Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning

Science

Volumn 284, Issue 5421, 1999, Pages 1805-1811

  Zamanillo, Daniel ^a,e   Sprengel, Rolf ^a   Hvalby, Øivind ^f   Jensen, Vidar ^f   Burnashev, Nail ^a   Rozov, Andrei ^a   Kaiser, Katharina M M ^a   Köster, Helmut J ^a   Borchardt, Thilo ^a   Worley, Paul ^b   Lübke, Joachim ^c   Frotscher, Michael ^c   Kelly, Peter H ^d   Sommer, Bernd ^d   Andersen, Per ^f   Seeburg, Peter H ^a   Sakmann, Bert ^a  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d NOVARTIS PHARMA AG   (Switzerland)

^e Laboratorios Dr Esteve SA   (Spain)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; CALCIUM ION; GLUTAMATE RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CALCIUM CURRENT; CONTROLLED STUDY; GENE ACTIVATION; LEARNING; LONG TERM POTENTIATION; MAZE TEST; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PYRAMIDAL NERVE CELL; SPATIAL MEMORY; DENDRITE; HIPPOCAMPUS; LIFE EXPECTANCY; SYNAPSE;

ACTION POTENTIALS; ANIMALS; BICUCULLINE; CALCIUM; DENDRITES; GABA ANTAGONISTS; GENE EXPRESSION; GENE TARGETING; GENES, IMMEDIATE-EARLY; GLUTAMIC ACID; HIPPOCAMPUS; LONG-TERM POTENTIATION; MAZE LEARNING; MICE; MICE, INBRED C57BL; PYRAMIDAL CELLS; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 0033546059     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.284.5421.1805     Document Type: Article

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66. Supported in part by the Volkswagen-Stiftung (R.S., P.H.S., B.S.), the Deutsche Forschungsgemeinschaft (P.H.S.), and Bristol-Myers Squibb (P.H.S.). We thank H. Cu for the plasmid pMC-Cre, A. Nagy for the R1 ES cell line, R. Morrison and J. R. Wenthold for providing antibodies, and M. Lang, A. Herold, S. Nestel, and B. Joch for technical assistance. D.Z. was the recipient of a postdoctoral fellowship from the Human Frontier Science Program.