Diabetic cardiomyopathy: Evidence, mechanisms, and therapeutic implications

Endocrine Reviews

Volumn 25, Issue 4, 2004, Pages 543-567

  Zhi, You Fang ^a   Prins, Johannes B ^a   Marwick, Thomas H ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; ANTIOXIDANT; CAPTOPRIL; CATECHOLAMINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; INSULIN SENSITIZING AGENT; PROTEIN DERIVATIVE;

CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CARDIOMYOPATHY; CELL DEATH; CORRELATION ANALYSIS; DIABETES MELLITUS; DIABETIC CARDIOMYOPATHY; DIASTOLE; DISEASE ASSOCIATION; DISEASE COURSE; DRUG EFFECT; ELECTROCARDIOGRAM; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FILLING PRESSURE; HEART MUSCLE COMPLIANCE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART MUSCLE METABOLISM; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN RESISTANCE; ISCHEMIC HEART DISEASE; METABOLIC DISORDER; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; STATISTICAL SIGNIFICANCE; TECHNIQUE;

ANIMALS; CARDIOMYOPATHIES; DIABETES COMPLICATIONS; HUMANS;

EID: 4143140134     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.2003-0012     Document Type: Review

References (284)

1. Hamby RI, Zoneraich S, Sherman L 1974 Diabetic cardiomyopathy. JAMA 229:1749-1754
2. Regan TJ, Lyons MM, Ahmed SS, Levinson GE, Oldewurtel HA, Ahmad MR, Haider B 1977 Evidence for cardiomyopathy in familial diabetes mellitus. J Clin Invest 60:884-899
3. Mizushige K, Yao L, Noma T, Kiyomoto H, Yu Y, Hosomi N, Ohmori K, Matsuo H 2000 Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model. Circulation 101:899-907
4. Rubler S, Dlugash J, Yuceoglu YZ, Kumral T, Branwood AW, Grishman A 1972 New type of cardiomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol 30:595-602
5. Sohn DW, Chai IH, Lee DJ, Kim HC, Kim HS, Oh BH, Lee MM, Park YB, Choi YS, Seo JD, Lee YW 1997 Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol 30:474-480
6. Matsumura Y, Elliott PM, Virdee MS, Sorajja P, Doi Y, McKenna WJ 2002 Left ventricular diastolic function assessed using Doppler tissue imaging in patients with hypertrophic cardiomyopathy: relation to symptoms and exercise capacity. Heart 87:247-251
7. Schober KE, Fuentes VL, Bonagura JD 2003 Comparison between invasive hemodynamic measurements and noninvasive assessment of left ventricular diastolic function by use of Doppler echocardiography in healthy anesthetized cats. Am J Vet Res 64:93-103
8. Garcia MJ, Thomas JD, Klein AL 1998 New Doppler echocardiographic applications for the study of diastolic function. J Am Coll Cardiol 32:865-875
9. von Bibra H, Tuchnitz A, Klein A, Schneider-Eicke J, Schomig A, Schwaiger M 2000 Regional diastolic function by pulsed Doppler myocardial mapping for the detection of left ventricular ischemia during pharmacologic stress testing: a comparison with stress echocardiography and perfusion scintigraphy. J Am Coll Cardiol 36:444-452
10. Semeniuk LM, Kryski AJ, Severson DL 2002 Echocardiographic assessment of cardiac function in diabetic db/db and transgenic db/db-hGLUT4 mice. Am J Physiol Heart Circ Physiol 283:H976-H982
11. Ganguly PK, Thliveris JA, Mehta A 1990 Evidence against the involvement of nonenzymatic glycosylation in diabetic cardiomyopathy. Metabolism 39:769-773
12. Rajan SK, Gokhale SM 2002 Cardiovascular function in patients with insulin-dependent diabetes mellitus: a study using noninvasive methods. Ann NY Acad Sci 958:425-430
13. Giampietro O, Di Bello V, Matteucci E, Talarico L, Rubetti F, Boldrini E, Giorgi D, Giusti C 1997 Erythrocyte Na+/H+ exchange and preclinical abnormalities of the left ventricular diastolic function in normotensive type 1 (insulin-dependent) diabetic patients. Acta Diabetol 34:223-229
14. Lind L, Berne C, Andren B, Lithell H 1996 Relationship between diastolic hypertension and myocardial morphology and function in elderly males with diabetes mellitus. Diabetologia 39:1603-1606
15. Matteucci E, Di Bello V, Giampietro O 1995 Integrated analysis of erythrocyte Na+/H+ antiport activity and left ventricular myocardial function in type I insulin-dependent diabetes mellitus. J Diabetes Complications 9:208-211
16. Cerutti F, Vigo A, Sacchetti C, Bessone A, Barattia G, Morello M, Casalucci D, Gastaldi L 1994 Evaluation of left ventricular diastolic function in insulin dependent diabetic children by M-mode and Doppler echocardiography. Panminerva Med 36:109-114
17. Raev DC 1994 Which left ventricular function is impaired earlier in the evolution of diabetic cardiomyopathy? An echocardiographic study of young type I diabetic patients. Diabetes Care 17:633-639
18. Raev DC 1994 Left ventricular function and specific diabetic complications in other target organs in young insulin-dependent diabetics: an echocardiographic study. Heart Vessels 9:121-128
19. Shimizu M, Sugihara N, Kita Y, Shimizu K, Shibayama S, Takeda R 1991 Increase in left ventricular chamber stiffness in patients with non-insulin dependent diabetes mellitus. Jpn Circ J 55:657-664
20. Bouchard A, Sanz N, Botvinick EH, Phillips N, Heilbron D, Byrd III BF, Karam JH, Schiller NB 1989 Noninvasive assessment of cardiomyopathy in normotensive diabetic patients between 20 and 50 years old. Am J Med 87:160-166
21. Park JW, Ziegler AG, Janka HU, Doering W, Mehnert H 1988 Left ventricular relaxation and filling pattern in diabetic heart muscle disease: an echocardiographic study. Klin Wochenschr 66:773-778
22. Zarich SW, Arbuckle BE, Cohen LR, Roberts M, Nesto RW 1988 Diastolic abnormalities in young asymptomatic diabetic patients assessed by pulsed Doppler echocardiography. J Am Coll Cardiol 12:114-120
23. Ruddy TD, Shumak SL, Liu PP, Barnie A, Seawright SJ, McLaughlin PR, Zinman B 1988 The relationship of cardiac diastolic dysfunction to concurrent hormonal and metabolic status in type I diabetes mellitus. J Clin Endocrinol Metab 66:113-118
24. Airaksinen J, Ikaheimo M, Kaila J, Linnaluoto M, Takkunen J 1984 Impaired left ventricular filling in young female diabetics. An echocardiographic study. Acta Med Scand 216:509-516
25. Trost SU, Belke DD, Bluhm WF, Meyer M, Swanson E, Dillmann WH 2002 Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy. Diabetes 51:1166-1171
26. Brown RA, Filipovich P, Walsh MF, Sowers JR 1996 Influence of sex, diabetes and ethanol on intrinsic contractile performance of isolated rat myocardium. Basic Res Cardiol 91:353-360
27. Joffe II, Travers KE, Perreault-Micale CL, Hampton T, Katz SE, Morgan JP, Douglas PS 1999 Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with Doppler echocardiography and contribution of the nitric oxide pathway. J Am Coll Cardiol 34:2111-2119
28. Dent CL, Bowman AW, Scott MJ, Allen JS, Lisauskas JB, Janif M, Wickline SA, Kovacs SJ 2001 Echocardiographic characterization of fundamental mechanisms of abnormal diastolic filling in diabetic rats with a parameterized diastolic filling formalism. J Am Soc Echocardiogr 14:1166-1172
