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Volumn 82, Issue 1-2, 1999, Pages 3-21

Ten years of gene targeting: Targeted mouse mutants, from vector design to phenotype analysis

Author keywords

Gene targeting; Genetic background; Homologous recombination; Inducible gene expression; Knockout; Modifier loci

Indexed keywords

GENE TARGETING; GENETIC ANALYSIS; GENETIC RECOMBINATION; KNOCKOUT MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

EID: 0342449328     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(99)00021-0     Document Type: Review
Times cited : (210)

References (150)
  • 1
    • 0029278832 scopus 로고
    • Site-specific integration of DNA into wild-type and mutant lox sites placed in the plant genome
    • Albert H., Dale E.C., Lee E., Ow D.W. Site-specific integration of DNA into wild-type and mutant lox sites placed in the plant genome. Plant Journal. 7:1995;649-659.
    • (1995) Plant Journal , vol.7 , pp. 649-659
    • Albert, H.1    Dale, E.C.2    Lee, E.3    Ow, D.W.4
  • 3
    • 0028928854 scopus 로고
    • Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase
    • Araki K., Araki M., Miyazaki J., Vassalli P. Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase. Proc. Natl. Acad. Sci. USA. 92:1995;160-164.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 160-164
    • Araki, K.1    Araki, M.2    Miyazaki, J.3    Vassalli, P.4
  • 4
    • 0030809406 scopus 로고    scopus 로고
    • Targeted integration of DNA using mutant lox sites in embryonic stem cells
    • Araki K., Araki M., Yamamura K. Targeted integration of DNA using mutant lox sites in embryonic stem cells. Nucleic Acids Res. 25:1997;868-872.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 868-872
    • Araki, K.1    Araki, M.2    Yamamura, K.3
  • 5
    • 0027316203 scopus 로고
    • Site-directed point mutations in embryonic stem cells: A gene-targeting tag-and-exchange strategy
    • Askew G.R., Doetschman T., Lingrel J.B. Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy. Mol. Cell. Biol. 13:1993;4115-4124.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4115-4124
    • Askew, G.R.1    Doetschman, T.2    Lingrel, J.B.3
  • 6
    • 0028607055 scopus 로고
    • Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice
    • Baribault H., Penner J., Iozzo R.V., Wilson-Heiner M. Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes Dev. 8:1994;2964-2973.
    • (1994) Genes Dev. , vol.8 , pp. 2964-2973
    • Baribault, H.1    Penner, J.2    Iozzo, R.V.3    Wilson-Heiner, M.4
  • 8
    • 0030839002 scopus 로고    scopus 로고
    • Segmental genomic replacement by Cre-mediated recombination: Genotoxic stress activation of the p53 promoter in single-copy transformants
    • Bethke, B., Sauer, B., 1997. Segmental genomic replacement by Cre-mediated recombination: genotoxic stress activation of the p53 promoter in single-copy transformants. Nucleic Acids Research 25(14), 2828-2834.
    • (1997) Nucleic Acids Research , vol.25 , Issue.14 , pp. 2828-2834
    • Bethke, B.1    Sauer, B.2
  • 9
    • 0030267396 scopus 로고    scopus 로고
    • Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination
    • Betz U.A., Vosshenrich C.A., Rajewsky K., Muller W. Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination. Curr. Biol. 6:1996;1307-1316.
    • (1996) Curr. Biol. , vol.6 , pp. 1307-1316
    • Betz, U.A.1    Vosshenrich, C.A.2    Rajewsky, K.3    Muller, W.4
  • 11
    • 0021358883 scopus 로고
    • Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
    • Bradley A., Evans M., Kaufman M.H., Robertson E. Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature. 309:1984;255-256.
    • (1984) Nature , vol.309 , pp. 255-256
    • Bradley, A.1    Evans, M.2    Kaufman, M.H.3    Robertson, E.4
  • 12
    • 0029163860 scopus 로고
    • Targeting the mouse genome: A compendium of knockouts
    • 758-765 (Part II), 873-881 (Part III)
    • Brandon, E.P., Idzerda, R.L., McKnight, G.S., 1995. Targeting the mouse genome: a compendium of knockouts. Curr. Biol. 5, 625-634 (Part I), 758-765 (Part II), 873-881 (Part III).
    • (1995) Curr. Biol. , vol.5 , Issue.PART I , pp. 625-634
    • Brandon, E.P.1    Idzerda, R.L.2    McKnight, G.S.3
  • 14
    • 0030951337 scopus 로고    scopus 로고
    • The origin and efficient derivation of embryonic stem cells in the mouse
    • Brook F.A., Gardner R.L. The origin and efficient derivation of embryonic stem cells in the mouse. Proc. Natl. Acad. Sci. USA. 94:1997;5709-5712.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5709-5712
    • Brook, F.A.1    Gardner, R.L.2
  • 15
    • 0029860719 scopus 로고    scopus 로고
    • Different thermostabilities of FLP and Cre recombinases: Implications for applied site-specific recombination
    • Buchholz F., Ringrose L., Angrand P.O., Rossi F., Stewart A.F. Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res. 24:1996;4256-4262.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4256-4262
    • Buchholz, F.1    Ringrose, L.2    Angrand, P.O.3    Rossi, F.4    Stewart, A.F.5
  • 17
    • 0030296634 scopus 로고    scopus 로고
    • Three-part inventions: Intracellular signaling and induced proximity
    • Crabtree G.R., Schreiber S.L. Three-part inventions: intracellular signaling and induced proximity. Trends Biochem. Sci. 21:1996;418-422.
