ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease

Cell Death and Differentiation

Volumn 19, Issue 7, 2012, Pages 1109-1116

  Lee, J ^a,b   Hong, Y K ^c   Jeon, G S ^d   Hwang, Y J ^d   Kim, K Y ^d   Seong, K H ^d   Jung, M K ^d   Picketts, D J ^e   Kowall, N W ^a,b   Cho, K S ^c   Ryu, H ^a,b,d  

^a VA BOSTON HEALTHCARE SYSTEM   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Konkuk University   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

^e OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

ATRX; Cdx 2; heterochromatin condensation; huntingtin; Huntington's disease

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALPHA THALASSEMIA MENTAL RETARDATION X LINKED PROTEIN; HELICASE; HUNTINGTIN; MUTANT PROTEIN; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LINE; CELL NUCLEUS INCLUSION BODY; CELL SIZE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN CONDENSATION; CONTROLLED STUDY; DEGENERATION; DISEASE EXACERBATION; EYE DEGENERATION; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE INDUCTION; GENE SILENCING; HETEROCHROMATIN; HETEROCHROMATIN CONDENSATION; HUNTINGTON CHOREA; MALE; MOUSE; NEUROMODULATION; NEUROPATHOLOGY; NONHUMAN; PERICENTROMERIC HETEROCHROMATIN; PRIORITY JOURNAL; PROMOTER REGION; PROMYELOCYTIC LEUKEMIA NUCLEAR BODY; PROTEIN METHYLATION; TRANSCRIPTION REGULATION; TRIMETHYLATION;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA HELICASES; DROSOPHILA; DROSOPHILA PROTEINS; HETEROCHROMATIN; HISTONES; HOMEODOMAIN PROTEINS; HUMANS; HUNTINGTON DISEASE; MALE; METHYLATION; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84862786311     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2011.196     Document Type: Article

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