-
1
-
-
0036254607
-
Insulin resistance in type 2 diabetes: Role of fatty acids
-
Arner P. Insulin resistance in type 2 diabetes: role of fatty acids. Diabetes Metab Res Rev 18: S5-S9, 2002.
-
(2002)
Diabetes Metab Res Rev
, vol.18
-
-
Arner, P.1
-
2
-
-
0037059549
-
Inhibition of protein kinase C β prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans
-
Beckman JA, Goldfine AB, Gordon MB, Garrett LA, and Creager MA. Inhibition of protein kinase C β prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans. Circ Res 90: 107-111, 2002.
-
(2002)
Circ Res
, vol.90
, pp. 107-111
-
-
Beckman, J.A.1
Goldfine, A.B.2
Gordon, M.B.3
Garrett, L.A.4
Creager, M.A.5
-
3
-
-
0032917447
-
2+-sensitive isoforms in the failing human heart
-
2+-sensitive isoforms in the failing human heart. Circulation 99: 384-391, 1999.
-
(1999)
Circulation
, vol.99
, pp. 384-391
-
-
Bowling, N.1
Walsh, R.A.2
Song, G.3
Estridge, T.4
Sandusky, G.E.5
Fouts, R.L.6
Mintze, K.7
Pickard, T.8
Roden, R.9
Bristow, M.R.10
Sabbah, H.N.11
Mizrahi, J.L.12
Gromo, G.13
King, G.L.14
Vlahos, C.J.15
-
4
-
-
0030696157
-
Expression of protein kinase C β in the heart causes hypertrophy in adult mice and sudden death in neonates
-
Bowman JC, Steinberg SF, Jiang T, Geenen DL, Fishman GI, and Buttrick PM. Expression of protein kinase C β in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest 100: 2189-2195, 1997.
-
(1997)
J Clin Invest
, vol.100
, pp. 2189-2195
-
-
Bowman, J.C.1
Steinberg, S.F.2
Jiang, T.3
Geenen, D.L.4
Fishman, G.I.5
Buttrick, P.M.6
-
5
-
-
0035856980
-
Biochemistry and molecular cell biology of diabetic complications
-
Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820, 2001.
-
(2001)
Nature
, vol.414
, pp. 813-820
-
-
Brownlee, M.1
-
6
-
-
0031459855
-
Specific retinal diacylglycerol and protein kinase C β isoform modulation mimics abnormal retinal hemodynamics in diabetic rats
-
Bursell SE, Takagi C, Clermont AC, Takagi H, Mori F, Ishii H, and King GL. Specific retinal diacylglycerol and protein kinase C β isoform modulation mimics abnormal retinal hemodynamics in diabetic rats. Invest Ophthalmol Vis Sci 38: 2711-2720, 1997.
-
(1997)
Invest Ophthalmol Vis Sci
, vol.38
, pp. 2711-2720
-
-
Bursell, S.E.1
Takagi, C.2
Clermont, A.C.3
Takagi, H.4
Mori, F.5
Ishii, H.6
King, G.L.7
-
7
-
-
0033775615
-
Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays
-
Bustin SA. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 25: 169-193, 2000.
-
(2000)
J Mol Endocrinol
, vol.25
, pp. 169-193
-
-
Bustin, S.A.1
-
8
-
-
0033830338
-
Protein kinase C isozymes and the regulation of diverse cell responses
-
Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, and Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol 279: L429-L438, 2000.
-
(2000)
Am J Physiol Lung Cell Mol Physiol
, vol.279
-
-
Dempsey, E.C.1
Newton, A.C.2
Mochly-Rosen, D.3
Fields, A.P.4
Reyland, M.E.5
Insel, P.A.6
Messing, R.O.7
-
9
-
-
0028105717
-
Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy
-
Derubertis FR and Craven PA. Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy. Diabetes 43: 1-8, 1994.
-
(1994)
Diabetes
, vol.43
, pp. 1-8
-
-
Derubertis, F.R.1
Craven, P.A.2
-
10
-
-
0036796875
-
Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes
-
Evans JL, Goldfine ID, Maddux BA, and Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23: 599-622, 2002.
