Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 277, Issue 2 46-2, 1999, Pages

  Russell III, Raymond R ^a   Bergeron, Raynald ^a   Shulman, Gerald I ^a   Young, Lawrence H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 aminoimidazole 4 carboxyamide 1 D ribofuranoside; Adenosine 5' monophosphate activated protein kinase; GLUT 4; Ischemia

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE PHOSPHATE; CYANIDE; DEOXYGLUCOSE; GLUCOSE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; TUBERCIDIN DERIVATIVE; VIDARABINE; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; GLUCOSE TRANSPORT; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HYPOXIA; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOLEMMA;

EID: 0032881635     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.277.2.h643     Document Type: Article

References (42)

1. Bergeron, R., R. R. Russell, L. H. Young, J.-M. Ren, M. Marcucci, A. Lee, and G. I. Shulman. Effect of AMPK activation on muscle glucose metabolism in conscious rats. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E938-E944, 1999.
2. Brozinick, J. T., Jr., and M. J. Birnbaum. Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle. J. Biol. Chem. 273: 14679-14682, 1998.
3. Carling, D., P. R. Clarke, V. A. Zammit, and D. G. Hardie. Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities. Eur. J. Biochem. 186: 129-136, 1989.
4. Clarke, J. F., P. W. Young, K. Yonewzawa, M. Kasuga, and G. D. Holman. Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin. Biochem. J. 300: 631-635, 1994.
5. Coderre, L., K. V. Kandror, G. Vallega, and P. F. Pilch. Identification and characterization of an exercise-sensitive pool of glucose transporters in skeletal muscle. J. Biol. Chem. 270: 27584-27588, 1995.
6. Corton, J. M., J. G. Gillespie, S. A. Hawley, and D. G. Hardie. 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur. J. Biochem. 229: 558-565, 1995.
7. Davies, S. P., D. Carling, and D. G. Hardie. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. Eur. J. Biochem. 186: 123-128, 1989.
8. Egert, S., N. Nguyen, F. C. Brosius III, and M. Schwaiger. Effects of wortmannin on insulin-and ischemia-induced stimulation of GLUT4 translocation and FDG uptake in perfused rat hearts. Cardiovasc. Res. 35: 283-293, 1997.
9. Fujitaki, J. M., T. M. Sandoval, L. A. Lembach, and R. Dixon. Spectrophotometric determination of acadesine (AICA-riboside) in plasma using a diazotization coupling technique with N-(1-napthyl)ethylenediamine. J. Biochem. Biophys. Methods 29: 143-148, 1994.
10. Gruber, H. E., M. E. Hoffer, D. R. McAllister, P. K. Laikind, T. A. Lane, G. W. Schmidt-Schoenbein, and R. L. Engler. Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects of flow, granulocytes, and injury. Circulation 80: 1400-1411, 1989.
11. Hansen, P. A., J. A. Corbett, and J. O. Holloszy. Phorbol esters stimulate muscle glucose transport by a mechanism distinct from the insulin and hypoxia pathway. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E28-E36, 1997.
12. Hardie, D. G., and D. Carling. The AMP-activated protein kinase: fuel gauge of the mammalian cell? Eur. J. Biochem. 246: 259-273, 1997.
13. Hardie, D. G., D. Carling, and N. Halford. Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress. Semin. Cell Biol. 5: 409-416, 1994.
14. Hayashi, T., M. F. Hirshman, E. J. Kurth, W. W. Winder, and L. J. Goodyear. Evidence for 5′ AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes 47: 1369-1373, 1998.
15. Hayashi, T., J. F. P. Wojtaszewski, and L. J. Goodyear. Exercise regulation of glucose transport in skeletal muscle. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E1039-E1051, 1997.
16. Henin, N., M. F. Vincent, and G. Van den Berghe. Stimulation of rat liver AMP-activated protein kinase by AMP analogues. Biochim. Biophys. Acta 1290: 197-203, 1996.
17. Hutber, C. A., D. G. Hardie, and W. W. Winder. Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E262-E266, 1997.
18. Jacob, R., X. Hu, D. Niederstock, S. Hasan, P. H. McNulty, R. S. Sherwin, and L. H. Young. IGF-I stimulation of muscle protein synthesis in the awake rat: permissive role of insulin and amino acids. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E60-E66, 1996.
19. Kudo, N., A. J. Barr, R. L. Barr, S. Desai, and G. D. Lopaschuk. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. J. Biol. Chem. 270: 17513-17520, 1995.
