMISTRY; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN IMMUNOPRECIPITATION; CLUSTER ANALYSIS; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HIGH THROUGHPUT SEQUENCING; METABOLISM; MUTATION; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT;

ALLELES; ANIMALS; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN IMMUNOPRECIPITATION; CLUSTER ANALYSIS; EMBRYONIC STEM CELLS; GENE DELETION; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HISTONES; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NEURAL STEM CELLS; NUCLEAR PROTEINS; POLYCOMB REPRESSIVE COMPLEX 2; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84930421685     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv006     Document Type: Article

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