-
(2002)
Endocr Rev
, vol.23
, pp. 599-622
-
-
Evans, J.L.1
Goldfine, I.D.2
Maddux, B.A.3
Grodsky, G.M.4
-
11
-
-
0031913329
-
Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat
-
Giles TD, Ouyang J, Kerut EK, Given MB, Allen GE, McIlwain EF, and Greenberg SS. Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat. Am J Physiol Heart Circ Physiol 274: H295-H307, 1998.
-
(1998)
Am J Physiol Heart Circ Physiol
, vol.274
-
-
Giles, T.D.1
Ouyang, J.2
Kerut, E.K.3
Given, M.B.4
Allen, G.E.5
McIlwain, E.F.6
Greenberg, S.S.7
-
12
-
-
0035866371
-
Elevated protein kinase C βII is an early promotive event in colon carcinogenesis
-
Gokmen-Polar Y, Murray NR, Velasco MA, Gatalica Z, and Fields AP. Elevated protein kinase C βII is an early promotive event in colon carcinogenesis. Cancer Res 61: 1375-1381, 2001.
-
(2001)
Cancer Res
, vol.61
, pp. 1375-1381
-
-
Gokmen-Polar, Y.1
Murray, N.R.2
Velasco, M.A.3
Gatalica, Z.4
Fields, A.P.5
-
13
-
-
0037059511
-
Vascular dysfunction in hyperglycemia: Is protein kinase C the culprit?
-
Gutterman DD. Vascular dysfunction in hyperglycemia: is protein kinase C the culprit? Circ Res 90: 5-7, 2002.
-
(2002)
Circ Res
, vol.90
, pp. 5-7
-
-
Gutterman, D.D.1
-
14
-
-
0030743466
-
High glucose concentrations increase endothelial cell permeability via activation of protein kinase Ca
-
Hempel A, Maasch C, Heintze U, Lindschau C, Dietz R, Luft FC, and Haller H. High glucose concentrations increase endothelial cell permeability via activation of protein kinase Ca. Circ Res 81: 363-371, 1997.
-
(1997)
Circ Res
, vol.81
, pp. 363-371
-
-
Hempel, A.1
Maasch, C.2
Heintze, U.3
Lindschau, C.4
Dietz, R.5
Luft, F.C.6
Haller, H.7
-
15
-
-
0034852862
-
Protein kinase C activation: Isozyme-specific effects on metabolism and cardiovascular complications in diabetes
-
Idris I, Gray S, and Donnelly R. Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes. Diabetologia 44: 659-673, 2001.
-
(2001)
Diabetologia
, vol.44
, pp. 659-673
-
-
Idris, I.1
Gray, S.2
Donnelly, R.3
-
16
-
-
0026489335
-
Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
-
Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, and King GL. Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 89: 11059-11063, 1992.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 11059-11063
-
-
Inoguchi, T.1
Battan, R.2
Handler, E.3
Sportsman, J.R.4
Heath, W.5
King, G.L.6
-
17
-
-
0027977387
-
Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues
-
Inoguchi T, Xia P, Kunisaki M, Higashi S, Feener EP, and King GL. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol Endocrinol Metab 267: E1-E11, 1994.
-
(1994)
Am J Physiol Endocrinol Metab
, vol.267
-
-
Inoguchi, T.1
Xia, P.2
Kunisaki, M.3
Higashi, S.4
Feener, E.P.5
King, G.L.6
-
18
-
-
13344293711
-
Amelioration of vascular dysfunctions in diabetic rats by an oral PKCβ inhibitor
-
Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, Bursell SE, Kern TS, Ballas LM, Heath WF, Stramm LE, Feener EP, and King GL. Amelioration of vascular dysfunctions in diabetic rats by an oral PKCβ inhibitor. Science 272: 728-731, 1996.
-
(1996)
Science
, vol.272
, pp. 728-731
-
-
Ishii, H.1
Jirousek, M.R.2
Koya, D.3
Takagi, C.4
Xia, P.5
Clermont, A.6
Bursell, S.E.7
Kern, T.S.8
Ballas, L.M.9
Heath, W.F.10
Stramm, L.E.11
Feener, E.P.12
King, G.L.13
-
19
-
-
0032704786
-
Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats
-
Kang N, Alexander G, Park JK, Maasch C, Buchwalow I, Luft FC, and Haller H. Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats. Kidney Int 6: 1737-1750, 1999.
