메뉴 건너뛰기




Volumn 12, Issue , 2003, Pages 139-146

Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes

Author keywords

Gene and protein expression; Hyperglycemia; Protein kinase C; Real time reverse transcription polymerase chain reaction

Indexed keywords

COMPLEMENTARY DNA; GLUCOSE; ISOENZYME; MESSENGER RNA; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; STREPTOZOCIN;

EID: 0037440204     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00125.2002     Document Type: Article
Times cited : (73)

References (44)
  • 1
    • 0036254607 scopus 로고    scopus 로고
    • Insulin resistance in type 2 diabetes: Role of fatty acids
    • Arner P. Insulin resistance in type 2 diabetes: role of fatty acids. Diabetes Metab Res Rev 18: S5-S9, 2002.
    • (2002) Diabetes Metab Res Rev , vol.18
    • Arner, P.1
  • 2
    • 0037059549 scopus 로고    scopus 로고
    • Inhibition of protein kinase C β prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans
    • Beckman JA, Goldfine AB, Gordon MB, Garrett LA, and Creager MA. Inhibition of protein kinase C β prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans. Circ Res 90: 107-111, 2002.
    • (2002) Circ Res , vol.90 , pp. 107-111
    • Beckman, J.A.1    Goldfine, A.B.2    Gordon, M.B.3    Garrett, L.A.4    Creager, M.A.5
  • 4
    • 0030696157 scopus 로고    scopus 로고
    • Expression of protein kinase C β in the heart causes hypertrophy in adult mice and sudden death in neonates
    • Bowman JC, Steinberg SF, Jiang T, Geenen DL, Fishman GI, and Buttrick PM. Expression of protein kinase C β in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest 100: 2189-2195, 1997.
    • (1997) J Clin Invest , vol.100 , pp. 2189-2195
    • Bowman, J.C.1    Steinberg, S.F.2    Jiang, T.3    Geenen, D.L.4    Fishman, G.I.5    Buttrick, P.M.6
  • 5
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820, 2001.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 6
    • 0031459855 scopus 로고    scopus 로고
    • Specific retinal diacylglycerol and protein kinase C β isoform modulation mimics abnormal retinal hemodynamics in diabetic rats
    • Bursell SE, Takagi C, Clermont AC, Takagi H, Mori F, Ishii H, and King GL. Specific retinal diacylglycerol and protein kinase C β isoform modulation mimics abnormal retinal hemodynamics in diabetic rats. Invest Ophthalmol Vis Sci 38: 2711-2720, 1997.
    • (1997) Invest Ophthalmol Vis Sci , vol.38 , pp. 2711-2720
    • Bursell, S.E.1    Takagi, C.2    Clermont, A.C.3    Takagi, H.4    Mori, F.5    Ishii, H.6    King, G.L.7
  • 7
    • 0033775615 scopus 로고    scopus 로고
    • Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays
    • Bustin SA. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 25: 169-193, 2000.
    • (2000) J Mol Endocrinol , vol.25 , pp. 169-193
    • Bustin, S.A.1
  • 9
    • 0028105717 scopus 로고
    • Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy
    • Derubertis FR and Craven PA. Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy. Diabetes 43: 1-8, 1994.
    • (1994) Diabetes , vol.43 , pp. 1-8
    • Derubertis, F.R.1    Craven, P.A.2
  • 10
    • 0036796875 scopus 로고    scopus 로고
    • Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes
    • Evans JL, Goldfine ID, Maddux BA, and Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23: 599-622, 2002.
    • (2002) Endocr Rev , vol.23 , pp. 599-622
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 12
    • 0035866371 scopus 로고    scopus 로고
    • Elevated protein kinase C βII is an early promotive event in colon carcinogenesis
    • Gokmen-Polar Y, Murray NR, Velasco MA, Gatalica Z, and Fields AP. Elevated protein kinase C βII is an early promotive event in colon carcinogenesis. Cancer Res 61: 1375-1381, 2001.
    • (2001) Cancer Res , vol.61 , pp. 1375-1381
    • Gokmen-Polar, Y.1    Murray, N.R.2    Velasco, M.A.3    Gatalica, Z.4    Fields, A.P.5
  • 13
    • 0037059511 scopus 로고    scopus 로고
    • Vascular dysfunction in hyperglycemia: Is protein kinase C the culprit?
    • Gutterman DD. Vascular dysfunction in hyperglycemia: is protein kinase C the culprit? Circ Res 90: 5-7, 2002.
    • (2002) Circ Res , vol.90 , pp. 5-7
    • Gutterman, D.D.1
  • 14
    • 0030743466 scopus 로고    scopus 로고
    • High glucose concentrations increase endothelial cell permeability via activation of protein kinase Ca
    • Hempel A, Maasch C, Heintze U, Lindschau C, Dietz R, Luft FC, and Haller H. High glucose concentrations increase endothelial cell permeability via activation of protein kinase Ca. Circ Res 81: 363-371, 1997.
