Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation

Cardiovascular Diabetology

Volumn 13, Issue 1, 2014, Pages

  Zhang, Shaoping ^a,b   Liu, Hong ^a   Amarsingh, Greeshma V ^a   Cheung, Carlos C H ^a   Hogl, Sebastian ^a   Narayanan, Umayal ^a   Zhang, Lin ^a   McHarg, Selina ^c   Xu, Jingshu ^a,b   Gong, Deming ^a   Kennedy, John ^d   Barry, Bernard ^d   Choong, Yee S ^a   Phillips, Anthony R J ^a,b   Cooper, Garth J S ^a,b,c,e  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d GNS SCIENCE   (New Zealand)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Copper chaperones; Copper metalation; Copper transporters; Copper deficiency cardiomyopathy; Cu (II) chelation; Diabetic cardiomyopathy; Heart failure; Left ventricular dysfunction; Myocellular copper; Superoxide dismutase 1

Indexed keywords

COPPER; COPPER EXPORTING ADENOSINE TRIPHOSPHATASE; COPPER ZINC SUPEROXIDE DISMUTASE; METALLOTHIONEIN I; METALLOTHIONEIN II; PEROXIREDOXIN 3; TRIENTINE; WILSON DISEASE PROTEIN; ANTIOXIDANT; CHELATING AGENT; COPPER PROTEIN; COPPER TRANSPORTER 1; COPPER TRANSPORTER 2; MENKES PROTEIN; MESSENGER RNA; PROTEIN; STREPTOZOCIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; COPPER DEFICIENCY; COPPER METABOLISM; DIABETIC CARDIOMYOPATHY; ENZYME ACTIVITY; FLAME PHOTOMETRY; HEART FUNCTION; HEART OUTPUT; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; MALE; MYOCARDIAL COPPER DEFICIENCY; MYOCARDIAL DISEASE; NONHUMAN; PATHOGENESIS; PHASE 1 CLINICAL TRIAL; PROTEIN EXPRESSION; PROTEIN POLYMERIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; STUDENT T TEST; TREATMENT OUTCOME; WESTERN BLOTTING; ADULT; ANIMAL TISSUE; CHELATION; DRUG EFFECT; DRUG RESPONSE; GENE EXPRESSION; HEART LEFT VENTRICLE; HEART MUSCLE CELL; MOLECULAR PATHOLOGY; OXIDATIVE STRESS; PARTICLE INDUCED X RAY EMISSION SPECTROMETRY; QUANTITATIVE ANALYSIS; RUTHERFORD BACKSCATTERING SPECTROMETRY; SPECTROMETRY; STATISTICAL SIGNIFICANCE; WISTAR RAT;

ANIMALS; CELL MEMBRANE; CHELATING AGENTS; COPPER; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; MALE; RATS; RATS, WISTAR;

EID: 84902058520     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-13-100     Document Type: Article

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