The dorsal hippocampus is essential for context discrimination but not for contextual conditioning

Behavioral Neuroscience

Volumn 112, Issue 4, 1998, Pages 863-874

  Frankland, Paul W ^a   Filipkowski, Robert K ^a,c   Cestari, Vincenzo ^a,b   McDonald, Robert J ^d   Silva, Alcino J ^a,e  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b CNR   (Italy)

^c NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONDITIONING; CONTROLLED STUDY; DISCRIMINATION LEARNING; FEAR; FEMALE; HIPPOCAMPUS; MALE; NONHUMAN; RAT; TASK PERFORMANCE;

EID: 3543028003     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.112.4.863     Document Type: Article

References (35)

1. Chen, C., Kim, J. J., Thompson, R. F., & Tonegawa, S. (1996). Hippocampal lesions impair contextual fear conditioning in two strains of mice. Behavioral Neuroscience, 110, 1177-1180.
2. Cho, Y., Friedman, E., & Silva, A. J. (in press). Ibotenate lesions of the hippocampus impair spatial learning but not contextual fear conditioning in mice. Behavioral Brain Research.
3. Fanselow, M. S. (1984). What is conditioned fear? Trends in Neurosciences, 7, 460-462.
4. Fanselow, M. S. (1990). Factors governing one-trial contextual conditioning. Animal Learning & Behavior, 18, 264-270.
5. Fanselow, M. S., & Baackes, M. P. (1982). Conditioned fear-induced opiate analgesia on the formalin test: Evidence for two aversive motivational systems. Learning and Motivation, 13, 200-221.
6. Franklin, K. B. J., & Paxinos, G. (1997). The mouse brain in stereotaxic coordinates. San Diego, CA: Academic Press.
7. Giese, K. P., Frankland, P. W., & Silva, A. J. (1998). [Context discrimination in Kvβ1.l mutant mice]. Unpublished raw data.
8. Gisquet-Verrier, P., & Doyère, V. (1997). Lesions of the hippocampus in rats do not affect conditioning to context cues in classical fear conditioning. Society for Neuroscience Abstracts, 23, 1609.
9. Good, M., & Honey, R. C. (1997). Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning, and spatial learning. Behavioral Neuroscience, 111 487-493.
10. Kim, J. J., & Fanselow, M. S. (1992). Modality-specific retrograde amnesia of fear. Science, 256, 675-677.
11. Kim, J. J., Rison, R. A., & Fanselow, M. S. (1993). Effects of amygdala, hippocampus, and periaqueductal gray lesions on short- and long-term contextual fear. Behavioral Neuroscience, 107, 1093-1098.
12. LeDoux, J. E. (1994). Emotion, memory and the brain. Scientific American, 270, 50-57.
13. Logue, S. F., Paylor, R., & Wehner, J. M. (1997). Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task. Behavioral Neuroscience, 111, 104-113.
14. Maren, S., Aharonov, G., & Fanselow, M. S. (1997). Neurotoxic lesions of the dorsal and Pavlovian fear conditioning in rats. Behavioral Brain Research, 88, 261-274.
15. Maren, S., & Fanselow, M. S. (1995). Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. Journal of Neuroscience, 15, 7548-7564.
16. Maren, S., & Fanselow, M. S. (1997). Electrolytic lesions of the fimbria/fornix, dorsal hippocampus, or entorhinal cortex produce anterograde deficits in contextual fear conditioning in rats. Neurobiology of Learning and Memory, 67, 142-149.
17. Marowitz, Z., Bourtchuladze, R., & Silva, A. J. (1996). [Contextual fear conditioning in small and large conditioning chambers]. Unpublished raw data.
18. McDonald, R. J., Koerner, A., & Sutherland, R. J. (1995). Contextual fear conditioning and hippocampus. Society for Neuroscience Abstracts, 21, 1218.
19. McDonald, R. J., & White, N. M. (1995). Information acquired by the hippocampus interferes with acquisition of the amygdala-based conditioned-cue preference in the rat. Hippocampus, 5, 189-197.
20. McNish, K. A., Gewirtz, J. C., & Davis, M. (1997). Evidence of contextual fear after lesions of the hippocampus: A disruption of freezing but not fear-potentiated startle. Journal of Neuroscience, 17, 9353-9360.
21. Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982). Place navigation impaired in rats with hippocampal lesions. Nature, 297, 681-683.
22. Nadel, L., & Willner, J. (1980). Context and conditioning: A place for space. Physiological Psychology, 8, 218-228.
23. Nadel, L., Willner, J., & Kurz, E. M. (1985). Cognitive maps and environmental context. In P. D. Balsam & A. Tomie (Eds.), Context and learning (pp 285-406). London: Erlbaum.
24. National Institutes of Health. (1986). Guide for the care and use of laboratory animals (DHEW Publication No. 86-23). Washington, DC: U.S. Government Printing Office.
25. Phillips, R. G., & LeDoux, J. E. (1992). Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behavioral Neuroscience, 106, 274-285.
26. Phillips, R. G., & LeDoux, J. E. (1994). Lesions of the dorsal hippocampal formation interfere with background but not foreground contextual fear conditioning. Learning & Memory, 1, 34-44.
27. Phillips, R. G., & LeDoux, J. E. (1995). Lesions of the fornix but not the entorhinal or perirhinal cortex interfere with contextual fear conditioning. Journal of Neuroscience, 15, 5308-5315.
28. Rogan, M. T., & LeDoux, J. E. (1996). Emotion: Systems, cells, synaptic plasticity. Cell, 85, 469-475.
29. Selden, N. R. W., Everitt, B. J., Jarrard, L. E., & Robbins, T. W. (1991). Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues. Neuroscience, 42, 335-350.
30. Silva, A. J., Fedorov, N., Kogan, J., Frankland, P. W., Coblentz, J., Lundsten, R., Friedman, E., Smith, A., Cho, Y., & Giese, K. P. (1996). Genetic analysis of function and dysfunction in the central nervous system. In Cold Spring Harbor Symposia on Quantitative Biology; Function and Dysfunction in the Nervous System (Vol. 41, pp. 51). Plainview, NY: Cold Spring Harbor Laboratory Press.
31. Silva, A. J., Frankland, P. W., Marowitz, Z., Friedman, E., Lazlo, G., Cioffi, D., Jacks, T., & Bourtchuladze, R. (1997). A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nature Genetics, 15, 281-284.
32. Sutherland, R. J., Kolb, B., & Wishaw, I. Q. (1982). Spatial mapping: Definitive disruption by hippocampal or medial frontal cortical damage in the rat. Neuroscience Letters, 31, 271-276.
33. Sutherland, R. J., & McDonald, R. J. (1990). Hippocampus, amygdala, and memory deficits in rats. Behavioral Brain Research, 37, 57-79.
34. Sutherland, R. J., & Rudy, J. W. (1989). Configural association theory: The role of the hippocampal formation in learning, memory and amnesia. Psychobiology, 17, 129-144.
35. Young, S. L., Bohenek, D. L.,& Fanselow, M. S. (1994). NMDA processes mediate anterograde amnesia of contextual fear conditioning induced by hippocampal damage: Immunization against amnesia by context preexposure. Behavioral Neuroscience, 108, 19-29.