Cognition in rodents

Handbook of Behavior Genetics

Volumn , Issue , 2009, Pages 159-174

  Janus, Christopher ^a   Galsworthy, Michael J ^b   Wolfer, David P ^b   Welzl, Hans ^b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84919667076     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-76727-7_11     Document Type: Chapter

References (196)

1. Aiba, A., Chen, C., Herrup, K., Rosenmund, C., Stevens, C. F., & Tonegawa, S. (1994a). Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell, 79, 365-375.
2. Aiba, A., Kano, M., Chen, C., Stanton, M. E., Fox, G. D., Herrup, K., et al. (1994b). Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell, 79, 377-388.
3. Albert, M. S. (1996). Cognitive and neurobiological markers of early Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America, 93, 13547-13551.
4. Anderson, B. (1993). Evidence from the rat for a general factor that underlies cognitive performance and that relates to brain size: Intelligence? Neuroscience Letters, 153, 98-102.
5. Andra, K., Abramowski, D., Duke, M., Probst, A., Wiederhold, K. H., Burki, K., et al. (1996). Expression of APP in transgenic mice: A comparison of neuron-specific promoters. Neurobiology of Aging, 17, 183-190.
6. Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991). The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cerebral Cortex, 1, 103-116.
7. Ashe, K. (2001). Learning and memory in transgenic mice modelling Alzheimer's disease. Learning & Memory, 8, 301-308.
8. Austin, L., Arendash, G. W., Gordon, M. N., Diamond, D. M., Di Carlo, G., Dickey, C., et al. (2003). Short-term ß-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP+PS1 mice. Behavioral Neuroscience, 117, 478-84.
9. Bailey, C. H., & Kandel, E. R. (1993). Structural changes accompanying memory storage. Annual Review of Physiology, 55, 397-426.
10. Bakker, C. R., & Oostra, B. A. (2003). Understanding fragile X syndrome: Insights from animal models. Cytogenet. Genome Research, 100, 111-123.
11. Balschun, D., Wolfer, D. P., Gass, P., Mantamadiotis, T., Welzl, H., Schutz, G., et al. (2003). Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? The Journal of Neuroscience, 23, 6304-6314.
12. Berger, S., Wolfer, D. P., Selbach, O., Alter, H., Erdmann, G., Reichardt, H. M., et al. (2006). Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proceedings of the National Academy of Sciences of the United States of America, 103, 195-200.
13. Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & La Ferla, F. M. (2005). Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron, 45, 675-688.
14. Blendy, J. A., Kaestner, K. H., Schmid, W., Gass, P., & Schütz, G. (1996). Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform. EMBO Journal, 15, 1098-1106.
15. Bolivar, V., Cook, M., & Flaherty, L. (2000). List of transgenic and knockout mice: Behavioral profiles. Mammalian Genome, 11, 260-274.
16. Bontekoe, C. J., Bakker, C. E., Nieuwenhuizen, I. M., Van Der Linde, H., Lans, H., De Lange, D., et al. (2001). Instability of a (CGG) 98 repeat in the Fmr1 promotor. Human Molecular Genetics, 10, 1693-1699.
17. Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., et al. (1996). Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron, 17, 1005-1013.
18. Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., & Silva, A. J. (1994). Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell, 79, 59-68.
19. Braak, H., & Braak, E. (1994). Pathology of Alzheimer's disease. In D. B. Calne (Ed.), Neurodegenerative Diseases (pp. 585-613). Philadelphia: Saunders.
20. Brambilla, R., Gnesutta, N., Minichiello, L., White, G., Roylance, A. J., Herron, C. E., et al. (1997). A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature, 390, 281-286.
21. Branchi, I., Bichler, Z., Berger-Sweeney, J., & Ricceri, L. (2003). Animal models of mental retardation: From gene to cognitive function. Neuroscience & Biobehavioral Reviews, 27, 141-153.
22. Brooks, S. P., Pask, T., Jones, L., & Dunnett, S. B. (2005). Behavioral profiles of inbred mouse strains used as transgenic backgrounds. II: Cognitive tests. Genes, Brain and Behavior, 4, 307-17.
23. Buhot, M.-C., Wolff, M., Benhassine, N., Costet, P., Hen, R., & Segu, L. (2003). Spatial learning in the 5-HT1B receptor knockout mouse: Selective facilitation/impairment depending on the cognitive demand. Learning & Memory, 10, 466-477.
24. Bush, A. I. (2001). Therapeutic targets in the biology of Alzheimer's disease. Current Opinion in Psychiatry, 14, 341-348.
25. Butcher, L. M., Kennedy, J. K. J., & Plomin, R. (2006). Generalist genes and cognitive neuroscience. Current Opinion in Neurobiology, 16, 145-151.
26. Carlezon, W. A., Jr., Duman, R. S., & Nestler, E. J. (2005). The many faces of CREB. Trends in Neurosciences, 28, 436-445.
