Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 306, Issue 7, 2014, Pages

  Sato, Tatsuya ^a   Kobayashi, Takeshi ^a   Kuno, Atsushi ^a   Miki, Takayuki ^a   Tanno, Masaya ^a   Kouzu, Hidemichi ^a   Itoh, Takahito ^a   Ishikawa, Satoko ^a   Kojima, Takashi ^a   Miura, Tetsuji ^a   Tohse, Noritsugu ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cardiac ion channel remodeling; Iroquois homeobox 5; Kv4.2; Type 2 diabetes

Indexed keywords

GLUCOSE; IRX5 PROTEIN; POTASSIUM CHANNEL KV4.2; PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL INTERACTING PROTEIN 2;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENETIC ANALYSIS; GLUCOSE BLOOD LEVEL; HEART MUSCLE; HEART RATE; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; LONG EVANS TOKUSHIMA OTSUKA RAT; MALE; MEMBRANE STEADY POTENTIAL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEADY STATE; WHOLE CELL PATCH CLAMP;

CARDIAC ION CHANNEL REMODELING; IROQUOIS HOMEOBOX 5; KV4.2; TYPE 2 DIABETES; VOLTAGE-GATED K+ CHANNEL-INTERACTING PROTEIN 2;

ACTION POTENTIALS; ANIMALS; BLOOD GLUCOSE; CALCIUM CHANNELS, L-TYPE; DIABETES MELLITUS, TYPE 2; DIABETIC CARDIOMYOPATHIES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ELECTROCARDIOGRAPHY; HOMEODOMAIN PROTEINS; KINETICS; KV CHANNEL-INTERACTING PROTEINS; KV1.4 POTASSIUM CHANNEL; MALE; MYOCYTES, CARDIAC; POTASSIUM; RATS; RATS, INBRED OLETF; RNA, MESSENGER; SHAL POTASSIUM CHANNELS; TRANSCRIPTION FACTORS;

EID: 84900540996     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00414.2013     Document Type: Article

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