-
(1999)
Kidney Int
, vol.6
, pp. 1737-1750
-
-
Kang, N.1
Alexander, G.2
Park, J.K.3
Maasch, C.4
Buchwalow, I.5
Luft, F.C.6
Haller, H.7
-
20
-
-
0033847726
-
Ammonium chloride potentiation of streptozotocin-induced diabetes in juvenile pigs
-
Korompai FL, Ustinova E, Taulman AC, and Yuan SY. Ammonium chloride potentiation of streptozotocin-induced diabetes in juvenile pigs. Horm Metab Res 32: 256-258, 2000.
-
(2000)
Horm Metab Res
, vol.32
, pp. 256-258
-
-
Korompai, F.L.1
Ustinova, E.2
Taulman, A.C.3
Yuan, S.Y.4
-
21
-
-
0034053336
-
Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
-
Koya D, Haneda M, Nakagawa H, Isshiki K, Sato H, Maeda S, Sugimoto T, Yasuda H, Kashiwagi A, Ways DK, King GL, and Kikkawa R. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J 14: 439-447, 2000.
-
(2000)
FASEB J
, vol.14
, pp. 439-447
-
-
Koya, D.1
Haneda, M.2
Nakagawa, H.3
Isshiki, K.4
Sato, H.5
Maeda, S.6
Sugimoto, T.7
Yasuda, H.8
Kashiwagi, A.9
Ways, D.K.10
King, G.L.11
Kikkawa, R.12
-
22
-
-
0030760729
-
Characterization of protein kinase C β isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats
-
Koya D, Jirousek MR, Lin YW, Ishii H, Kuboki K, and King GL. Characterization of protein kinase C β isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest 100: 115-126, 1997.
-
(1997)
J Clin Invest
, vol.100
, pp. 115-126
-
-
Koya, D.1
Jirousek, M.R.2
Lin, Y.W.3
Ishii, H.4
Kuboki, K.5
King, G.L.6
-
23
-
-
0023629504
-
Primary structures of human protein kinase C βI and βII differ only in their C-terminal sequences
-
Kubo K, Ohno S, and Suzuki K. Primary structures of human protein kinase C βI and βII differ only in their C-terminal sequences. FEBS Lett 223: 138-142, 1987.
-
(1987)
FEBS Lett
, vol.223
, pp. 138-142
-
-
Kubo, K.1
Ohno, S.2
Suzuki, K.3
-
24
-
-
0028564935
-
Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels
-
Kunisaki M, Bursell SE, Umeda F, Nawata H, and King GL. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes 43: 1372-1377, 1994.
-
(1994)
Diabetes
, vol.43
, pp. 1372-1377
-
-
Kunisaki, M.1
Bursell, S.E.2
Umeda, F.3
Nawata, H.4
King, G.L.5
-
25
-
-
0032756850
-
Changes in cardiac protein kinase C activities and isozymes in streptozotocin-induced diabetes
-
Liu X, Wang J, Takeda N, Binaglia L, Panagia V, and Dhalla NS. Changes in cardiac protein kinase C activities and isozymes in streptozotocin-induced diabetes. Am J Physiol Endocrinol Metab 277: E798-E804, 1999.
-
(1999)
Am J Physiol Endocrinol Metab
, vol.277
-
-
Liu, X.1
Wang, J.2
Takeda, N.3
Binaglia, L.4
Panagia, V.5
Dhalla, N.S.6
-
26
-
-
0033816539
-
Fatty acids modulate protein kinase C activation in porcine vascular smooth muscle cells independently of their effect on de novo diacylglycerol synthesis
-
Lu X, Yang XY, Howard RL, and Walsh JP. Fatty acids modulate protein kinase C activation in porcine vascular smooth muscle cells independently of their effect on de novo diacylglycerol synthesis. Diabetologia 43: 1136-1144, 2000.