    • (1997) Circ Res , vol.81 , pp. 363-371
    • Hempel, A.1    Maasch, C.2    Heintze, U.3    Lindschau, C.4    Dietz, R.5    Luft, F.C.6    Haller, H.7
  • 15
    • 0034852862 scopus 로고    scopus 로고
    • Protein kinase C activation: Isozyme-specific effects on metabolism and cardiovascular complications in diabetes
    • Idris I, Gray S, and Donnelly R. Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes. Diabetologia 44: 659-673, 2001.
    • (2001) Diabetologia , vol.44 , pp. 659-673
    • Idris, I.1    Gray, S.2    Donnelly, R.3
  • 16
    • 0026489335 scopus 로고
    • Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
    • Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, and King GL. Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 89: 11059-11063, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11059-11063
    • Inoguchi, T.1    Battan, R.2    Handler, E.3    Sportsman, J.R.4    Heath, W.5    King, G.L.6
  • 19
    • 0032704786 scopus 로고    scopus 로고
    • Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats
    • Kang N, Alexander G, Park JK, Maasch C, Buchwalow I, Luft FC, and Haller H. Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats. Kidney Int 6: 1737-1750, 1999.
    • (1999) Kidney Int , vol.6 , pp. 1737-1750
    • Kang, N.1    Alexander, G.2    Park, J.K.3    Maasch, C.4    Buchwalow, I.5    Luft, F.C.6    Haller, H.7
  • 20
    • 0033847726 scopus 로고    scopus 로고
    • Ammonium chloride potentiation of streptozotocin-induced diabetes in juvenile pigs
    • Korompai FL, Ustinova E, Taulman AC, and Yuan SY. Ammonium chloride potentiation of streptozotocin-induced diabetes in juvenile pigs. Horm Metab Res 32: 256-258, 2000.
    • (2000) Horm Metab Res , vol.32 , pp. 256-258
    • Korompai, F.L.1    Ustinova, E.2    Taulman, A.C.3    Yuan, S.Y.4
  • 22
    • 0030760729 scopus 로고    scopus 로고
    • Characterization of protein kinase C β isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats
    • Koya D, Jirousek MR, Lin YW, Ishii H, Kuboki K, and King GL. Characterization of protein kinase C β isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest 100: 115-126, 1997.
    • (1997) J Clin Invest , vol.100 , pp. 115-126
    • Koya, D.1    Jirousek, M.R.2    Lin, Y.W.3    Ishii, H.4    Kuboki, K.5    King, G.L.6
  • 23
    • 0023629504 scopus 로고
    • Primary structures of human protein kinase C βI and βII differ only in their C-terminal sequences
    • Kubo K, Ohno S, and Suzuki K. Primary structures of human protein kinase C βI and βII differ only in their C-terminal sequences. FEBS Lett 223: 138-142, 1987.
    • (1987) FEBS Lett , vol.223 , pp. 138-142
    • Kubo, K.1    Ohno, S.2    Suzuki, K.3
  • 24
    • 0028564935 scopus 로고
    • Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels
    • Kunisaki M, Bursell SE, Umeda F, Nawata H, and King GL. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes 43: 1372-1377, 1994.
    • (1994) Diabetes , vol.43 , pp. 1372-1377
    • Kunisaki, M.1    Bursell, S.E.2    Umeda, F.3    Nawata, H.4    King, G.L.5
  • 26
    • 0033816539 scopus 로고    scopus 로고
    • Fatty acids modulate protein kinase C activation in porcine vascular smooth muscle cells independently of their effect on de novo diacylglycerol synthesis
    • Lu X, Yang XY, Howard RL, and Walsh JP. Fatty acids modulate protein kinase C activation in porcine vascular smooth muscle cells independently of their effect on de novo diacylglycerol synthesis. Diabetologia 43: 1136-1144, 2000.
    • (2000) Diabetologia , vol.43 , pp. 1136-1144
    • Lu, X.1    Yang, X.Y.2    Howard, R.L.3    Walsh, J.P.4
  • 27
    • 0030784596 scopus 로고    scopus 로고
    • Experimental diabetes is associated with functional activation of protein kinase Cε and phosphorylation of troponin I in the heart, which are prevented by angiotensin II receptor blockade
    • Malhotra A, Reich D, Reich D, Nakouzi A, Sanghi V, Geenen DL, and Buttrick PM. Experimental diabetes is associated with functional activation of protein kinase Cε and phosphorylation of troponin I in the heart, which are prevented by angiotensin II receptor blockade. Circ Res 81: 1027-1033, 1997.
    • (1997) Circ Res , vol.81 , pp. 1027-1033
    • Malhotra, A.1    Reich, D.2    Reich, D.3    Nakouzi, A.4    Sanghi, V.5    Geenen, D.L.6    Buttrick, P.M.7
  • 28
    • 0033781544 scopus 로고    scopus 로고
    • Protein kinase C activation and its pharmacological inhibition in vascular disease
