Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 16, 2009, Pages 6854-6859

  Lyon, Alexander R ^a   MacLeod, Ken T ^a   Zhang, Yanjun ^b   Garcia, Edwin ^a   Kanda, Gaelle Kikonda ^a   Lab, Max J ^b   Korchev, Yuri E ^b   Harding, Sian E ^a   Gorelik, Julia ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Calcium handling; Heart failure; Morphology; T tubule

Indexed keywords

CALCIUM CHANNEL; RYANODINE RECEPTOR; CALCIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL ISOLATION; CELL STRUCTURE; CELL SURFACE; CONFOCAL MICROSCOPY; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CORONARY ARTERY LIGATION; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE WALL; HUMAN; HUMAN TISSUE; HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY; IMAGE ANALYSIS; ISCHEMIC HEART DISEASE; NONHUMAN; OPTICAL INSTRUMENTATION; PRIORITY JOURNAL; RAT; SARCOPLASMIC RETICULUM; TRANSVERSE TUBULAR SYSTEM; ANIMAL; CALCIUM SIGNALING; CELL SEPARATION; CHRONIC DISEASE; DISEASE MODEL; HEART CONTRACTION; HEART INFARCTION; HEART VENTRICLE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SARCOLEMMA; SURFACE PROPERTY;

RATTUS; RODENTIA;

ANIMALS; CALCIUM; CALCIUM SIGNALING; CELL SEPARATION; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; HEART FAILURE; HEART VENTRICLES; HUMANS; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RATS; SARCOLEMMA; SURFACE PROPERTIES;

EID: 66149091985     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0809777106     Document Type: Article

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