-
1
-
-
0024317904
-
Prevalence of Alzheimer's disease in a community population of older persons: Higher than previously reported
-
Evans DA, Funkenstein HH, Albert MS, et al. Prevalence of Alzheimer's disease in a community population of older persons: higher than previously reported. JAMA 1989; 262 (18): 2551-6
-
(1989)
JAMA
, vol.262
, Issue.18
, pp. 2551-2556
-
-
Evans, D.A.1
Funkenstein, H.H.2
Albert, M.S.3
-
2
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
-
McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34 (7): 939-44
-
(1984)
Neurology
, vol.34
, Issue.7
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
-
3
-
-
0027156194
-
The human life span: Are we reaching the outer limits?
-
Olshansky SJ. The human life span: are we reaching the outer limits? Geriatrics 1993; 48 (3): 85-8
-
(1993)
Geriatrics
, vol.48
, Issue.3
, pp. 85-88
-
-
Olshansky, S.J.1
-
6
-
-
0028856460
-
Uber eine eigenartige erkankung der hirnrinde
-
Stelzmann RA, Schnitzlein HN, Murtagh FR. An English translation of Alzheimer's 1907 paper, "Uber eine eigenartige Erkankung der Hirnrinde". Clin Anat 1995; 8 (6): 429-31
-
(1995)
Clin Anat
, vol.8
, Issue.6
, pp. 429-431
-
-
Stelzmann, R.A.1
Schnitzlein, H.N.2
Murtagh, F.R.3
-
7
-
-
0030460740
-
Cognitive and neurobiologic markers of early Alzheimer's disease
-
Albert MS. Cognitive and neurobiologic markers of early Alzheimer's disease. Proc Natl Acad Sci U S A 1996; 93: 13547-51
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 13547-13551
-
-
Albert, M.S.1
-
8
-
-
0029901361
-
Physical aggression is associated with preservation of substantia nigra pars compacta in Alzheimer disease
-
Victoroff J, Zarow C, Mack WJ, et al. Physical aggression is associated with preservation of substantia nigra pars compacta in Alzheimer disease. Arch Neurol 1996; 53 (5): 428-34
-
(1996)
Arch Neurol
, vol.53
, Issue.5
, pp. 428-434
-
-
Victoroff, J.1
Zarow, C.2
Mack, W.J.3
-
9
-
-
0020072221
-
Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
-
Whitehouse PJ, Price DL, Struble RG, et al. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 1982; 215 (4537): 1237-9
-
(1982)
Science
, vol.215
, Issue.4537
, pp. 1237-1239
-
-
Whitehouse, P.J.1
Price, D.L.2
Struble, R.G.3
-
10
-
-
0030698871
-
Life and death of neurons in the aging brain
-
Morrison JH, Hof PR. Life and death of neurons in the aging brain. Science 1997; 278 (5337): 412-9
-
(1997)
Science
, vol.278
, Issue.5337
, pp. 412-419
-
-
Morrison, J.H.1
Hof, P.R.2
-
11
-
-
0025717816
-
The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
-
Arnold SE, Hyman BT, Flory J, et al. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereb Cortex 1991; 1 (1): 103-16
-
(1991)
Cereb Cortex
, vol.1
, Issue.1
, pp. 103-116
-
-
Arnold, S.E.1
Hyman, B.T.2
Flory, J.3
-
12
-
-
0021145680
-
Alzheimer's disease: Cell-specific pathology isolates the hippocampus formation
-
Hyman BT, Van Hoesen GW, Damasio AR, et al. Alzheimer's disease: cell-specific pathology isolates the hippocampus formation. Science 1984; 225: 1168-70
-
(1984)
Science
, vol.225
, pp. 1168-1170
-
-
Hyman, B.T.1
Van Hoesen, G.W.2
Damasio, A.R.3
-
13
-
-
0029817690
-
Atrophy of hippocampus in patients with Alzheimer's disease and other diseases with memory impairment
-
Horn R, Ostertun B, Fric M, et al. Atrophy of hippocampus in patients with Alzheimer's disease and other diseases with memory impairment. Dementia 1996; 7: 182-6
-
(1996)
Dementia
, vol.7
, pp. 182-186
-
-
Horn, R.1
Ostertun, B.2
Fric, M.3
-
14
-
-
0028132966
-
Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia
-
Samuel W, Terry RD, Deteresa R, et al. Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia. Arch Neurol 1994; 51 (8): 772-8
-
(1994)
Arch Neurol
, vol.51
, Issue.8
, pp. 772-778
-
-
Samuel, W.1
Terry, R.D.2
Deteresa, R.3
-
15
-
-
0031051353
-
Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain
-
Jope RS, Song L, Powers RE. Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain. Neurobiol Aging 1997; 18 (1): 111-20
-
(1997)
Neurobiol Aging
, vol.18
, Issue.1
, pp. 111-120
-
-
Jope, R.S.1
Song, L.2
Powers, R.E.3
-
16
-
-
0032999475
-
Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease
-
Tong XK, Hamel E. Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease. Neuroscience 1999; 92 (1): 163-75
-
(1999)
Neuroscience
, vol.92
, Issue.1
, pp. 163-175
-
-
Tong, X.K.1
Hamel, E.2
-
17
-
-
0032454039
-
Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease
-
Mattson MP, Pedersen WA. Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease. Int J Dev Neurosci 1998; 16 (7-8): 737-53
-
(1998)
Int J Dev Neurosci
, vol.16
, Issue.7-8
, pp. 737-753
-
-
Mattson, M.P.1
Pedersen, W.A.2
-
18
-
-
0001815909
-
Pathology of Alzheimer's disease
-
Calne DB, editor. Philadelphia (PA): Saunders
-
Braak H, Braak E. Pathology of Alzheimer's disease. In: Calne DB, editor. Neurodegenerative diseases. Philadelphia (PA): Saunders, 1994: 585-613
-
(1994)
Neurodegenerative Diseases
, pp. 585-613
-
-
Braak, H.1
Braak, E.2
-
19
-
-
0027379395
-
Characterization of beta-amyloid peptide from human cerebrospinal fluid
-
Vigo-Pelfrey C, Lee D, Keim P, et al. Characterization of beta-amyloid peptide from human cerebrospinal fluid. J Neurochem 1993; 61 (5): 1965-8
-
(1993)
J Neurochem
, vol.61
, Issue.5
, pp. 1965-1968
-
-
Vigo-Pelfrey, C.1
Lee, D.2
Keim, P.3
-
20
-
-
0022550027
-
Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein
-
Roher A, Wolfe D, Palutke M, et al. Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein. Proc Natl Acad Sci U S A 1986; 83 (8): 2662-6
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, Issue.8
, pp. 2662-2666
-
-
Roher, A.1
Wolfe, D.2
Palutke, M.3
-
21
-
-
0028169925
-
Visualization of A beta 42 (43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42 (43)
-
Iwatsubo T, Odaka A, Suzuki N, et al. Visualization of A beta 42 (43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42 (43). Neuron 1994; 13 (1): 45-53
-
(1994)
Neuron
, vol.13
, Issue.1
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
-
22
-
-
0029790283
-
Neurodegenerative disorders with extensive tau pathology: A comparative study and review
-
Feany MB, Dickson DW. Neurodegenerative disorders with extensive tau pathology: a comparative study and review. Ann Neurol 1996; 40 (2): 139-48
-
(1996)
Ann Neurol
, vol.40
, Issue.2
, pp. 139-148
-
-
Feany, M.B.1
Dickson, D.W.2
-
23
-
-
0023009658
-
Microtubule-associated protein tau: A component of Alzheimer paired helical filaments
-
Grundke-Iqbal I, Iqbal K, Quinlan M, et al. Microtubule-associated protein tau: a component of Alzheimer paired helical filaments. J Biol Chem 1986; 261 (13): 6084-9
-
(1986)
J Biol Chem
, vol.261
, Issue.13
, pp. 6084-6089
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Quinlan, M.3
-
24
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal I, Iqbal K, Tung YC, et al. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A 1986; 83 (13): 4913-7
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, Issue.13
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
-
25
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate A, Chartier-Harlin MC, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349 (6311): 704-6
-
(1991)
Nature
, vol.349
, Issue.6311
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
-
26
-
-
0025861341
-
Screening for the beta-amyloid precursor protein mutation (APP717: Val - Ile) in extended pedigrees with early onset Alzheimer's disease
-
Chartier-Harlin MC, Crawford F, Hamandi K, et al. Screening for the beta-amyloid precursor protein mutation (APP717: Val - Ile) in extended pedigrees with early onset Alzheimer's disease. Neurosci Lett 1991; 129 (1): 134-5