    • (1996) Trends Biochem. Sci. , vol.21 , pp. 418-422
    • Crabtree, G.R.1    Schreiber, S.L.2
  • 18
    • 0029925695 scopus 로고    scopus 로고
    • Unusual behavioral phenotype of inbred mouse strains
    • Crawley J.N. Unusual behavioral phenotype of inbred mouse strains. Trends Neurosci. 19:1996;181-182.
    • (1996) Trends Neurosci. , vol.19 , pp. 181-182
    • Crawley, J.N.1
  • 20
    • 0026753186 scopus 로고
    • Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus
    • Deng C., Capecchi M.R. Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol. Cell. Biol. 12:1992;3365-3371.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 3365-3371
    • Deng, C.1    Capecchi, M.R.2
  • 21
    • 0027938450 scopus 로고
    • Deletion and replacement of the mouse adult beta-globin genes by a 'plug and socket' repeated targeting strategy
    • Detloff P.J., Lewis J., John S.W., Shehee W.R., Langenbach R., Maeda N., Smithies O. Deletion and replacement of the mouse adult beta-globin genes by a 'plug and socket' repeated targeting strategy. Mol. Cell. Biol. 14:1994;6936-6943.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6936-6943
    • Detloff, P.J.1    Lewis, J.2    John, S.W.3    Shehee, W.R.4    Langenbach, R.5    Maeda, N.6    Smithies, O.7
  • 22
    • 0032518158 scopus 로고    scopus 로고
    • Microinjection of Cre recombinase RNA induces site-specific recombination of a transgene inmouse oocytes
    • de Wit T., Drabek D., Grosveld F. Microinjection of Cre recombinase RNA induces site-specific recombination of a transgene inmouse oocytes. Nucleic Acids Res. 26:1998;676-678.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 676-678
    • De Wit, T.1    Drabek, D.2    Grosveld, F.3
  • 26
    • 0028003254 scopus 로고
    • Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expression
    • Dorin J.R., Stevenson B.J., Fleming S., Alton E.W., Dickinson P., Porteous D.J. Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expression. Mamm. Genome. 5:1994;465-472.
    • (1994) Mamm. Genome , vol.5 , pp. 465-472
    • Dorin, J.R.1    Stevenson, B.J.2    Fleming, S.3    Alton, E.W.4    Dickinson, P.5    Porteous, D.J.6
  • 27
    • 0029954688 scopus 로고    scopus 로고
    • FLP recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice
    • Dymecki S.M. FLP recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc. Natl. Acad. Sci. USA. 93:1996;6191-6196.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6191-6196
    • Dymecki, S.M.1
  • 28
    • 0030460933 scopus 로고    scopus 로고
    • Mouse models of human genetic disease: Which mouse is more like a man?
    • Erickson R.P. Mouse models of human genetic disease: which mouse is more like a man? Bioessays. 18:1996;993-998.
    • (1996) Bioessays , vol.18 , pp. 993-998
    • Erickson, R.P.1
  • 30
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • Evans M.J., Kaufmann M.H. Establishment in culture of pluripotential cells from mouse embryos. Nature. 292:1981;154-156.
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufmann, M.H.2
  • 32
    • 0000798118 scopus 로고    scopus 로고
    • Inbred strains of mice
    • Festing M. Inbred strains of mice. Mouse Genome. 94:1996;523-677.
    • (1996) Mouse Genome , vol.94 , pp. 523-677
    • Festing, M.1
  • 33
    • 0029091902 scopus 로고
    • Targeted deletion of 5′HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus
    • Fiering S., Epner E., Robinson K., Zhuang Y., Telling A., Hu M., Martin D.I., Enver T., Ley T.J., Groudine M. Targeted deletion of 5′HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev. 9:1995;2203-2213.
    • (1995) Genes Dev. , vol.9 , pp. 2203-2213
    • Fiering, S.1    Epner, E.2    Robinson, K.3    Zhuang, Y.4    Telling, A.5    Hu, M.6    Martin, D.I.7    Enver, T.8    Ley, T.J.9    Groudine, M.10
  • 35
    • 0025992469 scopus 로고
    • Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice
    • Friedrich G., Soriano P. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5:1991;1513-1523.
    • (1991) Genes Dev. , vol.5 , pp. 1513-1523
    • Friedrich, G.1    Soriano, P.2
  • 36
    • 0029940557 scopus 로고    scopus 로고
    • Gene-targeting studies of mammalian behavior: Is it the mutation or the background genotype?
