Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain

Genes, Brain and Behavior

Volumn 5, Issue 1, 2006, Pages 96-106

  Uchida, S ^a   Sakai, S ^a   Furuichi, T ^a   Hosoda, H ^a   Toyota, K ^a   Ishii, T ^a   Kitamoto, A ^a   Sekine, M ^a   Koike, K ^a   Masushige, S ^a   Murphy, G ^b,c   Silva, A J ^b   Kida, S ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Conditional mutation; Gene expression regulation; Mouse genetics; Tetracycline dependent regulators; Transcription factor; Transgenic mice

Indexed keywords

DOXYCYCLINE; TETRACYCLINE; DNA;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; FEMALE; FOREBRAIN; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; INTERNAL RIBOSOME ENTRY SITE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; TRANSGENE; ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL STRAIN COS1; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INDUCTION; HELA CELL; MOUSE; NERVE CELL CULTURE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TIGHT JUNCTION;

ANIMALS; CELL LINE; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CLONING, MOLECULAR; COS CELLS; DOXYCYCLINE; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENES, REPORTER; HELA CELLS; HUMANS; MICE; MICE, TRANSGENIC; PROSENCEPHALON; REPRESSOR PROTEINS; RESPONSE ELEMENTS; RNA; RNA, MESSENGER; TRANS-ACTIVATORS;

ANIMALIA; MUS MUSCULUS;

EID: 33645088922     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2005.00139.x     Document Type: Article

References (39)