27. Cavallaro, S., D'Agata, V., Manickam, P., & Alkon, D. L. (2002). Memory-specific temporal profiles of gene expression in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America, 99, 16279-16284.
28. Chen, C., & Tonegawa, S. (1997). Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain. Annual Review of Neuroscience, 20, 157-184.
29. Chishti, M. A., Yang, D. S., Janus, C., Phinney, A. L., Horne, P., Pearson, J., et al. (2001). Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. The Journal of Biological Chemistry, 276, 21562-21570.
30. Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., et al. (1997). Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid ß-protein in both transfected cells and transgenic mice. Nature Medicine, 3, 67-72.
31. Conquet, F., Bashir, Z. I., Davies, C. H., Daniel, H., Ferraguti, F., Bordi, F., et al. (1994). Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature, 372, 237-243.
32. Costa, R. M., & Silva, A. J. (2003). Mouse models of neurofibromatosis type I: Bridging the GAP. Trends in Molecular Medicine, 9, 19-23.
33. Cremer, H., Lange, R., Christoph, A., Plomann, M., Vopper, G., Roes, J., et al. (1994). Inactivation of the NCAM gene in mice results in size-reduction of the olfactory bulb and deficits in spatial learning. Nature, 367, 455-459.
34. Crestani, F., Keist, R., Fritschy, J. M., Benke, D., Vogt, K., Prut, L., et al. (2002). Trace fear conditioning involves hippocampal alpha5 GABA (A) receptors. Proceedings of the National Academy of Sciences of the United States of America, 99, 8980-8985.
35. Crestani, F., Lorez, M., Baer, K., Essrich, C., Benke, D., Laurent, J. P., et al. (1999). Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues. Nature Neuroscience, 2, 833-839.
36. Crow, T. (2004). Pavlovian conditioning of Hermissenda: Current cellular, molecular, and circuit perspectives. Learning & Memory, 11, 229-38.
37. Cryan, J. F., Kelly, P. H., Neijt, H. C., Sansig, G., Flor, P. J., & Van Der Putten, H. (2003). Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. European Journal of Neuroscience, 17, 2409-2417.
38. Cui, Z., Lindl, K. A., Mei, B., Zhang, S., & Tsien, J. Z. (2005). Requirement of NMDA receptor reactivation for consolidation and storage of nondeclarative taste memory revealed by inducible NR1 knockout. European Journal of Neuroscience, 22, 755-763.
39. Cui, Z., Wang, H., Tan, Y., Zaia, K. A., Zhang, S., & Tsien, J. Z. (2004). Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Neuron, 41, 781-793.
40. D'Adamo, P., Welzl, H., Papadimitriou, S., Raffaele Di Barletta, M., Tiveron, C., Tatangelo, L., et al. (2002). Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice. Human Molecular Genetics, 11, 2567-2580.
41. D'Agata, V., & Cavallaro, S. (2003) Hippocampal gene expression profiles in passive avoidance conditioning. European Journal of Neuroscience, 18, 2835-2841.
42. Davis, H. P., & Squire, L. R. (1984). Protein synthesis and memory: A review. Psychological Bulletin, 96, 518-559.
43. Day, M., & Morris, R. G. M. (2001). Memory consolidation and NMDA receptors: Discrepancy between genetic and pharmacological approaches. Science, 293, 755a.
44. Deutsch, J. A. (1993). Spatial learning in mutant mice. Science, 262, 760-761.
45. Dineley, K. T., Xia, X., Bui, D., Sweatt, J. D., & Zheng, H. (2002). Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. The Journal of Biological Chemistry, 277, 22768-22780.
46. Dluzen, D. E., Gao, X., Story, G. M., Anderson, L. I., Kucera, J., & Walro, J. M. (2001). Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice. Experimental Neurology, 170, 121-8.
47. Dodart, J. C., Bales, K. R., Gannon, K. S., Greene, S. J., De Mattos, R. B., Mathis, C., et al. (2002a). Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nature Neuroscience, 5, 452-457.
48. Dodart, J.-C., Marr, R. A., Koistinaho, M., Gregersen, B. M., Malkani, S., Verma, I. M., et al. (2005). Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America, 102, 1211-1216.
49. Dodart, J. C., Mathis, C., Bales, K. R., & Paul, S. M. (2002b). Does my mouse have Alzheimer's disease? Genes, Brain and Behavior, 1, 142-155.
50. Drago, J., McColl, C. D., Horne, M. K., Finkelstein, D. I., & Ross, S. A. (2003). Neuronal nicotinic receptors: Insights gained from gene knockout and knockin mutant mice. Cellular and Molecular Life Sciences, 60, 1267-1280.
51. Duff, K. (1999). Curing amyloidosis: Will it work in humans? Trends in Neurosciences, 22, 485-486.
52. Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Perez-tur, J., et al. (1996). Increased amyloid-ß42 (43) in brains of mice expressing mutant presenilin 1. Nature, 383, 710-713.
