Production of prenylated flavonoids in tomato fruits expressing a prenyltransferase gene from Streptomyces coelicolor A3(2)

Plant Biology

Volumn 13, Issue 2, 2011, Pages 411-415

  Koeduka, T ^a   Shitan, N ^a,d   Kumano, T ^b   Sasaki, K ^a   Sugiyama, A ^a   Linley, P ^a   Kawasaki, T ^a   Ezura, H ^c   Kuzuyama, T ^b   Yazaki, K ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Dimethylallyl naringenin; E8 promoter; Prenyltransferase; Streptomyces coelicolor; Transgenic tomato

Indexed keywords

6 (1,1 DIMETHYLALLYL)NARINGENIN; 6-(1,1-DIMETHYLALLYL)NARINGENIN; BACTERIAL PROTEIN; DIMETHYLALLYLTRANSFERASE; FLAVANONE DERIVATIVE; FLAVONOID; PLANT RNA;

ANTIMICROBIAL ACTIVITY; BACTERIUM; BIOACCUMULATION; ENZYME ACTIVITY; FRUIT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEIN; RECOMBINATION; TRANSGENIC PLANT;

ARTICLE; BIOSYNTHESIS; CHEMISTRY; ENZYMOLOGY; FRUIT; GENETICS; METABOLISM; PRENYLATION; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOMYCES COELICOLOR; TANDEM MASS SPECTROMETRY; TOMATO; TRANSGENIC PLANT;

BACTERIAL PROTEINS; DIMETHYLALLYLTRANSTRANSFERASE; FLAVANONES; FLAVONOIDS; FRUIT; LYCOPERSICON ESCULENTUM; PLANTS, GENETICALLY MODIFIED; PRENYLATION; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, PLANT; STREPTOMYCES COELICOLOR; TANDEM MASS SPECTROMETRY;

BACTERIA (MICROORGANISMS); LYCOPERSICON ESCULENTUM; STREPTOMYCES; STREPTOMYCES COELICOLOR;

EID: 79751510995     PISSN: 14358603     EISSN: 14388677     Source Type: Journal    
DOI: 10.1111/j.1438-8677.2010.00409.x     Document Type: Article

References (11)

1. Ahmed-Belkacem A., Pozza A., Munoz-Martinez F., Bates S.E., Castanys S., Gamarro F., Di Pietro A., Perez-Victoria J.M. (2005) Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. Cancer Research, 65, 4852-4860.
2. Ioset J.R., Marston A., Gupta M.P., Hostettmann K. (2001) Five new prenylated stilbenes from the root bark of Lonchocarpus chiricanus. Journal of Natural Products, 64, 710-715.
3. Kumano T., Richard S.B., Noel J.P., Nishiyama M., Kuzuyama T. (2008) Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities. Bioorganic & Medicinal Chemistry, 16, 8117-8126.
4. Maitrejean M., Comte G., Barron D., El Kirat K., Conseil G., Di Pietro A. (2000) The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein. Bioorganic & Medical Chemistry Letters, 10, 157-160.
5. Murakami A., Gao G., Omura M., Yano M., Ito C., Furukawa H., Takahashi D., Koshimizu K., Ohigashi H. (2000) 1, 1-Dimethylallylcoumarins potently suppress both lipopolysaccharide- and interferon-gamma-induced nitric oxide generation in mouse macrophage RAW 264.7 cells. Bioorganic & Medical Chemistry Letters, 10, 59-62.
6. Sasaki K., Mito K., Ohara K., Yamamoto H., Yazaki K. (2008) Cloning and characterization of naringenin 8-prenyltransferase, a flavonoid-specific prenyltransferase of Sophora flavescens. Plant Physiology, 146, 1075-1084.
7. Sasaki K., Tsurumaru Y., Yazaki K. (2009) Prenylation of flavonoids by biotransformation of yeast expressing plant membrane-bound prenyltransferase SfN8DT-1. Bioscience, Biotechnology, and Biochemistry, 73, 759-761.
8. Savikin-Fodulovic K., Aljancic I., Vajs V., Menkovic N., Macura S., Gojgic G., Milosavljevic S. (2003) Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp. degenii. Journal of Natural Products, 66, 1236-1238.
9. Schijlen E.G.W.M., deVos R.C.H., Martens S., Jonker H.H., Rosin F.M., Molthoff J.W., Tikunov Y.M., Angenent G.C., van Tunen A.J., Bovy A.G. (2007) RNA interference silencing of chalcone synthase, the first step in the flavonoid biosynthesis pathway, leads to parthenocarpic tomato fruits. Plant Physiology, 144, 1520-1530.
10. Sun H.J., Uchii S., Watanabe S., Ezura H. (2006) A highly efficient transformation protocol for Micro-Tom, a model cultivar for tomato functional genomics. Plant Cell Physiology, 47, 426-431.
11. Zhao P., Inoue K., Kouno I., Yamamoto H. (2003) Characterization of leachianone G 2″-dimethylallyltransferase, a novel prenyl side-chain elongation enzyme for the formation of the lavandulyl group of sophoraflavanone G in Sophora flavescens Ait. cell suspension cultures. Plant Physiology, 133, 1306-1313.