Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

Journal of Biological Chemistry

Volumn 276, Issue 24, 2001, Pages 21562-21570

  Chishti, M Azhar ^a   Yang, Dun Shen ^a   Janus, Christopher ^a   Phinney, Amie L ^a   Horne, Patrick ^a   Pearson, Jacqueline ^a   Strome, Robert ^a   Zuker, Noah ^a   Loukides, James ^a   French, Janet ^a   Turner, Sherry ^d   Lozza, Gianluca ^e   Grilli, Mariagrazia ^e   Kunicki, Suzanne ^f   Morissette, Céline ^f   Paquette, Julie ^f   Gervais, Francine ^f   Bergeron, Catherine ^a,b,c   Fraser, Paul E ^a,b   Carlson, George A ^d   St George Hyslop, Peter ^a,b,c   Westawaya, David ^a,b   more..

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d MCLAUGHLIN RESEARCH INSTITUTE   (United States)

^e Schering Plough Research Institute   (Italy)

^f INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; DISEASES; GENES; IMMUNOLOGY; PROTEINS;

BIOGENESIS; MUTATIONS;

BIOCHEMISTRY;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; AMYLOID;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOGENESIS; CHROMOSOME 21; COGNITIVE DEFECT; CONTROLLED STUDY; FAMILIAL AMYLOIDOSIS; GENE MUTATION; GENETIC SUSCEPTIBILITY; MOUSE; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROPHYLAXIS; PROTEIN AGGREGATION; PROTEIN EXPRESSION; TRANSGENIC MOUSE; AGING; AMINO ACID SUBSTITUTION; AMYLOIDOSIS; ANIMAL; BRAIN; C3H MOUSE; C57BL MOUSE; CHEMISTRY; CROSS BREEDING; FEMALE; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MALE; MAZE TEST; METABOLISM; PATHOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; RESTRICTION MAPPING; SITE DIRECTED MUTAGENESIS;

ANIMALIA; JANUS; MUS MUSCULUS;

AGING; AMINO ACID SUBSTITUTION; AMYLOID; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOIDOSIS; ANIMALS; BRAIN; COGNITION DISORDERS; CROSSES, GENETIC; FEMALE; HUMANS; MALE; MAZE LEARNING; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); RESTRICTION MAPPING;

EID: 0035877756     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100710200     Document Type: Article

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