Targeting caveolin-3 for the treatment of diabetic cardiomyopathy

Pharmacology and Therapeutics

Volumn 151, Issue , 2015, Pages 50-71

  Murfitt, Lucy ^a   Whiteley, Gareth ^a,b   Iqbal, Mohammad M ^a   Kitmitto, Ashraf ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Cardiac remodelling; Caveolin 3; Diabetes; Diabetic cardiomyopathy; Excitation contraction coupling

Indexed keywords

ANTAGOMIR; CAVEOLIN 3; GLUCOSE; INSULIN; ION CHANNEL; MICRORNA; CAVEOLIN 1; NITRIC OXIDE SYNTHASE;

ACTION POTENTIAL; ANIMAL MODEL; ARTICLE; CELL MEMBRANE; CLINICAL TRIAL (TOPIC); DIABETIC CARDIOMYOPATHY; DISEASE COURSE; DRUG TARGETING; EXCITATION CONTRACTION COUPLING; EXERCISE; GENE THERAPY; GLUCOSE TRANSPORT; HEART MUSCLE CONTRACTILITY; HEART RHYTHM; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; LIFESTYLE MODIFICATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TISSUE SCAFFOLD; UPREGULATION; ANIMAL; DIABETIC CARDIOMYOPATHIES; GENETICS; HEART CONTRACTION; HEART MUSCLE; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN PROCESSING;

ANIMALS; CAVEOLIN 1; CAVEOLIN 3; DIABETIC CARDIOMYOPATHIES; GENETIC THERAPY; GLUCOSE; HUMANS; INSULIN; MICRORNAS; MOLECULAR TARGETED THERAPY; MYOCARDIAL CONTRACTION; MYOCARDIUM; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION;

EID: 84930082128     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2015.03.002     Document Type: Review

References (329)

1. E. Aasum, A.D. Hafstad, D.L. Severson, and T.S. Larsen Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice Diabetes 52 2003 434 441
2. T. Adachi, R.M. Weisbrod, D.R. Pimentel, J. Ying, V.S. Sharov, and C. Schoneich S-glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide Nat Med 10 2004 1200 1207
3. J.R. Alegria, T.D. Miller, R.J. Gibbons, Q.L. Yi, S. Yusuf, and Collaborative Organization of RheothRx Evaluation Trial, I. Infarct size, ejection fraction, and mortality in diabetic patients with acute myocardial infarction treated with thrombolytic therapy Am Heart J 154 2007 743 750
4. American Diabetes Association Diagnosis and classification of diabetes mellitus Diabetes Care 33 1 2010 S62 69
5. A. Aneja, W.H. Tang, S. Bansilal, M.J. Garcia, and M.E. Farkouh Diabetic cardiomyopathy: Insights into pathogenesis, diagnostic challenges, and therapeutic options Am J Med 121 2008 748 757
6. B. Aravamudan, D. Volonte, R. Ramani, E. Gursoy, M.P. Lisanti, and B. London Transgenic overexpression of caveolin-3 in the heart induces a cardiomyopathic phenotype Hum Mol Genet 12 2003 2777 2788
7. M. Armoni, C. Harel, F. Bar-Yoseph, S. Milo, and E. Karnieli Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response elements J Biol Chem 280 2005 34786 34795
8. A. Avogaro, R. Nosadini, A. Doria, P. Fioretto, M. Velussi, and C. Vigorito Myocardial metabolism in insulin-deficient diabetic humans without coronary artery disease Am J Physiol 258 1990 E606 E618
9. R.C. Balijepalli, B.P. Delisle, S.Y. Balijepalli, J.D. Foell, J.K. Slind, and T.J. Kamp Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol Channels (Austin) 1 2007 263 272
10. R.C. Balijepalli, J.D. Foell, D.D. Hall, J.W. Hell, and T.J. Kamp Localization of cardiac L-type Ca2+ channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation Proc Natl Acad Sci U S A 103 2006 7500 7505
11. R.C. Balijepalli, J.D. Foell, D.D. Hall, J.W. Hell, and T.J. Kamp Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation Proc Natl Acad Sci U S A 103 2006 7500 7505
12. D. Bansal, Y. Badhan, K. Gudala, and F. Schifano Ruboxistaurin for the treatment of diabetic peripheral neuropathy: a systematic review of randomized clinical trials Diabetes Metab J 37 2013 375 384
13. L.A. Barouch, R.W. Harrison, M.W. Skaf, G.O. Rosas, T.P. Cappola, and Z.A. Kobeissi Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms Nature 416 2002 337 339
14. P.M. Bauer, D. Fulton, Y.C. Boo, G.P. Sorescu, B.E. Kemp, and H. Jo Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase J Biol Chem 278 2003 14841 14849
15. M. Bayeva, K.T. Sawicki, and H. Ardehali Taking diabetes to heart - deregulation of myocardial lipid metabolism in diabetic cardiomyopathy J Am Heart Assoc 2 2013 e000433
16. K. Bedard, and K.H. Krause The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology Physiol Rev 87 2007 245 313
17. A. Belevych, Z. Kubalova, D. Terentyev, R.L. Hamlin, C.A. Carnes, and S. Gyorke Enhanced ryanodine receptor-mediated calcium leak determines reduced sarcoplasmic reticulum calcium content in chronic canine heart failure Biophys J 93 2007 4083 4092
18. D.D. Belke, T.S. Larsen, E.M. Gibbs, and D.L. Severson Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice Am J Physiol Endocrinol Metab 279 2000 E1104 E1113
19. D.D. Belke, E.A. Swanson, and W.H. Dillmann Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heart Diabetes 53 2004 3201 3208
20. D.A. Bellinger, E.P. Merricks, and T.C. Nichols Swine models of type 2 diabetes mellitus: Insulin resistance, glucose tolerance, and cardiovascular complications ILAR J 47 2006 243 258
21. A.M. Bellinger, S. Reiken, C. Carlson, M. Mongillo, X. Liu, and L. Rothman Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle Nat Med 15 2009 325 330
22. J.K. Bendall, T. Damy, P. Ratajczak, X. Loyer, V. Monceau, and I. Marty Role of myocardial neuronal nitric oxide synthase-derived nitric oxide in beta-adrenergic hyporesponsiveness after myocardial infarction-induced heart failure in rat Circulation 110 2004 2368 2375
23. J.P. Benitah, B.G. Kerfant, G. Vassort, S. Richard, and A.M. Gomez Altered communication between L-type calcium channels and ryanodine receptors in heart failure Front Biosci 7 2002 e263 e275
24. H.J. Bennett, J.B. Davenport, R.F. Collins, A.W. Trafford, C. Pinali, and A. Kitmitto Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response Biochem J 456 2013 205 217
25. J. Berger, C. Biswas, P.P. Vicario, H.V. Strout, R. Saperstein, and P.F. Pilch Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting Nature 340 1989 70 72
26. D.M. Bers Excitation-Contraction Coupling and Cardiac Contractile Force K. A. Publishers Vol. ed2 2001
27. D.M. Bers Cardiac excitation-contraction coupling Nature 415 2002 198 205
28. D.M. Bers Macromolecular complexes regulating cardiac ryanodine receptor function J Mol Cell Cardiol 37 2004 417 429
29. K.R. Bidasee, U.D. Dincer, and H.R. Besch Jr. Ryanodine receptor dysfunction in hearts of streptozotocin-induced diabetic rats Mol Pharmacol 60 2001 1356 1364
30. 2+-ATPase Diabetes 53 2004 463 473
31. A. Bosman, L. Sartiani, V. Spinelli, M. Del Lungo, F. Stillitano, and D. Nosi Molecular and functional evidence of HCN4 and caveolin-3 interaction during cardiomyocyte differentiation from human embryonic stem cells Stem Cells Dev 22 2013 1717 1727
32. J. Bossuyt, B.E. Taylor, M. James-Kracke, and C.C. Hale The cardiac sodium-calcium exchanger associates with caveolin-3 Ann N Y Acad Sci 976 2002 197 204
33. S. Boudina, and E.D. Abel Diabetic cardiomyopathy, causes and effects Rev Endocr Metab Disord 11 2010 31 39
34. S. Boudina, S. Sena, B.T. O'Neill, P. Tathireddy, M.E. Young, and E.D. Abel Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity Circulation 112 2005 2686 2695
35. S. Boudina, S. Sena, H. Theobald, X. Sheng, J.J. Wright, and X.X. Hu Mitochondrial energetics in the heart in obesity-related diabetes: Direct evidence for increased uncoupled respiration and activation of uncoupling proteins Diabetes 56 2007 2457 2466