-
(2000)
Diabetologia
, vol.43
, pp. 1136-1144
-
-
Lu, X.1
Yang, X.Y.2
Howard, R.L.3
Walsh, J.P.4
-
27
-
-
0030784596
-
Experimental diabetes is associated with functional activation of protein kinase Cε and phosphorylation of troponin I in the heart, which are prevented by angiotensin II receptor blockade
-
Malhotra A, Reich D, Reich D, Nakouzi A, Sanghi V, Geenen DL, and Buttrick PM. Experimental diabetes is associated with functional activation of protein kinase Cε and phosphorylation of troponin I in the heart, which are prevented by angiotensin II receptor blockade. Circ Res 81: 1027-1033, 1997.
-
(1997)
Circ Res
, vol.81
, pp. 1027-1033
-
-
Malhotra, A.1
Reich, D.2
Reich, D.3
Nakouzi, A.4
Sanghi, V.5
Geenen, D.L.6
Buttrick, P.M.7
-
28
-
-
0033781544
-
Protein kinase C activation and its pharmacological inhibition in vascular disease
-
Meier M and King GL. Protein kinase C activation and its pharmacological inhibition in vascular disease. Vasc Med 5: 173-185, 2000.
-
(2000)
Vasc Med
, vol.5
, pp. 173-185
-
-
Meier, M.1
King, G.L.2
-
29
-
-
0031964645
-
Anchoring proteins for protein kinase C: A means for isozyme selectivity
-
Mochly-Rosen D and Gordon AS. Anchoring proteins for protein kinase C: a means for isozyme selectivity. FASEB J 12: 35-42, 1998.
-
(1998)
FASEB J
, vol.12
, pp. 35-42
-
-
Mochly-Rosen, D.1
Gordon, A.S.2
-
30
-
-
0035413601
-
Protein kinase C: Structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions
-
Newton AC. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev 101: 2353-2364, 2001.
-
(2001)
Chem Rev
, vol.101
, pp. 2353-2364
-
-
Newton, A.C.1
-
31
-
-
0023278635
-
Expression and properties of two types of protein kinase C: Alternative splicing from a single gene
-
Ono Y, Kikkawa U, Ogita K, Fujii T, Kurokawa T, Asaoka Y, Sekiguchi K, Ase K, Igarashi K, and Nishizuka Y. Expression and properties of two types of protein kinase C: alternative splicing from a single gene. Science 236: 1116-1120, 1987.
-
(1987)
Science
, vol.236
, pp. 1116-1120
-
-
Ono, Y.1
Kikkawa, U.2
Ogita, K.3
Fujii, T.4
Kurokawa, T.5
Asaoka, Y.6
Sekiguchi, K.7
Ase, K.8
Igarashi, K.9
Nishizuka, Y.10
-
32
-
-
0032849088
-
New insights into the regulation of protein kinase C and novel phorbol ester receptors
-
Ron D and Kazanietz MG. New insights into the regulation of protein kinase C and novel phorbol ester receptors. FASEB J 13: 1658-1676, 1999.
-
(1999)
FASEB J
, vol.13
, pp. 1658-1676
-
-
Ron, D.1
Kazanietz, M.G.2
-
33
-
-
0027454103
-
Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation
-
Shiba T, Inoguchi T, Sportsman JR, Heath WF, Bursell S, and King GL. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol Endocrinol Metab 265: E783-E793, 1993.
-
(1993)
Am J Physiol Endocrinol Metab
, vol.265
-
-
Shiba, T.1
Inoguchi, T.2
Sportsman, J.R.3
Heath, W.F.4
Bursell, S.5
King, G.L.6
-
34
-
-
0032946408
-
β-protein kinase C and hypertrophic signaling in human heart failure
-
Simpson PC. β-Protein kinase C and hypertrophic signaling in human heart failure. Circulation 99: 334-337, 1999.
-
(1999)
Circulation
, vol.99
, pp. 334-337
-
-
Simpson, P.C.1
-
36
-
-
0032128254
-
In vivo phosphorylation of cardiac troponin I by protein kinase C β 2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts
-
Takeishi Y, Chu G, Kirkpatrick DM, Li Z, Wakasaki H, Kranias EG, King GL, and Walsh RA. In vivo phosphorylation of cardiac troponin I by protein kinase C β2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts. J Clin Invest 102: 72-78, 1998.