53. Elgersma, Y., Sweatt, J. D., & Giese, K. P. (2004). Mouse Genetic Approaches to Investigating Calcium/Calmodulin-Dependent Protein Kinase II Function in Plasticity and Cognition The Journal of Neurosciences, 24, 8410-8415.
54. Frankland, P. W., Cestari, V., Filipkowski, R. K., McDonald, R. J., & Silva, A. J. (1998). The dorsal hippocampus is essential for context discrimination but not for contextual conditioning. Behavioral Neuroscience, 112, 863-874.
55. Fransen, E., D'Hooge, R., Van Camp, G., Verhoye, M., Sijbers, J., Reyniers, E., et al. (1998). L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns. Human Molecular Genetetics, 7, 999-1009.
56. Fratiglioni, L., Small, B. J., Winblad, B., & Bäckman, L. (2001). The Transition from Normal Functioning to Dementia in the Aging Population. In K. Iqbal, S. Sisodia, & B. Winblad (Eds.), Alzheimer's disease: Advances in etiology, pathogenesis and therapeutics (pp. 3-10). Chichester: John Wiley & Sons. Ltd.
57. Galsworthy, M. J., Paya-Cano, J. L., Liu, L., Monleón, S., Gregoryan, G., Fernandes, C., et al. (2005). Assessing reliability, heritability and general cognitive ability in a battery of cognitive tasks for laboratory mice. Behavior Genetics, 35, 675-692.
58. Galsworthy, M. J., Paya-Cano, J. L., Monleón, S., & Plomin, R. (2002). Evidence for general cognitive ability (g) in heterogeneous stock (HS) mice and an analysis of potential confounds. Genes, Brain and Behavior, 1, 88-95.
59. Games, D., Adams, D., Alessandrini, R., Barbour, R., Berthelette, P., Blackwell, C., et al. (1995). Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature, 373, 523-527.
60. Gardner, H. (1983) Frames of Mind: The theory of multiple intelligences. New York: Basic Books.
61. Gass, P., Wolfer, D. P., Balschun, D., Rudolph, D., Frey, U., Lipp, H. P., et al. (1998). Deficits in memory tasks of mice with CREB mutations depend on gene dosage. Learning & Memory, 5, 274-288.
62. Genoux, D., Haditsch, U., Knobloch, M., Michalon, A., Storm, D., & Mansuy, I. M. (2002). Protein phosphatase 1 is a molecular constraint on learning and memory. Nature, 418, 929-930.
63. Gerlai, R., McNamara, A., Choi-Lundberg, D. L., Armanini, M., Ross, J., Powell-Braxton, L., et al. (2001). Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation. European Journal of Neuroscience, 14, 1153-63.
64. Giese, K. P., Friedman, E., Telliez, J. B., Fedorov, N. B., Wines, M., Feig, L. A., et al. (2001). Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1). Neuropharmacology, 41, 791-800.
65. Gilman, S., Koller, M., Black, R. S., Jenkins, L., Griffith, S. G., Fox, N. C., et al. (2005). Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology, 64, 1553-1562.
66. Grant, S. G., O'Dell, T. J., Karl, K. A., Stein, P. L., Soriano, P., & Kandel, E. R. (1992). Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science, 258, 1903-10.
67. Greenberg, B. D., Savage, M. J., Howland, D. S., Ali, S. M., Siedlak, S. L., Perry, G., et al. (1996). APP transgenesis: Approaches toward the development of animal models for Alzheimer disease neuropathology. Neurobiology of Aging, 17, 153-171.
68. Hardy, J., & Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science, 297, 353-356.
69. Higgins, G. A., & Jacobsen, H. (2003). Transgenic mouse models of Alzheimer's disease: Phenotype and application. Behavioural Pharmacology, 14, 419-438.
70. Hock, C., Konietzko, U., Papassotiropoulos, A., Wollmer, A., Streffer, J., Von Rotz, R., et al. (2002). Generation of antibodies specific for ß-amyloid by vaccination of patients with Alzheimer disease. Nature Medicine, 8, 1270-1275.
71. Hock, C., Konietzko, U., Streffer, J. R., Tracy, J., Signorell, A., Muller-Tillmanns, B., et al. (2003). Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron, 38, 547-554.
72. Holcomb, L. A., Gordon, M. N., Jantzen, P., Hsiao, K., Duff, K., & Morgan, D. (1999). Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits. Behavior Genetics, 29, 177-185.
73. Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., et al. (1998). Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Medicine, 4, 97-100.
74. Hölscher, C., Schmid, S., Pilz, P. K. D., Sansig, G., Van Der Putten, H., & Plappert, C. F. (2004). Lack of the metabotropic glutamate receptor subtype 7 selectively impairs short-term working memory but not long-term memory. Behavioural Brain Research, 154, 473-481.
75. Horn, R., Ostertun, B., Fric, M., Solymosi, L., Steudel, A., & Möller, H.-J. (1996). Atrophy of hippocampus in patients with Alzheimer's Disease and other diseases with memory impairment. Dementia, 7, 182-186.