36. J.K. Boyer, S. Thanigaraj, K.B. Schechtman, and J.E. Perez Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus Am J Cardiol 93 2004 870 875
37. M. Brault, J. Ray, Y.H. Gomez, C.S. Mantzoros, and S.S. Daskalopoulou Statin treatment and new-onset diabetes: A review of proposed mechanisms Metabolism 63 2014 735 745
38. M. Brownlee Advanced protein glycosylation in diabetes and aging Annu Rev Med 46 1995 223 234
39. N.J. Bryant, R. Govers, and D.E. James Regulated transport of the glucose transporter GLUT4 Nat Rev Mol Cell Biol 3 2002 267 277
40. S. Bryant, T.E. Kimura, C.H. Kong, J.J. Watson, A. Chase, and M.S. Suleiman Stimulation of ICa by basal PKA activity is facilitated by caveolin-3 in cardiac ventricular myocytes J Mol Cell Cardiol 68 2014 47 55
41. M. Bucci, J.P. Gratton, R.D. Rudic, L. Acevedo, F. Roviezzo, and G. Cirino In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation Nat Med 6 12 2000 1362 1367
42. J. Buchanan, P.K. Mazumder, P. Hu, G. Chakrabarti, M.W. Roberts, and U.J. Yun Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity Endocrinology 146 2005 5341 5349
43. D.P. Byrne, C. Dart, and D.J. Rigden Evaluating caveolin interactions: Do proteins interact with the caveolin scaffolding domain through a widespread aromatic residue-rich motif? PLoS ONE 7 2012 e44879
44. E. Camors, and H.H. Valdivia CaMKII regulation of cardiac ryanodine receptors and inositol triphosphate receptors Front Pharmacol 5 2014 101
45. M. Camps, A. Castello, P. Munoz, M. Monfar, X. Testar, and M. Palacin Effect of diabetes and fasting on GLUT-4 (muscle/fat) glucose-transporter expression in insulin-sensitive tissues. Heterogeneous response in heart, red and white muscle Biochem J 282 Pt 3 1992 765 772
46. F. Capozza, A.W. Cohen, M.W. Cheung, F. Sotgia, W. Schubert, and M. Battista Muscle-specific interaction of caveolin isoforms: Differential complex formation between caveolins in fibroblastic vs. muscle cells Am J Physiol Cell Physiol 288 2005 C677 C691
47. S. Carugo, C. Giannattasio, I. Calchera, F. Paleari, M.G. Gorgoglione, and A. Grappiolo Progression of functional and structural cardiac alterations in young normotensive uncomplicated patients with type 1 diabetes mellitus J Hypertens 19 2001 1675 1680
48. O. Casis, M. Gallego, M. Iriarte, and J.A. Sanchez-Chapula Effects of diabetic cardiomyopathy on regional electrophysiologic characteristics of rat ventricle Diabetologia 43 2000 101 109
49. L.H. Chamberlain, and G.W. Gould The vesicle- and target-SNARE proteins that mediate Glut4 vesicle fusion are localized in detergent-insoluble lipid rafts present on distinct intracellular membranes J Biol Chem 277 2002 49750 49754
50. S. Chen, P. Puthanveetil, B. Feng, S.J. Matkovich, G.W. Dorn II, and S. Chakrabarti Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes J Cell Mol Med 18 2014 415 421
51. H. Cheng, W.J. Lederer, and M.B. Cannell Calcium sparks: Elementary events underlying excitation-contraction coupling in heart muscle Science 262 1993 740 744
52. J. Cheng, C.R. Valdivia, R. Vaidyanathan, R.C. Balijepalli, M.J. Ackerman, and J.C. Makielski Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A J Mol Cell Cardiol 61 2013 102 110
53. W.J. Cho, A.K. Chow, R. Schulz, and E.E. Daniel Caveolin-1 exists and may function in cardiomyocytes Can J Physiol Pharmacol 88 2010 73
54. K.M. Choi, Y. Zhong, B.D. Hoit, I.L. Grupp, H. Hahn, and K.W. Dilly Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats Am J Physiol Heart Circ Physiol 283 2002 H1398 H1408
55. C. Christoffersen, E. Bollano, M.L. Lindegaard, E.D. Bartels, J.P. Goetze, and C.B. Andersen Cardiac lipid accumulation associated with diastolic dysfunction in obese mice Endocrinology 144 2003 3483 3490
56. T.H. Chung, S.M. Wang, J.Y. Liang, S.H. Yang, and J.C. Wu The interaction of estrogen receptor alpha and caveolin-3 regulates connexin43 phosphorylation in metabolic inhibition-treated rat cardiomyocytes Int J Biochem Cell Biol 41 2009 2323 2333
57. A.W. Cohen, T.P. Combs, P.E. Scherer, and M.P. Lisanti Role of caveolin and caveolae in insulin signaling and diabetes Am J Physiol Endocrinol Metab 285 2003 E1151 E1160
58. A.W. Cohen, D.S. Park, S.E. Woodman, T.M. Williams, M. Chandra, and J. Shirani Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts Am J Physiol Cell Physiol 284 2003 C457 C474
59. A.W. Cohen, B. Razani, X.B. Wang, T.P. Combs, T.M. Williams, and P.E. Scherer Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue Am J Physiol Cell Physiol 285 2003 C222 C235
60. B.M. Collins, M.J. Davis, J.F. Hancock, and R.G. Parton Structure-based reassessment of the caveolin signaling model: Do caveolae regulate signaling through caveolin-protein interactions? Dev Cell 23 2012 11 20
61. M.E. Cooper Importance of advanced glycation end products in diabetes-associated cardiovascular and renal disease Am J Hypertens 17 2004 31S 38S
62. S.L. Coort, J.J. Luiken, G.J. van der Vusse, A. Bonen, and J.F. Glatz Increased FAT (fatty acid translocase)/CD36-mediated long-chain fatty acid uptake in cardiac myocytes from obese Zucker rats Biochem Soc Trans 32 2004 83 85
63. D.J. Crossman, P.N. Ruygrok, C. Soeller, and M.B. Cannell Changes in the organization of excitation-contraction coupling structures in failing human heart PLoS ONE 6 2011 e17901
64. M.J. Cutler, B.N. Plummer, X. Wan, Q.A. Sun, D. Hess, and H. Liu Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart Proc Natl Acad Sci U S A 109 2012 18186 18191
65. T. Damy, P. Ratajczak, A.M. Shah, E. Camors, I. Marty, and G. Hasenfuss Increased neuronal nitric oxide synthase-derived NO production in the failing human heart Lancet 363 2004 1365 1367
66. M. Das, J. Cui, and D.K. Das Generation of survival signal by differential interaction of p38MAPKalpha and p38MAPKbeta with caveolin-1 and caveolin-3 in the adapted heart J Mol Cell Cardiol 42 2007 206 213
67. M. Das, S. Das, P. Wang, S.R. Powell, and D.K. Das Caveolin and proteasome in tocotrienol mediated myocardial protection Cell Physiol Biochem 22 2008 287 294
68. S. Das, S.R. Powell, P. Wang, A. Divald, K. Nesaretnam, and A. Tosaki Cardioprotection with palm tocotrienol: Antioxidant activity of tocotrienol is linked with its ability to stabilize proteasomes Am J Physiol Heart Circ Physiol 289 2005 H361 H367
69. L.M. Davies, G.I. Purves, R. Barrett-Jolley, and C. Dart Interaction with caveolin-1 modulates vascular ATP-sensitive potassium (KATP) channel activity J Physiol 588 2010 3255 3266
70. C. Depre, M.E. Young, J. Ying, H.S. Ahuja, Q. Han, and N. Garza Streptozotocin-induced changes in cardiac gene expression in the absence of severe contractile dysfunction J Mol Cell Cardiol 32 6 2000 985 996
71. G. de Simone, R.B. Devereux, M. Chinali, E.T. Lee, J.M. Galloway, and A. Barac Diabetes and incident heart failure in hypertensive and normotensive participants of the Strong Heart Study J Hypertens 28 2010 353 360
72. Diabetes, UK. Diabetes in the UK: Key statistics on diabetes In. http://www.diabetes.org.uk/Documents/Reports/Diabetes-in-the-UK-2012.pdf 2012
73. X. Diao, E. Shen, X. Wang, and B. Hu Differentially expressed microRNAs and their target genes in the hearts of streptozotocin-induced diabetic mice Mol Med Rep 4 2011 633 640
74. V. Di Bello, L. Talarico, E. Picano, C. Di Muro, L. Landini, and M. Paterni Increased echodensity of myocardial wall in the diabetic heart: an ultrasound tissue characterization study J Am Coll Cardiol 25 6 1995 1408 1415
75. A. Doria, R. Nosadini, A. Avogaro, P. Fioretto, and G. Crepaldi Myocardial metabolism in type 1 diabetic patients without coronary artery disease Diabet Med 8 1991 S104 S107 (Spec No)
76. M. Drab, P. Verkade, M. Elger, M. Kasper, M. Lohn, and B. Lauterbach Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice Science 293 2001 2449 2452
77. A. Dresner, D. Laurent, M. Marcucci, M.E. Griffin, S. Dufour, and G.W. Cline Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity J Clin Invest 103 1999 253 259
78. H. Drexler, S. Kastner, A. Strobel, R. Studer, O.E. Brodde, and G. Hasenfuss Expression, activity and functional significance of inducible nitric oxide synthase in the failing human heart J Am Coll Cardiol 32 1998 955 963
79. X. Du, T. Matsumura, D. Edelstein, L. Rossetti, Z. Zsengeller, and C. Szabo Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells J Clin Invest 112 2003 1049 1057
80. W.J. Durham, P. Aracena-Parks, C. Long, A.E. Rossi, S.A. Goonasekera, and S. Boncompagni RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice Cell 133 2008 53 65
81. M. Edidin Shrinking patches and slippery rafts: scales of domains in the plasma membrane Trends Cell Biol 11 2001 492 496
82. S. Egert, N. Nguyen, and M. Schwaiger Contribution of alpha-adrenergic and beta-adrenergic stimulation to ischemia-induced glucose transporter (GLUT) 4 and GLUT1 translocation in the isolated perfused rat heart Circ Res 84 1999 1407 1415
83. J.A. Engelman, C. Chu, A. Lin, H. Jo, T. Ikezu, and T. Okamoto Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain FEBS Lett 428 1998 205 211
84. J.R. Erickson, L. Pereira, L. Wang, G. Han, A. Ferguson, and K. Dao Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation Nature 502 2013 372 376
85. Z.Y. Fang, J.B. Prins, and T.H. Marwick Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications Endocr Rev 25 2004 543 567
86. O. Feron, L. Belhassen, L. Kobzik, T.W. Smith, R.A. Kelly, and T. Michel Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells J Biol Chem 271 1996 22810 22814
87. O. Feron, C. Dessy, D.J. Opel, M.A. Arstall, R.A. Kelly, and T. Michel Modulation of the endothelial nitric-oxide synthase-caveolin interaction in cardiac myocytes. Implications for the autonomic regulation of heart rate J Biol Chem 273 1998 30249 30254
88. O. Feron, F. Saldana, J.B. Michel, and T. Michel The endothelial nitric-oxide synthase-caveolin regulatory cycle J Biol Chem 273 1998 3125 3128
89. P. Ferrer Systems biology and biological systems diversity for the engineering of microbial cell factories Microb Cell Fact 6 2007 35
90. C.J. Fielding, A. Bist, and P.E. Fielding Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers Proc Natl Acad Sci U S A 94 1997 3753 3758
91. I. Fleming, B. Fisslthaler, S. Dimmeler, B.E. Kemp, and R. Busse Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity Circ Res 88 2001 E68 E75
92. M.S. Forbes, and N. Sperelakis Association between mitochondria and gap junctions in mammalian myocardial cells Tissue Cell 14 1982 25 37
93. A.M. Fra, E. Williamson, K. Simons, and R.G. Parton De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin Proc Natl Acad Sci U S A 92 1995 8655 8659
94. C. Franzini-Armstrong, F. Protasi, and V. Ramesh Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles Biophys J 77 1999 1528 1539
95. R.C. Friedman, K.K. Farh, C.B. Burge, and D.P. Bartel Most mammalian mRNAs are conserved targets of microRNAs Genome Res 19 2009 92 105
96. 2+-dependent manner J Cell Mol Med 10 2006 216 224
97. M. Fukuchi, S.N. Hussain, and A. Giaid Heterogeneous expression and activity of endothelial and inducible nitric oxide synthases in end-stage human heart failure: Their relation to lesion site and beta-adrenergic receptor therapy Circulation 98 1998 132 139
98. F. Galbiati, J.A. Engelman, D. Volonte, X.L. Zhang, C. Minetti, and M. Li Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities J Biol Chem 276 2001 21425 21433
99. F. Galbiati, D. Volonte, J.B. Chu, M. Li, S.W. Fine, and M. Fu Transgenic overexpression of caveolin-3 in skeletal muscle fibers induces a Duchenne-like muscular dystrophy phenotype Proc Natl Acad Sci U S A 97 2000 9689 9694
100. F. Galbiati, D. Volonte, and M.P. Lisanti Caveolin-3 knock-out mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and T-tubule abnormalities Mol Biol Cell 12 2001 80A 81A
101. M. Gallego, A. Alday, J. Urrutia, and O. Casis Transient outward potassium channel regulation in healthy and diabetic hearts Can J Physiol Pharmacol 87 2009 77 83
102. G. Garcia-Cardena, R. Fan, D.F. Stern, J. Liu, and W.C. Sessa Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1 J Biol Chem 271 1996 27237 27240
103. V. Garg, J. Jiao, and K. Hu Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes Cardiovasc Res 82 2009 51 58
104. V. Garg, W. Sun, and K. Hu Caveolin-3 negatively regulates recombinant cardiac K(ATP) channels Biochem Biophys Res Commun 385 2009 472 477
105. S.M. Genuth, J.Y. Backlund, M. Bayless, D.A. Bluemke, P.A. Cleary, and J. Crandall Effects of prior intensive versus conventional therapy and history of glycemia on cardiac function in type 1 diabetes in the DCCT/EDIC Diabetes 62 2013 3561 3569
106. A. Goldin, J.A. Beckman, A.M. Schmidt, and M.A. Creager Advanced glycation end products: Sparking the development of diabetic vascular injury Circulation 114 2006 597 605
107. D.R. Gonzalez, A.V. Treuer, J. Castellanos, R.A. Dulce, and J.M. Hare Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failure J Biol Chem 285 2010 28938 28945
108. J.P. Gratton, M.I. Lin, J. Yu, E.D. Weiss, Z.L. Jiang, and T.A. Fairchild Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice Cancer Cell 4 2003 31 39
109. S. Greco, P. Fasanaro, S. Castelvecchio, Y. D'Alessandra, D. Arcelli, and M. Di Donato MicroRNA dysregulation in diabetic ischemic heart failure patients Diabetes 61 2012 1633 1641
110. B. Greenberg, A. Yaroshinsky, K.M. Zsebo, J. Butler, G.M. Felker, and A.A. Voors Design of a phase 2b trial of intracoronary administration of AAV1/SERCA2a in patients with advanced heart failure: the CUPID 2 trial (calcium up-regulation by percutaneous administration of gene therapy in cardiac disease phase 2b) JACC Heart Fail 2 2014 84 92
111. M.E. Griffin, M.J. Marcucci, G.W. Cline, K. Bell, N. Barucci, and D. Lee Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade Diabetes 48 1999 1270 1274
112. J. Guo, T. Wang, X. Li, H. Shallow, T. Yang, and W. Li Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2 J Biol Chem 287 2012 33132 33141
113. M. Guo, M.H. Wu, F. Korompai, and S.Y. Yuan Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes Physiol Genomics 12 2003 139 146
114. J. Gustavsson, S. Parpal, M. Karlsson, C. Ramsing, H. Thorn, and M. Borg Localization of the insulin receptor in caveolae of adipocyte plasma membrane FASEB J 13 1999 1961 1971
115. H. Ha, and Y. Pak Modulation of the caveolin-3 and Akt status in caveolae by insulin resistance in H9c2 cardiomyoblasts Exp Mol Med 37 2005 169 178
116. S.M. Haffner, S. Lehto, T. Ronnemaa, K. Pyorala, and M. Laakso Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction N Engl J Med 339 1998 229 234
117. D. Hailstones, L.S. Sleer, R.G. Parton, and K.K. Stanley Regulation of caveolin and caveolae by cholesterol in MDCK cells J Lipid Res 39 1998 369 379
118. J.M. Hare, R.A. Lofthouse, G.J. Juang, L. Colman, K.M. Ricker, and B. Kim Contribution of caveolin protein abundance to augmented nitric oxide signaling in conscious dogs with pacing-induced heart failure Circ Res 86 2000 1085 1092
