Biotechnology of fruit quality

Fruit Ripening: Physiology, Signalling and Genomics

Volumn , Issue , 2014, Pages 259-290

  Handa, Avtar K ^a   Anwar, Raheel ^a,b   Mattoo, Autar K ^c  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF AGRICULTURE   (Pakistan)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84927978724     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (239)

1. Abeles, F.B., Morgan, P.W. and Saltveit, M.E.J. (1992) Ethylene in Plant Biology. Academic Press, San Diego.
2. Adato, A., Mandel, T., Mintz-Oron, S., Venger, I., Levy, D., Yativ, M., Domínguez, E., Wang, Z., De Vos, R.C.H., Jetter, R., Schreiber, L., Heredia, A., Rogachev, I. and Aharoni, A. (2009) Fruitsurface flavonoid accumulation in tomato is controlled by a SlMYB12-regulated transcriptional network. PLOS Genetics 5, e1000777.
3. Aharoni, A., De Vos, C.H.R., Wein, M., Sun, Z., Greco, R., Kroon, A., Mol, J.N.M. and O'Connell, A.P. (2001) The strawberry FaMYB1 transcription factor suppresses anthocyanin and flavonol accumulation in transgenic tobacco. Plant Journal 28, 319-332.
4. Amiot, M.J., Tacchini, M., Aubert, S. and Nicolas, J. (1992) Phenolic composition and browning susceptibility of various apple cultivars at maturity. Journal of Food Science 57, 958-962.
5. Andrade, E.H.A., Maia, J.G.S. and Zoghbi, M.d.G.B. (2000) Aroma volatile constituents of Brazilian varieties of mango fruit. Journal of Food Composition and Analysis 13, 27-33.
6. Anterola, A.M. and Lewis, N.G. (2002) Trends in lignin modification: a comprehensive analysis of the effects of genetic manipulations/mutations on lignification and vascular integrity. Phytochemistry 61, 221-294.
7. Auger, B., Baron, C., Lucas, M.-O., Vautrin, S., Bergès, H., Chalhoub, B., Fautrel, A., Renard, M. and Nesi, N. (2009) Brassica orthologs from BANYULS belong to a small multigene family, which is involved in procyanidin accumulation in the s eed. Planta 230, 1167-1183.
8. Azari, R., Tadmor, Y., Meir, A., Reuveni, M., Evenor, D., Nahon, S., Shlomo, H., Chen, L. and Levin, I. (2010a) Light signaling genes and their manipulation towards modulation of phytonutrient content in tomato fruits. Biotechnology Advances 28, 108-118.
9. Azari, R., Reuveni, M., Evenor, D., Nahon, S., Shlomo, H., Chen, L. and Levin, I. (2010b) Overexpression of UV-DAMAGED DNA BINDING PROTEIN 1 links plant development and phytonutrient accumulation in high pigment-1 tomato. Journal of Experimental Botany 61, 3627-3637.
10. Baldwin, E.A., Scott, J.W., Shewmaker, C.K. and Schuch, W. (2000) Flavor trivia and tomato aroma:biochemistry and possible mechanisms for control of important aroma components. Hortscience 35, 1013-1022.
11. Ban, Y., Honda, C., Hatsuyama, Y., Igarashi, M., Bessho, H. and Moriguchi, T. (2007) Isolation and functional analysis of a MYB transcription factor gene that is a key regulator for the development of red coloration in apple skin. Plant and Cell Physiology 48, 958-970.
12. Battilana, J., Emanuelli, F., Gambino, G., Gribaudo, I., Gasperi, F., Boss, P.K. and Grando, M.S. (2011) Functional effect of grapevine 1-deoxy-D-xylulose 5-phosphate synthase substitution K284N on Muscat flavour formation. Journal of Experimental Botany 62, 5497-5508.
13. Beekwilder, J., Alvarez-Huerta, M., Neef, E., Verstappen, F.W.A., Bouwmeester, H.J. and Aharoni, A. (2004) Functional characterization of enzymes forming volatile esters from strawberry and banana. Plant Physiology 135, 1865-1878.
14. Ben Chaim, A., Borovsky, Y., Rao, G., Gur, A., Zamir, D. and Paran, I. (2006) Comparative QTL mapping of fruit size and shape in tomato and pepper. Israel Journal of Plant Sciences 54, 191-203.
15. Bewley, J.D., Banik, M., Bourgault, R., Feurtado, J.A., Toorop, P. and Hilhorst, H.W.M. (2000) Endo-β- mannanase activity increases in the skin and outer pericarp of tomato fruits during ripening. Journal of Experimental Botany 51, 529-538.
16. Biggs, M.S. and Handa, A.K. (1989) Temporal regulation of polygalacturonase gene-expression in fruits of normal, mutant, and heterozygous tomato genotypes. Plant Physiology 89, 117-125.
17. Bogs, J., Jaffé, F.W., Takos, A.M., Walker, A.R. and Robinson, S.P. (2007) The grapevine transcription factor VvMYBPA1 regulates proanthocyanidin synthesis during fruit development. Plant Physiology 143, 1347-1361.
18. Bohner, J. and Bangerth, F. (1988) Cell number, cell size and hormone levels in semi-isogenic mutants of Lycopersicon pimpinellifolium differing in fruit size. Physiologia Plantarum 72, 316-320.
19. Boss, P.K., Davies, C. and Robinson, S.P. (1996) Analysis of the expression of anthocyanin pathway genes in developing Vitis vinifera L. cv Shiraz grape berries and the implications for pathway regulation. Plant Physiology 111, 1059-1066.
20. Bovy, A., de Vos, R., Kemper, M., Schijlen, E., Almenar Pertejo, M., Muir, S., Collins, G., Robinson, S., Verhoeyen, M., Hughes, S., Santos-Buelga, C. and van Tunen, A. (2002) High-flavonol tomatoes resulting from the heterologous expression of the maize transcription factor genes LC and C1. Plant Cell Online 14, 2509-2526.
21. Brady, C.J. (1987) Fruit ripening. Annual Review of Plant Physiology 38, 155-178.
22. Brown, S.K. (2009) Breeding and biotechnology for flavor development in apple (Malus × Domestica Borkh.). In: Havkin-Frenkel, D. and Belanger, F. (eds) Biotechnology in Flavor Production. Blackwell Publishing, Ames, IA, pp. 147-160.
23. Brummell, D., Hall, B. and Bennett, A. (1999a) Antisense suppression of tomato endo-1,4-β- glucanase Cel2 mRNA accumulation increases the force required to break fruit abscission zones but does not affect fruit softening. Plant Molecular Biology 40, 615-622.
24. Brummell, D.A., Harpster, M.H., Civello, P.M., Palys, J.M., Bennett, A.B. and Dunsmuir, P. (1999b) Modification of expansin protein abundance in tomato fruit alters softening and cell wall polymer metabolism during ripening. Plant Cell Online 11, 2203-2216.
25. Burkhardt, P.K., Beyer, P., Wünn, J., Klöti, A., Armstrong, G.A., Schledz, M., von Lintig, J. and Potrykus, I. (1997) Transgenic rice (Oryza sativa) endosperm expressing daffodil (Narcissus pseudonarcissus) phytoene synthase accumulates phytoene, a key intermediate of provitamin A biosynthesis. Plant Journal 11, 1071-1078.
26. Butelli, E., Titta, L., Giorgio, M., Mock, H.-P., Matros, A., Peterek, S., Schijlen, E.G.W.M., Hall, R.D., Bovy, A.G., Luo, J. and Martin, C. (2008) Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Nature Biotechnology 26, 1301-1308.
27. Buttery, R.G. and Ling, L.C. (1993) Volatile components of tomato fruit and plant parts. In: Bioactive Volatile Compounds from Plants. American Chemical Society, Washington, DC, pp. 23-34.
28. Buttery, R.G., Teranishi, R., Ling, L.C., Flath, R.A. and Stern, D.J. (1988) Quantitative studies on origins of fresh tomato aroma volatiles. Journal of Agricultural and Food Chemistry 36, 1247-1250.
29. Carbonell-Barrachina, A., Agustí, A. and Ruiz, J. (2006) Analysis of flavor volatile compounds by dynamic headspace in traditional and hybrid cultivars of Spanish tomatoes. European Food Research and Technology 222, 536-542.