    • Gerlai R. Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci. 19:1996;177-181.
    • (1996) Trends Neurosci. , vol.19 , pp. 177-181
    • Gerlai, R.1
  • 37
    • 0031898727 scopus 로고    scopus 로고
    • Inducible gene expression in the nervous system of transgenic mice
    • Gingrich J.R., Roder J. Inducible gene expression in the nervous system of transgenic mice. Annu. Rev. Neurosci. 21:1998;377-405.
    • (1998) Annu. Rev. Neurosci. , vol.21 , pp. 377-405
    • Gingrich, J.R.1    Roder, J.2
  • 38
    • 0025907542 scopus 로고
    • Site-specific recombination between homologous chromosomes in Drosophila
    • Golic K.G. Site-specific recombination between homologous chromosomes in Drosophila. Science. 252:1991;958-961.
    • (1991) Science , vol.252 , pp. 958-961
    • Golic, K.G.1
  • 39
    • 0030848338 scopus 로고    scopus 로고
    • Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: A model for Duchenne muscular dystrophy
    • Grady R.M., Teng H., Nichol M.C., Cunningham J.C., Wilkinson R.S., Sanes J.R. Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy. Cell. 90:1997;729-738.
    • (1997) Cell , vol.90 , pp. 729-738
    • Grady, R.M.1    Teng, H.2    Nichol, M.C.3    Cunningham, J.C.4    Wilkinson, R.S.5    Sanes, J.R.6
  • 40
    • 0028059099 scopus 로고
    • Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
    • Gu H., Marth J.D., Orban P.C., Mossmann H., Rajewsky K. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science. 265:1994;103-106.
    • (1994) Science , vol.265 , pp. 103-106
    • Gu, H.1    Marth, J.D.2    Orban, P.C.3    Mossmann, H.4    Rajewsky, K.5
  • 42
    • 0026429190 scopus 로고
    • Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells
    • Hasty P., Ramirez-Solis R., Krumlauf R., Bradley A. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature. 350:1991;243-246.
    • (1991) Nature , vol.350 , pp. 243-246
    • Hasty, P.1    Ramirez-Solis, R.2    Krumlauf, R.3    Bradley, A.4
  • 43
    • 0025943412 scopus 로고
    • The length of homology required for gene targeting in embryonic stem cells
    • Hasty P., Rivera-Perez J., Bradley A. The length of homology required for gene targeting in embryonic stem cells. Mol. Cell. Biol. 11:1991;5586-5591.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 5586-5591
    • Hasty, P.1    Rivera-Perez, J.2    Bradley, A.3
  • 44
    • 0029556979 scopus 로고
    • T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination
    • Hennet T., Hagen F.K., Tabak L.A., Marth J.D. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc. Natl. Acad. Sci. USA. 92:1995;12070-12074.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 12070-12074
    • Hennet, T.1    Hagen, F.K.2    Tabak, L.A.3    Marth, J.D.4
  • 47
  • 51
    • 0003483954 scopus 로고    scopus 로고
    • (Ed.), Oxford University Press, New York. Second edition, in press
    • Joyner, A.L. (Ed.), 1998. Gene Targeting: a Practical Approach. Oxford University Press, New York. Second edition, in press.
    • (1998) Gene Targeting: A Practical Approach
    • Joyner, A.L.1
  • 54
    • 0027422291 scopus 로고
    • Site-specific recombinases: Tools for genome engineering
    • Kilby N.J., Snaith M.R., Murray J.A. Site-specific recombinases: tools for genome engineering. Trends Genet. 9:1993;413-421.
    • (1993) Trends Genet. , vol.9 , pp. 413-421
    • Kilby, N.J.1    Snaith, M.R.2    Murray, J.A.3
  • 55
    • 0029816051 scopus 로고    scopus 로고
    • A novel strategy for the negative selection in mouse embryonic stem cells operated with immunotoxin-mediated cell targeting
    • Kobayashi K., Ohye T., Pastan I., Nagatsu T. A novel strategy for the negative selection in mouse embryonic stem cells operated with immunotoxin-mediated cell targeting. Nucleic Acids Res. 24:1996;3653-3655.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 3653-3655
    • Kobayashi, K.1    Ohye, T.2    Pastan, I.3    Nagatsu, T.4
  • 59
    • 0028090414 scopus 로고
    • Genetic dissection of complex traits
    • Lander E.S., Schork N.J. Genetic dissection of complex traits. Science. 265:1994;2037-2048.
    • (1994) Science , vol.265 , pp. 2037-2048
    • Lander, E.S.1    Schork, N.J.2
  • 60
    • 0030011889 scopus 로고    scopus 로고
    • Mice, gene targeting and behaviour: More than just genetic background
    • Lathe R. Mice, gene targeting and behaviour: more than just genetic background. Trends Neurosci. 19:1996;183-186.
    • (1996) Trends Neurosci. , vol.19 , pp. 183-186
    • Lathe, R.1
  • 61
    • 0026317793 scopus 로고
    • Establishment of a germ-line competent C57BL/6 embryonic stem cell line
    • Ledermann B., Burki K. Establishment of a germ-line competent C57BL/6 embryonic stem cell line. Exp. Cell Res. 197:1991;254-258.