119. R.D. Harvey, and S.C. Calaghan Caveolae create local signalling domains through their distinct protein content, lipid profile and morphology J Mol Cell Cardiol 52 2012 366 375
120. T. Hayashi, T. Arimura, K. Ueda, H. Shibata, S. Hohda, and M. Takahashi Identification and functional analysis of a caveolin-3 mutation associated with familial hypertrophic cardiomyopathy Biochem Biophys Res Commun 313 2004 178 184
121. T. Hayashi, P.A. Juliet, A. Miyazaki, L.J. Ignarro, and A. Iguchi High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase: Implications for atherosclerosis Biochim Biophys Acta 1772 2007 364 372
122. B.P. Head, H.H. Patel, D.M. Roth, N.C. Lai, I.R. Niesman, and M.G. Farquhar G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes J Biol Chem 280 2005 31036 31044
123. B.P. Head, H.H. Patel, D.M. Roth, F. Murray, J.S. Swaney, and I.R. Niesman Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components J Biol Chem 281 2006 26391 26399
124. R.A. Heptulla, A. Stewart, S. Enocksson, F. Rife, T.Y. Ma, and R.S. Sherwin In situ evidence that peripheral insulin resistance in adolescents with poorly controlled type 1 diabetes is associated with impaired suppression of lipolysis: A microdialysis study Pediatr Res 53 2003 830 835
125. P. Herrero, L.R. Peterson, J.B. McGill, S. Matthew, D. Lesniak, and C. Dence Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus J Am Coll Cardiol 47 2006 598 604
126. C. Heymes, J.K. Bendall, P. Ratajczak, A.C. Cave, J.L. Samuel, and G. Hasenfuss Increased myocardial NADPH oxidase activity in human heart failure J Am Coll Cardiol 41 2003 2164 2171
127. T. Hong, H. Yang, S.S. Zhang, H.C. Cho, M. Kalashnikova, and B. Sun Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia Nat Med 20 2014 624 632
128. Y.T. Horikawa, H.H. Patel, Y.M. Tsutsumi, M.M. Jennings, M.W. Kidd, and Y. Hagiwara Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury J Mol Cell Cardiol 44 2008 123 130
129. F.C. Howarth, M.A. Qureshi, Z. Hassan, L.T. Al Kury, D. Isaev, and K. Parekh Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+ signalling in young type 2 Zucker diabetic fatty rat heart Exp Physiol 96 2011 325 337
130. F.C. Howarth, M.A. Qureshi, Z. Hassan, D. Isaev, K. Parekh, and A. John Contractility of ventricular myocytes is well preserved despite alteredmechanisms of Ca2+ transport and a changing pattern of mRNA in aged type 2 Zucker diabetic fatty rat heart J Mol Cell Biochem 361 1-2 2012 267 280
131. D.J. Hunt, P.P. Jones, R. Wang, W. Chen, J. Bolstad, and K. Chen K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association Biochem J 404 2007 431 438
132. K. Huynh, B.C. Bernardo, J.R. McMullen, and R.H. Ritchie Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways Pharmacol Ther 142 2014 375 415
133. M. Ibrahim, J. Gorelik, M.H. Yacoub, and C.M. Terracciano The structure and function of cardiac t-tubules in health and disease Proc Biol Sci 278 2011 2714 2723
134. M. Ibrahim, U. Siedlecka, B. Buyandelger, M. Harada, C. Rao, and A. Moshkov A critical role for Telethonin in regulating t-tubule structure and function in the mammalian heart Hum Mol Genet 22 2013 372 383
135. F. Ichinose, K.D. Bloch, J.C. Wu, R. Hataishi, H.T. Aretz, and M.H. Picard Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency Am J Physiol Heart Circ Physiol 286 2004 H1070 H1075
136. M. Isfort, S.C. Stevens, S. Schaffer, C.J. Jong, and L.E. Wold Metabolic dysfunction in diabetic cardiomyopathy Heart Fail Rev 19 2014 35 48
137. S. Jesmin, S. Zaedi, S. Maeda, I. Yamaguchi, K. Goto, and T. Miyauchi Effects of a selective endothelin a receptor antagonist on the expressions of iNOS and eNOS in the heart of early streptozotocin-induced diabetic rats Exp Biol Med (Maywood) 231 2006 925 931
138. H. Jo, H. Otani, F. Jo, T. Shimazu, T. Okazaki, and K. Yoshioka Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice Clin Exp Pharmacol Physiol 38 2011 485 493
139. I.I. Joffe, K.E. Travers, C.L. Perreault-Micale, T. Hampton, S.E. Katz, and J.P. Morgan Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: Noninvasive assessment with Doppler echocardiography and contribution of the nitric oxide pathway J Am Coll Cardiol 34 1999 2111 2119
140. E.E. Jweied, R.D. McKinney, L.A. Walker, I. Brodsky, A.S. Geha, and M.G. Massad Depressed cardiac myofilament function in human diabetes mellitus Am J Physiol Heart Circ Physiol 289 2005 H2478 H2483
141. J.K. Kahn, J.C. Sisson, and A.I. Vinik QT interval prolongation and sudden cardiac death in diabetic autonomic neuropathy J Clin Endocrinol Metab 64 4 1987 751 754
142. 2+ homeostasis of single smooth muscle cells from rat cerebral resistance arteries Am J Physiol-Heart C 293 2007 H204 H214
143. W.B. Kannel, M. Hjortland, and W.P. Castelli Role of diabetes in congestive heart failure: The Framingham study Am J Cardiol 34 1974 29 34
144. M. Karlsson, H. Thorn, S. Parpal, P. Stralfors, and J. Gustavsson Insulin induces translocation of glucose transporter GLUT4 to plasma membrane caveolae in adipocytes FASEB J 16 2002 249 251
145. 2+ exchange Can J Physiol Pharmacol 78 2000 12 19
146. T. Khan, M.P. Hamilton, D.I. Mundy, S.C. Chua, and P.E. Scherer Impact of simvastatin on adipose tissue: Pleiotropic effects in vivo Endocrinology 150 2009 5262 5272
147. 2+-ATPase and phospholamban protein expression Life Sci 70 2001 367 379
148. A.J.F. King The use of animal models in diabetes research Br J Pharmacol 166 2012 877 894
149. M. Kirkham, S.J. Nixon, M.T. Howes, L. Abi-Rached, D.E. Wakeham, and M. Hanzal-Bayer Evolutionary analysis and molecular dissection of caveola biogenesis J Cell Sci 121 2008 2075 2086
150. R. Kluge, S. Scherneck, A. Schurmann, and H.G. Joost Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: A model of the human metabolic syndrome Methods Mol Biol 933 2012 59 73
151. A. Koga, N. Oka, T. Kikuchi, H. Miyazaki, S. Kato, and T. Imaizumi Adenovirus-mediated overexpression of caveolin-3 inhibits rat cardiomyocyte hypertrophy Hypertension 42 2003 213 219
152. M. Kohno, M. Yano, S. Kobayashi, M. Doi, T. Oda, and T. Tokuhisa A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure Am J Physiol Heart Circ Physiol 284 2003 H1035 H1042
153. S. Koneru, S.V. Penumathsa, M. Thirunavukkarasu, S.M. Samuel, L. Zhan, and Z. Han Redox regulation of ischemic preconditioning is mediated by the differential activation of caveolins and their association with eNOS and GLUT-4 Am J Physiol Heart Circ Physiol 292 2007 H2060 H2072
154. D. Koya, and G.L. King Protein kinase C activation and the development of diabetic complications Diabetes 47 1998 859 866
155. L. Kozera, E. White, and S. Calaghan Caveolae act as membrane reserves which limit mechanosensitive I(Cl, swell) channel activation during swelling in the rat ventricular myocyte PLoS ONE 4 2009 e8312
156. A.J. Krentz Lipoprotein abnormalities and their consequences for patients with type 2 diabetes Diabetes Obes Metab 5 Suppl. 1 2003 S19 S27
157. A.M. Krichevsky, K.S. King, C.P. Donahue, K. Khrapko, and K.S. Kosik A microRNA array reveals extensive regulation of microRNAs during brain development RNA 9 2003 1274 1281
158. T.V. Kurzchalia, P. Dupree, R.G. Parton, R. Kellner, H. Virta, and M. Lehnert VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles J Cell Biol 118 1992 1003 1014
159. V.A. Lacombe, S. Viatchenko-Karpinski, D. Terentyev, A. Sridhar, S. Emani, and J.D. Bonagura Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes Am J Physiol Regul Integr Comp Physiol 293 2007 R1787 R1797