30. Carey, A.T., Smith, D.L., Harrison, E., Bird, C.R., Gross, K.C., Seymour, G.B. and Tucker, G.A. (2001) Down-regulation of a ripening-related β-galactosidase gene (TBG1) in transgenic tomato fruits. Journal of Experimental Botany 52, 663-668.
31. Causse, M., Chaïb, J., Lecomte, L., Buret, M. and Hospital, F. (2007) Both additivity and epistasis control the genetic variation for fruit quality traits in tomato. Theoretical and Applied Genetics 115, 429-442.
32. Cebolla, A., Maria Vinardell, J., Kiss, E., Olah, B., Roudier, F., Kondorosi, A. and Kondorosi, E. (1999) The mitotic inhibitor ccs52 is required for endoreduplication and ploidy-dependent cell enlargement in plants. EMBO Journal 18, 4476-4484.
33. Chen, G., Hackett, R., Walker, D., Taylor, A., Lin, Z. and Grierson, D. (2004) Identification of a specific isoform of tomato lipoxygenase (TomloxC) involved in the generation of fatty acidderived flavor compounds. Plant Physiology 136, 2641-2651.
34. Cheniclet, C., Rong, W.Y., Causse, M., Frangne, N., Bolling, L., Carde, J.-P. and Renaudin, J.-P. (2005) Cell expansion and endoreduplication show a large genetic variability in pericarp and contribute strongly to tomato fruit growth. Plant Physiology 139, 1984-1994.
35. Choi, D., Cho, H.-T. and Lee, Y. (2006) Expansins: expanding importance in plant growth and development. Physiol ogia Plantarum 126, 511-518.
36. Christiansen, K.F., Olsen, E., Vegarud, G., Langsrud, T., Lea, P., Haugen, J.E. and Egelandsdal, B. (2011) Flavor release of the tomato flavor enhancer, 2-isobutylthiazole, from whey protein stabilized model dressings. Food Science and Technolog y International 17, 143-154.
37. Cong, B., Liu, J. and Tanksley, S.D. (2002) Natural alleles at a tomato fruit size quantitative trait locus differ by heterochronic regulatory mutations. Proceedings of the National Academy of Sciences USA 99, 13606-13611.
38. Cong, L., Wang, C., Chen, L., Liu, H., Yang, G. and He, G. (2009) Expression of phytoene synthase1 and carotene desaturase crtI genes result in an increase in the total carotenoids content in transgenic elite wheat (Triticum aestivum L.). Journal of Agricultural and Food Chemistry 57, 8652-8660.
39. Cook, M.S. (2010) Phyto power in the fight against disease. In: Cook, M.S. (ed.) The Phytozyme Cure:Treat or Reverse More Than 30 Serious Health Conditions with Powerful Plant Nutrients. Wiley, Miss issauga, Ontario, pp. 11-36.
40. Cookson, P.J., Kiano, J.W., Shipton, C.A., Fraser, P.D., Romer, S., Schuch, W., Bramley, P.M. and Pyke, K.A. (2003) Increases in cell elongation, plastid compartment size and phytoene synthase activity underlie the phenotype of the high pigment-1 mutant of tomato. Planta 217, 896-903.
41. Crozier, A., Lean, M.E.J., McDonald, M.S. and Black, C. (1997) quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuce, and celery. Journal of Agricultural and Food Chemistry 45, 590-595.
42. D'Ambrosio, C., Giorio, G., Marino, I., Merendino, A., Petrozza, A., Salfi, L., Stigliani, A.L. and Cellini, F. (2004) Virtually complete conversion of lycopene into β-carotene in fruits of tomato plants transformed with the tomato lycopene β-cyclase (tlcy-b) cDNA. Plant Science 166, 207-214.
43. D'Introno, A., Paradiso, A., Scoditti, E., D'Amico, L., De Paolis, A., Carluccio, M.A., Nicoletti, I., DeGara, L., Santino, A. and Giovinazzo, G. (2009) Antioxidant and anti-inflammatory properties of tomato fruits synthesizing different amounts of stilbenes. Plant Biotechnology Journal 7, 422-429.
44. Dal Cin, V., Tieman, D.M., Tohge, T., McQuinn, R., de Vos, R.C.H., Osorio, S., Schmelz, E.A., Taylor, M.G., Smits-Kroon, M.T., Schuurink, R.C., Haring, M.A., Giovannoni, J., Fernie, A.R. and Klee, H.J. (2011) Identification of genes in the phenylalanine metabolic pathway by ectopic expression of a MYB transcription factor in tomato fruit. Plant Cell Online 23, 2738-2753.
45. Dandekar, A.M., Teo, G., Defilippi, B.G., Uratsu, S.L., Passey, A.J., Kader, A.A., Stow, J.R., Colgan, R.J. and James, D.J. (2004) Effect of down-regulation of ethylene biosynthesis on fruit flavor complex in apple fruit. Transgenic Research 13, 373-384.
46. Davidovich-Rikanati, R., Sitrit, Y., Tadmor, Y., Iijima, Y., Bilenko, N., Bar, E., Carmona, B., Fallik, E., Dudai, N., Simon, J.E., Pichersky, E. and Lewinsohn, E. (2007) Enrichment of tomato flavor by diversion of the early plastidial terpenoid pathway. Nature Biotechnology 25, 899-901.
47. Davidovich-Rikanati, R., Lewinsohn, E., Bar, E., Iijima, Y., Pichersky, E. and Sitrit, Y. (2008) Overexpression of the lemon basil α-zingiberene synthase gene increases both mono- and sesquiterpene contents in tomato fru it. Plant Journal 56, 228-238.
48. Davuluri, G.R., van Tuinen, A., Mustilli, A.C., Manfredonia, A., Newman, R., Burgess, D., Brummell, D.A., King, S.R., Palys, J., Uhlig, J., Pennings, H.M.J. and Bowler, C. (2004) Manipulation of DET1 expression in tomato results in photomorphogenic phenotypes caused by posttranscriptional gene silenci ng. Plant Journal 40, 344-354.
49. Davuluri, G.R., van Tuinen, A., Fraser, P.D., Manfredonia, A., Newman, R., Burgess, D., Brummell, D.A., King, S.R., Palys, J., Uhlig, J., Bramley, P.M., Pennings, H.M.J. and Bowler, C. (2005) Fruitspecific RNAi-mediated suppression of DET1 enhances carotenoid and flavonoid content in tomatoes. Nature Biotechnology 23, 890-895.
50. de Freitas, S.T., Handa, A.K., Wu, Q., Park, S. and Mitcham, E.J. (2012) Role of pectin methylesterases in cellular calcium distribution and blossom-end rot development in tomato fruit. Plant Journal, 71, 824-835.
51. Defilippi, B.G., Dandekar, A.M. and Kader, A.A. (2004) Impact of suppression of ethylene action or biosynthesis on flavor metabolites in apple (Malus domestica Borkh) fruits. Journal of Agricultural and Food Chemistry 52, 5694-5701.
52. Defilippi, B.G., Dandekar, A.M. and Kader, A.A. (2005a) Relationship of ethylene biosynthesis to volatile production, related enzymes, and precursor availability in apple peel and flesh tissues. Journal of Agricultural and Food Chemistry 53, 3133-3141.
53. Defilippi, B.G., Kader, A.A. and Dandekar, A.M. (2005b) Apple aroma: alcohol acyltransferase, a rate limiting step for ester biosynthesis, is regulated by ethylene. Plant Science 168, 1199-1210.
54. DellaPenna, D., Lincoln, J.E., Fischer, R.L. and Bennett, A.B. (1989) Transcriptional analysis of polygalacturonase and other ripening associated genes in Rutgers, rin, nor, and Nr tomato fruit. Plant Physiology 90, 1372-1377.
55. Dharmapuri, S., Rosati, C., Pallara, P., Aquilani, R., Bouvier, F., Camara, B. and Giuliano, G. (2002) Metabolic engineering of xanthophyll content in tomato fr uits. FEBS Letters 519, 30-34.
56. Di, R. (2009) Increasing the methional content in potato through biotechnology. In: Havkin-Frenkel, D. and Belanger, F. (eds) Biotechnology in Flavor Production. Blackwell Publishing, Ames, IA, pp. 185-193.
57. Dixon, J. and Hewett, E.W. (2000) Factors affecting apple aroma/flavour volatile concentration: a review. New Zealand Journal of Crop and Horticultural Science 28, 155-173.