76. Hsiao, K. K., Borchelt, D. R., Olson, K., Johannsdottir, R., Kitt, C., Yunis, W., et al. (1995). Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron, 15, 1203-1218.
77. Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., et al. (1996). Correlative memory deficits, a-beta elevation, and amyloid plaques in transgenic mice. Science, 274, 99-102.
78. Huerta, P. T., Sun, L. D., Wilson, M. A., & Tonegawa, S. (2000). Formation of temporal memory requires NMDA receptors within CA1 pyramidal neurons. Neuron, 25, 473-80.
79. Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984). Alzheimer's Disease: Cell-specific pathology isolates the hippocampus formation. Science, 225, 1168-1170.
80. Inlow, J. K., & Restifo, L. L. (2004). Molecular and comparative genetics of mental retardation. Genetics, 166, 835-881.
81. Janus, C. (2003). Vaccines for Alzheimer's disease: how close are we? CNS Drugs, 17, 457-538.
82. Janus, C., D'Amelio, S., Amitay, O., Chishti, M. A., Strome, R., Fraser, P., et al. (2000a). Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes. Neurobiology of Aging, 21, 541-549.
83. Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., et al. (2000b). A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature, 408, 979-982.
84. Janus, C., Phinney, A. L., Chishti, M. A., & Westaway, D. (2001). New developments in animal models of Alzheimer's disease. Current Neurology and Neuroscience Reports, 1, 451-457.
85. Janus, C., & Westaway, D. (2001). Transgenic mouse models of Alzheimer's disease. Physiology & Behavior, 73, 873-886.
86. Jope, R. S., Song, L., & Powers, R. E. (1997). Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain. Neurobiology of Aging, 18, 111-120.
87. Jin, P., & Warren, S. T. (2003). New insights into fragile X syndrome: From molecules to neurobehaviors. Trends in Biochemical Sciences, 28, 152-158.
88. Kandel, E. R. (2001). The molecular biology of memory storage: A dialogue between genes and synapses. Science, 294, 1030-1038.
89. Kew, J. N.-C., Koester, A., Moreau, J.-L., Jenck, F., Ouagazzal, A.-M., Mutel, V., et al. (2000). Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site. The Journal of Neuroscience, 20, 4037-4049.
90. Kim, D., Chae, S., Lee, J., Yang, H., & Shin, H. S. (2005). Variations in the behaviors to novel objects among five inbred strains of mice. Genes, Brain and Behavior, 4, 302-6.
91. Kishimoto, Y., Kawahara, S., Kirino, Y., Kadotani, H., Nakamura, Y., Ikeda, M., et al. (1997). Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A. Neuroreport, 8, 3717-3721.
92. Kishimoto, Y., Kawahara, S., Mori, H., Mishina, M., & Kirino, Y. (2001a). Long-trace interval eyeblink conditioning is impaired in mutant mice lacking the NMDA receptor subunit e1. European Journal of Neuroscience, 13, 1221-1227.
93. Kishimoto, Y., Kawahara, S., Suzuki, M., Mori, H., Mishina, M., & Kirino, Y. (2001b). Classical eyeblink conditioning in glutamate receptor subunit delta 2 mutant mice is impaired in the delay paradigm but not in the trace paradigm. European Journal of Neuroscience, 13, 1249-53.
94. Kobayashi, K., & Kobayashi, T. (2001). Genetic evidence for noradrenergic control of long-term memory consolidation. Brain and Development, 23, S16-S23.
95. Kogan, J. H., Frankland, P. W., Blendy, J. A., Coblentz, J., Marowitz, Z., Schutz, G., et al. (1996). Spaced training induces normal long-term memory in CREB mutant mice. Current Biology, 7, 1-11.
96. Kooy, R. F. (2003). Of mice and the fragile X syndrome. Trends in Genetics, 19, 148-154.
97. Kotilinek, L. A., Bacskai, B., Westerman, M., Kawarabayashi, T., Younkin, L., Hyman, B. T., et al. (2002). Reversible memory loss in a mouse transgenic model of Alzheimer's disease. The Journal of Neuroscience, 22, 6331-6335.
98. Lamb, B. T., Sisodia, S. S., Lawler, A. M., Slunt, H. H., Kitt, C. A., Kearns, W. G., et al. (1993). Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice. Nature Genetics, 5, 22-30.
99. Law, J. W. S., Lee, A. Y. W., Sun, M., Nikonenko, A. G., Chung, S. K., Dityatev, A., et al. (2003). Decreased anxiety, altered place learning, and increased CA1 basal excitatory synaptic transmission in mice with conditional ablation of the neural cell adhesion molecule L1. The Journal of Neuroscience, 23, 10419-10432.
100. Lee, V. M., Goedert, M., & Trojanowski, J. Q. (2001). Neurodegenerative tauopathies. Annual Review of Neuroscience, 24, 1121-1159.