160. G.A. Langer, and A. Peskoff Calcium concentration and movement in the diadic cleft space of the cardiac ventricular cell Biophys J 70 1996 1169 1182
161. T.J. LaRocca, F. Fabris, J. Chen, D. Benhayon, S. Zhang, and L. McCollum Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-kappaB pathway Am J Physiol Heart Circ Physiol 303 2012 H353 H367
162. Y.I. Lee, J.Y. Cho, M.H. Kim, K.B. Kim, D.J. Lee, and K.S. Lee Effects of exercise training on pathological cardiac hypertrophy related gene expression and apoptosis Eur J Appl Physiol 97 2006 216 224
163. S.Q. Lei, H.B. Li, J.J. Xu, Y.A. Liu, X. Gao, and J.W. Wang Hyperglycemia-induced protein kinase C beta(2) activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/eNOS signaling Diabetes 62 2013 2318 2328
164. C. Lengyel, L. Virag, T. Biro, N. Jost, J. Magyar, and P. Biliczki Diabetes mellitus attenuates the repolarization reserve in mammalian heart Cardiovasc Res 73 2007 512 520
165. C.L. Li, W.J. Duan, F.Y. Yang, and X.J. Zhang Caveolin-3-anchored microdomains at the rabbit sarcoplasmic reticulum membranes Biochem Biophys Res Commun 344 2006 1135 1140
166. J.M. Li, N.P. Gall, D.J. Grieve, M. Chen, and A.M. Shah Activation of NADPH oxidase during progression of cardiac hypertrophy to failure Hypertension 40 2002 477 484
167. J. Li, H. Zhu, E. Shen, L. Wan, J.M. Arnold, and T. Peng Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes Diabetes 59 2010 2033 2042
168. G. Lim, L. Venetucci, D.A. Eisner, and B. Casadei Does nitric oxide modulate cardiac ryanodine receptor function? Implications for excitation-contraction coupling Cardiovasc Res 77 2008 256 264
169. M. Lind, I. Bounias, M. Olsson, S. Gudbjornsdottir, A.M. Svensson, and A. Rosengren Glycaemic control and incidence of heart failure in 20,985 patients with type 1 diabetes: An observational study Lancet 378 2011 140 146
170. M.P. Lisanti, P.E. Scherer, J. Vidugiriene, Z.L. Tang, A. Hermanowskivosatka, and Y.H. Tu Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source - Implications for human-disease J Cell Biol 126 1994 111 126
171. S.E. Litwin Diabetes and the heart: Is there objective evidence of a human diabetic cardiomyopathy? Diabetes 62 2013 3329 3330
172. Y. Liu, S. Lei, X. Gao, X. Mao, T. Wang, and G.T. Wong PKCbeta inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes Clin Sci (Lond) 122 2012 161 173
173. L. Liu, Y. Li, J. Lin, Q. Liang, X. Sheng, and J. Wu Connexin43 interacts with Caveolin-3 in the heart Mol Biol Rep 37 2010 1685 1691
174. R. Loganathan, M. Bilgen, B. Al-Hafez, M.D. Alenezy, and I.V. Smirnova Cardiac dysfunction in the diabetic rat: Quantitative evaluation using high resolution magnetic resonance imaging Cardiovasc Diabetol 5 2006 7
175. 2+-ATPase in human heart failure Circulation 111 2005 988 995
176. G.D. Lopaschuk, D.D. Belke, J. Gamble, T. Itoi, and B.O. Schonekess Regulation of fatty acid oxidation in the mammalian heart in health and disease Biochim Biophys Acta 1213 1994 263 276
177. G.D. Lopaschuk, J.R. Ussher, C.D. Folmes, J.S. Jaswal, and W.C. Stanley Myocardial fatty acid metabolism in health and disease Physiol Rev 90 2010 207 258
178. Z. Lu, Y.P. Jiang, X.H. Xu, L.M. Ballou, I.S. Cohen, and R.Z. Lin Decreased L-type Ca2+ current in cardiac myocytes of type 1 diabetic Akita mice due to reduced phosphatidylinositol 3-kinase signaling Diabetes 56 2007 2780 2789
179. M. Luo, X. Guan, E.D. Luczak, D. Lang, W. Kutschke, and Z. Gao Diabetes increases mortality after myocardial infarction by oxidizing CaMKII J Clin Invest 123 2013 1262 1274
180. A.R. Lyon, K.T. MacLeod, Y. Zhang, E. Garcia, G.K. Kanda, and M.J. Lab Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart Proc Natl Acad Sci U S A 106 2009 6854 6859
181. D.M. Maahs, L. Caramori, D.Z. Cherney, A.T. Galecki, C. Gao, and D. Jalal Uric acid lowering to prevent kidney function loss in diabetes: The preventing early renal function loss (PERL) allopurinol study Curr Diab Rep 13 2013 550 559
182. B. Maisch, P. Alter, and S. Pankuweit Diabetic cardiomyopathy - Fact or fiction? Herz 36 2011 102 115
183. C.A. Makarewich, R.N. Correll, H. Gao, H. Zhang, B. Yang, and R.M. Berretta A caveolae-targeted L-type Ca(2)+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility Circ Res 110 2012 669 674
184. A. Malhotra, S. Penpargkul, F.S. Fein, E.H. Sonnenblick, and J. Scheuer The effect of streptozotocin-induced diabetes in rats on cardiac contractile proteins Circ Res 49 1981 1243 1250
185. C. Marionneau, F. Aimond, S. Brunet, N. Niwa, B. Finck, and D.P. Kelly PPARalpha-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy J Mol Cell Cardiol 44 2008 1002 1015
186. Y.S. Markandeya, J.M. Fahey, F. Pluteanu, L.L. Cribbs, and R.C. Balijepalli Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels J Biol Chem 286 2011 2433 2444
187. R. Marone, V. Cmiljanovic, B. Giese, and M.P. Wymann Targeting phosphoinositide 3-kinase: moving towards therapy Biochim Biophys Acta 1784 1 2008 159 185
188. S.P. Marso, T. Miller, B.D. Rutherford, R.J. Gibbons, M. Qureshi, and A. Kalynych Comparison of myocardial reperfusion in patients undergoing percutaneous coronary intervention in ST-segment elevation acute myocardial infarction with versus without diabetes mellitus (from the EMERALD Trial) Am J Cardiol 100 2007 206 210
189. J.R. Martens, N. Sakamoto, S.A. Sullivan, T.D. Grobaski, and M.M. Tamkun Isoform-specific localization of voltage-gated K+ channels to distinct lipid raft populations - Targeting of Kv1.5 to 3 caveolae J Biol Chem 276 2001 8409 8414
190. C.C. Mastick, M.J. Brady, and A.R. Saltiel Insulin stimulates the tyrosine phosphorylation of caveolin J Cell Biol 129 1995 1523 1531
191. P.F. Mery, C. Pavoine, L. Belhassen, F. Pecker, and R. Fischmeister Nitric oxide regulates cardiac Ca2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation J Biol Chem 268 1993 26286 26295
192. T. Miki, S. Yuda, H. Kouzu, and T. Miura Diabetic cardiomyopathy: Pathophysiology and clinical features Heart Fail Rev 18 2013 149 166
193. S. Minamisawa, J. Oshikawa, H. Takeshima, M. Hoshijima, Y. Wang, and K.R. Chien Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies Biochem Biophys Res Commun 325 2004 852 856
194. S. Mirza, M. Hossain, C. Mathews, P. Martinez, P. Pino, and J.L. Gay Type 2-diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexican Americans: A cross-sectional study Cytokine 57 2012 136 142
195. M. Montagnani Diabetic cardiomyopathy: How much does it depend on AGE? Br J Pharmacol 154 2008 725 726
196. A. Moore, A. Shindikar, I. Fomison-Nurse, F. Riu, P.E. Munasinghe, and T.P. Ram Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1 Cardiovasc Diabetol 13 2014 68
197. A. Munteanu, J.M. Zingg, and A. Azzi Anti-atherosclerotic effects of vitamin E - Myth or reality? J Cell Mol Med 8 2004 59 76
198. M. Murata, J. Peranen, R. Schreiner, F. Wieland, T.V. Kurzchalia, and K. Simons Vip21/caveolin is a cholesterol-binding protein Proc Natl Acad Sci U S A 92 1995 10339 10343
199. R.M. Murphy, J.P. Mollica, and G.D. Lamb Plasma membrane removal in rat skeletal muscle fibers reveals caveolin-3 hot-spots at the necks of transverse tubules Exp Cell Res 315 2009 1015 1028
200. K.J. Nadeau, J.G. Regensteiner, T.A. Bauer, M.S. Brown, J.L. Dorosz, and A. Hull Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function J Clin Endocrinol Metab 95 2010 513 521