20. Kudo, N., J. G. Gillespie, L. Kung, L. A. Witters, R. Schulz, A. S. Clanachan, and G. D. Lopaschuk. Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia. Biochim. Biophys. Acta 1301: 67-75, 1996.
21. Law, W. R., and R. M. Raymond. Adenosine potentiates insulin-stimulated myocardial glucose uptake in vivo. Am. J. Physiol. 254 (Heart Circ. Physiol. 23): H970-H975, 1988.
22. Lee, A. D., P. A. Hansen, and J. O. Holloszy. Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle. FEBS Lett. 361: 51-54, 1995.
23. Lund, S., G. D. Holman, O. Schmitz, and O. Pedersen. Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin. Proc. Natl. Acad. Sci. USA 92: 5817-5821, 1995.
24. Merrill, G. F., E. J. Kurth, D. G. Hardie, and W. W. Winder. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E1107-E1112, 1997.
25. Nishimura, H., and I. A. Simpson. Staurosporine inhibits phorbol 12-myristate 13-acetate-and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells. Biochem. J. 302: 271-277, 1994.
26. Ponticos, M., Q. L. Lu, J. E. Morgan, D. G. Hardie, T. A. Partridge, and D. Carling. Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. EMBO J. 17:1688-1699, 1998.
27. Reibel, D. K., and M. J. Rovetto. Myocardial ATP synthesis and mechanical function following oxygen deficiency. Am. J. Physiol. 234 [Heart Circ. Physiol. 3): H620-H624, 1978.
28. Russell, R. R., G. W. Cline, P. H. Guthrie, G. W. Goodwin, G. I. Shulman, and H. Taegtmeyer. Regulation of exogenous and endogenous glucose metabolism by insulin and acetoacetate in the isolated working rat heart: a three tracer study of glycolysis, glycogen metabolism and glucose oxidation. J. Clin. Invest. 100: 2892-2899, 1997.
29. Russell, R. R., Y. Renfu, M. J. Caplan, X. Hu, J. Ren, G. I. Shulman, A. J. Sinusas, and L. H. Young. Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo. Circulation 98: 2180-2186, 1998.
30. Sullivan, J. E., K. J. Brocklehurst, A. E. Marley, F. Carey, D. Carling, and R. K. Beri. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Lett. 353: 33-36, 1994.
31. Sun, D., N. Nguyen, T. R. DeGrado, M. Schwaiger, and F. C. Brosius III. Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes. Circulation 89: 793-798, 1994.
32. Taniguchi, M., J. Y. Altarejos, A. S. Clanachan, and G. D. Lopaschuk. Inhibition of 5'AMP-activated protein kinase inhibits fatty acid oxidation and improves functional recovery of ischemic hearts (Abstract). Circulation 98, Suppl. 1:1759, 1998.
33. Tsakiridis, T., M. Vranic, and A. Klip. Phosphatidylinositol 3-kinase and the actin network are not required for the stimulation of glucose transport caused by mitochondrial uncoupling: comparison with insulin action. Biochem. J. 309: 1-5, 1995.
34. Vavvas, D., A. Apazidis, A. K. Saha, J. Gamble, A. Patel, B. E. Kemp, L. A. Witters, and N. B. Ruderman. Contractioninduced changes in acetyl-CoA carboxylase and 5′-AMP-activated kinase in skeletal muscle. J. Biol. Chem. 272: 13255-13261, 1997.
35. Vergauwen, L., P. Hespel, and E. A. Richter. Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle. J. Clin. Invest. 93: 974-981, 1994.
36. Vincent, M. F., M. D. Erion, H. E. Gruber, and G. Van den Berghe. Hypoglycemic effect of AICAriboside in mice. Diabetologia 39: 1148-1155, 1996.
37. Vincent, M. F., P. J. Marangos, H. E. Gruber, and G. Van den Berghe. Inhibition by AICA riboside of gluconeogenesis in isolated rat hepatocytes. Diabetes 40: 1259-1266, 1991.
38. Winder, W. W., and D. G. Hardie. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E299-E304, 1996.
39. Winder, W. W., H. A. Wilson, D. G. Hardie, B. B. Rasmussen, C. A. Hutber, G. B. Call, R. D. Clayton, L. M. Conley, S. Yoon, and B. Zhou. Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A. J. Appl. Physiol. 82: 219-225, 1997.
40. Yeh, J. I., E. A. Gulve, L. Rameh, and M. J. Birnbaum. The effects of wortmannin on rat skeletal muscle: dissociation of signaling pathways for insulin-and contraction-activated hexose transport. J. Biol. Chem. 270: 2107-2111, 1995.
41. Young, L. H., Y. Renfu, R. Russell, X. Hu, M. Caplan, J. Ren, G. I. Shulman, and A. J. Sinusas. Low flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo. Circulation 95: 415-422, 1997.
42. Young, M. E., G. K. Radda, and B. Leighton. Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR - an activator of AMP-activated protein kinase. FEBS Lett. 382: 43-47, 1996.