-
(1991)
Neurosci Lett
, vol.129
, Issue.1
, pp. 134-135
-
-
Chartier-Harlin, M.C.1
Crawford, F.2
Hamandi, K.3
-
27
-
-
0026075602
-
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
-
Chartier-Harlin MC, Crawford F, Houlden H, et al. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature 1991; 353 (6347): 844-6
-
(1991)
Nature
, vol.353
, Issue.6347
, pp. 844-846
-
-
Chartier-Harlin, M.C.1
Crawford, F.2
Houlden, H.3
-
28
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995; 375 (6534): 754-60
-
(1995)
Nature
, vol.375
, Issue.6534
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
-
29
-
-
0028812820
-
Mutations of the presenilin I gene in families with early-onset Alzheimer's disease
-
Campion D, Flaman JM, Brice A, et al. Mutations of the presenilin I gene in families with early-onset Alzheimer's disease. Hum Mol Genet 1995; 4 (12): 2373-7
-
(1995)
Hum Mol Genet
, vol.4
, Issue.12
, pp. 2373-2377
-
-
Campion, D.1
Flaman, J.M.2
Brice, A.3
-
30
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995; 269 (5226): 973-7
-
(1995)
Science
, vol.269
, Issue.5226
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
-
31
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev EI, Sherrington R, Rogaeva EA, et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 1995; 376 (6543): 775-8
-
(1995)
Nature
, vol.376
, Issue.6543
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
-
32
-
-
8944241774
-
Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant
-
Sherrington R, Froelich S, Sorbi S, et al. Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum Mol Genet 1996; 5 (7): 985-8
-
(1996)
Hum Mol Genet
, vol.5
, Issue.7
, pp. 985-988
-
-
Sherrington, R.1
Froelich, S.2
Sorbi, S.3
-
33
-
-
0029964207
-
Amyloid fibril toxicity in Alzheimer's disease and diabetes
-
Lorenzo A, Yankner BA. Amyloid fibril toxicity in Alzheimer's disease and diabetes. Ann N Y Acad Sci 1996; 777: 89-95
-
(1996)
Ann N Y Acad Sci
, vol.777
, pp. 89-95
-
-
Lorenzo, A.1
Yankner, B.A.2
-
34
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
-
Terry RD, Masliah E, Salmon DP, et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991; 30 (4): 572-80
-
(1991)
Ann Neurol
, vol.30
, Issue.4
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
-
35
-
-
0027490070
-
The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution
-
Hyman BT, Marzloff K, Arriagada PV. The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. J Neuropathol Exp Neurol 1993; 52 (6): 594-600
-
(1993)
J Neuropathol Exp Neurol
, vol.52
, Issue.6
, pp. 594-600
-
-
Hyman, B.T.1
Marzloff, K.2
Arriagada, P.V.3
-
36
-
-
0027468235
-
Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older
-
Berg L, McKeel DW, Miller JP, et al. Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. Arch Neurol 1993; 50 (4): 349-58
-
(1993)
Arch Neurol
, vol.50
, Issue.4
, pp. 349-358
-
-
Berg, L.1
McKeel, D.W.2
Miller, J.P.3
-
37
-
-
0026740795
-
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
-
Arriagada PV, Growdon JH, Hedley-Whyte ET, et al. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 1992; 42 (3 Pt 1): 631-9
-
(1992)
Neurology
, vol.42
, Issue.3 PART 1
, pp. 631-639
-
-
Arriagada, P.V.1
Growdon, J.H.2
Hedley-Whyte, E.T.3
-
38
-
-
0032560487
-
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
-
Spillantini MG, Murrell JR, Goedert M, et al. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci U S A 1998; 95 (13): 7737-41
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, Issue.13
, pp. 7737-7741
-
-
Spillantini, M.G.1
Murrell, J.R.2
Goedert, M.3
-
39
-
-
0029949755
-
APP transgenesis: Approaches toward the development of animal models for Alzheimer disease neuropathology
-
Greenberg BD, Savage MJ, Howland DS, et al. APP transgenesis: approaches toward the development of animal models for Alzheimer disease neuropathology. Neurobiol Aging 1996; 17 (2): 153-71
-
(1996)
Neurobiol Aging
, vol.17
, Issue.2
, pp. 153-171
-
-
Greenberg, B.D.1
Savage, M.J.2
Howland, D.S.3
-
40
-
-
0032417251
-
Transgenic mice expressing Alzheimer amyloid precursor proteins
-
Hsiao K. Transgenic mice expressing Alzheimer amyloid precursor proteins. Exp Gerontol 1998; 33: 883-9
-
(1998)
Exp Gerontol
, vol.33
, pp. 883-889
-
-
Hsiao, K.1
-
41
-
-
0033046817
-
Transgenic animals relevant to Alzheimer's disease
-
Seabrook GR, Rosahl TW. Transgenic animals relevant to Alzheimer's disease. Neuropharmacology 1999; 38 (1): 1-17
-
(1999)
Neuropharmacology
, vol.38
, Issue.1
, pp. 1-17
-
-
Seabrook, G.R.1
Rosahl, T.W.2
-
42
-
-
0032413192
-
Alzheimer's disease: Genetic studies and transgenic models
-
Price DL, Tanzi RE, Borchelt DR, et al. Alzheimer's disease: genetic studies and transgenic models. Ann Rev Genet 1998; 32: 461-93
-
(1998)
Ann Rev Genet
, vol.32
, pp. 461-493
-
-
Price, D.L.1
Tanzi, R.E.2
Borchelt, D.R.3
-
43
-
-
0031921466
-
Mutant genes in familial Alzheimer's disease and transgenic models
-
Price DL, Sisodia SS. Mutant genes in familial Alzheimer's disease and transgenic models. Ann Rev Neurosci 1998; 21: 479-505
-
(1998)
Ann Rev Neurosci
, vol.21
, pp. 479-505
-
-
Price, D.L.1
Sisodia, S.S.2
-
44
-
-
0034060692
-
What transgenic mice tell us about neurodegenerative disease
-
Gurney ME. What transgenic mice tell us about neurodegenerative disease. Bioessays 2000; 22 (3): 297-304
-
(2000)
Bioessays
, vol.22
, Issue.3
, pp. 297-304
-
-
Gurney, M.E.1
-
45
-
-
0034014950
-
Single and multiple transgenic mice as models for Alzheimer's disease
-
van Leuven F. Single and multiple transgenic mice as models for Alzheimer's disease. Prog Neurobiol 2000; 61 (3): 305-12
-
(2000)
Prog Neurobiol
, vol.61
, Issue.3
, pp. 305-312
-
-
Van Leuven, F.1
-
48
-
-
0035341018
-
Genes, models and Alzheimer's disease
-
Chapman PF, Falinska AM, Knevett SG, et al. Genes, models and Alzheimer's disease. Trends Genet 2001; 17 (5): 254-61
-
(2001)
Trends Genet
, vol.17
, Issue.5
, pp. 254-261
-
-
Chapman, P.F.1
Falinska, A.M.2
Knevett, S.G.3
-
49
-
-
0034837627
-
Transgenic mouse models of Alzheimer's disease
-
Janus C, Westaway D. Transgenic mouse models of Alzheimer's disease. Physiol Behav 2001; 73 (5): 873-86
-
(2001)
Physiol Behav
, vol.73
, Issue.5
, pp. 873-886
-
-
Janus, C.1
Westaway, D.2
-
50
-
-
0035674312
-
Learning and memory in transgenic mice modelling Alzheimer's disease
-
Hsiao Ashe K. Learning and memory in transgenic mice modelling Alzheimer's disease. Learn Mem 2001; 8: 301-8
-
(2001)
Learn Mem
, vol.8
, pp. 301-308
-
-
Hsiao Ashe, K.1
-
51
-
-
0037073558
-
The generation and characterisation of potentially therapeutic Aβ antibodies in mice: Differences according to strain and immunization protocol
-
Spooner ET, Desai RV, Mori C, et al. The generation and characterisation of potentially therapeutic Aβ antibodies in mice: differences according to strain and immunization protocol. Vaccine 2002; 21 (3-4): 290-7
-
(2002)
Vaccine
, vol.21
, Issue.3-4
, pp. 290-297
-
-
Spooner, E.T.1
Desai, R.V.2
Mori, C.3
-
52
-
-
0035863055
-
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
-
Kawarabayashi T, Younkin LH, Saido TC, et al. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 2001; 21 (2): 372-81
-
(2001)
J Neurosci
, vol.21
, Issue.2
, pp. 372-381
-
-
Kawarabayashi, T.1
Younkin, L.H.2
Saido, T.C.3
-
53
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996; 2 (8): 864-70
-
(1996)
Nat Med
, vol.2
, Issue.8
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
54
-
-
0033951985
-
Immunization with beta-amyloid: Could T-cell activation have a harmful effect?
-
Grubeck-Loebenstein B, Blasko I, Marx FK, et al. Immunization with beta-amyloid: could T-cell activation have a harmful effect? [letter]. Trends Neurosci 2000; 23 (3): 114
-
(2000)
Trends Neurosci
, vol.23
, Issue.3
, pp. 114
-
-
Grubeck-Loebenstein, B.1
Blasko, I.2
Marx, F.K.3
-
55
-
-
0035163347
-
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
-
Dovey HF, John V, Anderson JP, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem 2001; 76 (1): 173-81
-
(2001)
J Neurochem
, vol.76
, Issue.1
, pp. 173-181
-
-
Dovey, H.F.1
John, V.2
Anderson, J.P.3
-
56
-
-
0034718206
-
Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization
-
Findeis MA. Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization. Biochim Biophys Acta 2000; 1502 (1): 76-84
-
(2000)
Biochim Biophys Acta
, vol.1502
, Issue.1
, pp. 76-84
-
-
Findeis, M.A.1
-
57
-
-
0031873102
-
Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy
-
Soto C, Sigurdsson EM, Morelli L, et al. Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nat Med 1998; 4 (7): 822-6
-
(1998)
Nat Med
, vol.4
, Issue.7
, pp. 822-826
-
-
Soto, C.1
Sigurdsson, E.M.2
Morelli, L.3
-
58
-
-
0030971789
-
Disaggregation of Alzheimer beta-amyloid by site-directed mAb
-
Solomon B, Koppel R, Frankel D, et al. Disaggregation of Alzheimer beta-amyloid by site-directed mAb. Proc Natl Acad Sci U S A 1997; 94 (8): 4109-12
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, Issue.8
, pp. 4109-4112
-
-
Solomon, B.1
Koppel, R.2
Frankel, D.3
-
59
-
-
0030058382
-
Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide
-
Solomon B, Koppel R, Hanan E, et al. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc Natl Acad Sci U S A 1996; 93 (1): 452-5
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.1
, pp. 452-455
-
-
Solomon, B.1
Koppel, R.2
Hanan, E.3
-
60
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999; 400 (6740): 173-7
-
(1999)
Nature
, vol.400
, Issue.6740
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
-
61
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
-
Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 1995; 373 (6514): 523-7
-
(1995)
Nature
, vol.373
, Issue.6514
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
-
62
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard F, Cannon C, Barbour R, et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 2000; 6 (8): 916-9
-
(2000)
Nat Med
, vol.6
, Issue.8
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
-
63
-
-
0035106780
-
Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy
-
Bacskai BJ, Kajdasz ST, Christie RH, et al. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med 2001; 7 (3): 369-72
-
(2001)
Nat Med
, vol.7
, Issue.3
, pp. 369-372
-
-
Bacskai, B.J.1
Kajdasz, S.T.2
Christie, R.H.3
-
64
-
-
0037107177
-
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
-
Bacskai BJ, Kajdasz ST, McLellan ME, et al. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J Neurosci 2002; 22 (18): 7873-8
-
(2002)
J Neurosci
, vol.22
, Issue.18
, pp. 7873-7878
-
-
Bacskai, B.J.1
Kajdasz, S.T.2
McLellan, M.E.3
-
65
-
-
0034068261
-
Brain trauma in aged transgenic mice induces regression of established abeta deposits
-
Nakagawa Y, Reed L, Nakamura M, et al. Brain trauma in aged transgenic mice induces regression of established abeta deposits. Exp Neurol 2000; 163 (1): 244-52
-
(2000)
Exp Neurol
, vol.163
, Issue.1
, pp. 244-252
-
-
Nakagawa, Y.1
Reed, L.2
Nakamura, M.3
-
66
-
-
0035902619
-
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
-
DeMattos RB, Bales KR, Cummins DJ, et al. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 2001; 98 (15): 8850-5
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.15
, pp. 8850-8855
-
-
DeMattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
-
67
-
-
0027769596
-
Blood-brain barrier transport of circulating Alzheimer's amyloid beta
-
Zlokovic BV, Ghiso J, Mackic JB, et al. Blood-brain barrier transport of circulating Alzheimer's amyloid beta. Biochem Biophys Res Commun 1993; 197 (3): 1034-40
-
(1993)
Biochem Biophys Res Commun
, vol.197
, Issue.3
, pp. 1034-1040
-
-
Zlokovic, B.V.1
Ghiso, J.2
Mackic, J.B.3
-
68
-
-
0035888264
-
Distribution of intraventricularly administered antiamyloid-beta peptide (Abeta) antibody in the mouse brain
-
Chauhan NB, Siegel GJ, Lichtor T. Distribution of intraventricularly administered antiamyloid-beta peptide (Abeta) antibody in the mouse brain. J Neurosci Res 2001; 66 (2): 231-5
-
(2001)
J Neurosci Res
, vol.66
, Issue.2
, pp. 231-235
-
-
Chauhan, N.B.1
Siegel, G.J.2
Lichtor, T.3
-
69
-
-
0036240395
-
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
-
Dodart JC, Bales KR, Gannon KS, et al. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci 2002; 5 (5): 452-7
-
(2002)
Nat Neurosci
, vol.5
, Issue.5
, pp. 452-457
-
-
Dodart, J.C.1
Bales, K.R.2
Gannon, K.S.3
-
70
-
-
0034700471
-
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
-
Janus C, Pearson J, McLaurin J, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 2000; 408 (6815): 979-82
-
(2000)
Nature
, vol.408
, Issue.6815
, pp. 979-982
-
-
Janus, C.1
Pearson, J.2
McLaurin, J.3
-
71
-
-
84984755327
-
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan D, Diamond DM, Gottschall PE, et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 2000; 408 (6815): 982-5
-
(2000)
Nature
, vol.408
, Issue.6815
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
-
72
-
-
0035877756
-
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
-
Chishti MA, Yang DS, Janus C, et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem 2001; 276 (24): 21562-70
-
(2001)
J Biol Chem
, vol.276
, Issue.24
, pp. 21562-21570
-
-
Chishti, M.A.1
Yang, D.S.2
Janus, C.3
-
73
-
-
0005535917
-
Spatial localization does not require the presence of local cues
-
Morris RGM. Spatial localization does not require the presence of local cues. Learn Motiv 1981; 12: 239-60
-
(1981)
Learn Motiv
, vol.12
, pp. 239-260
-
-
Morris, R.G.M.1
-
74
-
-
0038085245
-
Water maze search patterns in APP transgenic mice immunised with Aβ42 peptide
-
Janus C, Zuker N, Pearson J, et al. Water maze search patterns in APP transgenic mice immunised with Aβ42 peptide [abstract]. Soc Neurosci 2001; 27: 649.5
-
(2001)
Soc Neurosci
, vol.27
, pp. 6495
-
-
Janus, C.1
Zuker, N.2
Pearson, J.3
-
75
-
-
16044366039
-
Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
-
Duff K, Eckman C, Zehr C, et al. Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1. Nature 1996; 383: 710-3
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
-
76
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb L, Gordon MN, McGowan E, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 1998; 4 (1): 97-100
-
(1998)
Nat Med
, vol.4
, Issue.1
, pp. 97-100
-
-
Holcomb, L.1
Gordon, M.N.2
McGowan, E.3
-
77
-
-
0032756213
-
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits
-
Holcomb LA, Gordon MN, Jantzen P, et al. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav Genet 1999; 29 (3): 177-85
-
(1999)
Behav Genet
, vol.29
, Issue.3
, pp. 177-185
-
-
Holcomb, L.A.1
Gordon, M.N.2
Jantzen, P.3
-
78
-
-
0032737316
-
Exposing rats to a predator impairs spatial working memory in the radial arm water maze
-
Diamond DM, Park CR, Heman KL, et al. Exposing rats to a predator impairs spatial working memory in the radial arm water maze. Hippocampus 1999; 9 (5): 542-52
-
(1999)
Hippocampus
, vol.9
, Issue.5
, pp. 542-552
-
-
Diamond, D.M.1
Park, C.R.2
Heman, K.L.3
-
79
-
-
0038085244
-
Short-term Aβ vaccinations do not improve cognitive performance in aged, cognitively-impaired APP+PS1 transgenic mice
-
Morgan D, Austin L, Diamond DM, et al. Short-term Aβ vaccinations do not improve cognitive performance in aged, cognitively-impaired APP+PS1 transgenic mice [abstract]. Soc Neurosci 2001; 27: 687.11
