Adenylyl cyclase subtype-specific compartmentalization: Differential regulation of L-Type Ca2+ current in ventricular myocytes

Circulation Research

Volumn 112, Issue 12, 2013, Pages 1567-1576

  Timofeyev, Valeriy ^a   Myers, Richard E ^a   Kim, Hyo Jeong ^b   Woltz, Ryan L ^a   Sirish, Padmini ^a   Heiserman, James P ^a   Li, Ning ^a   Singapuri, Anil ^a   Tang, Tong ^c   Yarov Yarovoy, Vladimir ^a   Yamoah, Ebenezer N ^b   Hammond, H Kirk ^b,c,d   Chiamvimonvat, Nipavan ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

adenylyl cyclase type 5; adenylyl cyclase type 6; adrenergic receptor; calcium channel; L type Ca2+ current; ventricular myocytes

Indexed keywords

ADENYLATE CYCLASE; BETA 1 ADRENERGIC RECEPTOR; CAVEOLIN 3; CILOSTAMIDE; ISOPRENALINE; PHOSPHODIESTERASE; ROLIPRAM; SCAFFOLD PROTEIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CURRENT; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HEART MUSCLE CELL; IMMUNOFLUORESCENCE; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; TRANSVERSE TUBULAR SYSTEM;

ADENYLYL CYCLASE TYPE 5; ADENYLYL CYCLASE TYPE 6; ADRENERGIC RECEPTOR; CALCIUM CHANNEL; L-TYPE CA2+ CURRENT; VENTRICULAR MYOCYTES;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; AMINO ACID SEQUENCE; ANIMALS; CALCIUM CHANNELS, L-TYPE; CAVEOLIN 3; CELL MEMBRANE; COMPUTER SIMULATION; FLUORESCENT ANTIBODY TECHNIQUE; HEART VENTRICLES; ISOENZYMES; ISOPROTERENOL; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; MYOCYTES, CARDIAC; PHOSPHORIC DIESTER HYDROLASES; RECEPTORS, ADRENERGIC, BETA-1; SIGNAL TRANSDUCTION;

EID: 84880046476     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.300370     Document Type: Article

References (39)