58. Dixon, R.A. (2005) A two-for-one in tomato nutritional enhancement. Nature Biotechnology 23, 825-826.
59. Doganlar, S., Frary, A., Daunay, M.-C., Lester, R.N. and Tanksley, S.D. (2002) Conservation of gene function in the solanaceae as revealed by comparative mapping of domestication traits in eggp lant. Genetics 161, 1713-1726.
60. Domínguez, T., Hernández, M.L., Pennycooke, J.C., Jiménez, P., Martínez-Rivas, J.M., Sanz, C., Stockinger, E.J., Sánchez-Serrano, J.J. and Sanmartín, M. (2010) Increasing ω-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. Plant Physiology 153, 655-665.
61. Dudai, N. and Belanger, F.C. (2009) Aroma as a factor in the breeding process of fresh herbs - the case of basil. In: Havkin-Frenkel, D. and Belanger, F. (eds) Biotechnology in Flavor Production. Blackwell Publishing, Ames, IA pp. 161-184.
62. Enfissi, E.M.A., Fraser, P.D., Lois, L.-M., Boronat, A., Schuch, W. and Bramley, P.M. (2005) Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. Plant Biotechnology Journal 3, 17-27.
63. Fatima, T., Mattoo, A.K., Rivera-Domínguez, M., Troncoso-Rojas, R., Tiznado-Hernández, M.-E. and Handa, A.K. (2009) Tomato. In: Kole, C. and Hall, T.C. (eds) Compendium of Transgenic Crop Plants. Blackwell Publishing, Oxford, 2008, pp. 1-46.
64. Ficcadenti, N., Sestili, S., Pandolfini, T., Cirillo, C., Rotino, G.L. and Spena, A. (1999) Genetic engineering of parthenocarpic fruit development in tomato. Molecular Breeding 5, 463-470.
65. Flachowsky, H., Szankowski, I., Fischer, T., Richter, K., Peil, A., Höfer, M., Dörschel, C., Schmoock, S., Gau, A., Halbwirth, H. and Hanke, M.-V. (2010) Transgenic apple plants overexpressing the Lc gene of maize show an altered growth habit and increased resistance to apple scab and fire blight. Planta 231, 623-635.
66. Flachowsky, H., Halbwirth, H., Treutter, D., Richter, K., Hanke, M.-V., Szankowski, I., Gosch, C., Stich, K. and Fischer, T.C. (2012) Silencing of flavanone-3-hydroxylase in apple (Malus × domestica Borkh.) leads to accumulation of flavanones, but not to reduced fire blight susceptibility. Plant Physiology and Biochemistry 51, 18-25.
67. Flores, F., El Yahyaoui, F., de Billerbeck, G., Romojaro, F., Latché, A., Bouzayen, M., Pech, J.C. and Ambid, C. (2002) Role of ethylene in the biosynthetic pathway of aliphatic ester aroma volatiles in Charentais Cantaloupe melons. Journal of Experimental Botany 53, 201-206.
68. Frary, A., Nesbitt, T.C., Frary, A., Grandillo, S., Knaap, E.v.d., Cong, B., Liu, J., Meller, J., Elber, R., Alpert, K.B. and Tanksley, S.D. (2000) fw2.2: a quantitative trait locus key to the evolution of tomato f ruit size. Science 289, 85-88.
69. Fraser, P.D., Romer, S., Shipton, C.A., Mills, P.B., Kiano, J.W., Misawa, N., Drake, R.G., Schuch, W. and Bramley, P.M. (2002) Evaluation of transgenic tomato plants expressing an additional phytoene synthase in a fruit-specific manner. Proceedings of the National Academy of Sciences USA 99, 1092-1097.
70. Fraser, P.D., Enfissi, E.M.A., Halket, J.M., Truesdale, M.R., Yu, D., Gerrish, C. and Bramley, P.M. (2007) Manipulation of phytoene levels in tomato fruit: effects on isoprenoids, plastids, and intermediary metabolism. Plant Cell Online 19, 3194-3211.
71. Fray, R.G., Wallace, A., Fraser, P.D., Valero, D., Hedden, P., Bramley, P.M. and Grierson, D. (1995) Constitutive expression of a fruit phytoene synthase gene in transgenic tomatoes causes dwarfism by redirecting metabolites from the gibberellin path way. Plant Journal 8, 693-701.
72. Frey, A., Boutin, J.-P., Sotta, B., Mercier, R. and Marion-Poll, A. (2006) Regulation of carotenoid and ABA accumulation during the development and germination of Nicotiana plumbaginifol ia seeds. Planta 224, 622-632.
73. Frydman, A., Weisshaus, O., Bar-Peled, M., Huhman, D.V., Sumner, L.W., Marin, F.R., Lewinsohn, E., Fluhr, R., Gressel, J. and Eyal, Y. (2004) Citrus fruit bitter flavors: isolation and functional characterization of the gene Cm1,2RhaT encoding a 1,2 rhamnosyltransferase, a key enzyme in the biosynthesis of the bitter flavonoids of citrus. Plant Journal 40, 88-100.
74. Fujisawa, M. and Misawa, N. (2010) Enrichment of carotenoids in flaxseed by introducing a bacterial phytoene synthase gene. In: Fett-Neto, A.G. (ed.) Plant Secondary Metabolism Engineering:Methods and Applications. Springer, New York, NY, pp. 201-211.
75. Fujisawa, M., Takita, E., Harada, H., Sakurai, N., Suzuki, H., Ohyama, K., Shibata, D. and Misawa, N. (2009) Pathway engineering of Brassica napus seeds using multiple key enzyme genes involved in ketocarotenoid formation. Journal of Experimental Botany 60, 1319-1332.
76. Furukawa, T., Maekawa, M., Oki, T., Suda, I., Iida, S., Shimada, H., Takamure, I. and Kadowaki, K.-i. (2007) The Rc and Rd genes are involved in proanthocyanidin synthesis in rice peric arp. Plant Journal 49, 91-102.
77. Gaffe, J., Tieman, D.M. and Handa, A.K. (1994) Pectin methylesterase isoforms in tomato (Lycopersicon esculentum) tissues (effects of expression of a pectin methylesterase antisense gene). Plant Physiology 105, 199-203.
78. Gaffe, J., Tiznado, M.E. and Handa, A.K. (1997) Characterization and functional expression of a ubiquitously expressed tomato pectin methylesterase. Plant Physiology 114, 1547-1556.
79. Galpaz, N., Wang, Q., Menda, N., Zamir, D. and Hirschberg, J. (2008) Abscisic acid deficiency in the tomato mutant high-pigment 3 leading to increased plastid number and higher fruit lycopene conte nt. Plant Journal 53, 717-730.
80. Gao, H., Zhu, H., Shao, Y., Chen, A., Lu, C., Zhu, B. and Luo, Y. (2008) Lycopene accumulation affects the biosynthesis of some carotenoid-related volatiles independent of ethylene in tomato. Journal of Integrative Plant Biology 50, 991-996.
81. Giliberto, L., Perrotta, G., Pallara, P., Weller, J.L., Fraser, P.D., Bramley, P.M., Fiore, A., Tavazza, M. and Giuliano, G. (2005) Manipulation of the blue light photoreceptor Cryptochrome 2 in tomato affects vegetative development, flowering time, and fruit antioxidant content. Plant Physiology 137, 199-208.
82. Giovannoni, J.J. (2004) Genetic regulation of fruit development and ripen ing. Plant Cell 16, S170-S180.
83. Giovannoni, J.J. (2007) Fruit ripening mutants yield insights into ripening control. Current Opinion in Plant Biology 10, 283-289.
84. Giovannoni, J.J., Dellapenna, D., Bennett, A.B. and Fischer, R.L. (1989) Expression of a chimeric polygalacturonase gene in transgenic rin (ripening inhibitor) tomato fruit results in polyuronide degradation but not fruit s oftening. Plant Cell 1, 53-63.
85. Giovinazzo, G., D'Amico, L., Paradiso, A., Bollini, R., Sparvoli, F. and DeGara, L. (2005) Antioxidant metabolite profiles in tomato fruit constitutively expressing the grapevine stilbene synthase gene. Plant Biotechnology Journal 3, 57-69.
86. Goff, S.A. and Klee, H.J. (2006) Plant volatile compounds: sensory cues for health and nutritional value? Science 311, 815-819.
87. Goldsbrough, A.P., Tong, Y. and Yoder, J.I. (1996) Lc as a non-destructive visual reporter and transposition excision marker gone for tom ato. Plant Journal 9, 927-933.