29. Flarsheim CE, Grupp IL, Matlib MA 1996 Mitochondrial dysfunction accompanies diastolic dysfunction in diabetic rat heart. Am J Physiol 271:H192-H202
30. Poirier P, Bogaty P, Garneau C, Marois L, Dumesnil JG 2001 Diastolic dysfunction in nonnotensive men with well-controlled type 2 diabetes: importance of maneuvers in echocardiographic screening for preclinical diabetic cardiomyopathy. Diabetes Care 24:5-10
31. Schannwell CM, Schneppenheim M, Perings S, Plehn G, Strauer BE 2002 Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy. Cardiology 98:33-39
32. Strauer BE, Motz W, Vogt M, Schwartzkopff B 1997 Impaired coronary flow reserve in NIDDM: a possible role for diabetic cardiopathy in humans. Diabetes 46(Suppl 2):S119-S124
33. Paillole C, Dahan M, Paycha F, Solal AC, Passa P, Gourgon R 1989 Prevalence and significance of left ventricular filling abnormalities determined by Doppler echocardiography in young type I (insulin-dependent) diabetic patients. Am J Cardiol 64:1010-1016
34. Fang Z, Najos-Valencia O, Leano R, Marwick T 2003 Patients with early diabetic heart disease demonstrate a normal myocardial response to dobutamine. J Am Coll Cardiol 42:446-453
35. Attali JR, Sachs RN, Valensi P, Palsky D, Tellier P, Vulpillat M, Lanfranchi J, Sebaoun J 1988 Asymptomatic diabetic cardiomyopathy: a noninvasive study. Diabetes Res Clin Pract 4:183-190
36. Robillon JF, Sadoul JL, Jullien D, Morand P, Freychet P 1994 Abnormalities suggestive of cardiomyopathy in patients with type 2 diabetes of relatively short duration. Diabete Metab 20:473-480
37. Astorri E, Fiorina P, Contini GA, Albertini D, Magnati G, Astorri A, Lanfredini M 1997 Isolated and preclinical impairment of left ventricular filling in insulin-dependent and non-insulin-dependent diabetic patients. Clin Cardiol 20:536-540
38. Salazar J, Rivas A, Rodriguez M, Felipe J, Garcia MD, Bone J 1994 Left ventricular function determined by Doppler echocardiography in adolescents with type I (insulin-dependent) diabetes mellitus. Acta Cardiol 49:435-439
39. Mathew P, John L, Jose J, Krishnaswami S 1992 Assessment of left ventricular diastolic function in young diabetics-a two dimensional echo Doppler study. Indian Heart J 44:29-32
40. Posner J, Ilya R, Wanderman K, Weitzman S 1983 Systolic time intervals in diabetes. Diabetologia 24:249-252
41. Schaible TF, Malhotra A, Bauman WA, Scheuer J 1983 Left ventricular function after chronic insulin treatment in diabetic and normal rats. J Mol Cell Cardiol 15:445-458
42. Wold LE, Relling DP, Colligan PB, Scott GI, Hintz KK, Ren BH, Epstein PN, Ren J 2001 Characterization of contractile function in diabetic hypertensive cardiomyopathy in adult rat ventricular myocytes. J Mol Cell Cardiol 33:1719-1726
43. Hoit BD, Castro C, Bultron G, Knight S, Matlib MA 1999 Noninvasive evaluation of cardiac dysfunction by echocardiography in streptozotocin-induced diabetic rats. J Card Fail 5:324-333
44. Hayashi K, Okumura K, Matsui H, Murase K, Kamiya H, Saburi Y, Numaguchi Y, Toki Y, Hayakawa T 2001 Involvement of 1,2-diacylglycerol in improvement of heart function by etomoxir in diabetic rats. Life Sci 68:1515-1526
45. Coughlin SS, Pearle DL, Baughman KL, Wasserman A, Tefft MC 1994 Diabetes mellitus and risk of idiopathic dilated cardiomyopathy. The Washington, DC Dilated Cardiomyopathy Study. Ann Epidemiol 4:67-74
46. Kannel WB, Hjortland M, Castelli WP 1974 Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol 34:29-34
47. Friedman NE, Levitsky LL, Edidin DV, Vitullo DA, Lacina SJ, Chiemmongkoltip P 1982 Echocardiographic evidence for impaired myocardial performance in children with type I diabetes mellitus. Am J Med 73:846-850
48. Mbanya JC, Sobngwi E, Mbanya DS, Ngu KB 2001 Left ventricular mass and systolic function in African diabetic patients: association with microalbuminuria. Diabetes Metab 27:378-382
49. Fang ZY, Yuda S, Anderson V, Short L, Case C, Marwick TH 2003 Echocardiographic detection of early diabetic myocardial disease. J Am Coll Cardiol 41:611-617
50. Scognamiglio R, Casara D, Avogaro A 2000 Myocardial dysfunction and adrenergic innervation in patients with type 1 diabetes mellitus. Diabetes Nutr Metab 13:346-349
51. Baum VC, Levitsky LL, Englander RM 1987 Abnormal cardiac function after exercise in insulin-dependent diabetic children and adolescents. Diabetes Care 10:319-323
52. Zola B, Kahn JK, Juni JE, Vinik AI 1986 Abnormal cardiac function in diabetic patients with autonomic neuropathy in the absence of ischemic heart disease. J Clin Endocrinol Metab 63:208-214
53. Vered A, Battler A, Segal P, Liberman D, Yerushalmi Y, Berezin M, Neufeld HN 1984 Exercise-induced left ventricular dysfunction in young men with asymptomatic diabetes mellitus (diabetic cardiomyopathy). Am J Cardiol 54:633-637
54. Jermendy G, Kammerer L, Koltai ZM, Cserhalmi L, Szelenyi J, Tichy M, Pogatsa G 1983 Preclinical abnormality of left ventricular performance in patients with insulin-dependent diabetes mellitus. Acta Diabetol Lat 20:311-320
55. Carlstrom S, Karlefors T 1970 Haemodynamic studies on newly diagnosed diabetics before and after adequate insulin treatment. Br Heart J 32:355-358
56. Karlefors T 1966 Haemodynamic studies in male diabetics. Acta Med Scand Suppl 449:45-80
57. Hsu KL, Chiang FT, Lo HM, Tsai CH, Tseng CD, Tseng YZ 1997 Cardiac contractility in noninsulin dependent diabetes mellitus evaluated using the relation between endsystolic wall stress and velocity of circumferential fiber shortening. Jpn Heart J 38:463-471
58. Nugent AM, Steele IC, al Modaris F, Vallely S, Moore A, Campbell NP, Bell PM, Buchanan KD, Trimble ER, Nicholls DP 1997 Exercise responses in patients with IDDM. Diabetes Care 20:1814-1821
59. Borow KM, Jaspan JB, Williams KA, Neumann A, Wolinski-Walley P, Lang RM 1990 Myocardial mechanics in young adult patients with diabetes mellitus: effects of altered load, inotropic state and dynamic exercise. J Am Coll Cardiol 15:1508-1517
60. Howarth FC, Qureshi MA, White E, Calaghan SC 2002 Cardiac microtubules are more resistant to chemical depolymerisation in streptozotocin-induced diabetes in the rat. Pflugers Arch 444:432-437
61. Hileeto D, Cukiernik M, Mukherjee S, Evans T, Barbin Y, Downey D, Karmazyn M, Chakrabarti S 2002 Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium. Diabetes Metab Res Rev 18:386-394
62. Thompson EW 1994 Quantitative analysis of myocardial structure in insulin-dependent diabetes mellitus: effects of immediate and delayed insulin replacement. Proc Soc Exp Biol Med 205:294-305
63. Shimada T 1993 Correlation between metabolic and histopathological changes in the myocardium of the KK mouse. Effect of diltiazem on the diabetic heart. Jpn Heart J 34:617-626
64. Thompson EW 1988 Structural manifestations of diabetic cardiomyopathy in the rat and its reversal by insulin treatment. Am J Anat 182:270-282
65. Naito J, Koretsune Y, Sakamoto N, Shutta R, Yoshida J, Yasuoka Y, Yoshida S, Chin W, Kusuoka H, Inoue M 2001 Transmural heterogeneity of myocardial integrated backscatter in diabetic patients without overt cardiac disease. Diabetes Res Clin Pract 52:11-20
66. Sunni S, Bishop SP, Kent SP, Geer JC 1986 Diabetic cardiomyopathy. A morphological study of intramyocardial arteries. Arch Pathol Lab Med 110:375-381
67. Lababidi ZA, Goldstein DE 1983 High prevalence of echocardiographic abnormalities in diabetic youths. Diabetes Care 6:18-22
68. Warley A, Powell JM, Skepper JN 1995 Capillary surface area is reduced and tissue thickness from capillaries to myocytes is increased in the left ventricle of streptozotocin-diabetic rats. Diabetologia 38:413-421
69. Eto M, Watanabe K, Sekiguchi M, Iwashima Y, Morikawa A, Oshima E, Ishii K 1987 Metabolic and morphological changes of the heart in Chinese hamsters (CHAD strain) with spontaneous long-term diabetes. Diabetes Res Clin Pract 3:297-305
70. Bhimji S, Godin DV, McNeill JH 1986 Myocardial ultrastructural changes in alloxan-induced diabetes in rabbits. Acta Anat (Basel) 125:195-200
71. Seager MJ, Singal PK, Orchard R, Pierce GN, Dhalla NS 1984 Cardiac cell damage: a primary myocardial disease in streptozotocin-induced chronic diabetes. Br J Exp Pathol 65:613-623
72. Kerut EK, Given MB, McIlwain E, Allen G, Espinoza C, Giles TD 2000 Echocardiographic texture analysis using the wavelet transform: differentiation of early heart muscle disease. Ultrasound Med Biol 26:1445-1453
73. Nunoda S, Genda A, Sugihara N, Nakayama A, Mizuno S, Takeda R 1985 Quantitative approach to the histopathology of the biopsied right ventricular myocardium in patients with diabetes mellitus. Heart Vessels 1:43-47
74. Vitolo E, Madoi S, Sponzilli C, Palvarini M, Silvestri D, Castini D, Morabito A 1988 Vectorcardiographic evaluation of diabetic cardiomyopathy and of its contributing factors. Acta Diabetol Lat 25:227-234
75. Di Bello V, Talarico L, Picano E, Di Muro C, Landini L, Paterni M, Matteucci E, Giusti C, Giampietro O 1995 Increased echodensity of myocardial wall in the diabetic heart: an ultrasound tissue characterization study. J Am Coll Cardiol 25:1408-1415
76. Picano E, Pelosi G, Marzilli M, Lattanzi F, Benassi A, Landini L, L'Abbate A 1990 In vivo quantitative ultrasonic-evaluation of myocardial fibrosis in humans. Circulation 81:58-64
77. van Hoeven KH, Factor SM 1990 A comparison of the pathological spectrum of hypertensive, diabetic, and hypertensive-diabetic heart disease. Circulation 82:848-855
78. Chatham JC, Seymour AM 2002 Cardiac carbohydrate metabolism in Zucker diabetic fatty rats. Cardiovasc Res 55:104-112
79. Mokuda O, Sakamoto Y, Ikeda T, Mashiba H 1990 Effects of anoxia and low free fatty acid on myocardial energy metabolism in streptozotocin-diabetic rats. Ann Nutr Metab 34:259-265
80. Rodrigues B, Cam MC, McNeill JH 1998 Metabolic disturbances in diabetic cardiomyopathy. Mol Cell Biochem 180:53-57
81. Chen V, lanuzzo CD, Fong BC, Spitzer JJ 1984 The effects of acute and chronic diabetes on myocardial metabolism in rats. Diabetes 33:1078-1084
82. Ohtake T, Yokoyama I, Watanabe T, Momose T, Serezawa T, Nishikawa J, Sasaki Y 1995 Myocardial glucose metabolism in noninsulin-dependent diabetes mellitus patients evaluated by FDG-PET. J Nucl Med 36:456-463
83. Eckel J, Reinauer H 1990 Insulin action on glucose transport in isolated cardiac myocytes: signalling pathways and diabetes-induced alterations. Biochem Soc Trans 18:1125-1127
84. Garvey WT, Hardin D, Juhaszova M, Dominguez JH 1993 Effects of diabetes on myocardial glucose transport system in rats: implications for diabetic cardiomyopathy. Am J Physiol 264:H837-H844
85. Russell III RR, Yin R, Caplan MJ, Hu X, Ren J, Shulman GI, Sinusas AJ, Young LH 1998 Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo. Circulation 98:2180-2186
86. Liedtke AJ, DeMaison L, Eggleston AM, Cohen LM, Nellis SH 1988 Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium. Circ Res 62:535-542
87. Rodriques B, Cam MC, Kong J, Goyal RK, McNeill JH 1997 Strain differences in susceptibility to streptozotocin-induced diabetes: Effects on hypertriglyceridemia and cardiomyopathy. Cardiovasc Res 34:199-205
88. Lopaschuk GD, Russell JC 1991 Myocardial function and energy substrate metabolism in the insulin-resistant JCR:LA corpulent rat. J Appl Physiol 71:1302-1308
89. Belke DD, Larsen TS, Gibbs EM, Severson DL 2000 Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. Am J Physiol Endocrinol Metab 279:E1104-E1113
90. Hall JL, Stanley WC, Lopaschuk GD, Wisneski JA, Pizzurro RD, Hamilton CD, McCormack JG 1996 Impaired pyruvate oxidation but normal glucose uptake in diabetic pig heart during dobutamine-induced work. Am J Physiol 271:H2320-H2329
91. Chatham JC, Gao ZP, Bonen A, Forder JR 1999 Preferential inhibition of lactate oxidation relative to glucose oxidation in the rat heart following diabetes. Cardiovasc Res 43:96-106
92. Nakayama H, Morozumi T, Nanto S, Shimonagata T, Ohara T, Takano Y, Kotani J, Watanabe T, Fujita M, Nishio M, Kusuoka H, Hori M, Nagata S 2001 Abnormal myocardial free fatty acid utilization deteriorates with morphological changes in the hypertensive heart. Jpn Circ J 65:783-787
93. Yazaki Y, Isobe M, Takahashi W, Kitabayashi H, Nishiyama O, Sekiguchi M, Takemura T 1999 Assessment of myocardial fatty acid abnormalities in patients with idiopathic dilated cardiomyopathy using 1123 BMIPP SPECT: correlation with clinicopathological findings and clinical course. Heart 81:153-159
94. Malone JI, Schocken DD, Morrison AD, Gilbert-Barness E 1999 Diabetic cardiomyopathy and carnitine deficiency. J Diabetes Complications 13:86-90
95. Malhotra A, Sanghi V 1997 Regulation of contractile proteins in diabetic heart. Cardiovasc Res 34:34-40
96. Takeda N, Nakamura I, Hatanaka T, Ohkubo T, Nagano M 1988 Myocardial mechanical and myosin isoenzyme alterations in streptozotocin-diabetic rats. Jpn Heart J 29:455-463
97. Abe T, Ohga Y, Tabayashi N, Kobayashi S, Sakata S, Misawa H, Tsuji T, Kohzuki H, Suga H, Taniguchi S, Takaki M 2002 Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats. Am J Physiol Heart Circ Physiol 282:H138-H148
98. Kotsanas G, Delbridge LM, Wendt IR 2000 Stimulus interval-dependent differences in Ca2+ transients and contractile responses of diabetic rat cardiomyocytes. Cardiovasc Res 46:450-462
99. Dhalla NS, Liu X, Panagia V, Takeda N 1998 Subcellular remodeling and heart dysfunction in chronic diabetes. Cardiovasc Res 40:239-247
100. Kita Y, Shimizu M, Sugihara N, Shimizu K, Yoshio H, Shibayama S, Takeda R 1991 Correlation between histopathological changes and mechanical dysfunction in diabetic rat hearts. Diabetes Res Clin Pract 11:177-188
101. Cerasola G, Donatelli M, Cottone S, D'Ignoto G, Grasso L, Morici ML, Terrizzi C, Verga S, Bompiani GD 1987 Effects of dynamic exercise and metabolic control on left ventricular performance in insulin-dependent diabetes mellitus. Acta Diabetol Lat 24:263-270
102. Jermendy G, Koltai MZ, Kammerer L, Cserhalmi L, Istvanffy M, Szelenyi J, Fogatsa G 1984 Myocardial systolic alterations of insulin-dependent diabetics in rest. Acta Cardiol 39:185-190
103. Garay-Sevilla ME, Nava LE, Malacara JM, Wrobel K, Wrobel K, Perez U 2000 Advanced glycosylation end products (AGEs), insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) in patients with type 2 diabetes mellitus. Diabetes Metab Res Rev 16:106-113
104. Pogatsa G, Bihari-Varga M, Szinay G 1979 Effect of diabetes therapy on the myocardium in experimental diabetes. Acta Diabetol Lat 16:129-138
105. Litwin SE, Raya TE, Anderson PG, Daugherty S, Goldman S 1990 Abnormal cardiac function in the streptozotocin-diabetic rat. Changes in active and passive properties of the left ventricle. J Clin Invest 86:481-488
106. Stroedter D, Schmidt T, Bretzel RG, Federlin K 1995 Glucose metabolism and left ventricular dysfunction are normalized by insulin and islet transplantation in mild diabetes in the rat. Acta Diabetol 32:235-243
107. Shehadeh A, Regan TJ 1995 Cardiac consequences of diabetes mellitus. Clin Cardiol 18:301-305
108. Sykes CA, Wright AD, Malins JM, Pentecost BL 1977 Changes in systolic time intervals during treatment of diabetes mellitus. Br Heart J 39:255-259
109. Shapiro LM, Leatherdale BA, Coyne ME, Fletchet RF, Mackinnon J 1980 Prospective study of heart disease in untreated maturity onset diabetics. Br Heart J 44:342-348
110. Regan TJ, Wu CF, Yeh CK, Oldewurtel HA, Haider B 1981 Myocardial composition and function in diabetes. The effects of chronic insulin use. Circ Res 49:1268-1277
111. Ganguly PK, Pierce GN, Dhalla KS, Dhalla NS 1983 Defective sarcoplasmic reticular calcium transport in diabetic cardiomyopathy. Am J Physiol 244:E528-E535
112. Giacomelli F, Wiener J 1979 Primary myocardial disease in the diabetic mouse. An ultrastructural study. Lab Invest 40:460-473
113. Guerra S, Leri A, Wang X, Finato N, Di Loreto C, Beltrami CA, Kajstura J, Anversa P 1999 Myocyte death in the failing human heart is gender dependent. Circ Res 85:856-866
114. Frustaci A, Kajstura J, Chimenti C, Jakoniuk I, Leri A, Maseri A, Nadal-Ginard B, Anversa P 2000 Myocardial cell death in human diabetes. Circ Res 87:1123-1132
115. Haunstetter A, Izumo S 1998 Apoptosis: basic mechanisms and implications for cardiovascular disease. Circ Res 82:1111-1129
116. Gerschenson LE, Rotello RJ 1992 Apoptosis: a different type of cell death. FASEB J 6:2450-2455
117. Anversa P, Kajstura J 1998 Myocyte cell death in the diseased heart. Circ Res 82:1231-1233
118. Li B, Setoguchi M, Wang X, Andreoli AM, Leri A, Malhotra A, Kajstura J, Anversa P 1999 Insulin-like growth factor-1 attenuates the detrimental impact of nonocclusive coronary artery constriction on the heart. Circ Res 84:1007-1019
119. Anversa P, Leri A, Beltrami CA, Guerra S, Kajstura J 1998 Myocyte death and growth in the failing heart. Lab Invest 78:767-786
120. Weber KT, Brilla CG 1991 Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation 83:1849-1865
121. Fiordaliso F, Leri A, Cesselli D, Limana F, Safai B, Nadal-Ginard B, Anversa P, Kajstura J 2001 Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death. Diabetes 50:2363-2375
122. Cai L, Li W, Wang G, Guo L, Jiang Y, Kang YJ 2002 Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes 51:1938-1948
123. Schaffer SW, Croft CB, Solodushko V 2000 Cardioprotective effect of chronic hyperglycemia: effect on hypoxia-induced apoptosis and necrosis. Am J Physiol Heart Circ Physiol 278:H1948-H1954
124. Fiordaliso F, Li B, Latini R, Sonnenblick EH, Anversa P, Leri A, Kajstura J 2000 Myocyte death in streptozotocin-induced diabetes in rats in angiotensin II-dependent. Lab Invest 80:513-527
125. Sechi LA, Griffin CA, Schambelan M 1994 The cardiac renin-angiotensin system in STZ-induced diabetes. Diabetes 43:1180-1184
126. Bojestig M, Nystrom FH, Arnqvist HJ, Ludvigsson J, Karlberg BE 2000 The renin-angiotensin-aldosterone system is suppressed in adults with type 1 diabetes. J Renin Angiotensin Aldosterone Syst 1:353-356
127. Deleted in proof
128. Lijnen PJ, Petrov W, Fagard RH 2000 Induction of cardiac fibrosis by angiotensin II. Methods Find Exp Clin Pharmacol 22:709-723
129. Chen S, Evans T, Mukherjee K, Karmazyn M, Chakrabarti S 2000 Diabetes-induced myocardial structural changes: role of endothelin-1 and its receptors. J Mol Cell Cardiol 32:1621-1629
130. Kajstura J, Fiordaliso F, Andreoli AM, Li B, Chimenti S, Medow MS, Limana F, Nadal-Ginard B, Leri A, Anversa P 2001 IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes 50:1414-1424
131. Lee AA, Dillmann WH, McCulloch AD, Villarreal FJ 1995 Angiotensin II stimulates the autocrine production of transforming growth factor-β1 in adult rat cardiac fibroblasts. J Mol Cell Cardiol 27:2347-2357
132. Campbell SE, Katwa LC 1997 Angiotensin II stimulated expression of transforming growth factor-β1 in cardiac fibroblasts and myofibroblasts. J Mol Cell Cardiol 29:1947-1958
133. Benjamin IJ, Jalil JE, Tan LB, Cho K, Weber KT, Clark WA 1989 Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. Circ Res 65:657-670
134. Buja LM, Willerson JT 1987 The role of coronary artery lesions in ischemic heart disease: insights from recent clinicopathologic, coronary arteriographic, and experimental studies. Hum Pathol 18:451-461
135. Shimizu M, Umeda K, Sugihara N, Yoshio H, Ino H, Takeda R, Okada Y, Nakanishi I 1993 Collagen remodelling in myocardia of patients with diabetes. J Clin Pathol 46:32-36
136. Mihm MJ, Seifert JL, Coyle CM, Bauer JA 2001 Diabetes related cardiomyopathy time dependent echocardiographic evaluation in an experimental rat model. Life Sci 69:527-542
137. Howarth FC, Qureshi MA, Lawrence P, Adeghate E 2000 Chronic effects of streptozotocin-induced diabetes on the ultrastructure of rat ventricular and papillary muscle. Acta Diabetol 37:119-124
138. Sutherland CG, Fisher BM, Frier BM, Dargie HJ, More IA, Lindop GB 1989 Endomyocardial biopsy pathology in insulin-dependent diabetic patients with abnormal ventricular function. Histopathology 14:593-602
139. Das AK, Das JP, Chandrasekar S 1987 Specific heart muscle disease in diabetes mellitus - a functional structural correlation. Int J Cardiol 17:299-302
140. Zoneraich S 1988 Small-vessel disease, coronary artery vasodilator reserve, and diabetic cardiomyopathy. Chest 94:5-7
141. Harrower AD, Small DR, Railton R 1986 Variability of left ventricular function at diagnosis and after treatment in insulin-dependent diabetes. Diabetes Res 3:149-152
142. Miric G, Dallemagne C, Endre Z, Margolin S, Taylor SM, Brown L 2001 Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats. Br J Pharmacol 133:687-694
143. Norton GR, Candy G, Woodiwiss AJ 1996 Aminoguanidine prevents the decreased myocardial compliance produced by streptozotocin-induced diabetes mellitus in rats. Circulation 93:1905-1912
144. Kawaguchi M, Techigawara M, Ishihata T, Asakura T, Saito F, Maehara K, Maruyama Y 1997 A comparison of ultrastructural changes on endomyocardial biopsy specimens obtained from patients with diabetes mellitus with and without hypertension. Heart Vessels 12:267-274
145. Sonnenblick EH, Fein F, Capasso JM, Factor SM 1985 Microvascular spasm as a cause of cardiomyopathies and the calcium-blocking agent verapamil as potential primary therapy. Am J Cardiol 55:179B-184B
146. Factor SM, Minase T, Cho S, Fein F, Capasso JM, Sonnenblick EH 1984 Coronary microvascular abnormalities in the hypertensive-diabetic rat. A primary cause of cardiomyopathy? Am J Pathol 116:9-20
147. Blumenthal HT, Alex M, Goldenberg S 1960 A study of lesions of the intramural coronary branches in diabetes mellitus. Arch Pathol 70:27-42
148. Fischer VW, Barner HB, Leskiw ML 1979 Capillary basal laminar thickness in diabetic human myocardium. Diabetes 28:713-719
149. Nitenberg A, Foult JM, Blanchet F, Zouioueche S 1985 Multifactorial determinants of reduced coronary flow reserve after dipyridamole in dilated cardiomyopathy. Am J Cardiol 55:748-754
150. Treasure CB, Vita JA, Cox DA, Fish RD, Gordon JB, Mudge GH, Colucci WS, Sutton MG, Selwyn AP, Alexander RW 1990 Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy. Circulation 81:772-779
151. Nitenberg A, Valensi P, Sachs R, Dali M, Aptecar E, Attali JR 1993 Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function. Diabetes 42:1017-1025
152. Durante W, Sunahara FA, Sen AK 1989 Effect of diabetes on metabolic coronary dilatation in the rat. Cardiovasc Res 23:40-45
153. Pitkanen OP, Nuutila P, Raitakari OT, Ronnemaa T, Koskinen PJ, Iida H, Lehtimaki TJ, Laine HK, Takala T, Viikari JS, Knuuti J 1998 Coronary flow reserve is reduced in young men with IDDM. Diabetes 47:248-254
154. Yokoyama I, Ohtake T, Momomura S, Yonekura K, Woo-Soo S, Nishikawa J, Sasaki Y, Omata M 1998 Hyperglycemia rather than insulin resistance is related to reduced coronary flow reserve in NIDDM. Diabetes 47:119-124
155. Meyer C, Schwaiger M 1997 Myocardial blood flow and glucose metabolism in diabetes mellitus. Am J Cardiol 80:94A-101A
156. Sakamoto K, Yamasaki Y, Nanto S, Shimonagata T, Morozumi T, Ohara T, Takano Y, Nakayama H, Kamado K, Nagata S, Kusuoka H, Nishimura T, Hori M 1998 Mechanism of impaired left ventricular wall motion in the diabetic heart without coronary artery disease. Diabetes Care 21:2123-2128
157. Calles-Escandon J, Cipolla M 2001 Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev 22:36-52
158. Mayhan WG, Simmons LK, Sharpe GM 1991 Mechanism of impaired responses of cerebral arterioles during diabetes mellitus. Am J Physiol 260:H319-H326
159. Taylor PD, Graves JE, Poston L 1995 Selective impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated resistance arteries of the streptozotocin-induced diabetic rat. Clin Sci (Lond) 88:519-524
160. Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creager MA 1993 Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 88:2510-2516
161. Pieper GM, Langenstroer P, Gross GJ 1993 Hydroxyl radicals mediate injury to endothelium-dependent relaxation in diabetic rat. Mol Cell Biochem 122:139-145
162. Hattori Y, Kawasaki H, Abe K, Kanno M 1991 Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol 261:H1086-H1094
163. Rosen P, Ballhausen T, Bloch W, Addicks K 1995 Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant. Diabetologia 38:1157-1168
164. Bucala R, Tracey KJ, Cerami A 1991 Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest 87:432-438
165. Tesfamariam B, Jakubowski JA, Cohen RA 1989 Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TxA2. Am J Physiol 257:H1327-H1333
166. Tesfamariam B, Brown ML, Cohen RA 1991 Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C. J Clin Invest 87:1643-1648
167. Koya D, King GL 1998 Protein kinase C activation and the development of diabetic complications. Diabetes 47:859-866
168. Takahashi N, Nakagawa M, Saikawa T, Ooie T, Yufu K, Shigematsu S, Haia M, Sakino H, Katsuragi I, Qkeda T, Yoshimatsu H, Sakata T 2001 Effect of essential hypertension on cardiac autonomie function in type 2 diabetic patients. J Am Coll Cardiol 38:232-237
169. Mantysaari M, Kuikka J, Mustonen J, Tahvanainen K, Vanninen E, Lansimies E, Uusitupa M 1992 Noninvasive detection of cardiac sympathetic nervous dysfunction in diabetic patients using [123I]metaiodobenzylguanidine. Diabetes 41:1069-1075
170. Schnell O, Muhr D, Weiss M, Dresel S, Haslbeck M, Standl E 1996 Reduced myocardial 123I-metaiodobenzylguanidine uptake in newly diagnosed IDDM patients. Diabetes 45:801-805
171. Stein PK, Kleiger RE 1999 Insights from the study of heart rate variability. Annu Rev Med 50:249-261
172. Kahn JK, Zola B, Juni JE, Vinik AI 1986 Decreased exercise heart rate and blood pressure response in diabetic subjects with cardiac autonomic neuropathy. Diabetes Care 9:389-394
173. Lee KH, Yoon JK, Lee MG, Lee SH, Lee WR, Kim BT 2001 Dipyridamole myocardial SPECT with low heart rate response indicates cardiac autonomic dysfunction in patients with diabetes. J Nucl Cardiol 8:129-135
174. Sampson MJ, Wilson S, Karagiannis P, Edmonds M, Watkins PJ 1990 Progression of diabetic autonomic neuropathy over a decade in insulin-dependent diabetics. Q J Med 75:635-646
175. Nagamachi S, Jinnouchi S, Nakahara H, Flores LG, Ohnishi T, Hoshi H, Futami S, Watanabe K, Nakatsuru K, Toshimori T, Matsukura S 1996 123I-MIBG myocardial scintigraphy in diabetic patients: relationship to autonomic neuropathy. Nucl Med Commun 17:621-632
176. Murata K, Sumida Y, Murashima S, Matsumura K, Takeda H, Nakagawa T, Shima T 1996 A novel method for the assessment of autonomic neuropathy in type 2 diabetic patients: a comparative evaluation of 123I-MIBG myocardial scintigraphy and power spectral analysis of heart rate variability. Diabet Med 13:266-272
177. Mantysaari M, Kuikka J, Mustonen J, Tahvanainen K, Vanninen E, Lansimies E, Uusitupa M 1996 Measurement of myocardial accumulation of 123I-metaiodobenzylguanidine for studying cardiac autonomic neuropathy in diabetes mellitus. Clin Auton Res 6:163-169
178. Schmid H, Forman LA, Cao X, Sherman PS, Stevens MJ 1999 Heterogeneous cardiac sympathetic denervation and decreased myocardial nerve growth factor in streptozotocin-induced diabetic rats: implications for cardiac sympathetic dysinnervation complicating diabetes. Diabetes 48:603-608
179. Hutchins GD, Chen T, Carlson KA, Fain RL, Winkle W, Vavrek T, Mock BH, Zipes DP 1999 PET imaging of oxidative metabolism abnormalities in sympathetically denervated canine myocardium. J Nucl Med 40:846-853
