The genetics of cognitive processes: Candidate genes in humans and animals

Behavior Genetics

Volumn 31, Issue 6, 2001, Pages 511-531

  Morley, Katherine I ^a   Montgomery, Grant W ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Cognition; Drosophila melanogaster; Genetics; Human; Mouse

Indexed keywords

ALPHA 2C ADRENERGIC RECEPTOR; APOLIPOPROTEIN E; CANNABINOID RECEPTOR;

ARTICLE; COGNITION; DROSOPHILA MELANOGASTER; GENE LOCUS; GENETIC VARIABILITY; GENETICS; HUMAN; LEARNING; MOUSE; NONHUMAN; SCIENTIFIC LITERATURE; WORKING MEMORY;

ANIMALS; CHROMOSOME MAPPING; DROSOPHILA MELANOGASTER; GENETIC MARKERS; HUMANS; INTELLIGENCE; MENTAL RETARDATION; MICE; PHENOTYPE; QUANTITATIVE TRAIT, HERITABLE;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0035703853     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013337209957     Document Type: Article

References (207)

1. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory
2. PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning
3. A new inherited interstitial deletion of the distal long arm of chromosome 4
4. Relation of age and apolipoprotein E to cognitive function in down syndrome adults
5. Watson syndrome: Is it a subtype of type 1 neurofibromatosis?
6. PAK3 mutation in nonsyndromic X-linked mental retardation
7. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
8. The deletion allele of the angiotensin I converting enzyme gene as a genetic susceptibility factor for cognitive impairment
9. Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice
10. Protein phosphatase 1-deficient mutant Drosophila is affected in habituation and associative learning
11. Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning
12. Polymorphisms of genes controlling homocysteine folate metabolism and cognitive function
13. Loss of Dp140 regulatory sequences is associated with cognitive impairment in dystrophinopathies
14. Atm-deficient mice: A paradigm of ataxia telangiectasia
15. 22q11 deletion syndrome: A genetic subtype of schizophrenia
16. Transgenic expression of human acetylcholinesterase induces progressive cognitive deterioration in mice
17. Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein
18. Polymorphism of the prion protein is associated with cognitive impairment in the elderly: The EVA study
19. Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation
20. Alpha2C-adrenoceptor-overexpressing mice are impaired in executing nonspatial and spatial escape strategies
21. Enhanced long-term potentiation in mice lacking cannabinoid CB1 receptors
22. Molecular cloning of linotte in Drosophila: A novel gene that functions in adults during associative learning
23. Current status and future prospects in twin studies of the development of cognitive abilities, infancy to old age
24. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice
25. Familial studies of intelligence: A review
26. Immunocytochemical and learning studies of a Drosophila melanogaster neurological mutant, no-bridgeKS49, as an approach to the possible role of the central complex
27. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
28. Latheo, a new gene involved in associative learning and memory in Drosophila melanogaster, identified from P element mutagenesis
29. A role for the Ras signalling pathway in synaptic transmission and long-term memory
30. A gene for FG syndrome maps in the Xq12-q21.31 region
31. Cognitive deficits in spinocerebellar ataxia 2
32. Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster
33. Age-related cognitive decline in hereditary spastic paraparesis linked to chromosome 2p
34. Quantitative trait locus for reading disability on chromosome 6
35. A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation
36. Familial syndromic esophageal atresia maps to 2p23-p24
37. Novel PRNP sequence variant associated with familial encephalopathy
38. Impaired memory retention and decreased long-term potentiation in integrin-associated protein-deficient mice
39. Deficient protein kinase C activity in turnip, a Drosophila learning mutant
40. A quantitative trait locus associated with cognitive ability in children
41. Additive effect of three noradrenergic genes (ADRA2A, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects
42. Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1
43. Association of attention-deficit disorder and the dopamine transporter gene
44. Drosophila mutations that alter ionic conduction disrupt acquisition and retention of a conditioned odor avoidance response
45. Mutations in GDI1 are responsible for X-linked non-specific mental retardation
46. The cyclic AMP system and Drosophila learning
47. Familial dementia caused by polymerization of mutant neuroserpin
48. Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome
49. The heritability of IQ
50. Nalyot, a mutation of the Drosophila myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory
51. Developmental expression of an amn(+) transgene rescues the mutant memory defect of amnesiac adults
52. Identification of linotte, a new gene affecting learning and memory in Drosophila melanogaster
53. The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product
54. Fmr1 knockout mice: A model to study fragile X mental retardation. The Dutch-Belgian fragile X consortium
55. Molecular mechanisms of synaptic plasticity and memory
56. Mild impairment of learning and memory in mice overexpressing the msim2 gene located on chromosome 16: An animal model of down syndrome
57. A new gene (DYX3) for dyslexia is located on chromosome 2
58. A neuropeptide gene defined by the Drosophila memory mutant amnesiac
59. Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B
60. Intellectual impairment in neurofibromatosis 1
61. Localisation of a gene implicated in a severe speech and language disorder
62. DNA pooling identifies QTLs on chromosome 4 for general cognitive ability in children
63. The genetics basis of cognition
64. Radish, a Drosophila mutant deficient in consolidated memory