201. P.R. Nagareddy, H. Soliman, G. Lin, P.S. Rajput, U. Kumar, and J.H. McNeill Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats Diabetes 58 2009 2355 2364
202. M. Nakata, S. Nagasaka, I. Kusaka, H. Matsuoka, S. Ishibashi, and T. Yada Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): Implications in glycaemic control Diabetologia 49 2006 1881 1892
203. S.P. Nana-Sinkam, and C.M. Croce Clinical applications for microRNAs in cancer Clin Pharmacol Ther 93 2013 98 104
204. National Cholesterol Education Program Expert Panel on Detection, E., and Treatment of High Blood Cholesterol in, A Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report Circulation 106 2002 3143 3421
205. E.P. Navarese, A. Buffon, F. Andreotti, M. Kozinski, N. Welton, and T. Fabiszak Meta-analysis of impact of different types and doses of statins on new-onset diabetes mellitus Am J Cardiol 111 2013 1123 1130
206. J.R. Neely, and H.E. Morgan Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle Annu Rev Physiol 36 1974 413 459
207. L.A. Nikolaidis, A. Sturzu, C. Stolarski, D. Elahi, Y.T. Shen, and R.P. Shannon The development of myocardial insulin resistance in conscious dogs with advanced dilated cardiomyopathy Cardiovasc Res 61 2004 297 306
208. Y. Numakawa, T. Numakawa, T. Matsumoto, Y. Yagasaki, E. Kumamaru, and H. Kunugi Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase J Neurochem 97 2006 1191 1202
209. P. Nuutila, V.A. Koivisto, J. Knuuti, U. Ruotsalainen, M. Teras, and M. Haaparanta Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo J Clin Invest 89 1992 1767 1774
210. F.H. Nystrom, H. Chen, L.-N. Cong, Y. Li, and M.J. Quon Caveolin-1 interacts with the insulin receptor and can differentially modulate insulin signaling in transfected cos-7 cells and rat adipose cells Mol Endocrinol 13 1999 2013 2024
211. Y. Ohsawa, H. Toko, M. Katsura, K. Morimoto, H. Yamada, and Y. Ichikawa Overexpression of P104L mutant caveolin-3 in mice develops hypertrophic cardiomyopathy with enhanced contractility in association with increased endothelial nitric oxide synthase activity Hum Mol Genet 13 2004 151 157
212. T. Okamoto, A. Schlegel, P.E. Scherer, and M.P. Lisanti Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane J Biol Chem 273 1998 5419 5422
213. M. Ono, M. Yano, A. Hino, T. Suetomi, X. Xu, and T. Susa Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure Cardiovasc Res 87 2010 609 617
214. J. Oshikawa, K. Otsu, Y. Toya, T. Tsunematsu, R. Hankins, and J. Kawabe Insulin resistance in skeletal muscles of caveolin-3-null mice Proc Natl Acad Sci U S A 101 2004 12670 12675
215. P. Pacher, L. Liaudet, F.G. Soriano, J.G. Mabley, E. Szabo, and C. Szabo The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes Diabetes 51 2002 514 521
216. N.F. Paradise, C.F. Pilati, W.R. Payne, and J.A. Finkelstein Left ventricular function of the isolated, genetically obese rat's heart Am J Physiol 248 1985 H438 H444
217. D.S. Park, S.E. Woodman, W. Schubert, A.W. Cohen, P.G. Frank, and M. Chandra Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype Am J Pathol 160 2002 2207 2217
218. S. Parpal, M. Karlsson, H. Thorn, and P. Stralfors Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control J Biol Chem 276 2001 9670 9678
219. R.G. Parton, and K. Simons The multiple faces of caveolae Nat Rev Mol Cell Biol 8 2007 185 194
220. R.G. Parton, M. Way, N. Zorzi, and E. Stang Caveolin-3 associates with developing T-tubules during muscle differentiation J Cell Biol 136 1997 137 154
221. H.H. Patel, Y.M. Tsutsumi, B.P. Head, I.R. Niesman, M. Jennings, and Y. Horikawa Mechanisms of cardiac protection from ischemia/reperfusion injury: A role for caveolae and caveolin-1 FASEB J 21 2007 1565 1574
222. D. Pavlovic, L.M. McLatchie, and M.J. Shattock The rate of loss of T-tubules in cultured adult ventricular myocytes is species dependent Exp Physiol 95 2010 518 527
223. S.V. Penumathsa, M. Thirunavukkarasu, S.M. Samuel, L. Zhan, G. Maulik, and M. Bagchi Niacin bound chromium treatment induces myocardial Glut-4 translocation and caveolar interaction via Akt, AMPK and eNOS phosphorylation in streptozotocin induced diabetic rats after ischemia-reperfusion injury Biochim Biophys Acta 1792 2009 39 48
224. S.V. Penumathsa, M. Thirunavukkarasu, L. Zhan, G. Maulik, V.P. Menon, and D. Bagchi Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium J Cell Mol Med 12 2008 2350 2361
225. L. Pereira, J. Matthes, I. Schuster, H.H. Valdivia, S. Herzig, and S. Richard Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db/db type 2 diabetic mice Diabetes 55 2006 608 615
226. G. Perseghin, G. Lattuada, M. Danna, L.P. Sereni, P. Maffi, and F. De Cobelli Insulin resistance, intramyocellular lipid content, and plasma adiponectin in patients with type 1 diabetes Am J Physiol Endocrinol Metab 285 2003 E1174 E1181
227. L.R. Peterson, P. Herrero, K.B. Schechtman, S.B. Racette, A.D. Waggoner, and Z. Kisrieva-Ware Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women Circulation 109 2004 2191 2196
228. C. Pinali, H. Bennett, J.B. Davenport, A.W. Trafford, and A. Kitmitto Three-dimensional reconstruction of cardiac sarcoplasmic reticulum reveals a continuous network linking transverse-tubules: This organization is perturbed in heart failure Circ Res 113 2013 1219 1230
229. S.K. Powers, S.L. Lennon, J. Quindry, and J.L. Mehta Exercise and cardioprotection Curr Opin Cardiol 17 2002 495 502
230. A. Pralle, P. Keller, E.L. Florin, K. Simons, and J.K. Horber Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells J Cell Biol 148 2000 997 1008
231. C. Radel, and V. Rizzo Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization Am J Physiol-Heart C 288 2005 H936 H945
232. P.J. Randle, E.A. Newsholme, and P.B. Garland Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles Biochem J 93 1964 652 665
233. B. Razani, J.A. Engelman, X.B. Wang, W. Schubert, X.L. Zhang, and C.B. Marks Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities J Biol Chem 276 2001 38121 38138
234. B. Razani, S.E. Woodman, and M.P. Lisanti Caveolae: From cell biology to animal physiology Pharmacol Rev 54 2002 431 467
235. V. Ricchiuti, N. Lapointe, L. Pojoga, T. Yao, L. Tran, and G.H. Williams Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart J Endocrinol 211 2011 47 54
236. E.B. Rimm, M.J. Stampfer, A. Ascherio, E. Giovannucci, G.A. Colditz, and W.C. Willett Vitamin E consumption and the risk of coronary heart disease in men N Engl J Med 328 1993 1450 1456
237. H. Robenek, G. Weissen-Plenz, and N.J. Severs Freeze-fracture replica immunolabelling reveals caveolin-1 in the human cardiomyocyte plasma membrane J Cell Mol Med 12 2008 2519
238. B. Rodrigues, M.C. Cam, and J.H. McNeill Metabolic disturbances in diabetic cardiomyopathy Mol Cell Biochem 180 1998 53 57
239. A. Ros-Baro, C. Lopez-Iglesias, S. Peiro, D. Bellido, M. Palacin, and A. Zorzano Lipid rafts are required for GLUT4 internalization in adipose cells Proc Natl Acad Sci U S A 98 2001 12050 12055
240. K.G. Rothberg, J.E. Heuser, W.C. Donzell, Y.S. Ying, J.R. Glenney, and R.G.W. Anderson Caveolin, a protein-component of caveolae membrane coats Cell 68 1992 673 682
241. S. Rubler, J. Dlugash, Y.Z. Yuceoglu, T. Kumral, A.W. Branwood, and A. Grishman New type of cardiomyopathy associated with diabetic glomerulosclerosis Am J Cardiol 30 1972 595 602
242. R.R. Russell III, R. Bergeron, G.I. Shulman, and L.H. Young Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR Am J Physiol 277 1999 H643 H649