180. Hartmann F, Ziegler S, Nekolla S, Hadamitzky M, Seyfarth M, Richardt G, Schwaiger M 1999 Regional patterns of myocardial sympathetic denervation in dilated cardiomyopathy: an analysis using carbon-11 hydroxyephedrine and positron emission tomography. Heart 81:262-270
181. Miyanaga H, Yoneyama S, Kamitani T, Kawasaki S, Takahashi T, Kunishige H 1995 Clinical usefulness of 1231-metaiodobenzylguanidine myocardial scintigraphy in diabetic patients with cardiac sympathetic nerve dysfunction. Jpn Circ J 59:599-607
182. Schnell O, Kirsch CM, Stemplinger J, Haslbeck M, Standl E 1995 Scintigraphic evidence for cardiac sympathetic dysinnervation in long-term IDDM patients with and without ECG-based autonomic neuropathy. Diabetologia 38:1345-1352
183. Turpeinen AK, Vanninen E, Kuikka JT, Uusitupa MI 1996 Demonstration of regional sympathetic denervation of the heart in diabetes. Comparison between patients with NIDDM and IDDM. Diabetes Care 19:1083-1090
184. Allman KC, Stevens MJ, Wieland DM, Hutchins GD, Wolfe Jr ER, Greene DA, Schwaiger M 1993 Noninvasive assessment of cardiac diabetic neuropathy by carbon-11 hydroxyephedrine and positron emission tomography. J Am Coll Cardiol 22:1425-1432
185. Stevens MJ, Raffel DM, Allman KC, Dayanikli F, Ficaro E, Sandford T, Wieland DM, Pfeifer MA, Schwaiger M 1998 Cardiac sympathetic dysinnervation in diabetes: implications for enhanced cardiovascular risk. Circulation 98:961-968
186. Stevens MJ, Dayanikli F, Raffel DM, Allman KC, Sandford T, Feldman EL, Wieland DM, Corbett J, Schwaiger M 1998 Scintigraphic assessment of regionalized defects in myocardial sympathetic innervation and blood flow regulation in diabetic patients with autonomic neuropathy. J Am Coll Cardiol 31:1575-1584
187. Felten SY, Peterson RG, Shea PA, Besch Jr HR, Felten DL 1982 Effects of streptozotocin diabetes on the noradrenergic innervation of the rat heart: a longitudinal histofluorescence and neurochemical study. Brain Res Bull 8:593-607
188. Uekita K, Tobise K, Onodera S 1997 Enhancement of the cardiac β-adrenergic system at an early diabetic state in spontaneously diabetic Chinese hamsters. Jpn Circ J 61:64-73
189. Pietrzyk Z, Vogel S, Dietze GJ, Rabito SF 2000 Augmented sympathetic response to bradykinin in the diabetic heart before autonomic denervation. Hypertension 36:208-214
190. Manzella D, Barbieri M, Rizzo MR, Ragno E, Passariello N, Gambardella A, Marfella R, Giugliano D, Paolisso G 2001 Role of free fatty acids on cardiac autonomic nervous system in noninsulin-dependent diabetic patients: effects of metabolic control. J Clin Endocrinol Metab 86:2769-2774
191. Kondo K, Matsubara T, Nakamura J, Hotta N 2002 Characteristic patterns of circadian variation in plasma catecholamine levels, blood pressure and heart rate variability in type 2 diabetic patients. Diabet Med 19:359-365
192. Ahlborg G, Lundberg JM 1996 Exercise-induced changes in neuropeptide Y, noradrenaline and endothelin-1 levels in young people with type I diabetes. Clin Physiol 16:645-655
193. el Hage AN, Herman EH, Jordan AW, Ferrans VJ 1985 Influence of the diabetic state on isoproterenol-induced cardiac necrosis. J Mol Cell Cardiol 17:361-369
194. Communal C, Singh K, Pimentel DR, Colucci WS 1998 Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. Circulation 98:1329-1334
195. Iwai-Kanai E, Hasegawa K, Araki M, Kakita T, Morimoto T, Sasayama S 1999 α- and β-adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytes. Circulation 100:305-311
196. Shizukuda Y, Buttrick PM, Geenen DL, Borczuk AC, Kitsis RN, Sonnenblick EH 1998 β-Adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy. Am J Physiol 275:H961-H968
197. von Harsdorf R, Li PF, Dietz R 1999 Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation 99:2934-2941
198. Khorchid A, Fragoso G, Shore G, Almazan G 2002 Catecholamine-induced oligodendrocyte cell death in culture is developmentally regulated and involves free radical generation and differential activation of caspase-3. Glia 40:283-299
199. Tappia PS, Hata T, Hozaima L, Sandhu MS, Panagia V, Dhalla NS 2001 Role of oxidative stress in catecholamine-induced changes in cardiac sarcolemmal Ca2+ transport. Arch Biochem Biophys 387: 85-92
200. Qin F, Rounds NK, Mao W, Kawai K, Liang CS 2001 Antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets. Cardiovasc Res 51:736-748
201. Singh K, Xiao L, Remondino A, Sawyer DB, Colucci WS 2001 Adrenergic regulation of cardiac myocyte apoptosis. J Cell Physiol 189:257-265
202. Bisognano JD, Weinberger HD, Bohlmeyer TJ, Pende A, Raynolds MV, Sastravaha A, Roden R, Asano K, Blaxall BC, Wu SC, Communal C, Singh K, Colucci W, Bristow MR, Port DJ 2000 Myocardial-directed overexpression of the human β(1)-adrenergic receptor in transgenic mice. J Mol Cell Cardiol 32:817-830
203. Irlbeck M, Zimmer HG 1996 Functional responses of the left and right heart of diabetic rats to α- and β-adrenergic receptor stimulation. Diabetes Res Clin Pract 31 Suppl:S79-S86
204. Erbas T, Erbas B, Kabakci G, Aksoyek S, Koray Z, Gedik O 2000 Plasma big-endothelin levels, cardiac autonomic neuropathy, and cardiac functions in patients with insulin-dependent diabetes mellitus. Clin Cardiol 23:259-263
205. Kahn JK, Zola B, Juni JE, Vinik AI 1986 Radionuclide assessment of left ventricular diastolic filling in diabetes mellitus with and without cardiac autonomic neuropathy. J Am Coll Cardiol 7:1303-1309
206. Scognamiglio R, Fasoli G, Ferri M, Nistri S, Miorelli M, Egloff C, Buja G, Fedele D, Dalla-Volta S 1995 Myocardial dysfunction and abnormal left ventricular exercise response in autonomic diabetic patients. Clin Cardiol 18:276-282
207. Erbas T, Erbas B, Gedik O, Biberoglu S, Bekdik CF 1992 Scintigraphic evaluation of left ventricular function and correlation with autonomic cardiac neuropathy in diabetic patients. Cardiology 81:14-24
208. Kreiner G, Wolzt M, Fasching P, Leitha T, Edlmayer A, Korn A, Waldhausl W, Dudczak R 1995 Myocardial m-[123I]iodobenzylguanidine scintigraphy for the assessment of adrenergic cardiac innervation in patients with IDDM. Comparison with cardiovascular reflex tests and relationship to left ventricular function. Diabetes 44:543-549
209. Taskiran M, Fritz-Hansen T, Rasmussen V, Larsson HB, Hilsted J 2002 Decreased myocardial perfusion reserve in diabetic autonomie neuropathy. Diabetes 51:3306-3310
210. Scognamiglio R, Avogaro A, Casara D, Ciepaldi C, Marin M, Palisi M, Mingardi R, Erle G, Fasoli G, Dalla VS 1998 Myocardial dysfunction and adrenergic cardiac innervation in patients with insulin-dependent diabetes mellitus. J Am Coll Cardiol 31:404-412
211. Eiro M, Katoh T, Sakuma Y, Sakurai K, Suzuki H, Asahi K, Watanabe K, Watanabe T 2003 Insulin resistance highly associates with hypertension in IgA nephropathy. Clin Nephrol 59:71-78