101. Leil, T. A., Ossadtchi, A., Cortes, J. S., Leahy, R. M., & Smith, D. J. (2002). Finding new candidate for learning and memory. Journal of Neuroscience Research, 68, 127-137.
102. Leil, T. A., Ossadtchi, A., Nichols, T. E., Leahy, R. M., & Smith, D. J. (2003). Genes regulated by learning in the hippocampus. Journal of Neuroscience Research, 71, 763-768.
103. Letwin, N. E., Kafkafi, N., Benjamini, Y., Mayo, C., Frank, B. C., Luu, T., et al. (2006). Combined application of behavior genetics and microarray analysis to identify regional expression themes and gene-behavior associations. The Journal of Neuroscience, 26, 5277-87.
104. Li, F., Calingasan, N. Y., Yu, F., Mauck, W. M., Toidze, M., Almeida, C. G., et al. (2004). Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. Journal of Neurochemistry, 89, 1308-1312.
105. Linnarsson, S., Bjorklund, A., & Ernfors, P. (1997). Learning deficit in BDNF mutant mice. European Journal of Neuroscience, 9, 2581-7.
106. Locurto, C., Fortin, E., & Sullivan, R. (2003). The structure of individual differences in Heterogeneous Stock mice across problem types and motivational systems. Genes, Brain and Behavior, 2, 40-55.
107. Lonze, B. E., & Ginty, D. D. (2002). Function and regulation of CREB family transcription factors in the nervous system. Neuron, 35, 605-623.
108. Lu, Y.-M., Jia, Z., Janus, C., Henderson, J. T., Gerlai, R., Wojtowicz, J. M., et al. (1997). Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentia t i o n (LT P) bu t n o r m a l C A 3 LT P. The Journal of Neuroscience, 17, 5196-5205.
109. Malinow, R., & Malenka, R. C. (2002). AMPA receptor trafficking and synaptic plasticity. Annual Review of Neuroscience, 25, 103-126.
110. Masugi, M., Yokoi, M., Shigemoto, R., Muguruma, K., Watanabe, Y., Sansig, G., et al. (1999). Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion. The Journal of Neuroscience, 19, 955-963.
111. Matsui, M., Yamada, S., Oki, T., Manabe, T., Taketo, M. M., & Ehlert, F. J. (2004). Functional analysis of muscarinic acetylcholine receptors using knockout mice. Life Sciences, 75, 2971-2981.
112. Mattson, M. P., & Pedersen, W. A. (1998). Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease. International Journal of Developmental Neuroscience, 16, 737-753.
113. Matzel, L. D., Han, Y. R., Grossman, H., Karnik, M. S., Patel, D., Scott, N., et al. (2003). Individual differences in the expression of a 'general' learning ability in mice. The Journal of Neuroscience, 23, 6423-6433.
114. Mazzucchelli, C., Vantaggiato, C., Ciamei, A., Fasano, S., Pakhotin, P., Krezel, W., et al. (2002). Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron, 34, 807-820.
115. McManus, M. T., & Sharp, P. A. (2002). Gene silencing in mammals by small interfering RNAs. Nature Reviews Genetics, 3, 737-747.
116. Michalon, A., Koshibu, K., Baumgartel, K., Spirig, D. H., & Mansuy, I. M. (2005). Inducible and neuron-specific gene expression in the adult mouse brain with the rtTA2S-M2 system. Genesis, 43, 205-12.
117. Minichiello, L., Korte, M., Wolfer, D., Kuhn, R., Unsicker, K., Cestari, V., et al. (1999). Essential role for TrkB receptors in hippocampusmediated learning. Neuron, 24, 401-14.
118. Miyamoto, Y., Yamada, K., Noda, Y., Mori, H., Mishina, M., & Nabeshima, T. (2001). Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor 1 subunit. The Journal of Neuroscience, 21, 750-757.
119. Moechars, D., Dewachter, I., Lorent, K., Reverse, D., Baekelandt, V., Naidu, A., et al. (1999). Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. Journal of Biological Chemistry, 274, 6483-6492.
120. Moran, J. L., Bolton, A. D., Tran, P. V., Brown, A., Dwyer, N. D., Manning, D. K., et al. (2006). Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. Genome Research, 16, 436-440.
121. Moriya, T., Kouzu, Y., Shibata, S., Kadotani, H., Fukunaga, K., Miyamoto, E., et al. (2000). Close linkage between calcium/calmodulin kinase II α/β and NMDA-2A receptors in the lateral amygdala and significance for retrieval of auditory fear conditioning. European Journal of Neuroscience, 12, 3307-14.
122. Morley, K. I., & Montgomery, G. W. (2001). The genetics of cognitive processes: Candidate genes in humans and animals. Behavior Genetics, 31, 511-531.
123. Morris, R. G., Anderson, E., Lynch, G. S., & Baudry, M. (1986). Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature, 319, 774-776.