65. LIM-kinasel hemizygosity implicated in impaired visuospatial constructive cognition
66. Genotype-phenotype correlation in L1 associated diseases
67. Superior water maze performance and increase in fear-related behavior in the endothelial nitric oxide synthase-deficient mouse together with monoamine changes in cerebellum and ventral striatum
68. A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation
69. Isolation and characterization of a human gene containing a nuclear localization signal from the critical region for velo-cardio-facial syndrome on 22q11
70. Impaired cued and contextual memory in NPAS2-deficient mice
71. Opitz G/BBB syndrome in Xp22: Mutations in the MID1 gene cluster in the carboxyterminal domain
72. Characterization of the human glutamate receptor sub-unit 3 gene (GRIA3), a candidate for bipolar disorder and non-specific X-linked mental retardation
73. Identification of the gene FMR2, associated with FRAXE mental retardation
74. Impaired motor learning performance in cerebellar En-2 mutant mice
75. Multiple behavioral anomalies in GluR2 mutant mice exhibiting enhanced LTP
76. Altered spatial learning and memory in mice lacking the mGluR4 subtype of metabotropic glutamate receptor
77. Identification of a locus on chromosome 14q for idiopathic basal ganglia calcification (Fahr disease)
78. Antisense 'knockdowns' of M1 receptors induces transient anterograde amnesia in mice
79. A newly formed amyloidogenic fragment due to a stop codon mutation causes familial British dementia
80. Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)
81. Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning
82. + channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning
83. Tau gene mutation in familial progressive subcortical gliosis
84. The gene encoding proline dehydrogenase modulates sensorimotor gating in mice
85. Defective learning in mutants of the Drosophila gene for a regulatory subunit of cAMP-dependent protein kinase
86. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
87. Genetics and visual attention: Selective deficits in healthy adult carriers of the varepsilon 4 allele of the apolipoprotein E gene
88. Inhibition of calcium/calmodulin-dependent protein kinase in Drosophila disrupts behavioral plasticity
89. Calcium/calmodulin-dependent protein kinase II and potassium channel subunit eag similarly affect plasticity in Drosophila
90. Chromosome 6p influences on different dyslexia-related cognitive processes: Further confirmation
91. Integrin-mediated short-term memory in Drosophila
92. Evidence relating human verbal memory to hippocampal N-methyl-D-aspartate receptors
93. A neurofibromatosis-1-regulated pathway is required for learning in Drosphila
94. Allelic variation of human serotonin transporter gene expression
95. Mapping of a complicated familial spastic paraplegia to locus SPG4 on chromosome 2p
96. Drosophila mushroom body mutants are deficient in olfactory learning
97. Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample
98. Neurofibromatosis type 1: The cognitive phenotype
99. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
100. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
101. Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice
102. Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning
103. Primary autosomal recessive microcephaly (MCPH1) maps to chromosome 8p22-pter
104. Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation
105. Association between the cannabinoid receptor gene (CNR1) and the P300 event-related potential
106. Comprehensive mutation analysis of TSC1 and TSC2- and phenotypic correlations in 150 families with tuberous sclerosis
107. Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the beta-amyloid precursor protein gene
108. Genotype, molecular phenotype, and cognitive phenotype: Correlations in fragile X syndrome
109. Possible locus for bipolar disorder near the dopamine transporter on chromosome 5
110. UBE3A/E6-AP mutations cause Angelman syndrome
111. Neurodevelopmental profile of a new dysmorphic syndrome associated with submicroscopic partial deletion of 1p36.3
112. Modest neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hydroxylase gene
113. Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-End rule pathway
114. Molecular manipulations of extracellular superoxide dismutase: Functional importance for learning
115. 2+ Calmodulin-responsive adenylyl cyclase
116. Candidate gene for the chromosome 1 familial Alzheimer's disease locus
117. A familial Alzheimer's disease locus on chromosome 1
118. Effects of a conditional Drosophila PKA mutant on olfactory learning and memory
119. Pathological mechanisms in Huntington's disease and other polyglutamine expansion diseases
120. Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice
121. Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice
122. Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors
123. Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory
124. Correlations between individual clinical manifestations and CTG repeat amplification in myotonic dystrophy
125. Mice lacking àtaxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation
126. Mice lacking the cell adhesion molecule Thy-1 fail to use socially transmitted cues to direct their choice of food
127. Hyperactivity and learning deficits in transgenic mice bearing a human mutant thyroid hormone beta 1 receptor gene
128. Association of serum AACT levels and AACT signal polymorphism with late-onset Alzheimer's disease in Northern Ireland
129. Functional brain activation during cognition is related to FMR1 gene expression
130. A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation
131. Essential role for TrkB receptors in hippocampusmediated learning
132. A third novel locus for primary autosomal recessive microcephaly maps to chromosome 9q34
133. Genetics advances and learning disability
134. Familial multiple-system tauopathy with presenile dementia is localized to chromosome 17
135. Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour
136. Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
137. Motor and learning dysfunction during postnatal development in mice defective in dopamine neuronal transmission
138. Prolonged P300 latency in children with the D2 dopamine receptor A1 allele
139. Cognitive function and academic performance in children with neurofibromatosis type 1
140. Genetic linkage analysis with dyslexia: Evidence for linkage of spelling disability to chromosome 15
141. Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: Implication for a dominant-negative mechanism
142. Cognitive impairment in neurofibromatosis type 1
143. Angiotensin converting enzyme deletion allele in different kinds of dementia disorders
144. Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1
145. Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice
146. Behavioral assessment of c-fos mutant mice
147. Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75
148. Impaired learning and memory and altered hippocampal neurodevelopment resulting from interleukin-2 gene deletion
149. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
150. DNA markers associated with general and specific cognitive abilities
151. The genomic structure and development expression patterns of the human OPA-containing gene (HOPA)
152. The structure and expression of the human neuroligin-3 gene
153. No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice
154. Absence of expression of the FMR-1 gene in fragile X syndrome
155. LIS1 and XLIS (DCX) mutations cause most classical lissencephaly, but different patterns of malformation
156. Human behavioural genetics of cognitive abilities and disabilities
157. DNA markers associated with high versus low IQ: The IQ Quantitative Trait Loci (QTL) project
158. Allelic associations between 100 DNA markers and high versus low IQ
159. CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide
160. Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22
161. Apolipoprotein E and cognitive performance
162. Enhancement of memory in cannabinoid CB 1 receptor knock-out mice
163. The second locus for autosomal recessive primary microcephaly (MCPH2) maps to chromosome 19q13.1-13.2
164. Enhanced learning after genetic overexpression of a brain growth protein
165. Homozygosity mapping in families with Joubert syndrome identifies a locus on chromosome 9q34.3 and evidence for genetic heterogeneity
166. A heteroallelic mutant mouse model: A new orthologue for human hyperphenylalaninemia
167. Apolipoprotein E e4 allele in the normal elderly: Neuropsychologic and brain MRI correlates
168. + channel components from the Shaker locus and differential distribution of splicing variants in Drosophila
169. Monogenic traits are not simple: Lessons from phenylketonuria
170. A unique form of mental retardation with a distinctive phenotype maps to Xq26-q27
171. The effects of thyroid hormone level and action in developing brain: Are these targets for the actions of polychlorinated biphenyls and dioxins?
172. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
173. A mouse model for the learning and memory deficits associated with neurofibromatosis type I
174. Olfactory learning deficits in mutants for leonardo, a Drosophila gene encoding a 14-13-3 protein
175. Two cases with interstitial deletions of chromosome 2 and sex reversal in one
176. Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with down syndrome
177. Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo
178. Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein delta
179. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasialike disorder
180. A higher control center of locomotor behavior in the Drosophila brain
181. Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development
182. Genetic enhancement of learning and memory in mice
183. Role of alpha2C-adrenoceptor subtype in spatial working memory as revealed by mice with targeted disruption of the alpha2C-adrenoceptor gene
184. Dissection of behaviour and psychiatric disorders using the mouse as a model
185. Perturbed dentate gyrus function in serotonin 5-HT2C receptor mutant mice
186. Minibrain: A new protein kinase family involved in postembryonic neurogenesis in Drosophila
187. Mutations in the dopa decarboxylase gene affect learning in Drosophila
188. Disruption of the dopamine beta-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning and memory
189. Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene
190. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
191. Differential effects of dunce mutations on associative learning and memory in Drosophila
192. Neuropsychological function in patients with Gerstmann-Straussler-Scheinker disease from the Indiana kindred (F198S)
193. Cloning and characterization of DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1
194. Functional analysis of mouse Polycomb group genes
195. A stop-codon mutation in the BRI gene associated with familial British dementia
196. Two unrelated patients with inversions of the X chromosome and non-specific mental retardation: Physical and transcriptional mapping of their common breakpoint region in Xq13.1
197. Single gene influences on brain and behavior
198. Autosomal dominant hereditary spastic paraparesis with cognitive loss linked to chromosome 2p
199. Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late-phase LTP
200. NCAM-180 knockout mice display increased lateral ventricle size and reduced prepulse inhibition of startle
201. G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP
202. CREB as a memory modulator: Induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila
203. Induction of a dominant negative CREB transgene specifically blocks
204. Cognitive deficits in a genetic mouse model of the most common biochemical cause of human mental retardation
205. Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning
206. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation
207. Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors