Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure

Circulation Research

Volumn 103, Issue 12, 2008, Pages 1466-1472

  Terentyev, Dmitry ^a   Györke, Inna ^a   Belevych, Andriy E ^a   Terentyeva, Radmila ^a   Sridhar, Arun ^c   Nishijima, Yoshinori ^c   De Blanco, Esperanza Carcache ^c   Khanna, Savita ^b   Sen, Chandan K ^b   Cardounel, Arturo J ^d   Carnes, Cynthia A ^a,c   Györke, Sandor ^a,e  

^a Department of Molecular Genetics and Microbiology   (United States)

^b Departments of Surgery

^c OHIO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e OHIO STATE UNIVERSITY   (United States)

Author keywords

Ca2 induced Ca2; Disulfide oxidation; Heart failure; Release; Ryanodine receptor

Indexed keywords

ANTIOXIDANT; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; RYANODINE RECEPTOR 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; CALCIUM; RYANODINE RECEPTOR;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOSOL; DOG; EXPOSURE; HEART FAILURE; HYPOTHESIS; LIPID BILAYER; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; ANIMAL; CHRONIC DISEASE; COMPARATIVE STUDY; DISEASE MODEL; HEART MUSCLE CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN PROCESSING; SARCOPLASMIC RETICULUM;

ANIMALS; CALCIUM; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DOGS; HEART FAILURE; MYOCYTES, CARDIAC; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEIN PROCESSING, POST-TRANSLATIONAL; REACTIVE OXYGEN SPECIES; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM;

EID: 58149387380     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.184457     Document Type: Article

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