    • (1991) Exp. Cell Res. , vol.197 , pp. 254-258
    • Ledermann, B.1    Burki, K.2
  • 62
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li E., Bestor T.H., Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 69:1992;915-926.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 63
    • 0029954239 scopus 로고    scopus 로고
    • Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells
    • Li Z.W., Stark G., Gotz J., Rulicke T., Gschwind M., Huber G., Muller U., Weissmann C. Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells. Proc. Natl. Acad. Sci. USA. 93:1996;6158-6162.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6158-6162
    • Li, Z.W.1    Stark, G.2    Gotz, J.3    Rulicke, T.4    Gschwind, M.5    Huber, G.6    Muller, U.7    Weissmann, C.8
  • 64
    • 0030878873 scopus 로고    scopus 로고
    • Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen
    • Liberles S.D., Diver S.T., Austin D.J., Schreiber S.L. Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen. Proc. Natl. Acad. Sci. USA. 94:1997;7825-7830.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 7825-7830
    • Liberles, S.D.1    Diver, S.T.2    Austin, D.J.3    Schreiber, S.L.4
  • 65
    • 0033551143 scopus 로고    scopus 로고
    • Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the β-amyloid-precursor protein
    • in press
    • Magara, F., Müller, U., Lipp, H.P., Weissmann, C., Stagliar, M., Wolfer, D.P., 1999. Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the β-amyloid-precursor protein. Proc. Natl. Acad. Sci. USA, in press.
    • (1999) Proc. Natl. Acad. Sci. USA
    • Magara, F.1    Müller, U.2    Lipp, H.P.3    Weissmann, C.4    Stagliar, M.5    Wolfer, D.P.6
  • 66
    • 0027500633 scopus 로고
    • Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
    • Mansour S.L., Goddard J.M., Capecchi M.R. Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development. 117:1993;13-28.
    • (1993) Development , vol.117 , pp. 13-28
    • Mansour, S.L.1    Goddard, J.M.2    Capecchi, M.R.3
  • 67
    • 0024296027 scopus 로고
    • Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
    • Mansour S.L., Thomas K.R., Capecchi M.R. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature. 336:1988;348-352.
    • (1988) Nature , vol.336 , pp. 348-352
    • Mansour, S.L.1    Thomas, K.R.2    Capecchi, M.R.3
  • 68
    • 0001007610 scopus 로고
    • Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
    • Martin G.R. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci. USA. 78:1981;7634-7638.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 7634-7638
    • Martin, G.R.1
  • 69
    • 0030215316 scopus 로고    scopus 로고
    • PCR-analyzed microsatellites for the inbred mouse strain 129/Sv, the strain most commonly used in gene knockout technology
    • Matouk C., Gosselin D., Malo D., Skamene E., Radzioch D. PCR-analyzed microsatellites for the inbred mouse strain 129/Sv, the strain most commonly used in gene knockout technology. Mamm. Genome. 7:1996;603-605.
    • (1996) Mamm. Genome , vol.7 , pp. 603-605
    • Matouk, C.1    Gosselin, D.2    Malo, D.3    Skamene, E.4    Radzioch, D.5
  • 70
    • 0026621796 scopus 로고
    • Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice
    • Matzuk M.M., Finegold M.J., Su J.G., Hsueh A.J., Bradley A. Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature. 360:1992;313-319.
    • (1992) Nature , vol.360 , pp. 313-319
    • Matzuk, M.M.1    Finegold, M.J.2    Su, J.G.3    Hsueh, A.J.4    Bradley, A.5
  • 71
    • 0029807527 scopus 로고    scopus 로고
    • Control of memory formation through regulated expression of a CaMKII transgene
    • Mayford M., Bach M.E., Huang Y.Y., Wang L., Hawkins R.D., Kandel E.R. Control of memory formation through regulated expression of a CaMKII transgene. Science. 274:1996;1678-1683.
    • (1996) Science , vol.274 , pp. 1678-1683
    • Mayford, M.1    Bach, M.E.2    Huang, Y.Y.3    Wang, L.4    Hawkins, R.D.5    Kandel, E.R.6
  • 72
    • 0029798044 scopus 로고    scopus 로고
    • Selective ablation of differentiated cells permits isolation of embryonic stem cell lines from murine embryos with a non-permissive genetic background
    • McWhir J., Schnieke A.E., Ansell R., Wallace H., Colman A., Scott A.R., Kind A.J. Selective ablation of differentiated cells permits isolation of embryonic stem cell lines from murine embryos with a non-permissive genetic background. Nature Genet. 14:1996;223-226.