212. Hong T, Zhao G, Gao W, Huo Y, Zhu G 2002 Insulin sensitivity and the diffuseness of coronary artery disease in humans. Chin Med J (Engl) 115:1886-1888
213. Snehalatha C, Ramachandran A, Saltyamurthy I, Satyavani K, Sivasankari S, Misra J, Viswanathan V 2001 Association of proinsulin and insulin resistance with coronary artery disease in non-diabetic south Indian men. Diabet Med 18:706-708
214. Nakano S, Kitazawa M, Ito T, Hatakeyama H, Nishizawa M, Nakagawa A, Kigoshi T, Uchida K 2003 Insulin resistant state in type 2 diabetes is related to advanced autonomic neuropathy. Clin Exp Hypertens 25:155-167
215. Bonora E, Targher G, Alberiche M, Formentini G, Calcaterra F, Lombardi S, Marini F, Poli M, Zenari L, Raffaelli A, Perbellini S, Zenere MB, Saggiani F, Bonadonna RC, Muggeo M 2002 Predictors of insulin sensitivity in type 2 diabetes mellitus. Diabet Med 19:535-542
216. Fernandez-Real JM, Lainez B, Vendrell J, Rigla M, Castro A, Penarroja G, Broch M, Ferez A, Richart C, Engel P, Ricart W 2002 Shedding of TNF-α receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 282:E952-E959
217. Fernandez-Real JM, Ricart W 1999 Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness. Diabetologia 42:1367-1374
218. Quilliot D, Fluckiger L, Zannad F, Drouin P, Ziegler O 2001 Impaired autonomic control of heart rate and blood pressure in obesity: role of age and of insulin-resistance. Clin Auton Res 11:79-86
219. Valensi P, Nguyen TN, Idriss S, Gazes P, Karam G, Paries J, Miossec P, Attali JR 1998 Influence of parasympathetic dysfunction and hyperinsulinemia on the hemodynamic response to an isometric exercise in non-insulin-dependent diabetic patients. Metabolism 47:934-939
220. Aso Y, Fujiwara Y, Tayama K, Takanashi K, Inukai T, Takemura Y 2001 Relationship between plasma soluble thrombomodulin levels and insulin resistance syndrome in type 2 diabetes: a comparison with von Willebrand factor. Exp Clin Endocrinol Diabetes 109:210-216
221. Galderisi M, Paolisso G, Tagliamonte MR, Alfieri A, Petrocelli A, de Divitiis M, Varricchio M, de Divitiis O 1997 Is insulin action a determinant of left ventricular relaxation in uncomplicated essential hypertension? J Hypertens 15:745-750
222. Guida L, Celentano A, Iannuzzi R, Ferrara LA 2001 Insulin resistance, ventricular mass and function in normoglycaemic hypertensives. Nutr Metab Cardiovasc Dis 11:306-311
223. Utriainen T, Takala T, Luotolahti M, Ronnemaa T, Laine H, Ruotsalainen U, Haaparanta M, Nuutila P, Yki-Jarvinen H 1998 Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM. Diabetologia 41:555-559
224. Hintz KK, Ren J 2002 Prediabetic insulin resistance is not permissive to the development of cardiac resistance to insulin-like growth factor I in ventricular myocytes. Diabetes Res Clin Pract 55:89-98
225. Dutta K, Podolin DA, Davidson MB, Davidoff AJ 2001 Cardiomyocyte dysfunction in sucrose-fed rats is associated with insulin resistance. Diabetes 50:1186-1192
226. Hirayama H, Sugano M, Abe N, Yonemoch H, Makino N 2001 Troglitazone, an antidiaberic drug, improves left ventricular mass and diastolic function in normotensive diabetic patients. Int J Cardiol 77:75-79
227. Paternostro G, Pagano D, Gnecchi-Ruscone T, Bonser RS, Camici PG 1999 Insulin resistance in patients with cardiac hypertrophy. Cardiovasc Res 42:246-253
228. Davis CL, Kapuku G, Snieder H, Kumar M, Treiber FA 2002 Insulin resistance syndrome and left ventricular mass in healthy young people. Am J Med Sci 324:72-75
229. de Kreutzenberg SV, Avogaro A, Tiengo A, Del Prato S 2000 Left ventricular mass in type 2 diabetes mellitus. A study employing a simple ECG index: the Cornell voltage. J Endocrinol Invest 23:139-144
230. Galvan AQ, Galetta F, Natali A, Muscelli E, Sironi AM, Cini G, Camastra S, Ferrannini E 2000 Insulin resistance and hyperinsulinemia: no independent relation to left ventricular mass in humans. Circulation 102:2233-2238
231. Rutter MK, Parise H, Benjamin EJ, Levy D, Larson MG, Meigs JB, Nesto RW, Wilson PW, Vasan RS 2003 Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study. Circulation 107:448-454
232. Factor SM, Bhan R, Minase T, Wolinsky H, Sonnenblick EH 1981 Hypertensive-diabetic cardiomyopathy in the rat: an experimental model of human disease. Am J Pathol 102:219-228
233. 1994 National High Blood Pressure Education Program Working Group report on hypertension in diabetes. Hypertension 23:145-158
234. Sowers JR, Epstein M 1995 Diabetes mellirus and associated hypertension, vascular disease, and nephropathy. An update. Hypertension 26:869-879
235. Brands MW, Fitzgerald SM 2002 Blood pressure control early in diabetes: a balance between angiotensin II and nitric oxide. Clin Exp Pharmacol Physiol 29:127-131
236. Kamata K, Yamashita K 1999 Insulin resistance and impaired endothelium-dependent renal vasodilatation in fructose-fed hypertensive rats. Res Commun Mol Pathol Pharmacol 103:195-210
237. Mathis DR, Uu SS, Rodrigues BB, McNeill JH 2000 Effect of hypertension on the development of diabetic cardiomyopathy. Can J Physiol Pharmacol 78:791-798
238. Danielsen R 1988 Factors contributing to left ventricular diastolic dysfunction in long-term type I diabetic subjects. Acta Med Scand 224:249-256
239. Gress TW, Nieto FJ, Shahar E, Wofford MR, Brancati FL 2000 Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis Risk in Communities Study. N Engl J Med 342:905-912
240. Strawn WB, Ferrario CM 2002 Mechanisms linking angiotensin II and atherogenesis. Curr Opin Lipidol 13:505-512
241. Dahlen GH 1994 Lp(a) lipoprotein in cardiovascular disease. Atherosclerosis 108:111-126
242. Rhoads GG, Dahlen G, Berg K, Morton NE, Dannenberg AL 1986 Lp(a) lipoprotein as a risk factor for myocardial infarction. JAMA 256:2540-2544
243. Wild SH, Fortmann SP, Marcovina SM 1997 A prospective case-control study of lipoprotein(a) levels and apo(a) size and risk of coronary heart disease in Stanford Five-City Project participants. Arterioscler Thromb Vasc Biol 17:239-245
244. Florys B, Urban M, Glowinska B 2000 Association of lipid metabolism with subclinical diabetic cardiomyopathy in children and adolescents with type 1 diabetes. Med Sci Monit 6:342-347
245. Grossman E, Messerli FH 1996 Diabetic and hypertensive heart disease. Ann Intern Med 125:304-310
246. Hansen A, Johansson BL, Wahren J, von Bibra H 2002 C-peptide exerts beneficial effects on myocardial blood flow and function in patients with type 1 diabetes. Diabetes 51:3077-3082
247. Norby FL, Wold LE, Duan J, Hintz KK, Ren J 2002 IGF-I attenuates diabetes-induced cardiac contractile dysfunction in ventricular myocytes. Am J Physiol Endocrinol Metab 283:E658-E666
248. Afzal N, Ganguly PK, Dhalla KS, Pierce GN, Singal PK, Dhalla NS 1988 Beneficial effects of verapamil in diabetic cardiomyopathy. Diabetes 37:936-942
249. Afzal N, Pierce GN, Elimban V, Beamish RE, Dhalla NS 1989 Influence of verapamil on some subcellular defects in diabetic cardiomyopathy. Am J Physiol 256:E453-E458