    • Meier M and King GL. Protein kinase C activation and its pharmacological inhibition in vascular disease. Vasc Med 5: 173-185, 2000.
    • (2000) Vasc Med , vol.5 , pp. 173-185
    • Meier, M.1    King, G.L.2
  • 29
    • 0031964645 scopus 로고    scopus 로고
    • Anchoring proteins for protein kinase C: A means for isozyme selectivity
    • Mochly-Rosen D and Gordon AS. Anchoring proteins for protein kinase C: a means for isozyme selectivity. FASEB J 12: 35-42, 1998.
    • (1998) FASEB J , vol.12 , pp. 35-42
    • Mochly-Rosen, D.1    Gordon, A.S.2
  • 30
    • 0035413601 scopus 로고    scopus 로고
    • Protein kinase C: Structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions
    • Newton AC. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev 101: 2353-2364, 2001.
    • (2001) Chem Rev , vol.101 , pp. 2353-2364
    • Newton, A.C.1
  • 32
    • 0032849088 scopus 로고    scopus 로고
    • New insights into the regulation of protein kinase C and novel phorbol ester receptors
    • Ron D and Kazanietz MG. New insights into the regulation of protein kinase C and novel phorbol ester receptors. FASEB J 13: 1658-1676, 1999.
    • (1999) FASEB J , vol.13 , pp. 1658-1676
    • Ron, D.1    Kazanietz, M.G.2
  • 34
    • 0032946408 scopus 로고    scopus 로고
    • β-protein kinase C and hypertrophic signaling in human heart failure
    • Simpson PC. β-Protein kinase C and hypertrophic signaling in human heart failure. Circulation 99: 334-337, 1999.
    • (1999) Circulation , vol.99 , pp. 334-337
    • Simpson, P.C.1
  • 36
    • 0032128254 scopus 로고    scopus 로고
    • In vivo phosphorylation of cardiac troponin I by protein kinase C β 2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts
    • Takeishi Y, Chu G, Kirkpatrick DM, Li Z, Wakasaki H, Kranias EG, King GL, and Walsh RA. In vivo phosphorylation of cardiac troponin I by protein kinase C β2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts. J Clin Invest 102: 72-78, 1998.
    • (1998) J Clin Invest , vol.102 , pp. 72-78
    • Takeishi, Y.1    Chu, G.2    Kirkpatrick, D.M.3    Li, Z.4    Wakasaki, H.5    Kranias, E.G.6    King, G.L.7    Walsh, R.A.8
  • 38
    • 0035669720 scopus 로고    scopus 로고
    • Protein kinase C and the development of diabetic vascular complications
    • Way KJ, Katai N, and King GL. Protein kinase C and the development of diabetic vascular complications. Diabet Med 18: 945-959, 2001.
    • (2001) Diabet Med , vol.18 , pp. 945-959
    • Way, K.J.1    Katai, N.2    King, G.L.3
  • 39
    • 0033994409 scopus 로고    scopus 로고
    • Radicals and oxidative stress in diabetes
    • West IC. Radicals and oxidative stress in diabetes. Diabet Med 17: 171-180, 2000.
    • (2000) Diabet Med , vol.17 , pp. 171-180
    • West, I.C.1
  • 40
    • 0026035977 scopus 로고
    • Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels
    • Wolf BA, Williamson JR, Easom RA, Chang K, Sherman WR, and Turk J. Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels. J Clin Invest 87: 31-38, 1991.
    • (1991) J Clin Invest , vol.87 , pp. 31-38
    • Wolf, B.A.1    Williamson, J.R.2    Easom, R.A.3    Chang, K.4    Sherman, W.R.5    Turk, J.6
  • 42
    • 0026785409 scopus 로고
    • Protein kinase C activity is altered in diabetic rat hearts
    • Xiang H and McNeill JH. Protein kinase C activity is altered in diabetic rat hearts. Biochem Biophys Res Commun 187: 703-710, 1992.
    • (1992) Biochem Biophys Res Commun , vol.187 , pp. 703-710
    • Xiang, H.1    McNeill, J.H.2
  • 43
    • 0035011093 scopus 로고    scopus 로고
    • Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase C activity in cultured aortic smooth muscle cells
    • Yu HY, Inoguchi T, Kakimoto M, Nakashima N, Imamura M, Hashimoto T, Umeda F, and Nawata H. Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase C activity in cultured aortic smooth muscle cells. Diabetologia 44: 614-620.
    • Diabetologia , vol.44 , pp. 614-620
    • Yu, H.Y.1    Inoguchi, T.2    Kakimoto, M.3    Nakashima, N.4    Imamura, M.5    Hashimoto, T.6    Umeda, F.7    Nawata, H.8
  • 44
    • 0034283423 scopus 로고    scopus 로고
    • Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes
    • Yuan SY, Ustinova EE, Wu MH, Tinsley JH, Xu W, Korompai FL, and Taulman AC. Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes. Circ Res 87: 412-417, 2000.
    • (2000) Circ Res , vol.87 , pp. 412-417
    • Yuan, S.Y.1    Ustinova, E.E.2    Wu, M.H.3    Tinsley, J.H.4    Xu, W.5    Korompai, F.L.6    Taulman, A.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.