88. Gong, Z.-Z., Yamagishi, E., Yamazaki, M. and Saito, K. (1999) A constitutively expressed Myc-like gene involved in anthocyanin biosynthesis from Perilla frutescens: molecular characterization, heterologous expression in transgenic plants and transactivation in yeast cells. Plant Molecular Biology 41, 33-44.
89. Gonzalez, N., Gévaudant, F., Hernould, M., Chevalier, C. and Mouras, A. (2007) The cell cycleassociated protein kinase WEE1 regulates cell size in relation to endoreduplication in developing tomato fru it. Plant Journal 51, 642-655.
90. Goupy, P., Amiot, M.J., Richard-Forget, F., Duprat, F., Aubert, S. and Nicolas, J. (1995) Enzymatic browning of model solutions and apple phenolic extracts by apple polyphenoloxidase. Journal of Food Science 60, 497-501.
91. Grandillo, S., Ku, H.M. and Tanksley, S.D. (1999) Identifying the loci responsible for natural variation in fruit size and shape in tomato. Theoretical and Applied Genetics 99, 978-987.
92. Gross, K.C. and Sams, C.E. (1984) Changes in cell wall neutral sugar composition during fruit ripening: a species survey. Phytochemistry 23, 2457-2461.
93. Guo, F., Zhou, W., Zhang, J., Xu, Q. and Deng, X. (2012) Effect of the citrus lycopene β-cyclase transgene on carotenoid metabolism in transgenic toma to fruits. PLOS One 7, e32221.
94. Han, Y., Vimolmangkang, S., Soria-Guerra, R.E. and Korban, S.S. (2012) Introduction of apple ANR genes into tobacco inhibits expression of both CHI and DFR genes in flowers, leading to loss of anthocyanin. Journal of Experimental Botany 63, 2437-2447.
95. Handa, A.K., Singh, N.K. and Biggs, M.S. (1985) Effect of tunicamycin on in vitro ripening of tomato pericarp tissue. Phys iologia Plantarum 63, 417-424.
96. Handa, A.K., Tiznado-Hernández, M.-E. and Mattoo, A.K. (2012) Fruit development and ripening: a molecular perspective. In: Altman, A. and Hasegawa, P.M. (eds) Plant Biotechnology and Agriculture: Prospects for 21st Century. Elsevier, New York, NY, pp. 405-424.
97. Harborne, J.B. and Herbert, B. (1999) The Handbook of Natural Flavo noids. John Wiley, Chichester.
98. Harborne, J.B. and Williams, C.A. (2000) Advances in flavonoid research since 1992. Phytochemistry 55, 481-504.
99. Harriman, R.W., Tieman, D.M. and Handa, A.K. (1991) Molecular cloning of tomato pectin methylesterase gene and its expression in Rutgers, ripening inhibitor, nonripening, and never ripe tomato fruit s. Plant Physiology 97, 80-87.
100. Hüsken, A., Baumert, A., Milkowski, C., Becker, H., Strack, D. and Möllers, C. (2005) Resveratrol glucoside (Piceid) synthesis in seeds of transgenic oilseed rape (Brassica napus L.). Theoretical and Applied Genetics 111, 1553-1562.
101. Iijima, Y., Davidovich-Rikanati, R., Fridman, E., Gang, D.R., Bar, E., Lewinsohn, E. and Pichersky, E. (2004) The biochemical and molecular basis for the divergent patterns in the biosynthesis of terpenes and phenylpropenes in the peltate glands of three cultivars of basil. Plant Physiology 136, 3724-3736.
102. Ingrosso, I., Bonsegna, S., De Domenico, S., Laddomada, B., Blando, F., Santino, A. and Giovinazzo, G. (2011) Over-expression of a grape stilbene synthase gene in tomato induces parthenocarpy and causes abnormal pollen development. Plant Physiology and Biochemistry 49, 1092-1099.
103. Itkin, M., Seybold, H., Breitel, D., Rogachev, I., Meir, S. and Aharoni, A. (2009) TOMATO AGAMOUS-LIKE 1 is a component of the fruit ripening regulatory network. Plant Journal 60, 1081-1095.
104. Jiménez-Bermúdez, S., Redondo-Nevado, J., Muñoz-Blanco, J., Caballero, J.L., López-Aranda, J.M., Valpuesta, V., Pliego-Alfaro, F., Quesada, M.A. and Mercado, J.A. (2002) Manipulation of strawberry fruit softening by antisense expression of a pectate lyase gene. Plant Physiology 128, 751-759.
105. Klee, H.J. (2010) Improving the flavor of fresh fruits: genomics, biochemistry, and biotechnolog y. New Phytologist 187, 44-56.
106. Klee, H.J. and Giovannoni, J.J. (2011) Genetics and control of tomato fruit ripening and quality attributes. Annual Review of Genetics 45, 41-59.
107. Koca, U., Berhow, M.A., Febres, V.J., Champ, K.I., Carrillo-Mendoza, O. and Moore, G.A. (2009) Decreasing unpalatable flavonoid components in Citrus: the effect of transformation construct. Physiologia Plantarum 137, 101-114.
108. Kochevenko, A., Araújo, W.L., Maloney, G.S., Tieman, D.M., Do, P.T., Taylor, M.G., Klee, H.J. and Fernie, A.R. (2012) Catabolism of branched chain amino acids supports respiration but not volatile synthesis in tomato fruit s. Molecular Plant 5, 366-375.
109. Koeduka, T., Shitan, N., Kumano, T., Sasaki, K., Sugiyama, A., Linley, P., Kawasaki, T., Ezura, H., Kuzuyama, T. and Yazaki, K. (2011) Production of prenylated flavonoids in tomato fruits expressing a prenyltransferase gene from Streptomyces coelicolor A3( 2). Plant Biology 13, 411-415.
110. Kolotilin, I., Koltai, H., Bar-Or, C., Chen, L., Nahon, S., Shlomo, H., Levin, I. and Reuveni, M. (2011) Expressing yeast SAMdc gene confers broad changes in gene expression and alters fatty acid composition in tomato fruit. Physiologia Plantarum 142, 211-223.
111. Kramer, M.G. and Redenbaugh, K. (1994) Commercialization of a tomato with an antisense polygalacturonase gene: the FLAVR SAVR™ tomato story. Euphytica 79, 293-297.
112. Krumbein, A. and Auerswald, H. (1998) Characterization of aroma volatiles in tomatoes by sensory analyses. Nahrung 42, 395-399.
113. Ku, H.M., Doganlar, S., Chen, K.Y. and Tanksley, S.D. (1999) The genetic basis of pear-shaped tomato fruit. Theoretical and Applied Genetics 99, 844-850.
114. Ku, H.M., Grandillo, S. and Tanksley, S.D. (2000) fs8.1, a major QTL, sets the pattern of tomato carpel shape well before anthesis. Theoretical and Applied Genetics 101, 873-878.
115. Lashbrook, C.C., Giovannoni, J.J., Hall, B.D., Fischer, R.L. and Bennett, A.B. (1998) Transgenic analysis of tomato endo-β-1,4-glucanase gene function. Role of cel1 in floral absciss ion. Plant Journal 13, 303-310.
116. Le Gall, G., DuPont, M.S., Mellon, F.A., Davis, A.L., Collins, G.J., Verhoeyen, M.E. and Colquhoun, I.J. (2003) Characterization and content of flavonoid glycosides in genetically modified tomato (Lycopersicon esculentum) fruits. Journal of Agricultural and Food Chemistry 51, 2438-2446.
117. Levin, I., Frankel, P., Gilboa, N., Tanny, S. and Lalazar, A. (2003) The tomato dark green mutation is a novel allele of the tomato homolog of the DEETIOLATED1 gene. Theoretical and Applied Genetics 106, 454-460.
118. Lewinsohn, E., Schalechet, F., Wilkinson, J., Matsui, K., Tadmor, Y., Nam, K.-H., Amar, O., Lastochkin, E., Larkov, O., Ravid, U., Hiatt, W., Gepstein, S. and Pichersky, E. (2001) Enhanced levels of the aroma and flavor compound S-linalool by metabolic engineering of the terpenoid pathway in tomato fruits. Plant Physiology 127, 1256-1265.
119. Lewinsohn, E., Sitrit, Y., Bar, E., Azulay, Y., Ibdah, M., Meir, A., Yosef, E., Zamir, D. and Tadmor, Y. (2005) Not just colors - carotenoid degradation as a link between pigmentation and aroma in tomato and watermelon fruit. Trends in Food Science and Technology 16, 407-415.