    • (1996) Nature Genet. , vol.14 , pp. 223-226
    • McWhir, J.1    Schnieke, A.E.2    Ansell, R.3    Wallace, H.4    Colman, A.5    Scott, A.R.6    Kind, A.J.7
  • 73
    • 0028953604 scopus 로고
    • Intra-chromosomal rearrangements generated by Cre-lox site-specific recombination
    • Medberry S.L., Dale E., Qin M., Ow D.W. Intra-chromosomal rearrangements generated by Cre-lox site-specific recombination. Nucleic Acids Res. 23:1995;485-490.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 485-490
    • Medberry, S.L.1    Dale, E.2    Qin, M.3    Ow, D.W.4
  • 74
    • 0031916557 scopus 로고    scopus 로고
    • An Fgf8 mutant allelic series generated by Cre- And FLP-mediated recombination
    • Meyers E.N., Lewandoski M., Martin G.R. An Fgf8 mutant allelic series generated by Cre- and FLP-mediated recombination. Nature Genet. 18:1998;136-141.
    • (1998) Nature Genet. , vol.18 , pp. 136-141
    • Meyers, E.N.1    Lewandoski, M.2    Martin, G.R.3
  • 75
    • 0026628060 scopus 로고
    • A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung
    • Moens C.B., Auerbach A.B., Conlon R.A., Joyner A.L., Rossant J. A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung. Genes Dev. 6:1992;691-704.
    • (1992) Genes Dev. , vol.6 , pp. 691-704
    • Moens, C.B.1    Auerbach, A.B.2    Conlon, R.A.3    Joyner, A.L.4    Rossant, J.5
  • 76
    • 0029092955 scopus 로고
    • Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations
    • Moore R.C., Redhead N.J., Selfridge J., Hope J., Manson J.C., Melton D.W. Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations. Biotechnology. 13:1995;999-1004.
    • (1995) Biotechnology , vol.13 , pp. 999-1004
    • Moore, R.C.1    Redhead, N.J.2    Selfridge, J.3    Hope, J.4    Manson, J.C.5    Melton, D.W.6
  • 80
    • 0029865151 scopus 로고    scopus 로고
    • Ecdysone-inducible gene expression in mammalian cells and transgenic mice
    • No D., Yao T.P., Evans R.M. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl. Acad. Sci. USA. 93:1996;3346-3351.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3346-3351
    • No, D.1    Yao, T.P.2    Evans, R.M.3
  • 81
    • 0031443874 scopus 로고    scopus 로고
    • Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells
    • O'Gorman S., Dagenais N.A., Qian M., Marchuk Y. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc. Natl. Acad. Sci. USA. 94:1997;14602-14607.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14602-14607
    • O'Gorman, S.1    Dagenais, N.A.2    Qian, M.3    Marchuk, Y.4
  • 82
    • 0028178518 scopus 로고
    • Targeted disruption of the CD3 eta locus causes high lethality in mice: Modulation of Oct-1 transcription on the opposite strand
    • Ohno H., Goto S., Taki S., Shirasawa T., Nakano H., Miyatake S., Aoe T., Ishida Y., Maeda H., Shirai T. Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand. EMBO J. 13:1994;1157-1165.
    • (1994) EMBO J. , vol.13 , pp. 1157-1165
    • Ohno, H.1    Goto, S.2    Taki, S.3    Shirasawa, T.4    Nakano, H.5    Miyatake, S.6    Aoe, T.7    Ishida, Y.8    Maeda, H.9    Shirai, T.10
  • 83
    • 0029993449 scopus 로고    scopus 로고
    • Know your neighbors: Three phenotypes in null mutants of the myogenic bHLH gene MRF4
    • Olson E.N., Arnold H.H., Rigby P.W., Wold B.J. Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell. 85:1996;1-4.
    • (1996) Cell , vol.85 , pp. 1-4
    • Olson, E.N.1    Arnold, H.H.2    Rigby, P.W.3    Wold, B.J.4
  • 84
    • 0025054185 scopus 로고
    • Formation of germ-line chimeras from embryonic stem cells maintained with recombinant leukemia inhibitory factor
    • Pease S., Williams R.L. Formation of germ-line chimeras from embryonic stem cells maintained with recombinant leukemia inhibitory factor. Exp. Cell Res. 190:1990;209-211.
    • (1990) Exp. Cell Res. , vol.190 , pp. 209-211
    • Pease, S.1    Williams, R.L.2
  • 86
    • 0028114235 scopus 로고
    • Regulation of protein function through expression of chimaeric proteins
    • Picard D. Regulation of protein function through expression of chimaeric proteins. Curr. Opin. Biotech. 5:1994;511-515.
    • (1994) Curr. Opin. Biotech. , vol.5 , pp. 511-515
    • Picard, D.1
  • 88
    • 0029562967 scopus 로고
    • Chromosome engineering in mice
    • Ramirez-Solis R., Liu P., Bradley A. Chromosome engineering in mice. Nature. 378:1995;720-724.
    • (1995) Nature , vol.378 , pp. 720-724
    • Ramirez-Solis, R.1    Liu, P.2    Bradley, A.3
  • 89
    • 0027189536 scopus 로고
    • Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments
    • Ramirez-Solis R., Zheng H., Whiting J., Krumlauf R., Bradley A. Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell. 73:1993;279-794.