250. Shah TS, Satia MC, Gandhi TP, Bangaru RA, Goyal RK 1995 Effects of chronic nifedipine treatment on streptozotocin-induced diabetic rats. J Cardiovasc Pharmacol 26:6-12
251. Rosen R, Rump AF, Rosen P 1995 The ACE-inhibitor captopril improves myocardial perfusion in spontaneously diabetic (BB) rats. Diabetologia 38:509-517
252. Sowers JR, Epstein M, Frohlich ED 2001 Diabetes, hypertension, and cardiovascular disease: an update. Hypertension 37:1053-1059
253. Vuorinen-Markkola H, Yki-Jarvinen H 1995 Antihypertensive therapy with enalapril improves glucose storage and insulin sensitivity in hypertensive patients with non-insulin-dependent diabetes mellitus. Metabolism 44:85-89
254. Henriksen EJ, Jacob S, Kinnick TR, Youngblood EB, Schmit MB, Dietze GJ 1999 ACE inhibition and glucose transport in insulin, resistant muscle: roles of bradykinin and nitric oxide. Am J Physiol 277:R332-R336
255. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G 2000 Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 342:145-153
256. Hall JL, Sexton WL, Stanley WC 1995 Exercise training attenuates the reduction in myocardial GLUT-4 in diabetic rats. J Appl Physiol 78:76-81
257. Osborn BA, Daar JT, Laddaga RA, Romano FD, Paulson DJ 1997 Exercise training increases sarcolemmal GLUT-4 protein and mRNA content in diabetic heart. J Appl Physiol 82:828-834
258. DeBlieux PM, Barbee RW, McDonough KH, Shepherd RE 1993 Exercise training improves cardiac performance in diabetic rats. Proc Soc Exp Biol Med 203:209-213
259. De Angelis KL, Oliveira AR, Dall'Ago P, Peixoto LR, Gadonski G, Lacchini S, Fernandes TG, Irigoyen MC 2000 Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats. Braz J Med Biol Res 33:635-641
260. Paulson DJ, Mathews R, Bowman J, Zhao J 1992 Metabolic effects of treadmill exercise training on the diabetic heart. J Appl Physiol 73:265-271
261. Belcastro AN, Maybank P, Rossiter M, Secord D 1985 Effect of endurance swimming on rat cardiac myofibrillar ATPase with experimental diabetes. Can J Physiol Pharmacol 63:1202-1205
262. Ziegler D, Weise F, Langen KJ, Piolot R, Boy C, Hubinger A, Muller-Gartner HW, Gries FA 1998 Effect of glycaemic control on myocardial sympathetic innervation assessed by [123I]metaiodobertzylguanidine scintigraphy: a 4-year prospective study in IDDM patients. Diabetologia 41:443-451
263. Schnell O, Muhr D, Dresel S, Weiss M, Haslbeck M, Standl E 1997 Partial restoration of scintigraphically assessed cardiac sympathetic denervation in newly diagnosed patients with insulin-dependent (type 1) diabetes mellitus at one-year follow-up. Diabet Med 14:57-62
264. Burger AJ, Weinrauch LA, D'Elia JA, Aronson D 1999 Effect of glycemic control on heart rate variability in type I diabetic patients with cardiac autonomic neuropathy. Am J Cardiol 84:687-691
265. Manzella D, Barbieri M, Ragno E, Paolisso G 2001 Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type 2 diabetes. Am J Clin Nutr 73:1052-1057
266. Ustinova EE, Barrett CJ, Sun SY, Schultz HD 2000 Oxidative stress impairs cardiac chemoreflexes in diabetic rats. Am J Physiol Heart Circ Physiol 279:H2176-H2187
267. Lo GP, Careddu A, Magni G, Quagliata T, Pacifici L, Carminati P 2002 Autonomic neuropathy in streptozotocin diabetic rats: effect of acetyl-L-carnitine. Diabetes Res Clin Pract 56:173-180
268. Androne L, Gavan NA, Veresiu IA, Orasan R 2000 In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo 14:327-330
269. Ziegler D, Schatz H, Conrad F, Gries FA, Ulrich H, Reichel G 1997 Effects of treatment with the antioxidant α-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Deutsche Kardiale Autonome Neuropathie. Diabetes Care 20:369-373
270. Ziegler D, Gries FA 1997 α-Lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes 46(Suppl 2):S62-S66
271. Haak ES, Usadel KH, Kohleisen M, Yilmaz A, Kusterer K, Haak T 1999 The effect of α-lipoic acid on the neurovascular reflex arc in patients with diabetic neuropathy assessed by capillary microscopy. Microvasc Res 58:28-34
272. Kontopoulos AG, Athyros VG, Didangelos TP, Papageorgiou AA, Avramidis MJ, Mayroudi MC, Karamitsos DT 1997 Effect of chronic quinapril administration on heart rate variability in patients with diabetic autonomic neuropathy. Diabetes Care 20:355-361
273. Roy TM, Broadstone VL, Peterson HR, Snider HL, Cyrus J, Fell R, Rothchild AH, Samols E, Pfeifer MA 1990 The effect of an aldose reductase inhibitor on cardiovascular performance in patients with diabetes mellitus. Diabetes Res Clin Pract 10:91-97
274. Kurata C, Okayama K, Wakabayashi Y, Shouda S, Mikami T, Tawarahara K, Sugiyama T 1997 Cardiac sympathetic neuropathy and effects of aldose reductase inhibitor in streptozotocin-induced diabetic rats. J Nucl Med 38:1677-1680
275. Williams KV, Bertoldo A, Kinahan P, Cobelli C, Kelley DE 2003 Weight loss-induced plasticity of glucose transport and phosphorylation in the insulin resistance of obesity and type 2 diabetes. Diabetes 52:1619-1626
276. Dixon JB, Dixon AF, O'Brien PE 2003 Improvements in insulin sensitivity and β-cell function (HOMA) with weight loss in the severely obese. Homeostatic model assessment. Diabet Med 20:127-134
277. Stolar MW 2002 Insulin resistance, diabetes, and the adipocyte. Am J Health Syst Pharm 59 Suppl 9:S3-S8
278. Jones TA, Sautter M, Van Gaal LF, Jones NP 2003 Addition of rosiglitazone to metformin is most effective in obese, insulin-resistant patients with type 2 diabetes. Diabetes Obes Metab 5:163-170
279. Pavo I, Jermendy G, Varkonyi TT, Kerenyi Z, Gyimesi A, Shoustov S, Shestakova M, Herz M, Johns D, Schluchter BJ, Festa A, Tan MH 2003 Effect of pioglitazone compared with metformin on glycemic control and indicators of insulin sensitivity in recently diagnosed patients with type 2 diabetes. J Clin Endocrinol Metab 88:1637-1645
280. Sekiya M, Suzuki J, Watanabe K, Funada J, Otani T, Akutsu H 2001 Beneficial effect of troglitazone, an insulin-sensitizing antidiabetic agent, on coronary circulation in patients with non-insulin-dependent diabetes mellitus. Jpn Circ J 65:487-490
281. Usala AL, Madigan T, Burguera B, Cefalu W, Sinha MK, Powell JG, Usala SJ 1994 High dose intravenous, but not low dose subcutaneous, insulin-like growth factor-I therapy induces sustained insulin sensitivity in severely resistant type I diabetes mellitus. J Clin Endocrinol Metab 79:435-440
282. Ploug T, van Deurs B, Ai H, Cushman SW, Ralston E 1998 Analysis of GLUT4 distribution in whole skeletal muscle fibers: identification of distinct storage compartments that are recruited by insulin and muscle contractions. J Cell Biol 142:1429-1446
283. Goodyear LJ, Kahn BB 1998 Exercise, glucose transport, and insulin sensitivity. Annu Rev Med 49:235-261
284. Schaffer SW, Warner BA, Wilson GL 1993 Effects of chronic glipizide treatment on the NIDD heart. Horm Metab Res 25:348-352