Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice

Clinical and Experimental Pharmacology and Physiology

Volumn 38, Issue 8, 2011, Pages 485-493

  Jo, Hiromi ^a   Otani, Hajime ^a   Jo, Fusakazu ^a   Shimazu, Takayuki ^a   Okazaki, Toru ^a   Yoshioka, Kei ^a   Fujita, Masanori ^a   Kosaki, Atsushi ^a   Iwasaka, Toshiji ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Cardiomyopathy; Diabetes mellitus; Nitric oxide synthase; Oxidative stress; Tetrahydrobiopterin

Indexed keywords

3 NITROTYROSINE; 4 HYDROXY NONEAL; BIOLOGICAL MARKER; DIHYDROBIOPTERIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; NITRIC OXIDE SYNTHASE; SEPIAPTERIN; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DISEASE MARKER; ECHOCARDIOGRAPHY; ENZYME INHIBITION; GENOTYPE; HEART FUNCTION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE FAILURE; MALE; MOUSE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; STREPTOZOCIN DIABETES;

ANIMALS; BIOPTERIN; CARDIOTONIC AGENTS; COENZYMES; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; ENZYME INHIBITORS; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PTERINS; TYROSINE; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 79960711345     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2011.05535.x     Document Type: Article

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