1. Sutherland EW, Oye I, Butcher RW. The action of epinephrine and the role of the adenyl cyclase system in hormone action. Recent Prog Horm Res. 1965;21:623-646
2. Sutherland EW, Robison GA. The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones. Pharmacol Rev. 1966;18:145-161
3. Tang T, Gao MH, Hammond HK. Prospects for gene transfer for clinical heart failure. Gene Ther. 2012;19:606-612
4. Sunahara RK, Dessauer CW, Gilman AG. Complexity and diversity of mammalian adenylyl cyclases. Annu Rev Pharmacol Toxicol. 1996;36:461-480 (Pubitemid 26168706)
5. Beazely MA, Watts VJ. Regulatory properties of adenylate cyclases type 5 and 6: a progress report. Eur J Pharmacol. 2006;535:1-12
6. Cooper DM. Molecular and cellular requirements for the regulation of adenylate cyclases by calcium. Biochem Soc Trans. 2003;31:912-915 (Pubitemid 37305015)
7. Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, Guo T, Yuan JX, Roth DM, Hammond HK. Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation. 2008;117:61-69 (Pubitemid 350291182)
8. Roth DM, Bayat H, Drumm JD, Gao MH, Swaney JS, Ander A, Hammond HK. Adenylyl cyclase increases survival in cardiomyopathy. Circulation. 2002;105:1989-1994 (Pubitemid 34437629)
9. Vatner SF, Yan L, Ishikawa Y, Vatner DE, Sadoshima J. Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress. Circ J. 2009;73:195-200
10. Steinberg SF, Brunton LL. Compartmentation of G protein-coupled signaling pathways in cardiac myocytes. Annu Rev Pharmacol Toxicol. 2001;41:751-773 (Pubitemid 32385905)
11. Xiang YK. Compartmentalization of beta-adrenergic signals in cardiomyocytes. Circ Res. 2011;109:231-244
12. Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM. Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes. Ann N Y Acad Sci. 2005;1047:166-172 (Pubitemid 41123837)
13. Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. J Biol Chem. 2001;276:42063-42069
14. Fischmeister R, Castro LR, Abi-Gerges A, Rochais F, Jurevicius J, Leroy J, Vandecasteele G. Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases. Circ Res. 2006;99:816-828 (Pubitemid 44556380)
15. Rochais F, Abi-Gerges A, Horner K, Lefebvre F, Cooper DM, Conti M, Fischmeister R, Vandecasteele G. A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes. Circ Res. 2006;98:1081-1088
16. Leroy J, Richter W, Mika D, et al. Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice. J Clin Invest. 2011;121:2651-2661
17. Williams TM, Lisanti MP. The caveolin proteins. Genome Biol. 2004;5:214.
18. Head BP, Patel HH, Roth DM, Lai NC, Niesman IR, Farquhar MG, Insel PA. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J Biol Chem. 2005;280:31036-31044 (Pubitemid 41291837)
19. Nikolaev VO, Moshkov A, Lyon AR, Miragoli M, Novak P, Paur H, Lohse MJ, Korchev YE, Harding SE, Gorelik J. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science. 2010;327:1653-1657
20. Lee KW, Hong JH, Choi IY, Che Y, Lee JK, Yang SD, Song CW, Kang HS, Lee JH, Noh JS, Shin HS, Han PL. Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase. J Neurosci. 2002;22:7931-7940 (Pubitemid 35379098)
21. Brette F, Komukai K, Orchard CH. Validation of formamide as a detubulation agent in isolated rat cardiac cells. Am J Physiol Heart Circ Physiol. 2002;283:H1720-H1728
22. Lu L, Zhang Q, Timofeyev V, Zhang Z, Young JN, Shin HS, Knowlton AA, Chiamvimonvat N. Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res. 2007;100:112-120 (Pubitemid 46066779)
23. Bonneau R, Strauss CE, Baker D. Improving the performance of Rosetta using multiple sequence alignment information and global measures of hydrophobic core formation. Proteins. 2001;43:1-11 (Pubitemid 32194902)
24. Wang C, Bradley P, Baker D. Protein-protein docking with backbone flexibility. J Mol Biol. 2007;373:503-519 (Pubitemid 47445567)
25. Kelley LA, Sternberg MJ. Protein structure prediction on the Web: a case study using the Phyre server. Nat Protoc. 2009;4:363-371
26. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. UCSF Chimera: a visualization system for exploratory research and analysis. J Comput Chem. 2004;25:1605-1612
27. Moustakas DT, Lang PT, Pegg S, Pettersen E, Kuntz ID, Brooijmans N, Rizzo RC. Development and validation of a modular, extensible docking program: DOCK 5. J Comput Aided Mol Des. 2006;20:601-619 (Pubitemid 46023925)
28. Graves AP, Shivakumar DM, Boyce SE, Jacobson MP, Case DA, Shoichet BK. Rescoring docking hit lists for model cavity sites: predictions and experimental testing. J Mol Biol. 2008;377:914-934
29. Timofeyev V, Porter CA, Tuteja D, Qiu H, Li N, Tang T, Singapuri A, Han PL, Lopez JE, Hammond HK, Chiamvimonvat N. Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Galphaq protein-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2010;299:H1459-H1467
30. Brodde OE, Bruck H, Leineweber K. Cardiac adrenoceptors: physiological and pathophysiological relevance. J Pharmacol Sci. 2006;100: 323-337 (Pubitemid 44609527)
31. Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature. 2002;415:206-212 (Pubitemid 34059526)
32. Dorn GW 2nd, Liggett SB. Pharmacogenomics of beta-adrenergic receptors and their accessory signaling proteins in heart failure. Clin Transl Sci. 2008;1:255-262
33. Bristow MR. Treatment of chronic heart failure with ?-adrenergic receptor antagonists: a convergence of receptor pharmacology and clinical cardiology. Circ Res. 2011;109:1176-1194
34. Yan L, Vatner DE, O'Connor JP, Ivessa A, Ge H, Chen W, Hirotani S, Ishikawa Y, Sadoshima J, Vatner SF. Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell. 2007;130:247-258 (Pubitemid 47081133)
35. Rohrer DK, Desai KH, Jasper JR, Stevens ME, Regula DP Jr, Barsh GS, Bernstein D, Kobilka BK. Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. Proc Natl Acad Sci USA. 1996;93:7375-7380 (Pubitemid 26243558)
36. Toya Y, Schwencke C, Couet J, Lisanti MP, Ishikawa Y. Inhibition of adenylyl cyclase by caveolin peptides. Endocrinology. 1998;139: 2025-2031 (Pubitemid 28513865)
37. Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem. 1997;272:6525-6533 (Pubitemid 27118133)
38. Maltsev VA, Ji GJ, Wobus AM, Fleischmann BK, Hescheler J. Establishment of beta-adrenergic modulation of L-type Ca2+ current in the early stages of cardiomyocyte development. Circ Res. 1999;84:136-145 (Pubitemid 29070108)
39. Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 2005;123:25-35. (Pubitemid 41414526)