243. V.O. Rybin, P.W. Grabham, H. Elouardighi, and S.F. Steinberg Caveolae-associated proteins in cardiomyocytes: Caveolin-2 expression and interactions with caveolin-3 Am J Physiol Heart Circ Physiol 285 2003 H325 H332
244. M. Samso, T. Wagenknecht, and P.D. Allen Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM Nat Struct Mol Biol 12 2005 539 544
245. D.L. Santos, C.M. Palmeira, R. Seica, J. Dias, J. Mesquita, and A.J. Moreno Diabetes and mitochondrial oxidative stress: A study using heart mitochondria from the diabetic Goto-Kakizaki rat Mol Cell Biochem 246 2003 163 170
246. R.M. Saraiva, K.M. Minhas, M. Zheng, E. Pitz, A. Treuer, and D. Gonzalez Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and nitroso-redox imbalance in ob/ob mice Nitric Oxide 16 2007 331 338
247. T. Sato, T. Kobayashi, A. Kuno, T. Miki, M. Tanno, and H. Kouzu Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2 Am J Physiol Heart Circ Physiol 306 2014 H1054 H1065
248. D. Sayed, and M. Abdellatif MicroRNAs in development and disease Physiol Rev 91 2011 827 887
249. C.M. Schannwell, M. Schneppenheim, S. Perings, G. Plehn, and B.E. Strauer Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy Cardiology 98 2002 33 39
250. P.E. Scherer, M.P. Lisanti, G. Baldini, M. Sargiacomo, C.C. Mastick, and H.F. Lodish Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles J Cell Biol 127 1994 1233 1243
251. A. Schlegel, and M.P. Lisanti A molecular dissection of caveolin-1 membrane attachment and oligomerization - Two separate regions of the caveolin-1 C-terminal domain mediate membrane binding and oligomer/oligomer interactions in vivo J Biol Chem 275 2000 21605 21617
252. A. Schlegel, R.B. Schwab, P.E. Scherer, and M.P. Lisanti A role for the caveolin scaffolding domain in mediating the membrane attachment of caveolin-1 - The caveolin scaffolding domain is both necessary and sufficient for membrane binding in vitro J Biol Chem 274 1999 22660 22667
253. J.G. Schneider, N. Tilly, T. Hierl, U. Sommer, A. Hamann, and K. Dugi Elevated plasma endothelin-1 levels in diabetes mellitus Am J Hypertens 15 2002 967 972
254. J.E. Schnitzer Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivo Adv Drug Deliv Rev 49 2001 265 280
255. D.R.L. Scriven, A. Klimek, P. Asghari, K. Bellve, and E.D.W. Moore Caveolin-3 is adjacent to a group of extradyadic ryanodine receptors Biophys J 89 2005 1893
256. C.E. Sears, E.A. Ashley, and B. Casadei Nitric oxide control of cardiac function: Is neuronal nitric oxide synthase a key component? Philos Trans R Soc Lond B Biol Sci 359 2004 1021 1044
257. P.M. Seferovic, I. Milinkovic, A.D. Ristic, J.P. Seferovic Mitrovic, K. Lalic, and A. Jotic Diabetic cardiomyopathy: ongoing controversies in 2012 Herz 37 2012 880 886
258. R. Setien, A. Alday, C. Diaz-Asensio, J. Urrutia, M. Gallego, and O. Casis Mechanisms responsible for the trophic effect of beta-adrenoceptors on the I(to) current density in type 1 diabetic rat cardiomyocytes Cell Physiol Biochem 31 2013 25 36
259. M.H. Shanik, Y. Xu, J. Skrha, R. Dankner, Y. Zick, and J. Roth Insulin resistance and hyperinsulinemia: Is hyperinsulinemia the cart or the horse? Diabetes Care 31 Suppl. 2 2008 S262 S268
260. C.H. Shao, H.L. Capek, K.P. Patel, M. Wang, K. Tang, and C. DeSouza Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes Diabetes 60 2011 947 959
261. C.H. Shao, X.H. Wehrens, T.A. Wyatt, S. Parbhu, G.J. Rozanski, and K.P. Patel Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation J Appl Physiol (1985) 106 2009 1280 1292
262. E.D. Sheets, G.M. Lee, R. Simson, and K. Jacobson Transient confinement of a glycosylphosphatidylinositol-anchored protein in the plasma membrane Biochemistry 36 1997 12449 12458
263. A. Shirpoor, S. Salami, M.H. Khadem-Ansari, B. Ilkhanizadeh, F.G. Pakdel, and K. Khademvatani Cardioprotective effect of vitamin E: Rescues of diabetes-induced cardiac malfunction, oxidative stress, and apoptosis in rat J Diabet Complications 23 2009 310 316
264. B. Shivalkar, D. Dhondt, I. Goovaerts, L. Van Gaal, J. Bartunek, and P. Van Crombrugge Flow mediated dilatation and cardiac function in type 1 diabetes mellitus Am J Cardiol 97 2006 77 82
265. J.N. Simon, D. Duglan, B. Casadei, and R. Carnicer Nitric oxide synthase regulation of cardiac excitation-contraction coupling in health and disease J Mol Cell Cardiol 73 2014 80 91
266. V.P. Singh, B. Le, R. Khode, K.M. Baker, and R. Kumar Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis Diabetes 57 2008 3297 3306
267. B. Sinha, D. Koster, R. Ruez, P. Gonnord, M. Bastiani, and D. Abankwa Cells respond to mechanical stress by rapid disassembly of caveolae Cell 144 2011 402 413
268. E.M. Small, R.J. Frost, and E.N. Olson MicroRNAs add a new dimension to cardiovascular disease Circulation 121 2010 1022 1032
269. G.M. Smythe, and T.A. Rando Altered caveolin-3 expression disrupts PI(3) kinase signaling leading to death of cultured muscle cells Exp Cell Res 312 2006 2816 2825
270. H. Soliman, G.P. Craig, P. Nagareddy, V.G. Yuen, G. Lin, and U. Kumar Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats Cardiovasc Res 79 2008 322 330
271. H. Soliman, A. Gador, Y.H. Lu, G. Lin, G. Bankar, and K.M. MacLeod Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho kinase and PKCbeta2 Am J Physiol Heart Circ Physiol 303 2012 H989 H1000
272. G. Solinas, W. Naugler, F. Galimi, M.S. Lee, and M. Karin Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates Proc Natl Acad Sci U S A 103 2006 16454 16459
273. Y. Song, Y. Du, S.D. Prabhu, and P.N. Epstein Diabetic cardiomyopathy in OVE26 mice shows mitochondrial ROS production and divergence between in vivo and in vitro contractility Rev Diabet Stud 4 2007 159 168
274. K.S. Song, P.E. Scherer, Z.L. Tang, T. Okamoto, S.W. Li, and M. Chafel Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells - Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins J Biol Chem 271 1996 15160 15165
275. J.K. Srivastava, and S. Gupta Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells Biochem Biophys Res Commun 346 2006 447 453
276. M.J. Stampfer, C.H. Hennekens, J.E. Manson, G.A. Colditz, B. Rosner, and W.C. Willett Vitamin E consumption and the risk of coronary disease in women N Engl J Med 328 1993 1444 1449
277. 2+ release synchronicity in a mouse model of diabetic cardiomyopathy Circ Res 105 2009 527 536
278. D. Sun, N. Nguyen, T.R. DeGrado, M. Schwaiger, and F.C. Brosius III Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes Circulation 89 1994 793 798
279. Y. Sunada, H. Ohi, A. Hase, H. Ohi, T. Hosono, and S. Arata Transgenic mice expressing mutant caveolin-3 show severe myopathy associated with increased nNOS activity Hum Mol Genet 10 2001 173 178
280. Z.L. Tang, P.E. Scherer, T. Okamoto, K. Song, C. Chu, and D.S. Kohtz Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle J Biol Chem 271 1996 2255 2261
281. 2+ leak in failing hearts Cardiovasc Res 81 2009 536 545
282. 2+ leak in chronic heart failure Circ Res 103 2008 1466 1472
283. T. Thum, D. Fraccarollo, M. Schultheiss, S. Froese, P. Galuppo, and J.D. Widder Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes Diabetes 56 2007 666 674
284. C. Tian, C.H. Shao, C.J. Moore, S. Kutty, T. Walseth, and C. DeSouza Gain of function of cardiac ryanodine receptor in a rat model of type 1 diabetes Cardiovasc Res 91 2011 300 309
285. 2+ current in ventricular myocytes Circ Res 112 2013 1567 1576