-
(1998)
J Clin Invest
, vol.102
, pp. 72-78
-
-
Takeishi, Y.1
Chu, G.2
Kirkpatrick, D.M.3
Li, Z.4
Wakasaki, H.5
Kranias, E.G.6
King, G.L.7
Walsh, R.A.8
-
37
-
-
0030875166
-
Targeted overexpression of protein kinase C β 2 isoform in myocardium causes cardiomyopathy
-
Wakasaki H, Koya D, Schoen FJ, Jirousek MR, Ways DK, Hoit BD, Walsh RA, and King GL. Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy. Proc Natl Acad Sci USA 94: 9320-9325, 1997.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9320-9325
-
-
Wakasaki, H.1
Koya, D.2
Schoen, F.J.3
Jirousek, M.R.4
Ways, D.K.5
Hoit, B.D.6
Walsh, R.A.7
King, G.L.8
-
38
-
-
0035669720
-
Protein kinase C and the development of diabetic vascular complications
-
Way KJ, Katai N, and King GL. Protein kinase C and the development of diabetic vascular complications. Diabet Med 18: 945-959, 2001.
-
(2001)
Diabet Med
, vol.18
, pp. 945-959
-
-
Way, K.J.1
Katai, N.2
King, G.L.3
-
39
-
-
0033994409
-
Radicals and oxidative stress in diabetes
-
West IC. Radicals and oxidative stress in diabetes. Diabet Med 17: 171-180, 2000.
-
(2000)
Diabet Med
, vol.17
, pp. 171-180
-
-
West, I.C.1
-
40
-
-
0026035977
-
Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels
-
Wolf BA, Williamson JR, Easom RA, Chang K, Sherman WR, and Turk J. Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels. J Clin Invest 87: 31-38, 1991.
-
(1991)
J Clin Invest
, vol.87
, pp. 31-38
-
-
Wolf, B.A.1
Williamson, J.R.2
Easom, R.A.3
Chang, K.4
Sherman, W.R.5
Turk, J.6
-
41
-
-
0027981889
-
Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia
-
Xia P, Aiello LP, Ishii H, Jiang ZY, Park DJ, Robinson GS, Takagi H, Newsome WP, Jirousek MR, and King GL. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes 43: 1122-1129, 1994.
-
(1994)
Diabetes
, vol.43
, pp. 1122-1129
-
-
Xia, P.1
Aiello, L.P.2
Ishii, H.3
Jiang, Z.Y.4
Park, D.J.5
Robinson, G.S.6
Takagi, H.7
Newsome, W.P.8
Jirousek, M.R.9
King, G.L.10
-
42
-
-
0026785409
-
Protein kinase C activity is altered in diabetic rat hearts
-
Xiang H and McNeill JH. Protein kinase C activity is altered in diabetic rat hearts. Biochem Biophys Res Commun 187: 703-710, 1992.
-
(1992)
Biochem Biophys Res Commun
, vol.187
, pp. 703-710
-
-
Xiang, H.1
McNeill, J.H.2
-
43
-
-
0035011093
-
Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase C activity in cultured aortic smooth muscle cells
-
Yu HY, Inoguchi T, Kakimoto M, Nakashima N, Imamura M, Hashimoto T, Umeda F, and Nawata H. Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase C activity in cultured aortic smooth muscle cells. Diabetologia 44: 614-620.
-
Diabetologia
, vol.44
, pp. 614-620
-
-
Yu, H.Y.1
Inoguchi, T.2
Kakimoto, M.3
Nakashima, N.4
Imamura, M.5
Hashimoto, T.6
Umeda, F.7
Nawata, H.8
-
44
-
-
0034283423
-
Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes
-
Yuan SY, Ustinova EE, Wu MH, Tinsley JH, Xu W, Korompai FL, and Taulman AC. Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes. Circ Res 87: 412-417, 2000.
-
(2000)
Circ Res
, vol.87
, pp. 412-417
-
-
Yuan, S.Y.1
Ustinova, E.E.2
Wu, M.H.3
Tinsley, J.H.4
Xu, W.5
Korompai, F.L.6
Taulman, A.C.7
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