AMPA receptor trafficking and synaptic plasticity

Annual Review of Neuroscience

Volumn 25, Issue , 2002, Pages 103-126

  Malinow, Roberto ^a   Malenka, Robert C ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

Excitatory; LTD; LTP; Memory; Transmission

Indexed keywords

AMPA RECEPTOR; BINDING PROTEIN; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR;

CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM DEPRESSION; ELECTROPHYSIOLOGY; ENDOCYTOSIS; HUMAN; IMAGING; LONG TERM POTENTIATION; MEMORY; MOLECULAR INTERACTION; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; HIPPOCAMPUS; HUMANS; LONG-TERM POTENTIATION; MEMORY; NEURAL INHIBITION; NEURONAL PLASTICITY; PROTEIN TRANSPORT; RECEPTORS, AMPA; SYNAPTIC TRANSMISSION;

EID: 0036305484     PISSN: 0147006X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.neuro.25.112701.142758     Document Type: Review

References (138)

1. Specificity of molecular changes in neurons involved in memory storage
2. Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: Differential attachment of NMDA versus AMPA receptors
3. Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor
4. Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
5. High-resolution immunogold localization of AMPA-type glutamate receptor subunits at synaptic and non-synaptic sites in rat hippocampus
6. Interaction with the NMDA receptor locks CaMKII in an active conformation
7. Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
8. Modulation of AMPA receptor unitary conductance by synaptic activity
9. A synaptic model of memory: Long-term potentiation in the hippocampus
10. Long-lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path
11. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
12. Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region
13. Involvement of the secretory pathway for AMPA receptors in NMDA-induced potentiation in hippocampus
14. Dynamin-dependent endocytosis of ionotropic glutamate receptors
15. Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures
16. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II
17. Stargazing regulates synaptic targeting of AMPA receptors by two distinct mechanisms
18. Phosphorylation of the AMPR receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins
19. Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex
20. Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation
21. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses
22. Ca2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors
23. The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits
24. GRIP: A synaptic PDZ domain-containing protein that interacts with AMPA receptors
25. Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2
26. Long-term potentiation and functional synapse induction in developing hippocampus
27. Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting
28. Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation
29. A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation
30. Distinct roles for ionotropic and metabotropic glutamate receptors in the maturation of excitatory synapses
31. Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer
32. Driving AMPA receptors into synapses by LTP and CaMKII: Requirement for GluR1 and PDZ domain interaction
33. Bidirectional, activity-dependent regulation of glutamate receptors in the adult hippocampus in vivo
34. Cloned glutamate receptors
35. rDLG6: A novel homolog of Drosophila DLG expressed in rat brain
36. Silent synapses during development of thalamocortical inputs
37. Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells
38. Evidence for silent synapses: Implications for the expression of LTP
39. Enhanced LTP in mice deficient in the AMPA receptor GluR2
40. Genes, synapses, and long-term memory
41. A persistent postsynaptic modification mediates long-term potentiation in the hippocampus
42. GluR1-immunopositive interneurons in rat neocortex
43. A role of actin filament in synaptic transmission and long-term potentiation
44. A labile component of AMPA receptor-mediated synaptic transmission is dependent on microtubule motors, actin, and N-ethylmaleimide-sensitive factor
45. Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression
46. SynGAP: A synaptic RasGAP that associates with the PSD-95/SAP90 protein family
47. Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus
48. Long-term potentiation is associated with increases in quantal content and quantal amplitude
49. The site of expression of NMDA receptor-dependent LTP: New fuel for an old fire
50. The calcineurin-dynamin 1 complex as a calcium sensor for synaptic vesicle endocytosis
51. Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
52. SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit
53. Calcium/calmodulin-dependent protein kinase II is associated with the N-methyl-D-aspartate receptor
54. AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses
55. Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice
56. Deficiency in induction but not expression of LTP in hippocampal slices from young rats
57. Activation of silent synapses by rapid activity-dependent synaptic recruitment of AMPA receptors
58. Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons
59. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
60. Long-term synaptic depression in the mammalian brain
61. A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory
62. Learning mechanisms: The case for CaM-KII
63. A model of synaptic memory: A CaMKII/PP1 switch that potentiates transmission by organizing an AMPA receptor anchoring assembly
64. Rapid, activation-induced redistribution of ionotropic glutamate receptors in cultured hippocampal neurons
65. Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors
66. Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype
67. Postsynaptic membrane fusion and long-term potentiation
68. Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons
69. Role of AMPA receptor cycling in synaptic transmission and plasticity
70. Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction
71. The biochemistry of memory: A new and specific hypothesis
72. Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice
73. Mechanisms underlying long-term potentiation of synaptic transmission
74. Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression
75. Long-term potentiation - A decade of progress?
76. Calcium-evoked dendritic exocytosis in cultured hippocampal neurons. Part II: Mediation by calcium/calmodulin-dependent protein kinase II
77. Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices
78. Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II
79. Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization
80. Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents
81. Postsynaptic factors in the expression of long-term potentiation (LTP): Increased glutamate receptor binding following LTP induction in vivo
82. AMPA glutamate receptor subunits are differentially distributed in rat brain
83. Synaptic plasticity and memory: An evaluation of the hypothesis
84. Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons
85. Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein
86. Biochemical and immunocytochemical characterization of antipeptide antibodies to a cloned GluR1 glutamate receptor subunit: Cellular and subcellular distribution in the rat forebrain
87. Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression
88. An essential role for protein phosphatases in hippocampal long-term depression
89. Contributions of quisqualate and NMDA receptors to the induction and expression of LTP
90. NSF binding to GluR2 regulates synaptic transmission
91. Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism
92. Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus
93. Activity-dependent modulation of synaptic AMPA receptor accumulation
94. Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor
95. The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs
96. Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons
97. PICK1 targets activated protein kinase C alpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2
98. Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses
99. Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brain
100. A developmental switch in neurotransmitter flux enhances synaptic efficacy by affecting AMPA receptor activation
101. Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit
102. The tetrameric structure of a glutamate receptor channel
103. Mechanisms of intracellular protein transport
104. Silent synapses in the developing rat visual cortex: Evidence for postsynaptic expression of synaptic plasticity
105. Can molecules explain long-term potentiation?
106. Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway
107. Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation
108. Regulation of AMPA receptor GluR1 subunit surface expression by a 4.1N-linked actin cytoskeletal association
109. PDZ domains and the organization of supramolecular complexes
110. Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons
111. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation
112. Role of phosphorylation in regulation of the assembly of endocytic coat complexes
113. Internalization of ionotropic glutamate receptors in response to mGluR activation
114. Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors
115. Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP
116. Changes in reliability of synaptic function as a mechanism for plasticity
117. Autophosphorylation-dependent targeting of calcium/calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl-D-aspartate receptor
118. Mechanism and regulation of calcium/calmodulin-dependent protein kinase II targeting to the NR2B subunit of the N-methyl-D-aspartate receptor
119. Different modes of expression of AMPA and NMDA receptors in hippocampal synapses
120. Activity-dependent scaling of quantal amplitude in neocortical neurons
121. Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis
122. Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons
123. Mammalian ionotropic glutamate receptors
124. Maturation of a central glutamatergic synapse
125. Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins
126. Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1
127. Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning
128. Contribution of cytoskeleton to the internalization of AMPA receptors
129. Synaptic potentiation during early development: Delivery of GluR4-containing AMPA receptors by spontaneous activity
130. Neurobiology of disease