120. Li, H., Flachowsky, H., Fischer, T., Hanke, M.-V., Forkmann, G., Treutter, D., Schwab, W., Hoffmann, T. and Szankowski, I. (2007) Maize Lc transcription factor enhances biosynthesis of anthocyanins, distinct proanthocyanidins and phenylpropanoids in apple (Malus domestica Borkh.). Planta 226, 1243-1254.
121. Lin, Z.F., Zhong, S.L. and Grierson, D. (2009) Recent advances in ethylene research. Journal of Experimental Botany 60, 3311-3336.
122. Lind, K., Lafer, G., Schloffer, K. and Innerhofer, H.M. (2003) Organic Fruit Growing. CABI, Wallingford, UK.
123. Lippman, Z. and Tanksley, S.D. (2001) Dissecting the genetic pathway to extreme fruit size in tomato using a cross between the small-fruited wild species Lycopersicon pimpinellifolium and L. esculentum var. Giant Heirloom. Genetics 158, 413-422.
124. Liu, J., Van Eck, J., Cong, B. and Tanksley, S.D. (2002) A new class of regulatory genes underlying the cause of pear-shaped tomato fruit. Proceedings of the National Academy of Sciences USA 99, 13302-13306.
125. Liu, J.P., Cong, B. and Tanksley, S.D. (2003) Generation and analysis of an artificial gene dosage series in tomato to study the mechanisms by which the cloned quantitative trait locus fw2.2 controls fruit size. Plant Physiology 132, 292-299.
126. Liu, Y., Roof, S., Ye, Z., Barry, C., van Tuinen, A., Vrebalov, J., Bowler, C. and Giovannoni, J. (2004) Manipulation of light signal transduction as a means of modifying fruit nutritional quality in tomato. Proceedings of the National Academy of Sciences USA 101, 9897-9902.
127. Long, M., Millar, D.J., Kimura, Y., Donovan, G., Rees, J., Fraser, P.D., Bramley, P.M. and Bolwell, G.P. (2006) Metabolite profiling of carotenoid and phenolic pathways in mutant and transgenic lines of tomato: identification of a high antioxidant fruit line. Phytochemistry 67, 1750-1757.
128. Lorenc-Kukula, K., Amarowicz, R., Oszmianski, J., Doermann, P., Starzycki, M., Skala, J., Z˙uk, M., Kulma, A. and Szopa, J. (2005) Pleiotropic effect of phenolic compounds content increases in transgenic flax plant. Journal of Agricultural and Food Chemistry 53, 3685-3692.
129. Lunkenbein, S., Coiner, H., de Vos, C.H.R., Schaart, J.G., Boone, M.J., Krens, F.A., Schwab, W. and Salentijn, E.M.J. (2006) Molecular characterization of a stable antisense chalcone synthase phenotype in strawberry (Fragaria × ananassa). Journal of Agricultural and Food Chemistry 54, 2145-2153.
130. Luo, J., Butelli, E., Hill, L., Parr, A., Niggeweg, R., Bailey, P., Weisshaar, B. and Martin, C. (2008) AtMYB12 regulates caffeoyl quinic acid and flavonol synthesis in tomato: expression in fruit results in very high levels of both types of polyphe nol. Plant Journal 56, 316-326.
131. MacLeod, A.J. and Snyder, C.H. (1985) Volatile components of two cultivars of mango from Florida. Journal of Agricultural and Food Chemistry 33, 380-384.
132. MacLeod, A.J., Macleod, G. and Snyder, C.H. (1988) Volatile aroma constituents of mango (cv Kensington). Phytochemistry 27, 2189-2193.
133. Mageroy, M.H., Tieman, D.M., Floystad, A., Taylor, M.G. and Klee, H.J. (2012) A Solanum lycopersicum catechol-O-methyltransferase involved in synthesis of the flavor molecule guaiaco l. Plant Journal 69, 1043-1051.
134. Maitrejean, M., Comte, G., Barron, D., El Kirat, K., Conseil, G. and Di Pietro, A. (2000) The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of p-glycoprotein. Bioorganic and Medicinal Chemistry Letters 10, 157-160.
135. Malowicki, S.M.M., Martin, R. and Qian, M.C. (2008) Comparison of sugar, acids, and volatile composition in raspberry bushy dwarf virus-resistant transgenic raspberries and the wild type 'Meeker' (Rubus Idaeus L.). Journal of Agricultural and Food Chemistry 56, 6648-6655.
136. Marković, K., Vahčić, N., Ganić, K.K. and Banović, M. (2007) Aroma volatiles of tomatoes and tomato products evaluated by solid-phase microextraction. Flavour and Fragrance Journal 22, 395-400.
137. Mathews, H., Clendennen, S.K., Caldwell, C.G., Liu, X.L., Connors, K., Matheis, N., Schuster, D.K., Menasco, D.J., Wagoner, W., Lightner, J. and Wagner, D.R. (2003) Activation tagging in tomato identifies a transcriptional regulator of Anthocyanin biosynthesis, modification, and transport. Plant Cell Online 15, 1689-1703.
138. Mathieu, S., Cin, V.D., Fei, Z., Li, H., Bliss, P., Taylor, M.G., Klee, H.J. and Tieman, D.M. (2009) Flavour compounds in tomato fruits: identification of loci and potential pathways affecting volatile composition. Journal of Experimental Botany 60, 325-337.
139. Mathieu-Rivet, E., Gévaudant, F., Sicard, A., Salar, S., Do, P.T., Mouras, A., Fernie, A.R., Gibon, Y., Rothan, C., Chevalier, C. and Hernould, M. (2010) Functional analysis of the anaphase promoting complex activator CCS52A highlights the crucial role of endo-reduplication for fruit growth in tom ato. Plant Journal 62, 727-741.
140. Mattoo, A.K. and Suttle, J.C. (1991) The Plant Hormone Ethylene. CRC Press, Boca Raton, FL.
141. Mattoo, A.K., Chung, S.H., Goyal, R.K., Fatima, T., Solomos, T., Srivastava, A. and Handa, A.K. (2007) Overaccumulation of higher polyamines in ripening transgenic tomato fruit revives metabolic memory, upregulates anabolism-related genes, and positively impacts nutritional quality. Journal of AOAC International 90, 1456-1464.
142. Mattoo, A.K., Shukla, V., Fatima, T., Handa, A.K. and Yachha, S.K. (2010) Genetic engineering to enhance crop-based phytonutrients (nutraceuticals) to alleviate diet-related diseases. In: Giardi, G.M., Rea, T. and Berra, B. (eds) Bio-farms for Nutraceuticals: Functional Food and Safety Control by Biosensors. Landes Bioscience and Springer, Austin, TX, pp. 122-143.
143. Maul, F., Sargent, S., Huber, D., Balaban, M., Luzuriaga, D. and Baldwin, E. (1997) Non-destructive quality screening of tomato fruit using "Electronic Nose" technology. Proceedings of the Florida State Horticultural Society 110, 188-194.
144. Mayer, F., Takeoka, G.R., Buttery, R.G., Whitehand, L.C., Naim, M. and Rabinowitch, H.D. (2008) Studies on the aroma of five fresh tomato cultivars and the precursors of cis- and trans-4,5-epoxy-(E)-2-decenals and methional. Journal of Agricultural and Food Chemistry 56, 3749-3757.
145. Mehta, R.A., Cassol, T., Li, N., Ali, N., Handa, A.K. and Mattoo, A.K. (2002) Engineered polyamine accumulation in tomato enhances phytonutrient content, juice quality, and vine life. Nature Biotechnology 20, 613-618.
146. Meli, V.S., Ghosh, S., Prabha, T.N., Chakraborty, N., Chakraborty, S. and Datta, A. (2010) Enhancement of fruit shelf life by suppressing N-glycan processing enzymes. Proceedings of the National Academy of Sciences USA 107, 2413-2418.
147. Mercado, J.A., Trainotti, L., Jiménez-Bermúdez, L., Santiago-Doménech, N., Posé, S., Donolli, R., Barceló, M., Casadoro, G., Pliego-Alfaro, F. and Quesada, M.A. (2010) Evaluation of the role of the endo-β-(1,4)-glucanase gene FaEG3 in strawberry fruit softening. Postharvest Biology and Technology 55, 8-14.
148. Miedes, E., Herbers, K., Sonnewald, U. and Lorences, E.P. (2010) Overexpression of a cell wall enzyme reduces xyloglucan depolymerization and softening of transgenic tomato fruits. Journal of Agricultural and Food Chemistry 58, 5708-5713.
149. Mooney, M., Desnos, T., Harrison, K., Jones, J., Carpenter, R. and Coen, E. (1995) Altered regulation of tomato and tobacco pigmentation genes caused by the delila gene of Antirrh inum. Plant Journal 7, 333-339.
150. Moriguchi, T., Kita, M., Tomono, Y., Endo-Inagaki, T. and Omura, M. (2001) Gene expression in flavonoid biosynthesis: correlation with flavonoid accumulation in developing citrus fruit. Physiologia Plantarum 111, 66-74.
151. Muir, S.R., Collins, G.J., Robinson, S., Hughes, S., Bovy, A., Ric De Vos, C.H., van Tunen, A.J. and Verhoeyen, M.E. (2001) Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols. Nature Biotechnology 19, 470-474.
152. Murakami, A., Gao, G., Omura, M., Yano, M., Ito, C., Furukawa, H., Takahashi, D., Koshimizu, K. and Ohigashi, H. (2000) 1,1-Dimethylallylcoumarins potently supress both lipopolysaccharide- and interferon-γ-induced nitric oxide generation in mouse macrophage RAW 264.7 cells. Bioorganic and Medicinal Chemistry Letters 10, 59-62.
153. Mustilli, A.C., Fenzi, F., Ciliento, R., Alfano, F. and Bowler, C. (1999) Phenotype of the tomato high pigment-2 mutant is caused by a mutation in the tomato homolog of DEETIOLATED1. Plant Cell Online 11, 145-158.
154. Nagamatsu, A., Masuta, C., Senda, M., Matsuura, H., Kasai, A., Hong, J.-S., Kitamura, K., Abe, J. and Kanazawa, A. (2007) Functional analysis of soybean genes involved in flavonoid biosynthesis by virus-induced gene silencing. Plant Biotechnology Journal 5, 778-790.
155. Nambeesan, S., Datsenka, T., Ferruzzi, M.G., Malladi, A., Mattoo, A.K. and Handa, A.K. (2010) Overexpression of yeast spermidine synthase impacts ripening, senescence and decay symptoms in tom ato. Plant Journal 63, 836-847.
156. Namitha, K.K. and Negi, P.S. (2010) Chemistry and biotechnology of carotenoids. Critical Reviews in Food Science and Nutrition 50, 728-760.
157. Naqvi, S., Zhu, C., Farre, G., Sandmann, G., Capell, T. and Christou, P. (2011) Synergistic metabolism in hybrid corn indicates bottlenecks in the carotenoid pathway and leads to the accumulation of extraordinary levels of the nutritionally important carotenoid zeaxanthin. Plant Bi otechnology Journal 9, 384-393.
158. Negi, P.S. and Handa, A.K. (2008) Structural deterioration of the produce - the breakdown of cell wall components. In: Paliyath, G., Murr, D.P., Handa, A.K. and Lurie, S. (eds) Postharvest Biology and Technology of Fruits, Vegetables and Flowers, Wiley-Blackwell, Ames, IA, pp. 162-194.
159. Neily, M.H., Matsukura, C., Maucourt, M., Bernillon, S., Deborde, C., Moing, A., Yin, Y.-G., Saito, T., Mori, K., Asamizu, E., Rolin, D., Moriguchi, T. and Ezura, H. (2011) Enhanced polyamine accumulation alters carotenoid metabolism at the transcriptional level in tomato fruit overexpressing spermidine synthase. Journal of Plant Physiology 168, 242-252.
160. Nesbitt, T.C. and Tanksley, S.D. (2002) Comparative sequencing in the genus Lycopersicon:implications for the evolution of fruit size in the domestication of cultivated t omatoes. Genetics 162, 365-379.
161. Nesi, N., Lucas, M.-O., Auger, B., Baron, C., Lécureuil, A., Guerche, P., Kronenberger, J., Lepiniec, L., Debeaujon, I. and Renard, M. (2009) The promoter of the Arabidopsis thaliana BAN gene is active in proanthocyanidin-accumulating cells of the Brassica napus seed coat. Plant Cell Reports 28, 601-617.
162. Nicoletti, I., De Rossi, A., Giovinazzo, G. and Corradini, D. (2007) Identification and quantification of stilbenes in fruits of transgenic tomato plants (Lycopersicon esculentum Mill.) by reversed phase HPLC with photodiode array and mass spectrometry detection. Journal of Agricultural and Food Chemistry 55, 3304-3311.
163. Paine, J.A., Shipton, C.A., Chaggar, S., Howells, R.M., Kennedy, M.J., Vernon, G., Wright, S.Y., Hinchliffe, E., Adams, J.L., Silverstone, A.L. and Drake, R. (2005) Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nature Biotechnology 23, 482-487.
164. Pandolfini, T., Rotino, G., Camerini, S., Defez, R. and Spena, A. (2002) Optimisation of transgene action at the post-transcriptional level: high quality parthenocarpic fruits in industrial to matoes. BMC Biotechnology 2, 1.
165. Pang, X., Nada, K., Kurosawa, T., Ban, Y. and Moriguchi, T. (2010) Effect of methylglyoxal bis- (guanylhydrazone) on polyamine and ethylene biosynthesis of apple fruit after harvest. Acta Physiologia Plantarum 32, 1005-1010.
166. Pang, Y., Peel, G.J., Wright, E., Wang, Z. and Dixon, R.A. (2007) Early steps in proanthocyanidin biosynthesis in the model legume Medicago truncatula. Plant Physiology 145, 601-615.
167. Phan, T.D., Bo, W., West, G., Lycett, G.W. and Tucker, G.A. (2007) Silencing of the major saltdependent isoform of pectinesterase in tomato alters fruit softening. Plant Physiology 144, 1960-1967.
168. Porat, R., Tietel, Z., Zippori, I. and Dag, A. (2011) Aroma volatile compositions of high- and lowaromatic guava varieties. Journal of the Science of Food and Agriculture 91, 2794-2798.
169. Powell, A.L.T., Kalamaki, M.S., Kurien, P.A., Gurrieri, S. and Bennett, A.B. (2003) Simultaneous transgenic suppression of LePG and LeExp1 influences fruit texture and juice viscosity in a fresh market tomato variety. Journal of Agricultural and Food Chemistry 51, 7450-7455.
170. Qin, X. and Zeevaart, J.A.D. (2002) Overexpression of a 9-cis-epoxycarotenoid dioxygenase gene in Nicotiana plumbaginifolia increases abscisic acid and phaseic acid levels and enhances drought tolerance. Plant Physiology 128, 544-551.
171. Quesada, M.A., Blanco-Portales, R., Posé, S., García-Gago, J.A., Jiménez-Bermúdez, S., Muñoz-Serrano, A., Caballero, J.L., Pliego-Alfaro, F., Mercado, J.A. and Muñoz-Blanco, J. (2009) Antisense down-regulation of the FaPG1 gene reveals an unexpected central role for polygalacturonase in strawberry fruit softening. Plant Physiology 150, 1022-1032.
172. Rai, M., Datta, K., Parkhi, V., Tan, J., Oliva, N., Chawla, H. and Datta, S. (2007) Variable T-DNA linkage configuration affects inheritance of carotenogenic transgenes and carotenoid accumulation in transgenic indica rice. Plant Cell Reports 26, 1221-1231.
173. Ravanello, M.P., Ke, D., Alvarez, J., Huang, B. and Shewmaker, C.K. (2003) Coordinate expression of multiple bacterial carotenoid genes in canola leading to altered carotenoid production. M etabolic Engineering 5, 255-263.
174. Reich, L. (2012) Grow Fruit Naturally: A Hands-On Guide to Luscious, Home-Grown Fruit. Taunton Press, Newton, CT.
175. Rice-Evans, C., Miller, N. and Paganga, G. (1997) Antioxidant properties of phenolic compounds. Trends in Plant Science 2, 152-159.
176. Robards, K. and Antolovich, M. (1997) Analytical chemistry of fruit bioflavonoids - a review. Analyst 122, 11R-34R.
177. Rodríguez, A., Andrés, V., Cervera, M., Redondo, A., Alquézar, B., Shimada, T., Gadea, J., Rodrigo, M., Zacarías, L. and Palou, L. (2011b) The monoterpene limonene in orange peels attracts pests and microorganisms. Plant Signaling and Behavior 6, 1820.