124. Morrison, J. H., & Hof, P. R. (1997). Life and death of neurons in the aging brain. Science, 278, 412-419.
125. Mucke, L., Masliah, E., Yu, G. Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., et al. (2000). High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation. The Journal of Neuroscience, 20, 4050-4058.
126. Müller, U. (1999). Ten years of gene targeting: Targeted mouse mutants, from vector design to phenotype analysis. Mechanisms of Development, 82, 3-21.
127. Nakazawa, K., McHugh, T. J., Wilson, M. A., & Tonegawa, S. (2004). NMDA receptors, place cells and hippocampal spatial memory. Nature Review Neuroscience, 5, 361-372.
128. Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002). Structure and function of dendritic spines. Annual Review of Physiology, 64, 313-53.
129. Novina, C. D., & Sharp, P. A. (2004). The RNAi revolution. Nature, 430, 161-164.
130. Oddo, S., Caccamo, A., Kitazawa, M., Tseng, B. P., & La Ferla, F. M. (2003a). Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiology of Aging, 24, 1063-1070.
131. Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., et al. (2003b). Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction. Neuron, 39, 409-421.
132. Oitzl, M. S., De Kloet, E. R., Joels, M., Schmid, W., & Cole, T. J. (1997). Spatial learning deficits in mice with a targeted glucocorticoid receptor gene disruption. European Journal of Neuroscience, 9, 2284-96.
133. Oitzl, M. S., Reichardt, H. M., Joels, M., & De Kloet, E. R. (2000). Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory. Proceedings of the National Academy of Sciences of the United States of America, 98, 12790-12795.
134. Orgogozo, J. M., Gilman, S., Dartigues, J. F., Laurent, B., Puel, M., Kirby, L. C., et al. (2003). Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology, 61, 46-54.
135. Paratore, S., Alessi, E., Coffa, S., Torrisi, A., Mastrobuono, F., & Cavallaro, S. (2006). Early genomics of learning and memory: A review. Genes, Brain and Behavior, 5, 209-221.
136. Parish, C. L., Nunan, J., Finkelstein, D. I., McNamara, F. N., Wong, J. Y., Waddington, J. L., et al. (2005). Mice Lacking the 4 Nicotinic Receptor Subunit Fail to Modulate Dopaminergic Neuronal Arbors and Possess Impaired Dopamine Transporter Function. Molecular Pharmacology, 68, 1376-1386.
137. Petkov, P. M., Cassell, M. A., Sargent, E. E., Donnelly, C. J., Robinson, P., Crew, V., et al. (2004). Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics, 83, 902-911.
138. Pittenger, C., Huang, Y. Y., Paletzki, R. F., Bourtchouladze, R., Scanlin, H., Vronskaya, S., et al. (2002). Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory. Neuron, 34, 447-462.
139. Plomin, R. (2001). The genetics of g in human and mouse. Nature Review Neuroscience, 2, 136-141.
140. Plomin, R., De Fries, J. C., McClearn, G. E., & McGuffin, P. (2001). Behavioral genetics (4th ed.). New York: Worth Publishers.
141. Plomin, R., & Kosslyn, S. M. (2001). Genes, brain and cognition. Nature Neuroscience, 4, 1153-55.
142. Plomin, R., & Galsworthy, M. J. (2003). Intelligence and Cognition. In D. N. Cooper (Ed.), Nature Encyclopedia of the Human Genome (Vol. 3, pp. 508-514). London: Nature Publishing Group.
143. Poirier, R., Jacquot, S., Vaillend, C., Soutthiphong, A. A., Libbey, M., Davis, S., et al. (2006). Deletion of the Coffin-Lowry syndrome gene Rsk2 in mice is associated with impaired spatial learning and reduced control of exploratory behavior. Behavior Genetics, 37, 31-50.
144. Powell, C. M. (2006). Gene targeting of presynaptic proteins in synaptic plasticity and memory: Across the great divide. Neurobiology of Learning and Memory, 85, 2-15.
145. Price, J. L., Davies, P. B., Morris, J. C., & White, D. L. (1991). The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiology of Aging, 12, 295-312.
146. Rabenstein, R. L., Addy, N. A., Caldarone, B. J., Asaka, Y., Gruenbaum, L. M., Peters, L. L., et al. (2005). Impaired synaptic plasticity and learning in mice lacking β-adducin, an actin-regulating protein. The Journal of Neuroscience, 25, 2138-2145.
147. Rammes, G., Steckler, T., Kresse, A., Schutz, G., Zieglgansberger, W., & Lutz, B. (2000). Synaptic plasticity in the basolateral amygdala in transgenic mice expressing dominant-negative cAMP response element-binding protein (CREB) in forebrain. European Journal of Neuroscience, 12, 2534-2546.
148. Rampon, C., Tang, Y. P., Goodhouse, J., Shimizu, E., Kyin, M., & Tsien, J. Z. (2000). Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nature Neuroscience, 3, 238-244.