286. O. Torffvit, M. Lovestam-Adrian, E. Agardh, and C.D. Agardh Nephropathy, but not retinopathy, is associated with the development of heart disease in Type 1 diabetes: A 12-year observation study of 462 patients Diabet Med 22 2005 723 729
287. M. Trajkovski, J. Hausser, J. Soutschek, B. Bhat, A. Akin, and M. Zavolan MicroRNAs 103 and 107 regulate insulin sensitivity Nature 474 2011 649 653
288. S.U. Trost, D.D. Belke, W.F. Bluhm, M. Meyer, E. Swanson, and W.H. Dillmann Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy Diabetes 51 2002 1166 1171
289. Y.M. Tsutsumi, Y.T. Horikawa, M.M. Jennings, M.W. Kidd, I.R. Niesman, and U. Yokoyama Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning Circulation 118 2008 1979 1988
290. T. Utriainen, T. Takala, M. Luotolahti, T. Ronnemaa, H. Laine, and U. Ruotsalainen Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM Diabetologia 41 1998 555 559
291. R. Vaidyanathan, A.L. Vega, C. Song, Q. Zhou, B.H. Tan, and S. Berger The interaction of caveolin 3 protein with the potassium inward rectifier channel Kir2.1: Physiology and pathology related to long qt syndrome 9 (LQT9) J Biol Chem 288 2013 17472 17480
292. B. Vanhaesebroeck, S.J. Leevers, G. Panayotou, and M.D. Waterfield Phosphoinositide 3-kinases: A conserved family of signal transducers Trends Biochem Sci 22 1997 267 272
293. S.p. Vassilopoulos, S. Oddoux, S.v. Groh, M. Cacheux, J. Fauré, and J. Brocard Caveolin 3 is associated with the calcium release complex and is modified via in vivo triadin modification Biochemistry 49 2010 6130
294. M. Vatta, M.J. Ackerman, B. Ye, J.C. Makielski, E.E. Ughanze, and E.W. Taylor Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome Circulation 114 2006 2104 2112
295. D. Volonte, C.F. McTiernan, M. Drab, M. Kasper, and F. Galbiati Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis Am J Physiol Heart Circ Physiol 294 2008 H392 H401
296. H. Wakasaki, D. Koya, F.J. Schoen, M.R. Jirousek, D.K. Ways, and B.D. Hoit Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy Proc Natl Acad Sci U S A 94 1997 9320 9325
297. L. Wang, Y. Cui, M. Tang, X. Hu, H. Luo, and J. Hescheler Puerarin facilitates T-tubule development of murine embryonic stem cell-derived cardiomyocytes Cell Physiol Biochem 34 2014 383 392
298. D.W. Wang, T. Kiyosue, S. Shigematsu, and M. Arita Abnormalities of K+ and Ca2+ currents in ventricular myocytes from rats with chronic diabetes Am J Physiol 269 1995 H1288 H1296
299. L.H. Wang, C.H. Yu, Y. Fu, Q. Li, and Y.Q. Sun Berberine elicits anti-arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model Phytother Res 25 2011 33 37
300. M.L. Ward, and D.J. Crossman Mechanisms underlying the impaired contractility of diabetic cardiomyopathy World J Cardiol 6 2014 577 584
301. R.T. Watson, and J.E. Pessin Intracellular organization of insulin signaling and GLUT4 translocation Recent Prog Horm Res 56 2001 175 193
302. M. Way, and R.G. Parton M-caveolin, a muscle-specific caveolin-related protein FEBS Lett 378 1996 108 112
303. S. Wei, A. Guo, B. Chen, W.J. Kutschke, Y.P. Xie, and K. Zimmerman T-tubule remodeling during transition from hypertrophy to heart failure Circ Res 107 2010 520 531
304. M. Wei, L. Ong, M.T. Smith, F.B. Ross, K. Schmid, and A.J. Hoey The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes Heart Lung Circ 12 2003 44 50
305. W. Weng-Yew, and L. Brown Nutrapharmacology of tocotrienols for metabolic syndrome Curr Pharm Des 17 2011 2206 2214
306. T.J. Wheeler, R.D. Fell, and M.A. Hauck Translocation of two glucose transporters in heart: effects of rotenone, uncouplers, workload, palmitate, insulin and anoxia Biochim Biophys Acta 1196 1994 191 200
307. R.E. White, R. Gerrity, S.A. Barman, and G. Han Estrogen and oxidative stress: A novel mechanism that may increase the risk for cardiovascular disease in women Steroids 75 2010 788 793
308. G. Whiteley, R.F. Collins, and A. Kitmitto Characterization of the molecular architecture of human caveolin-3 and interaction with the skeletal muscle ryanodine receptor J Biol Chem 287 2012 40302 40316
309. P.D. Williams, P. Ranjzad, S.J. Kakar, and P.A. Kingston Development of viral vectors for use in cardiovascular gene therapy Viruses 2 2010 334 371
310. W.Y. Wong, H. Poudyal, L.C. Ward, and L. Brown Tocotrienols reverse cardiovascular, metabolic and liver changes in high carbohydrate, high fat diet-fed rats Nutrients 4 2012 1527 1541
311. S.E. Woodman, D.S. Park, A.W. Cohen, M.W.C. Cheung, M. Chandra, and J. Shirani Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade J Biol Chem 277 2002 38988 38997
312. C.Y. Wu, Z. Jia, W. Wang, L.M. Ballou, Y.P. Jiang, and B. Chen PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes PLoS ONE 6 2011 e24404
313. Z. Xia, K.H. Kuo, P.R. Nagareddy, F. Wang, Z. Guo, and T. Guo N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats Cardiovasc Res 73 2007 770 782
314. Y. Xiang, V.O. Rybin, S.F. Steinberg, and B. Kobilka Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes J Biol Chem 277 2002 34280 34286
315. J. Xiao, X. Tian, P.P. Jones, J. Bolstad, H. Kong, and R. Wang Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias J Biol Chem 282 2007 34828 34838
316. L. Xu, J.P. Eu, G. Meissner, and J.S. Stamler Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation Science 279 1998 234 237
317. T. Yagi, K. Hon-Nami, and T. Ohnishi Purification and characterization of two types of NADH-quinone reductase from Thermus thermophilus HB-8 Biochemistry 27 1988 2008
318. M. Yamamoto, Y. Toya, C. Schwencke, M.P. Lisanti, M.G. Myers, and Y. Ishikawa Caveolin is an activator of insulin receptor signaling J Biol Chem 273 1998 26962 26968
319. 2+ homeostasis in rat heart Diabetes 54 2005 3082 3088
320. T.L. Yarbrough, T. Lu, H.C. Lee, and E.F. Shibata Localization of cardiac sodium channels in caveolin-rich membrane domains - Regulation of sodium current amplitude Circ Res 90 2002 443 449
321. B. Ye, R.C. Balijepalli, J.D. Foell, S. Kroboth, Q. Ye, and Y.H. Luo Caveolin-3 associates with and affects the function of hyperpolarization-activated cyclic nucleotide-gated channel 4 Biochemistry 47 2008 12312 12318
322. L.H. Young, Y. Ikeda, and A.M. Lefer Caveolin-1 peptide exerts cardioprotective effects in myocardial ischemia-reperfusion via nitric oxide mechanism Am J Physiol Heart Circ Physiol 280 2001 H2489 H2495
323. C. Yu, Y. Chen, G.W. Cline, D. Zhang, H. Zong, and Y. Wang Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle J Biol Chem 277 2002 50230 50236
324. L. Zhang, D. Huang, D. Shen, C. Zhang, Y. Ma, and S.A. Babcock Inhibition of protein kinase C betaII isoform ameliorates methylglyoxal advanced glycation endproduct-induced cardiomyocyte contractile dysfunction Life Sci 94 2014 83 91
325. S. Zhang, H. Liu, G.V. Amarsingh, C.C. Cheung, S. Hogl, and U. Narayanan Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation Cardiovasc Diabetol 13 2014 100
326. 2+-ATPase activity contributes to cardiac dysfunction in streptozotocin-induced diabetic rats J Physiol Biochem 62 2006 1 8
327. G. Zhao, and R.U. Simpson Membrane localization, Caveolin-3 association and rapid actions of vitamin D receptor in cardiac myocytes Steroids 75 2010 555 559
328. Q. Zhou, D. Lv, P. Chen, T. Xu, S. Fu, and J. Li MicroRNAs in diabetic cardiomyopathy and clinical perspectives Front Genet 5 2014 185
329. K. Zsebo, A. Yaroshinsky, J.J. Rudy, K. Wagner, B. Greenberg, and M. Jessup Long-term effects of AAV1/SERCA2a gene transfer in patients with severe heart failure: Analysis of recurrent cardiovascular events and mortality Circ Res 114 2014 101 108