1. Alland L. Muhle R. Hou H. Jr. Potes J. Chin L. Schreiber-Agus N. DePinho R.A. 1997 Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression Nature 387 49 55
2. Ayer D.E. Lawrence Q.A. Eisenman R.N. 1995 Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3 Cell 80 767 776
3. Baron U. Bujard H. 2000 Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances Methods Enzymol 327 401 421
4. Baron U. Schnappinger D. Helbl V. Gossen M. Hillen W. Bujard H. 1999 Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes Proc Natl Acad Sci USA 96 1013 1018
5. Belli G. Gari E. Piedrafita L. Aldea M. Herrero E. 1998 An activator/repressor dual system allows tight tetracycline-regulated gene expression in budding yeast Nucleic Acids Res 26 942 947
6. Blau H.M. Rossi F.M. 1999 Tet B or not tet B: advances in tetracycline-inducible gene expression Proc Natl Acad Sci USA 96 797 799
7. Chen J. Kelz M.B. Zeng G. Sakai N. Steffen C. Shockett P.E. Picciotto M.R. Duman R.S. Nestler E.J. 1998 Transgenic animals with inducible, targeted gene expression in brain Mol Pharmacol 54 495 503
8. Chomczynski P. Sacchi N. 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 162 156 159
9. Collins T. Stone J.R. Williams A.J. 2001 All in the family: the BTB/POZ, KRAB, and SCAN domains Mol Cell Biol 21 3609 3615
10. Deuschle U. Meyer W.K. Thiesen H.J. 1995 Tetracycline-reversible silencing of eukaryotic promoters Mol Cell Biol 15 1907 1914
11. Dirks W. Wirth M. Hauser H. 1993 Dicistronic transcription units for gene expression in mammalian cells Gene 128 247 249
12. Forster K. Helbl V. Lederer T. Urlinger S. Wittenburg N. Hillen W. 1999 Tetracycline-inducible expression systems with reduced basal activity in mammalian cells Nucleic Acids Res 27 708 710
13. Freundlieb S. Schirra-Muller C. Bujard H. 1999 A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells J Gene Med 1 4 12
14. Genoux D. Haditsch U. Knobloch M. Michalon A. Storm D. Mansuy I.M. 2002 Protein phosphatase 1 is a molecular constraint on learning and memory Nature 418 970 975
15. Gossen M. Bujard H. 1992 Tight control of gene expression in mammalian cells by tetracycline-responsive promoters Proc Natl Acad Sci USA 89 5547 5551
16. Gossen M. Freundlieb S. Bender G. Muller G. Hillen W. Bujard H. 1995 Transcriptional activation by tetracyclines in mammalian cells Science 268 1766 1769
17. Grill M.A. Bales M.A. Fought A.N. Rosburg K.C. Munger S.J. Antin P.B. 2003 Tetracycline-inducible system for regulation of skeletal muscle-specific gene expression in transgenic mice Transgenic Res 12 33 43
18. Hennecke M. Kwissa M. Metzger K. Oumard A. Kroger A. Schirmbeck R. Reimann J. Hauser H. 2001 Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs Nucleic Acids Res 29 3327 3334
19. Hosoda H. Motohashi J. Kato H. Masushige S. Kida S. 2004 A BMAL1 mutant with arginine 91 substituted with alanine acts as a dominant negative inhibitor Gene 338 235 241
20. Jalabi W. Cerghet M. Skoff R.P. Ghandour M.S. 2003 Detection of oligodendrocytes in tissue sections using PCR synthesis of digoxigenin-labeled probes J Histochem Cytochem 51 913 919
21. Jiang W. Zhou L. Breyer B. Feng T. Cheng H. Haydon R. Ishikawa A. He T.C. 2001 Tetracycline-regulated gene expression mediated by a novel chimeric repressor that recruits histone deacetylases in mammalian cells J Biol Chem 276 45168 45174
22. Kida S. Josselyn S.A. de Ortiz S.P. Kogan J.H. Chevere I. Masushige S. Silva A.J. 2002 CREB required for the stability of new and reactivated fear memories Nat Neurosci 5 348 355
23. Kistner A. Gossen M. Zimmermann F. Jerecic J. Ullmer C. Lubbert H. Bujard H. 1996 Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice Proc Natl Acad Sci USA 93 10933 10938
24. Laherty C.D. Yang W.M. Sun J.M. Davie J.R. Seto E. Eisenman R.N. 1997 Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression Cell 89 349 356
25. Malleret G. Haditsch U. Genoux D. Jones M.W. Bliss T.V. Vanhoose A.M. Weitlauf C. Kandel E.R. Winder D.G. Mansuy I.M. 2001 Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin Cell 104 675 686
26. Mansuy I.M. Winder D.G. Moallem T.M. Osman M. Mayford M. Hawkins R.D. Kandel E.R. 1998 Inducible and reversible gene expression with the rtTA system for the study of memory Neuron 21 257 265
27. Martin D.I. Whitelaw E. 1996 The vagaries of variegating transgenes Bioessays 18 919 923
28. Mayford M. Bach M.E. Huang Y.Y. Wang L. Hawkins R.D. Kandel E.R. 1996a Control of memory formation through regulated expression of a CaMKII transgene Science 274 1678 1683
29. Mayford M. Baranes D. Podsypanina K. Kandel E.R. 1996b The 3′-untranslated region of CaMKII alpha is a cis-acting signal for the localization and translation of mRNA in dendrites Proc Natl Acad Sci USA 93 13250 13255
30. Mayford M. Kandel E.R. 1999 Genetic approaches to memory storage Trends Genet 15 463 470
31. Ramirez A. Milot E. Ponsa I. Marcos-Gutierrez C. Page A. Santos M. Jorcano J. Vidal M. 2001 Sequence and chromosomal context effects on variegated expression of keratin 5/lacZ constructs in stratified epithelia of transgenic mice Genetics 158 341 350
32. Rossi F.M. Guicherit O.M. Spicher A. Kringstein A.M. Fatyol K. Blakely B.T. Blau H.M. 1998 Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16 Nat Genet 20 389 393
33. Silva A.J. 2003 Molecular and cellular cognitive studies of the role of synaptic plasticity in memory J Neurobiol 54 224 237
34. Taunton J. Hassig C.A. Schreiber S.L. 1996 A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p Science 272 408 411
35. Tremblay P. Meiner Z. Galou M. Heinrich C. Petromilli C. Lisse T. Cayetano J. Torchia M. Mobley W. Bujard H. DeArmond S.J. Prusiner S.B. 1998 Doxycycline control of prion protein transgene expression modulates prion disease in mice Proc Natl Acad Sci USA 95 12580 12585
36. Urlinger S. Baron U. Thellmann M. Hasan M.T. Bujard H. Hillen W. 2000 Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity Proc Natl Acad Sci USA 97 7963 7968
37. Wang Z. Zheng T. Zhu Z. Homer R.J. Riese R.J. Chapman H.A. Jr. Shapiro S.D. Elias J.A. 2000 Interferon gamma induction of pulmonary emphysema in the adult murine lung J Exp Med 192 1587 1600
38. Yamamoto A. Lucas J.J. Hen R. 2000 Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease Cell 101 57 66
39. Zhu Z. Ma B. Homer R.J. Zheng T. Elias J.A. 2001 Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice J Biol Chem 276 25222 25229