149. Reisel, D., Bannerman, D. M., Schmitt, W. B., Deacon, R. M. J., Flint, J., Borchardt, T., et al. (2002). Spatial memory dissociations in mice lacking GluR1 Nature Neuroscience, 5, 868-873.
150. Riedel, G., Platt, B., & Micheau, J. (2003). Glutamate receptor function in learning and memory. Behavioural Brain Research, 140, 1-47.
151. Robbins, T. W., & Murphy, E. R. (2006). Behavioral pharmacology: 40+ years of progress, with a focus on glutamate receptors and cognition. Trends in Pharmacological Sciences, 27, 141-148.
152. Robles, Y., Vivas-Mejía, P. E., Ortiz-Zuazaga, H. G., Félix, J., Ramos, X., & Peña De Ortiz, S. (2003). Hippocampal gene expression profiling in spatial discrimination learning. Neurobiology of Learning and Memory, 80, 80-95.
153. Rondi-Reig, L., Petit, G. H., Tobin, C., Tonegawa, S., Mariani, J., & Berthoz, A. (2001). Impaired Sequential Egocentric and Allocentric Memories in Forebrain-Specific-NMDA Receptor Knock-Out Mice during a New Task Dissociating Strategies of Navigation. The Journal of Neuroscience, 26, 4071-4081.
154. Rousse, I., Beaulieu, S., Rowe, W., Meaney, M. J., Barden, N., & Rochford, J. (1997). Spatial memory in transgenic mice with impaired glucocorticoid receptor function. Neuroreport, 8, 841-845.
155. Sakagawa, T., Okuyama, S., Kawashima, N., Hozumi, S., Nakagawasai, O., Tadano, T., et al. (2000). Pain threshold, learning and formation of brain edema in mice lacking the angiotensin II type 2 receptor. Life Sciences, 67, 2577-2585.
156. Sakimura, K., Kutsuwada, T., Ito, I., Manabe, T., Takayama, C., Kushiya, E., et al. (1995). Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor 1 subunit. Nature, 373, 151-155.
157. Samuel, W., Terry, R. D., Deteresa, R., Butters, N., & Masliah, E. (1994). Clinical Correlates of Cortical and Nucleus Basalis Pathology in Alzheimer Dementia. Archives of Neurology, 51, 772-778.
158. Sapolsky, R. M. (2003). Altering behavior with gene transfer in the limbic system. Physiology & Behavior, 79, 479-486.
159. Savitz, J., Solms, M., & Ramesar, R. (2006). The molecular genetics of cognition: Dopamine, COMT and BDNF. Genes, Brain and Behavior, 5, 311-328.
160. Schmitt, W. B., Deacon, R. M. J., Seeburg, P. H., Rawlins, J. N. P., & Bannerman, D. M. (2003). A within-subjects, within-task demonstration of intact spatial reference memory and impaired spatial working memory in glutamate receptor-A-deficient mice. The Journal of Neuroscience, 23, 3953-3959.
161. Seabrook G. R., & Rosahl, T. W. (1999). Transgenic animals relevant to Alzheimer's disease. Neuropharmacology, 38, 1-17.
162. Selcher, J. C., Nekrasova, T., Paylor, R., Landreth, G. E., & Sweatt, J. D. (2001). Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning. Learning & Memory, 8, 11-19.
163. Selkoe, D. J. (1997). Alzheimer's Disease: Genotypes, phenotypes, and treatments. Science, 275, 630-631.
164. Shahbazian, M. D., Young, J. I., Yuva-Paylor, L. A., Spencer, C. M., Antalffy, B. A., Noebels, J. L., et al. (2002). Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron, 35, 243-254.
165. Shaw, P., Greenstein, D., Lerch, J., Clasen, L., Lenroot, R., Gogtay, N., et al. (2006). Intellectual ability and cortical development in children and adolescents. Nature, 440, 676-679.
166. Shimizu, E., Tang, Y. P., Rampon, C., & Tsien, J. Z. (2000). NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. Science, 290, 1170-1174.
167. Shors, T. J., & Matzel, L. D. (1997). Long-term potentiation: What's learning got to do with it? Behavioral and Brain Sciences, 20, 597-655.
168. Sigurdsson, E. M., Scholtzova, H., Mehta, P. D., Frangione, B., & Wisniewski, T. (2001). Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's diseaseassociated pathology in transgenic mice. American Journal of Pathology, 159, 439-447.
169. Silva, A. J., Paylor, R., Wehner, J. M., & Tonegawa, S. (1992). Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science, 257, 206-211.
170. Spearman, C. (1904). 'General intelligence' objectively determined and measured. American Journal of Psychology, 15, 201-293
171. Spreng, M., Cotecchia, S., & Schenk, F. (2001). A behavioral study of alpha-1b adrenergic receptor knockout mice: Increased reaction to novelty and selectively reduced learning capacities. Neurobiology of Learning and Memory, 75, 214-229.
172. Sprengel, R., Suchanek, B., Amico, C., Brusa, R., Burnashev, N., Rozov, A., et al. (1998). Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell, 92, 279-289.
173. Steckler, T., Weis, C., Sauvage, M., Mederer, A., & Holsboer, F. (1999). Disrupted allocentric but preserved egocentric spatial learning in transgenic mice with impaired glucocorticoid receptor function. Behavioural Brain Research, 100, 77-89.
174. Stork, O., & Welzl, H. (1999). Memory formation and the regulation of gene expression. Cellular and Molecular Life Sciences, 55, 575-592.
175. Stork, O., Welzl, H., Wolfer, D., Schuster, T., Mantei, N., Stork, S., et al. (2000). Recovery of emotional behavior in neural cell adhesion molecule. (NCAM) null mutant mice through transgenic expression of NCAM180. European Journal of Neuroscience, 12, 3291-3306.
176. Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., et al. (1997). Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proceedings of the National Academy of Sciences of the United States of America, 94, 13287-13292.
177. Sweatt, J. D. (2004). Mitogen-activated protein kinases in synaptic plasticity and memory. Current Opinion in Neurobiology, 14, 311-317.
178. Tang, Y. P., Shimizu, E., Dube, G. R., Rampon, C., Kerchner, G. A., Zhuo, M., et al. (1999). Genetic enhancement of learning and memory in mice. Nature, 401, 63-69.
179. Tang, Y. P., Wang, H., Feng, R., Kyin, M., & Tsien, J. Z. (2001). Differential effects of enrichment on learning and memory function in NR2B transgenic mice. Neuropharmacology, 41, 779-790.
180. Thomas, G. M., & Huganir, R. L. (2004). MAPK cascade signalling and synaptic plasticity. Nature Reviews Neuroscience, 5, 173-83.
181. Thorndike, R. L. (1935). Organization of behavior in the albino rat. Genetic Psychology Monographs, 17, 1-70.
182. Toga, A. W., & Thompson, P. M. (2005). Genetics of brain structure and intelligence. Annual Review of Neuroscience, 28, 1-23.
183. Tong, X. K., & Hamel, E. (1999). Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease. Neuroscience, 92, 163-175.
184. Tsang, S., Sun, Z., Luke, B., Stewart, C., Lum, N., Gregory, M., et al. (2005). A comprehensive SNP-based genetic analysis of inbred mouse strains. Mammalian Genome, 16, 476-80.
185. Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996). The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell, 87, 1327-1338.
186. Uchida, S., Sakai, S., Furuichi, T., Hosoda, H., Toyota, K., Ishii, T., et al. (2006). Tight regulation of transgene expression by tetracyclinedependent activator and repressor in brain. Genes, Brain and Behavior, 5, 96-106.
187. Van Leuven, F. (2000). Single and multiple transgenic mice as models for Alzheimer's disease. Progress in Neurobiology, 61, 305-312.
188. Victoroff, J., Zarow, C., Mack, W. J., Hsu, E., & Chui, H. C. (1996). Physical aggression is associated with preservation of substantia nigra pars compacta in Alzheimer disease. Archives of Neurology, 53, 428-434.
189. Waddell, S., & Quinn, W. G. (2001). Flies, genes, and learning. Annual Review of Neuroscience, 24, 1283-1309.
190. Waltereit, R., & Weller, M. (2003). Signaling from cAMP/PKAto MAPK and synaptic plasticity. Molecular Neurobiology, 27, 99-106.
191. Weeber, E. J., Levenson, J. M., & Sweatt, J. D. (2002). Molecular genetics of human cognition. Molecular Interventions, 2, 376-391.
192. Welzl, H., D'Adamo, P., Wolfer, D. P., & Lipp, H. P. (2006). Mouse models of hereditary mental retardation. In G. S. Fisch & J. Flint (Eds.), Transgenic and knockout models of neuropsychiatric disorders. R. Lydic & H. A. Baghdoyan (Series Eds.), Contemporary clinical neuroscience (pp. 101-125). Totowa, New Jersey USA: Humana Press.
193. Whitehouse, P. J., Price, D. L., Struble, R. G., Clark, A. W., Coyle, J. T., & Delon, M. R. (1982). Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science, 215, 1237-1239.
194. Wolfer, D. P., Mohajeri, H. M., Lipp, H. P., & Schachner, M. (1998). Increased flexibility and selectivity in spatial learning of transgenic mice ectopically expressing the neural cell adhesion molecule L1 in astrocytes. European Journal of Neuroscience, 10, 708-717.
195. Yan, Y., Wang, M., Lemon, W. J., & You, M. (2004). Single nucleotide polymorphism (SNP) analysis of mouse quantitative trait loci for identification of candidate genes. Journal of Medical Genetetics, 41, e111.
196. Zamanillo, D., Sprengel, R., Hvalby, Ø., Jensen, V., Burnashev, N., Rozov, A., et al. (1999). Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning. Science, 284, 1805-1811.