178. Rodríguez, A., San Andrés, V., Cervera, M., Redondo, A., Alquézar, B., Shimada, T., Gadea, J., Rodrigo, M.J., Zacarías, L., Palou, L., López, M.M., Castañera, P. and Peña, L. (2011c) Terpene down-regulation in orange reveals the role of fruit aromas in mediating interactions with insect herbivores and pathogens. Plant Physiology 156, 793-802.
179. Rodríguez, G.R., Muños, S., Anderson, C., Sim, S.-C., Michel, A., Causse, M., Gardener, B.B.M., Francis, D. and van der Knaap, E. (2011a) Distribution of SUN, OVATE, LC, and FAS in the tomato germplasm and the relationship to fruit shape diversity. Plant Physiology 156, 275-285.
180. Rodríguez-Concepción, M. (2010) Supply of precursors for carotenoid biosynthesis in plants. Archives of Biochemistry and Biophysics 504, 118-122.
181. Römer, S., Fraser, P.D., Kiano, J.W., Shipton, C.A., Misawa, N., Schuch, W. and Bramley, P.M. (2000) Elevation of the provitamin A content of transgenic tomato plants. Nature Biotechnology 18, 666-669.
182. Ronen, G., Cohen, M., Zamir, D. and Hirschberg, J. (1999) Regulation of carotenoid biosynthesis during tomato fruit development: expression of the gene for lycopene epsilon-cyclase is downregulated during ripening and is elevated in the mutant De lta. Plant Journal 17, 341-351.
183. Ronen, G., Carmel-Goren, L., Zamir, D. and Hirschberg, J. (2000) An alternative pathway to β-carotene formation in plant chromoplasts discovered by map-based cloning of Beta and oldgold color mutations in tomato. Proceedings of the National Academy of Sciences USA 97, 11102-11107.
184. Rosati, C., Aquilani, R., Dharmapuri, S., Pallara, P., Marusic, C., Tavazza, R., Bouvier, F., Camara, B. and Giuliano, G. (2000) Metabolic engineering of β-carotene and lycopene content in tomato f ruit. Plant Journal 24, 413-420.
185. Rose, J.K.C., Lee, H.H. and Bennett, A.B. (1997) Expression of a divergent expansin gene is fruitspecific and ripening-regulated. Proceedings of the National Academy of Sciences USA 94, 5955-5960.
186. Ross, J.A. and Kasum, C.M. (2002) Dietary flavonoids: bioavailability, metabolic effects, and safety. Annual Review of Nutrition 22, 19-34.
187. Rotino, G.L., Perri, E., Zottini, M., Sommer, H. and Spena, A. (1997) Genetic engineering of parthenocarpic plants. Nature Biotechnology 15, 1398-1401.
188. Rühmann, S., Treutter, D., Fritsche, S., Briviba, K. and Szankowski, I. (2006) Piceid (resveratrol glucoside) synthesis in stilbene synthase transgenic apple fruit. Journal of Agricultural and Food Chemistry 54, 4633-4640.
189. Santiago-Doménech, N., Jiménez-Bemúdez, S., Matas, A.J., Rose, J.K.C., Muñoz-Blanco, J., Mercado, J.A. and Quesada, M.A. (2008) Antisense inhibition of a pectate lyase gene supports a role for pectin depolymerization in strawberry fruit softening. Journal of Experimental Botany 59, 2769-2779.
190. Schaffer, R.J., Friel, E.N., Souleyre, E.J.F., Bolitho, K., Thodey, K., Ledger, S., Bowen, J.H., Ma, J.-H., Nain, B., Cohen, D., Gleave, A.P., Crowhurst, R.N., Janssen, B.J., Yao, J.-L. and Newcomb, R.D. (2007) A genomics approach reveals that aroma production in apple is controlled by ethylene predominantly at the final step in each biosynthetic pathway. Plant Physiology 144, 1899-1912.
191. Schijlen, E., Ric de Vos, C.H., Jonker, H., Van Den Broeck, H., Molthoff, J., Van Tunen, A., Martens, S. and Bovy, A. (2006) Pathway engineering for healthy phytochemicals leading to the production of novel flavonoids in tomato fruit. Plant Biotechnology Journal 4, 433-444.
192. Schijlen, E.G.W.M., de Vos, C.H.R., Martens, S., Jonker, H.H., Rosin, F.M., Molthoff, J.W., Tikunov, Y.M., Angenent, G.C., van Tunen, A.J. and Bovy, A.G. (2007) RNA interference silencing of chalcone synthase, the first step in the flavonoid biosynthesis pathway, leads to parthenocarpic tomato fruits. Plant Physiology 144, 1520-1530.
193. Schreiber, G., Reuveni, M., Evenor, D., Oren-Shamir, M., Ovadia, R., Sapir-Mir, M., Bootbool-Man, A., Nahon, S., Shlomo, H., Chen, L. and Levin, I. (2012) ANTHOCYANIN1 from Solanum chilense is more efficient in accumulating anthocyanin metabolites than its Solanum lycopersicum counterpart in association with the ANTHOCYANIN FRUIT phenotype of tomato. Theoretical and Applied Genetics 124, 295-307.
194. Seymour, G.B., Manning, K., Eriksson, E.M., Popovich, A.H. and King, G.J. (2002) Genetic identification and genomic organization of factors affecting fruit texture. Journal of Experimental Botany 53, 2065-2071.
195. Shih, C.-H., Chen, Y., Wang, M., Chu, I.K. and Lo, C. (2008) Accumulation of isoflavone genistin in transgenic tomato plants overexpressing a soybean isoflavone synthase gene. Journal of Agricultural and Food Chemistry 56, 5655-5661.
196. Shin, Y.-M., Park, H.-J., Yim, S.-D., Baek, N.-I., Lee, C.-H., An, G. and Woo, Y.-M. (2006) Transgenic rice lines expressing maize C1 and R-S regulatory genes produce various flavonoids in the endosperm. Plant Biotechnology Journal 4, 303-315.
197. Sidorenko, L.V., Li, X., Cocciolone, S.M., Chopra, S., Tagliani, L., Bowen, B., Daniels, M. and Peterson, T. (2000) Complex structure of a maize Myb gene promoter: functional analysis in transgenic pl ants. Plant Journal 22, 471-482.
198. Simkin, A.J., Schwartz, S.H., Auldridge, M., Taylor, M.G. and Klee, H.J. (2004) The tomato carotenoid cleavage dioxygenase 1 genes contribute to the formation of the flavour volatiles β-ionone, pseudoionone, and geranylac etone. Plant Journal 40, 882-892.
199. Simkin, A.J., Gaffé, J., Alcaraz, J.-P., Carde, J.-P., Bramley, P.M., Fraser, P.D. and Kuntz, M. (2007) Fibrillin influence on plastid ultrastructure and pigment content in tomato fru it. Phytochemistry 68, 1545-1556.
200. Slimestad, R. and Verheul, M. (2009) Review of flavonoids and other phenolics from fruits of different tomato (Lycopersicon esculentum Mill.) cultivars. Journal of the Science of Food and Agriculture 89, 1255-1270.
201. Smartt, J. and Simmonds, N.W. (1995) Evolution of Crop Plants. Longman Scientific & Technical, Harlow, UK.
202. Smith, D.L. and Gross, K.C. (2000) A family of at least seven β-galactosidase genes is expressed during tomato fruit development. Plant Physiology 123, 1173-1184.
203. Smith, D.L., Abbott, J.A. and Gross, K.C. (2002) Down-regulation of tomato β-galactosidase 4 results in decreased fruit softening. Plant Physiology 129, 1755-1762.
204. Song, J., Fan, L. and Beaudry, R.M. (1998) Application of solid phase microextraction and gas chromatography/time-of-flight mass spectrometry for rapid analysis of flavour volatiles in tomato and strawberry fruits. Journal of Agricultural and Food Chemistry 46, 3721-3726.
205. Stigliani, A.L., Giorio, G. and D'Ambrosio, C. (2011) Characterization of P450 carotenoid β- and ε-hydroxylases of tomato and transcriptional regulation of xanthophyll biosynthesis in root, leaf, petal and fruit. Plant and Cell Physiology 52, 851-865.
