A role for the Ras signalling pathway in synaptic transmission and long-term memory

Nature

Volumn 390, Issue 6657, 1997, Pages 281-286

  Brambilla, Riccardo ^a,b,i   Gnesutta, Nerina ^a,c   Minichiello, Liliana ^b   Klein, Rüdiger ^b   Sturani, Emmapaola ^c   White, Gail ^d   Chapman, Paul F ^d   Roylance, Alistair J ^e   Herron, Caroline E ^e   Grant, Seth G N ^e   Ramsey, Mark ^e   Wolfer, David P ^f   Lipp, Hans Peter ^f   Cestari, Vincenzo ^g   Rossi Arnaud, Clelia ^h  

^a European Molecular Biology Laboratory ^*

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c UNIVERSITY OF MILAN   (Italy)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f UNIVERSITY OF ZURICH   (Switzerland)

^g CNR   (Italy)

^h SAPIENZA UNIVERSITY OF ROME   (Italy)

ⁱ SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHOSPHOPROTEIN PHOSPHATASE; RAS PROTEIN;

AMYGDALOID NUCLEUS; ANIMAL; ARTICLE; AVOIDANCE BEHAVIOR; BEHAVIOR; BRAIN; C57BL MOUSE; CELL STRAIN 3T3; CONDITIONED REFLEX; ELECTROPHYSIOLOGY; FEAR; GENETICS; HIPPOCAMPUS; MAZE TEST; MEMORY; MOUSE; MUTAGENESIS; NERVE CELL PLASTICITY; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SYNAPSE; CANCER CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; ENZYME ACTIVATION; ENZYME ACTIVITY; LONG TERM MEMORY; MULTIGENE FAMILY; NEUROTRANSMISSION; ONCOGENE RAS; PLASTICITY; PRIORITY JOURNAL; SHORT TERM MEMORY; SYNAPTIC TRANSMISSION;

3T3 CELLS; AMYGDALA; ANIMALS; AVOIDANCE LEARNING; BRAIN; CELL CYCLE PROTEINS; CONDITIONING, CLASSICAL; ELECTROPHYSIOLOGY; FEAR; HIPPOCAMPUS; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; MUTAGENESIS; NEURONAL PLASTICITY; PHOSPHOPROTEIN PHOSPHATASE; RAS PROTEINS; RAS-GRF1; SIGNAL TRANSDUCTION; SPATIAL BEHAVIOR; SYNAPSES;

EID: 0031581209     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/36849     Document Type: Article

References (30)

1. Lowy, D. R. & Willumsen, B. M. Function and regulation of Ras. Annu. Rev. Biochem. 62, 851-891 (1993).
2. Martegani, E. etal. Cloningbyfunctional complementation ofa mouse cDNAencodingahomologue of CDC25, a Saccharomyces cerevisiae RAS activator. EMBO 11, 2151-2157 (1992).
3. Cen, H., Papageorge, A. G., Zippel, R., Lowy, D. R. & Zhang, K. Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24. EMBO J. 11, 4007-4015 (1992).
4. Shou, C., Farnsworth, B. G. N. & Feig, L. A. Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21. Nature 358, 351-354 (1992).
5. Farnsworth, C. L. et al. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature 376, 524-526 (1995).
6. Mm exchange factor by muscarinic receptors and G-protein ßy subunits. Nature 382, 268-272 (1996).
7. 2+-dependent routes to Ras: mechanisms for neuronal survival, differentiation, and plasticity? Neuron 16, 233-236 (1996).
8. Marshall, C. in Guidebook to the Small GTPases (eds Zerial, M. & Huber, L. A.) 65-73 (Oxford Univ. Press, 1995).
9. Pawson, T. Protein modules and signalling networks. Nature 373, 573-580 (1995).
10. Rosen, L. B., Ginty, D. D., Weber, M. J. & Greenberg, M. E. Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron 12, 1207-1221 (1994).
11. Zippel, R. et al. Ras-GRF, the activator of Ras, is expressed preferentially in mature neurons of the central nervous system. Mol. Brain Res. 48, 140-144 (1997).
12. Sturani, E. etal. The Ras guanine nucleotide exchange factor is present at the synaptic junction. Exp. CellRes. 235, 117-123 (1997).
13. Plass, C. et al. Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS-M. Nature Genet. 14, 106-109 (1996).
14. Celio, M. R. Calbindin D-28k and parvalbumin in the rat nervous system. Neuroscience 35, 375-475 (1990).
15. Büeler, H. et al. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature 356, 577-582 (1992).
16. Schutz, R. A. & Izquierdo, I. Effect of brain lesions on rat shuttle behavior in four different tests. Physiol. Behav. 23, 97-105 (1979).
17. Cahill, L. & McCaugh, J. L. Amygdaloid complex lesions differentially affect retention oftasks using appetitive and aversive reinforcement. Behav. Neurosci. 104, 532-543 (1990).
18. Kim, J.J. &Fanselow, M.S.Modality-specificretrogradeamnesiaoffear. Science 256, 675-677 (1992).
19. Morris, R. G. M. Place navigation impaired in rats with hippocampal lesions. Nature 297, 681-683 (1982).
20. Müller, U. et al. Behavioral and anatomical deficits in mice homozygous for a modified ß-amyloid precursor protein gene. Cell 79, 755-765 (1994).
21. Olton, D. S., Walker, J. A. & Gage, F. H. Hippocampal connections and spatial discrimination. Brain Res. 139, 215-308 (1978).
22. Martinez, J. L. &Derrick, B.E. Long-termpotentiation and learning. Annu. Rev. Psychol. 47, 173-203 (1996).
23. Chapman, P. F., Kairiss, E. W., Keenan, C. L. & Brown, T. H. Long-term synaptic potentiation in the amygdala. Synapse 6, 271 -278 (1990).
24. Zucker, R. S. Short-term synaptic plasticity. Annu. Rev. Neurosci. 12, 13-31 (1989).
25. LeDoux, J. E. Emotion: clues from the brain. Annu. Rev. Psychol. 46, 209-235 (1995).
26. Maren, S. & Fanselow, M. S. The amygdala and fear conditioning: has the nut been cracked? Neuron 16, 237-240 (1996).
27. Chapman, P. F. & Bellavance, L. L. Induction of long-term potentiation in the basolateral amygdala does not depend on NMDA receptor activation. Synapse 11, 310-318 (1992).
28. Watanabe, Y., Ikenaya, Y., Saito, H. &Abe, K. Roles of GABA(A), NMDA and muscarinic receptors in induction of long-term potentiation in the medial and lateral amygdala in vitro. Neurosci. Res. 21, 317-322 (1995).
29. Mayford, M., Abel, T. & Kandel, E. R. Transgenic approaches to cognition. Curr. Opin. Neurobiol. 5, 141-148 (1995).
30. Bourtchuladze, B. etal. Deficient long-term memory in mice with a targeted mutation ofthe cAMP-responsive element-binding protein. Cell 79, 59-68 (1994).