    • (1993) Cell , vol.73 , pp. 279-794
    • Ramirez-Solis, R.1    Zheng, H.2    Whiting, J.3    Krumlauf, R.4    Bradley, A.5
  • 91
    • 0030818183 scopus 로고    scopus 로고
    • B lymphocyte-specific, Cre-mediated mutagenesis in mice
    • Rickert R.C., Roes J., Rajewsky K. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25:1997;1317-1378.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 1317-1378
    • Rickert, R.C.1    Roes, J.2    Rajewsky, K.3
  • 92
    • 0028606333 scopus 로고
    • Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression
    • Rijli F.M., Dolle P., Fraulob V., LeMeur M., Chambon P. Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression. Dev. Dynam. 201:1994;366-377.
    • (1994) Dev. Dynam. , vol.201 , pp. 366-377
    • Rijli, F.M.1    Dolle, P.2    Fraulob, V.3    LeMeur, M.4    Chambon, P.5
  • 94
  • 96
    • 0026440992 scopus 로고
    • Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development
    • Rudnicki M.A., Braun T., Hinuma S., Jaenisch R. Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development. Cell. 71:1992;383-390.
    • (1992) Cell , vol.71 , pp. 383-390
    • Rudnicki, M.A.1    Braun, T.2    Hinuma, S.3    Jaenisch, R.4
  • 97
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B., Merz H., Schorle H., Schimpl A., Feller A.C., Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 75:1993;253-261.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 98
    • 0021702488 scopus 로고
    • Expression of prokaryotic genes for hygromycin B and G418 resistance as dominant-selection markers in mouse L cells
    • Santerre R.F., Allen N.E., Hobbs J.N. Jr., Rao R.N., Schmidt R.J. Expression of prokaryotic genes for hygromycin B and G418 resistance as dominant-selection markers in mouse L cells. Gene. 30:1984;147-156.
    • (1984) Gene , vol.30 , pp. 147-156
    • Santerre, R.F.1    Allen, N.E.2    Hobbs J.N., Jr.3    Rao, R.N.4    Schmidt, R.J.5
  • 99
    • 0025360095 scopus 로고
    • Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase
    • Sauer B., Henderson N. Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase. New Biol. 2:1990;441-449.
    • (1990) New Biol. , vol.2 , pp. 441-449
    • Sauer, B.1    Henderson, N.2
  • 100
    • 0030887853 scopus 로고    scopus 로고
    • Genetic determinants of susceptibility to excitotoxic cell death: Implications for gene targeting approaches
    • Schauwecker P.E., Steward O. Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches. Proc. Natl. Acad. Sci. USA. 94:1997;4103-4108.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4103-4108
    • Schauwecker, P.E.1    Steward, O.2
  • 102
    • 0029670584 scopus 로고    scopus 로고
    • Efficient control of gene expression by single step integration of the tetracycline system in transgenic mice
    • Schultze N., Burki Y., Lang Y., Certa U., Bluethmann H. Efficient control of gene expression by single step integration of the tetracycline system in transgenic mice. Nature Biotech. 14:1996;499-503.
    • (1996) Nature Biotech. , vol.14 , pp. 499-503
    • Schultze, N.1    Burki, Y.2    Lang, Y.3    Certa, U.4    Bluethmann, H.5
  • 103
    • 0024473608 scopus 로고
    • Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells
    • Schwartzberg P.L., Goff S.P., Robertson E.J. Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. Science. 246:1989;799-803.
    • (1989) Science , vol.246 , pp. 799-803
    • Schwartzberg, P.L.1    Goff, S.P.2    Robertson, E.J.3
  • 104
    • 0020674749 scopus 로고
    • Hereditary covariations of neuronal circuitry and behavior: Correlations between the proportions of hippocampal synaptic fields in the region inferior and two-way avoidance in mice and rats
    • Schwegler H., Lipp H.P. Hereditary covariations of neuronal circuitry and behavior: correlations between the proportions of hippocampal synaptic fields in the region inferior and two-way avoidance in mice and rats. Behav. Brain Res. 7:1983;1-38.
    • (1983) Behav. Brain Res. , vol.7 , pp. 1-38
    • Schwegler, H.1    Lipp, H.P.2
  • 106
    • 0030662479 scopus 로고    scopus 로고
    • Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains
    • Schwenk F., Sauer B., Kukoc N., Hoess R., Muller W., Kocks C., Kuhn R., Rajewsky K. Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains. J. Immunol. Methods. 207:1997;203-212.