206. Sun, L., Yuan, B., Zhang, M., Wang, L., Cui, M., Wang, Q. and Leng, P. (2012) Fruit-specific RNAimediated suppression of SlNCED1 increases both lycopene and β-carotene contents in tomato fruit. Journal of Experimental Botany 63, 3097-3108.
207. Sun, Y., Dilkes, B.P., Zhang, C., Dante, R.A., Carneiro, N.P., Lowe, K.S., Jung, R., Gordon-Kamm, W.J. and Larkins, B.A. (1999) Characterization of maize (Zea mays L.) Wee1 and its activity in developing endosperm. Proceedings of the National Academy of Sciences USA 96, 4180-4185.
208. Tanksley, S.D. (2004) The genetic, developmental, and molecular bases of fruit size and shape variation i n tomato. Plant Cell 16, S181-S189.
209. Thakur, B.R., Singh, R.K. and Handa, A.K. (1996a) Effect of an antisense pectin methylesterase gene on the chemistry of pectin in tomato (Lycopersicon esculentum) juice. Journal of Agricultural and Food Chemistry 44, 628-630.
210. Thakur, B.R., Singh, R.K., Tieman, D.M. and Handa, A.K. (1996b) Tomato product quality from transgenic fruits with reduced pectin methylesterase. Journal of Food Science 61, 85-87.
211. Thakur, B.R., Singh, R.K., Handa, A.K. and Rao, M.A. (1997) Chemistry and uses of pectin - A review. Critical Reviews in Food Science and Nutrition 37, 47-73.
212. Tieman, D., Taylor, M., Schauer, N., Fernie, A.R., Hanson, A.D. and Klee, H.J. (2006b) Tomato aromatic amino acid decarboxylases participate in synthesis of the flavour volatiles 2-phenylethanol and 2-phenylacetaldehyde. Proceedings of the National Academy of Sciences USA 103, 8287-8292.
213. Tieman, D., Zeigler, M., Schmelz, E., Taylor, M.G., Rushing, S., Jones, J.B. and Klee, H.J. (2010) Functional analysis of a tomato salicylic acid methyl transferase and its role in synthesis of the flavour volatile methyl salicylate. Plant Journal 62, 113-123.
214. Tieman, D.M. and Handa, A.K. (1994) Reduction in pectin methylesterase activity modifies tissue integrity and cation levels in ripening tomato (Lycopersicon esculentum Mill.) fru its. Plant Physiology 106, 429-436.
215. Tieman, D.M., Harriman, R.W., Ramamohan, G. and Handa, A.K. (1992) An antisense pectin methylesterase gene alters pectin chemistry and soluble solids in tomato fruit. Plant Cell 4, 667-679.
216. Tieman, D.M., Zeigler, M., Schmelz, E.A., Taylor, M.G., Bliss, P., Kirst, M. and Klee, H.J. (2006a) Identification of loci affecting flavour volatile emissions in tomato fruits. Journal of Experimental Botany 57, 887-896.
217. Tieman, D.M., Loucas, H.M., Kim, J.Y., Clark, D.G. and Klee, H.J. (2007) Tomato phenylacetaldehyde reductases catalyze the last step in the synthesis of the aroma volatile 2-phenyleth anol. Phytochemistry 68, 2660-2669.
218. Tigchelaar, E., McGlasson, W. and Buescher, R. (1978) Genetic regulation of tomato fruit ripening. Hortscience 13, 508-513.
219. Tsaballa, A., Pasentsis, K., Darzentas, N. and Tsaftaris, A. (2011) Multiple evidence for the role of an Ovate-like gene in determining fruit shape i n pepper. BMC Plant Biology 11, 46.
220. USDA (2007) USDA Database for the Flavonoid Content of Selected Foods. US Department of Agriculture, Beltsville, MD, pp. 128.
221. USDA-APHIS (1991) Environmental assessment and finding of no significant impact on tomato containing an antisense polygalacturo nase gene. Permit Number 91-268-01.
222. USDA-APHIS (1992) Interpretive ruling on Calgene, Inc., petition for determination of regulatory status of FLAVR SAVR™ tomato (Docket no. 92-087-2). Federal Register 57, 47608-47616.
223. Van der Knaap, E., Lippman, Z.B. and Tanksley, S.D. (2002) Extremely elongated tomato fruit controlled by four quantitative trait loci with epistatic interactions. Theoretical and Applied Genetics 104, 241-247.
224. van der Knaap, E., Sanyal, A., Jackson, S.A. and Tanksley, S.D. (2004) High-resolution fine mapping and fluorescence in situ hybridization analysis of sun, a locus controlling tomato fruit shape, reveals a region of the tomato genome prone to DNA rearr angements. Genetics 168, 2127-2140.
225. Ververidis, F., Trantas, E., Douglas, C., Vollmer, G., Kretzschmar, G. and Panopoulos, N. (2007a) Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part II:Reconstruction of multienzyme pathways in plants and microbes. Biotechnology Journal 2, 1235-1249.
226. Ververidis, F., Trantas, E., Douglas, C., Vollmer, G., Kretzschmar, G. and Panopoulos, N. (2007b) Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I:Chemical diversity, impacts on plant biology and human health. Biotechnology Journal 2, 1214-1234.
227. Wang, S., Chang, Y., Guo, J. and Chen, J.-G. (2007) Arabidopsis Ovate Family Protein 1 is a transcriptional repressor that suppresses cell elo ngation. Plant Journal 50, 858-872.
228. Wang, S., Liu, J., Feng, Y., Niu, X., Giovannoni, J. and Liu, Y. (2008) Altered plastid levels and potential for improved fruit nutrient content by downregulation of the tomato DDB1-interacting prot ein CUL4. Plant Journal 55, 89-103.
229. Wei, S., Li, X., Gruber, M.Y., Li, R., Zhou, R., Zebarjadi, A. and Hannoufa, A. (2009) RNAi-mediated suppression of DET1 alters the levels of carotenoids and sinapate esters in seeds of Brassica napus. Journal of Agricultural and Food Chemistry 57, 5326-5333.
230. Wilson, C.W., Shaw, P.E. and Campbell, C.W. (1982) Determination of organic acids and sugars in guava (Psidium guajava L.) cultivars by high-performance liquid chromatography. Journal of the Science of Food and Agriculture 33, 777-780.
231. Wurbs, D., Ruf, S. and Bock, R. (2007) Contained metabolic engineering in tomatoes by expression of carotenoid biosynthesis genes from the plastid genome. Plant Journal 49, 276-288.
232. Xiao, H., Jiang, N., Schaffner, E., Stockinger, E.J. and van der Knaap, E. (2008) A retrotransposonmediated gene duplication underlies morphological variation of to mato fruit. Science 319, 1527-1530.
233. Ye, X., Al-Babili, S., Klöti, A., Zhang, J., Lucca, P., Beyer, P. and Potrykus, I. (2000) Engineering the provitamin A (β-carotene) biosynthetic pathway into (carotenoid-free) r ice endosperm. Science 287, 303-305.
234. Yu, B., Lydiate, D., Young, L., Schäfer, U. and Hannoufa, A. (2008) Enhancing the carotenoid content of Brassica napus seeds by downregulating lycopene epsilon cycla se. Transgenic Research 17, 573-585.
235. Zawirska-Wojtasiak, R., Gośliński, M., Szwacka, M., Gajc-Wolska, J. and Mildner-Szkudlarz, S. (2009) Aroma evaluation of transgenic, thaumatin II-producing cucumber fruits. Journal of Food Science 74, C204-C210.
236. Zeigler, M.L. (2007) Role of Methylsalicylate in Tomato Flavour and Response to Bacterial Pathogen Infection. University of Florida, FL.
237. Zhang, J., Tao, N., Xu, Q., Zhou, W., Cao, H., Xu, J. and Deng, X. (2009) Functional characterization of Citrus PSY gene in Hongkong kumquat (Fortunella hindsii Swingle). Plant Cell Reports 28, 1737-1746.
238. Zuk, M., Kulma, A., Dymińska, L., Szołtysek, K., Prescha, A., Hanuza, J. and Szopa, J. (2011) Flavonoid engineering of flax potentiate its biotechnological ap plication. BMC Biotechnology 11, 10.
239. Zygier, S., Chaim, A.B., Efrati, A., Kaluzky, G., Borovsky, Y. and Paran, I. (2005) QTLs mapping for fruit size and shape in chromosomes 2 and 4 in pepper and a comparison of the pepper QTL map with that of tomato. Theoretical and Applied Genetics 111, 437-445.