Overexpression of the sarcoplasmic reticulum CA2+-ATPase improves myocardial contractility in diabetic cardiomyopathy

Diabetes

Volumn 51, Issue 4, 2002, Pages 1166-1171

  Trost, Susanne U ^a   Belke, Darrell D ^a   Bluhm, Wolfgang F ^a   Meyer, Markus ^a   Swanson, Eric ^a   Dillmann, Wolfgang H ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM);

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CONTRACTILITY; ISOLATED HEART; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; STREPTOZOCIN DIABETES; TRANSGENIC MOUSE;

EID: 0036227758     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.4.1166     Document Type: Article

References (39)

1. Preclinical abnormality of left ventricular function in diabetes mellitus
2. Noninvasive estimation of myocardial performance in patients with diabetes: Effect of alcohol administration
3. Longevity of diabetic patients in recent years
4. Role of diabetes in congestive heart failure: The Framingham study
5. Increased congestive heart failure after myocardial infarction of modest extent in patients with diabetes mellitus
6. The effect of diabetes on performance and metabolism of rat hearts
7. Pathogenesis of cardiac dysfunction in diabetes mellitus
8. Depressed cardiac sarcoplasmic reticular function from diabetic rats
9. Influence of experimental diabetes on sarcoplasmic reticulum function in rat ventricular muscle
10. Altered Ca2+ handling in ventricular myocytes isolated from diabetic rats
11. Defective sarcoplasmic reticular calcium transport in diabetic cardiomyopathy
12. Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts
13. Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation
14. Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients
15. Overexpression of sarcoplasmic reticulum Ca(2+)-ATPase improves cardiac contractile function in hypothyroid mice
16. Influence of thyroid hormone and retinoic acid on slow sarcoplasmic reticulum Ca2+ ATPase and myosin heavy chain alpha gene expression in cardiac myocytes: Delineation of cis-active DNA elements that confer responsiveness to thyroid hormone but not to retinoic acid
17. Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70
18. Phorbol myristate acetate-induced hypertrophy of neonatal rat cardiac myocytes is associated with decreased sarcoplasmic reticulum Ca2+ ATPase (SERCA2) gene expression and calcium reuptake
19. Phospholamban-to-SERCA2 ratio controls the force-frequency relationship
20. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
21. Regulation of intracellular Ca2+ in the heart during diabetes
22. i responses to isoproterenol and cAMP in isolated cardiomyocytes from experimental diabetic rats
23. Relaxation in rabbit and rat cardiac cells: Species-dependent differences in cellular mechanisms
24. Diabetes-induced decrease in the mRNA coding for sarcoplasmic reticulum Ca(2+)-ATPase in adult rat cardiomyocytes
25. Cardiac sarcoplasmic reticulum Ca(2+)-ATPase expression in streptozotocin-induced diabetic rat heart
26. Reversibility of diabetic cardiomyopathy with insulin in rats
27. Accelerated desensitization of nicotinic receptor channels and its dependence on extracellular calcium in isolated skeletal muscles of streptozotocin-diabetic mice
28. Diabetic cardiomyopathy
29. Altered myocardial mechanics in diabetic rats
30. Diabetes mellitus induces changes in cardiac myosin of the rat
31. Mechanisms of the defect in cardiac myofibrillar function during diabetes
32. Calcium uptake by cardiac sarcoplasmic reticulum in human dilated cardiomyopathy
33. Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding
34. Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy
35. Function of the sarcoplasmic reticulum and expression of its Ca2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat
36. Age-induced decreases in the messenger RNA coding for the sarcoplasmic reticulum Ca2(+)-ATPase of the rat heart
37. 2+-ATPase in a rat model of heart failure
38. Influence of thyroid hormone administration on myosin ATPase activity and myosin isoenzyme distribution in the heart of diabetic rats
39. 2+ transients and contractile responses of diabetic rat cardiomyocytes