    • (1997) J. Immunol. Methods , vol.207 , pp. 203-212
    • Schwenk, F.1    Sauer, B.2    Kukoc, N.3    Hoess, R.4    Muller, W.5    Kocks, C.6    Kuhn, R.7    Rajewsky, K.8
  • 107
    • 0029566108 scopus 로고
    • A Cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells
    • Schwenk F., Baron U., Rajewsky K. A Cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23:1995;5080-5081.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 5080-5081
    • Schwenk, F.1    Baron, U.2    Rajewsky, K.3
  • 110
    • 0029951481 scopus 로고    scopus 로고
    • Diverse strategies for tetracycline-regulated inducible gene expression
    • Shockett P.E., Schatz D.G. Diverse strategies for tetracycline-regulated inducible gene expression. Proc. Natl. Acad. Sci. USA. 93:1996;5173-5176.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 5173-5176
    • Shockett, P.E.1    Schatz, D.G.2
  • 111
    • 0029045856 scopus 로고
    • Strain-dependent epithelial defects in mice lacking the EGF receptor
    • Sibilia M., Wagner E.F. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science. 269:1995;234-238.
    • (1995) Science , vol.269 , pp. 234-238
    • Sibilia, M.1    Wagner, E.F.2
  • 113
    • 0030777698 scopus 로고    scopus 로고
    • Mutant mice and neuroscience: Recommendations concerning genetic background. Banbury conference on genetic background in mice
    • Silva A.J. Mutant mice and neuroscience: recommendations concerning genetic background. Banbury conference on genetic background in mice. Neuron. 19:1997;755-759.
    • (1997) Neuron , vol.19 , pp. 755-759
    • Silva, A.J.1
  • 116
    • 0022389290 scopus 로고
    • Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination
    • Smithies O., Gregg R.G., Boggs S.S., Koralewski M.A., Kucherlapati R.S. Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature. 317:1985;230-234.
    • (1985) Nature , vol.317 , pp. 230-234
    • Smithies, O.1    Gregg, R.G.2    Boggs, S.S.3    Koralewski, M.A.4    Kucherlapati, R.S.5
  • 117
    • 0029788269 scopus 로고    scopus 로고
    • Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter
    • St-Onge L., Furth P.A., Gruss P. Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter. Nucleic Acids Res. 24:1996;3875-3877.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 3875-3877
    • St-Onge, L.1    Furth, P.A.2    Gruss, P.3
  • 118
    • 0028158627 scopus 로고
    • Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice
    • Stacey A., Schnieke A., McWhir J., Cooper J., Colman A., Melton D.W. Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice. Mol. Cell. Biol. 14:1994;1009-1016.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1009-1016
    • Stacey, A.1    Schnieke, A.2    McWhir, J.3    Cooper, J.4    Colman, A.5    Melton, D.W.6
  • 119
    • 0027066738 scopus 로고
    • Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop
    • Stanton B.R., Perkins A.S., Tessarollo L., Sassoon D.A., Parada L.F. Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev. 6:1992;2235-2247.
    • (1992) Genes Dev. , vol.6 , pp. 2235-2247
    • Stanton, B.R.1    Perkins, A.S.2    Tessarollo, L.3    Sassoon, D.A.4    Parada, L.F.5
  • 120
    • 0028170518 scopus 로고
    • Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice
    • Stein P.L., Vogel H., Soriano P. Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. Genes Dev. 8:1994;1999-2007.
    • (1994) Genes Dev. , vol.8 , pp. 1999-2007
    • Stein, P.L.1    Vogel, H.2    Soriano, P.3
  • 122
    • 0026771287 scopus 로고
    • Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs
    • te Riele H., Maandag E.R., Berns A. Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. Proc. Natl. Acad. Sci. USA. 89:1992;5128-5132.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5128-5132
    • Te Riele, H.1    Maandag, E.R.2    Berns, A.3
  • 123
    • 0029740354 scopus 로고    scopus 로고
    • Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice
    • Telling G.C., Haga T., Torchia M., Tremblay P., DeArmond S.J., Prusiner S.B. Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice. Genes Dev. 10:1996;1736-1750.
    • (1996) Genes Dev. , vol.10 , pp. 1736-1750
    • Telling, G.C.1    Haga, T.2    Torchia, M.3    Tremblay, P.4    DeArmond, S.J.5    Prusiner, S.B.6
  • 124
    • 0028882424 scopus 로고
    • Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
    • Telling G.C., Scott M., Mastrianni J., Gabizon R., Torchia M., Cohen F.E., DeArmond S.J., Prusiner S.B. Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein. Cell. 83:1995;79-90.
    • (1995) Cell , vol.83 , pp. 79-90
    • Telling, G.C.1    Scott, M.2    Mastrianni, J.3    Gabizon, R.4    Torchia, M.5    Cohen, F.E.6    DeArmond, S.J.7    Prusiner, S.B.8
  • 126
    • 0031239469 scopus 로고    scopus 로고
    • Cre-mediated generation of a VCAM-1 null allele in transgenic mice
    • Terry R.W., Kwee L., Baldwin H.S., Labow M.A. Cre-mediated generation of a VCAM-1 null allele in transgenic mice. Trans. Res. 6:1997;349-356.
    • (1997) Trans. Res. , vol.6 , pp. 349-356
    • Terry, R.W.1    Kwee, L.2    Baldwin, H.S.3    Labow, M.A.4
  • 127
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • Thomas K.R., Capecchi M.R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell. 51:1987;503-512.
