A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 284, Issue 3 53-3, 2003, Pages

  Kohno, Masateru ^a   Yano, Masafumi ^a   Kobayashi, Shigeki ^a   Doi, Masahiro ^a   Oda, Tetsuro ^a   Tokuhisa, Takahiro ^a   Okuda, Shinichi ^a   Ohkusa, Tomoko ^a   Kohno, Michihiro ^a   Matsuzaki, Masunori ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Binding protein; Excitation contraction coupling; Ion channel; Sarcoplasmic reticulum

Indexed keywords

4 [3 (4 BENZYL 1 PIPERIDINYL)PROPIONYL] 2,3,4,5 TETRAHYDRO 7 METHOXY 1,4 BENZOTHIAZEPINE; BENZOTHIAZEPINE DERIVATIVE; CALCIUM ION; COUMARIN DERIVATIVE; DILTIAZEM; ION CHANNEL; METHYLCOUMARIN ACETAMIDE; NIFEDIPINE; POLYLYSINE; RYANODINE; RYANODINE RECEPTOR; TACROLIMUS; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DOG; DRUG MECHANISM; FLUORESCENCE; HEART FAILURE; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART PROTECTION; HEART RATE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; TACHYCARDIA; TIME SERIES ANALYSIS; TREATMENT OUTCOME;

EID: 0037372101     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00722.2002     Document Type: Article

References (22)

1. Arai M, Matsui H, and Periasamy M. Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure. Circ Res 74: 555-564, 1994.
2. 2+ sensitivity in intact cardiac cells. In: Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters, edited by Morad M, Ebashi S, Trautwein W, and Kurachi Y. London: Kluwer, 1996, p. 513-529.
3. 2+ channel in SR from dogs with heart failure. Am J Physiol Heart Circ Physiol 264: H926-H937, 1993.
4. 2+ channel. J Biol Chem 274: 33341-33347, 1999.
5. 2+ re]ease from sarcoplasmic reticulum. J Biol Chem 270: 15634-15638, 1995.
6. Ikemoto N, Antoniu B, and Kim DH. Rapid calcium release from the isolated sarcoplasmic reticulum is triggered via the attached transverse tubular system. J Biol Chem 259: 13151-13158, 1984.
7. Ikemoto N, Yano M, El-Hayek R, Antoniu B, and Morii M. Chemical depolarization-induced SR calcium release in triads isolated from rabbit skeletal muscle. Biochemistry 33: 10961-10968, 1994.
8. Kaneko N. New 1,4-benzothiazepine derivative, K201, demonstrates cardioprotective effects against sudden cardiac cell death and intracellular calcium blocking action. Drug Dev Res 33: 429-438, 1994.
9. Kranias E, Schwarts A, and Jungmann RA. Characterization of cyclic 3':5'-AMP-dependent protein kinase in sarcoplasmic reticulum and cytosol of canine myocardium. Biochim Biophys Acta 709: 28-37, 1982.
10. Kuo TH, Tsang W, Wang KK, and Carlock L. Simultaneous reduction of the sarcolemmal and SR calcium ATPase activities and gene expression in cardiomyopathic hamster. Biochim Biophys Acta 1138: 343-349, 1992.
11. 2+-ATPase in failing and nonfailing human hearts. Cardiovasc Res 31: 625-632, 1996.
12. Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, and Marks AR. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101: 365-376, 2000.
13. 2+-release channel and ATP-synthesis activities are early myocardial markers of heart failure produced by rapid ventricular pacing in dogs. Can J Physiol Pharmacol 72: 999-1006, 1994.
14. 2+ release in heart failure. Cardiovasc Res 48: 323-331, 2000.
15. 2+ leak from the sarcoplasmic reticulum and increases contractility. Circ Res 88: 188-194, 2001.
16. Timerman AP, Ogunbumni E, Freund E, Wiederrecht G, Marks AR, and Fleischer S. The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum. J Biol Chem 268:22992-22999, 1993.
17. 2+ release from cardiac sarcoplasmic reticulum in tachycardiainduced heart failure. Cardiovasc Res 44: 146-155, 1999.
18. 2+ release from sarcoplasmic reticulum. J Biol Chem 270: 3017-3021, 1995.
19. Yano M, El-Hayek R, and Ikemoto N. Role of calcium feed back in excitation-contraction coupling in isolated triads. J Biol Chem 270:19936-19942, 1995.
20. Yano M, Kobayashi S, Kohno M, Doi M, Tokuhisa T, Okuda S, Suetsugu M, Hisaoka T, Obayashi M, Ohkusa T, Kohno M, and Matsuzaki M. FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure. Circulation. In press.
21. 2+ leak through ryanodine receptor in heart failure. Circulation 102: 2131-2136, 2000.
22. 2+ release from cardiac sarcoplasmic reticulum. J Cardiovasc Pharmacol 32: 96-100, 1998.