Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

Biochemical Journal

Volumn 456, Issue 2, 2013, Pages 205-217

  Bennett, Hayley J ^a   Davenport, John Bernard ^a   Collins, Richard F ^b   Trafford, Andrew W ^a   Pinali, Christian ^a   Kitmitto, Ashraf ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Junctophilin 2; Phosphatidylserine; PtdIns(3,4,5)P3; Quartz crystal microbalance with dissipation monitoring (QCM D); Supported lipid bilayer

Indexed keywords

JUNCTOPHILIN 2; PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARABIDOPSIS; ARTICLE; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; EXCITATION CONTRACTION COUPLING; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; ISOTHERM; LIPID BILAYER; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; QUARTZ CRYSTAL MICROBALANCE; SARCOPLASMIC RETICULUM; SITE DIRECTED MUTAGENESIS;

BINDING SITES; CALCIUM; CARDIOMYOPATHY, HYPERTROPHIC, FAMILIAL; HUMANS; MAGNESIUM; MEMBRANE PROTEINS; MUTATION, MISSENSE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOLIPIDS; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; QUARTZ CRYSTAL MICROBALANCE TECHNIQUES; THERMODYNAMICS;

EID: 84887412776     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130591     Document Type: Article

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