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 131
    • 0023866498 scopus 로고
    • Differences between inbred strains of mice in Moriis water maze performance
    • Upchurch M., Wehner J.M. Differences between inbred strains of mice in Moriis water maze performance. Behav. Genet. 18:1988;55-68.
    • (1988) Behav. Genet. , vol.18 , pp. 55-68
    • Upchurch, M.1    Wehner, J.M.2
  • 132
    • 0026100231 scopus 로고
    • Testing an 'in-out' targeting procedure for making subtle genomic modifications in mouse embryonic stem cells
    • Valancius V., Smithies O. Testing an 'in-out' targeting procedure for making subtle genomic modifications in mouse embryonic stem cells. Mol. Cell. Biol. 11:1991;1402-1408.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 1402-1408
    • Valancius, V.1    Smithies, O.2
  • 133
    • 0029077692 scopus 로고
    • Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors
    • van den Broek M.F., Muller U., Huang S., Aguet M., Zinkernagel R.M. Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors. J. Virol. 69:1995;4792-4796.
    • (1995) J. Virol. , vol.69 , pp. 4792-4796
    • Van Den Broek, M.F.1    Muller, U.2    Huang, S.3    Aguet, M.4    Zinkernagel, R.M.5
  • 134
  • 138
    • 0030025046 scopus 로고    scopus 로고
    • Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin
    • Wang Y., Schnegelsberg P.N., Dausman J., Jaenisch R. Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin. Nature. 379:1996;823-825.
    • (1996) Nature , vol.379 , pp. 823-825
    • Wang, Y.1    Schnegelsberg, P.N.2    Dausman, J.3    Jaenisch, R.4
  • 139
    • 0030965628 scopus 로고    scopus 로고
    • Ligand-inducible and liver-specific target gene expression in transgenic mice
    • Wang Y., DeMayo F.J., Tsai S.Y., O'Malley B.W. Ligand-inducible and liver-specific target gene expression in transgenic mice. Nature Biotechnol. 15:1997;239-243.
    • (1997) Nature Biotechnol. , vol.15 , pp. 239-243
    • Wang, Y.1    DeMayo, F.J.2    Tsai, S.Y.3    O'Malley, B.W.4
  • 140
    • 0000218874 scopus 로고    scopus 로고
    • Importance of strain differences in evaluation of learning and memory processes in null mutants
    • Wehner J.M., Silva A. Importance of strain differences in evaluation of learning and memory processes in null mutants. Ment. Retard. Dev. Disab. Res Rev. 2:1996;243-248.
    • (1996) Ment. Retard. Dev. Disab. Res Rev. , vol.2 , pp. 243-248
    • Wehner, J.M.1    Silva, A.2
  • 141
  • 143
    • 0038025431 scopus 로고    scopus 로고
    • Assessing the effects of the 129/Sv genetic background on swimming navigation learning in transgenic mutants: A study using mice with a modified beta-amyloid precursor protein gene
    • Wolfer D.P., Muller U., Stagliar M., Lipp H.P. Assessing the effects of the 129/Sv genetic background on swimming navigation learning in transgenic mutants: a study using mice with a modified beta-amyloid precursor protein gene. Brain Res. 771:1997;1-13.
    • (1997) Brain Res. , vol.771 , pp. 1-13
    • Wolfer, D.P.1    Muller, U.2    Stagliar, M.3    Lipp, H.P.4
  • 144
    • 0027461605 scopus 로고
    • Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice
    • Wu C.L., Melton D.W. Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice. Nature Genet. 3:1993;235-240.
    • (1993) Nature Genet. , vol.3 , pp. 235-240
    • Wu, C.L.1    Melton, D.W.2
  • 145
    • 0025672645 scopus 로고
    • Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection
    • Yagi T., Ikawa Y., Yoshida K., Shigetani Y., Takeda N., Mabuchi I., Yamamoto T., Aizawa S. Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection. Proc. Natl. Acad. Sci. USA. 87:1990;9918-9992.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 9918-9992
    • Yagi, T.1    Ikawa, Y.2    Yoshida, K.3    Shigetani, Y.4    Takeda, N.5    Mabuchi, I.6    Yamamoto, T.7    Aizawa, S.8
  • 149
    • 0028675511 scopus 로고
    • Cre-loxP-mediated gene replacement: A mouse strain producing humanized antibodies
    • Zou Y.R., Muller W., Gu H., Rajewsky K. Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies. Curr. Biol. 4:1994;1099-1203.
    • (1994) Curr. Biol. , vol.4 , pp. 1099-1203
    • Zou, Y.R.1    Muller, W.2    Gu, H.3    Rajewsky, K.4
  • 150
    • 0032554790 scopus 로고    scopus 로고
    • Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system
    • Zinyk D.L., Mercer E.H., Harris E., Anderson D.J., Joyner A.L. Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system. Curr. Biol. 8:1998;665-668.
    • (1998) Curr. Biol. , vol.8 , pp. 665-668
    • Zinyk, D.L.1    Mercer, E.H.2    Harris, E.3    Anderson, D.J.4    Joyner, A.L.5


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