-
(2001)
Soc Neurosci
, vol.27
, pp. 68711
-
-
Morgan, D.1
Austin, L.2
Diamond, D.M.3
-
80
-
-
0038423910
-
Dementia associated with Aβ accumulation reversed with Aβ antibodies
-
Kotilinek LA, Bacskai BJ, Hyman BT, et al. Dementia associated with Aβ accumulation reversed with Aβ antibodies [abstract]. Soc Neurosci 2001; 27: 546.10
-
(2001)
Soc Neurosci
, vol.27
, pp. 54610
-
-
Kotilinek, L.A.1
Bacskai, B.J.2
Hyman, B.T.3
-
81
-
-
0036703483
-
Reversible memory loss in a mouse transgenic model of Alzheimer's disease
-
Kotilinek LA, Bacskai B, Westerman M, et al. Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci 2002; 22 (15): 6331-5
-
(2002)
J Neurosci
, vol.22
, Issue.15
, pp. 6331-6335
-
-
Kotilinek, L.A.1
Bacskai, B.2
Westerman, M.3
-
82
-
-
0034530636
-
Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice
-
Lemere CA, Maron R, Spooner ET, et al. Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice. Ann N Y Acad Sci 2000; 920: 328-31
-
(2000)
Ann N Y Acad Sci
, vol.920
, pp. 328-331
-
-
Lemere, C.A.1
Maron, R.2
Spooner, E.T.3
-
83
-
-
0033801852
-
Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease
-
Weiner HL, Lemere CA, Maron R, et al. Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol 2000; 48 (4): 567-79
-
(2000)
Ann Neurol
, vol.48
, Issue.4
, pp. 567-579
-
-
Weiner, H.L.1
Lemere, C.A.2
Maron, R.3
-
84
-
-
0003181672
-
Aβ immunization of PDAPP mice leads to decreased cerebral Aβ and a corresponding increase in serum Aβ
-
Lemere CA, Spooner ET, Malester B, et al. Aβ immunization of PDAPP mice leads to decreased cerebral Aβ and a corresponding increase in serum Aβ [abstract]. Soc Neurosci 2002; 27: 687.10
-
(2002)
Soc Neurosci
, vol.27
, pp. 68710
-
-
Lemere, C.A.1
Spooner, E.T.2
Malester, B.3
-
85
-
-
0036860352
-
Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants
-
Lemere CA, Spooner ET, Leverone JF, et al. Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants. Neurobiol Aging 2002; 23 (6): 991-1000
-
(2002)
Neurobiol Aging
, vol.23
, Issue.6
, pp. 991-1000
-
-
Lemere, C.A.1
Spooner, E.T.2
Leverone, J.F.3
-
86
-
-
0034884382
-
Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
-
Sigurdsson EM, Scholtzova H, Mehta PD, et al. Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am J Pathol 2001; 159 (2): 439-47
-
(2001)
Am J Pathol
, vol.159
, Issue.2
, pp. 439-447
-
-
Sigurdsson, E.M.1
Scholtzova, H.2
Mehta, P.D.3
-
87
-
-
0032953541
-
Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis
-
Moechars D, Lorent K, Van-Leuven F. Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis. Neuroscience 1999; 91 (3): 819-30
-
(1999)
Neuroscience
, vol.91
, Issue.3
, pp. 819-830
-
-
Moechars, D.1
Lorent, K.2
Van-Leuven, F.3
-
88
-
-
0033525520
-
Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
-
Moechars D, Dewachter I, Lorent K, et al. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem 1999; 274 (10): 6483-92
-
(1999)
J Biol Chem
, vol.274
, Issue.10
, pp. 6483-6492
-
-
Moechars, D.1
Dewachter, I.2
Lorent, K.3
-
89
-
-
0033784099
-
Modeling Alzheimer's disease in transgenic mice: Effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice
-
Dewachter I, van Dorpe J, Spittaels K, et al. Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice. Exp Gerontol 2000; 35 (6-7): 831-41
-
(2000)
Exp Gerontol
, vol.35
, Issue.6-7
, pp. 831-841
-
-
Dewachter, I.1
Van Dorpe, J.2
Spittaels, K.3
-
90
-
-
0034280437
-
Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V7171 transgenic mice by a different mechanism than mutant presenilin1
-
Dewachter I, van Dorpe J, Smeijers L, et al. Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V7171 transgenic mice by a different mechanism than mutant presenilin1. J Neurosci 2000; 20 (17): 6452-8
-
(2000)
J Neurosci
, vol.20
, Issue.17
, pp. 6452-6458
-
-
Dewachter, I.1
Van Dorpe, J.2
Smeijers, L.3
-
91
-
-
0036582717
-
Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V7171] transgenic mice
-
Dewachter I, Reverse D, Caluwaerts N, et al. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V7171] transgenic mice. J Neurosci 2002; 22 (9): 3445-53
-
(2002)
J Neurosci
, vol.22
, Issue.9
, pp. 3445-3453
-
-
Dewachter, I.1
Reverse, D.2
Caluwaerts, N.3
-
92
-
-
0034700480
-
A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease
-
Chen GQ, Chen KS, Knox J, et al. A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature 2000; 408 (6815): 975-9
-
(2000)
Nature
, vol.408
, Issue.6815
, pp. 975-979
-
-
Chen, G.Q.1
Chen, K.S.2
Knox, J.3
-
93
-
-
0035112647
-
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons
-
Cai H, Wang Y, McCarthy D, et al. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci 2001; 4 (3): 233-4
-
(2001)
Nat Neurosci
, vol.4
, Issue.3
, pp. 233-234
-
-
Cai, H.1
Wang, Y.2
McCarthy, D.3
-
94
-
-
0035116273
-
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
-
Luo Y, Bolon B, Kahn S, et al. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci 2001; 4 (3): 231-2
-
(2001)
Nat Neurosci
, vol.4
, Issue.3
, pp. 231-232
-
-
Luo, Y.1
Bolon, B.2
Kahn, S.3
-
95
-
-
0033986037
-
Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains
-
Suh SW, Jensen KB, Jensen MS, et al. Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains. Brain Res 2000; 852 (2): 274-8
-
(2000)
Brain Res
, vol.852
, Issue.2
, pp. 274-278
-
-
Suh, S.W.1
Jensen, K.B.2
Jensen, M.S.3
-
96
-
-
0033551782
-
Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion
-
Chemy RA, Legg JT, McLean CA, et al. Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion. J Biol Chem 1999; 274 (33): 23223-8
-
(1999)
J Biol Chem
, vol.274
, Issue.33
, pp. 23223-23228
-
-
Chemy, R.A.1
Legg, J.T.2
McLean, C.A.3
-
97
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
-
Chemy RA, Atwood CS, Xilinas ME, et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 2001; 30 (3): 665-76
-
(2001)
Neuron
, vol.30
, Issue.3
, pp. 665-676
-
-
Chemy, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
-
98
-
-
0031900411
-
Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging
-
Mackenzie IR, Munoz DG. Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging. Neurology 1998; 50 (4): 986-90
-
(1998)
Neurology
, vol.50
, Issue.4
, pp. 986-990
-
-
Mackenzie, I.R.1
Munoz, D.G.2
-
99
-
-
0037167542
-
Reduced incidence of AD with NSAID but not H (2) receptor antagonists: The Cache County Study
-
Zandi PP, Anthony JC, Hayden KM, et al. Reduced incidence of AD with NSAID but not H (2) receptor antagonists: the Cache County Study. Neurology 2002; 59 (6): 880-6
-
(2002)
Neurology
, vol.59
, Issue.6
, pp. 880-886
-
-
Zandi, P.P.1
Anthony, J.C.2
Hayden, K.M.3
-
100
-
-
0030000385
-
The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease
-
Breitner JC. The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease. Annu Rev Med 1996; 47: 401-11
-
(1996)
Annu Rev Med
, vol.47
, pp. 401-411
-
-
Breitner, J.C.1
-
101
-
-
0033551547
-
A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease
-
Scharf S, Mander A, Ugoni A, et al. A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease. Neurology 1999; 53 (1): 197-201
-
(1999)
Neurology
, vol.53
, Issue.1
, pp. 197-201
-
-
Scharf, S.1
Mander, A.2
Ugoni, A.3
-
102
-
-
0034254924
-
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease
-
Lim GP, Yang F, Chu T, et al. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci 2000; 20 (15): 5709-14
-
(2000)
J Neurosci
, vol.20
, Issue.15
, pp. 5709-5714
-
-
Lim, G.P.1
Yang, F.2
Chu, T.3
-
103
-
-
0035691115
-
Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice
-
Lim GP, Yang F, Chu T, et al. Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging 2001; 22 (6): 983-91
-
(2001)
Neurobiol Aging
, vol.22
, Issue.6
, pp. 983-991
-
-
Lim, G.P.1
Yang, F.2
Chu, T.3
-
104
-
-
0037088914
-
Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice
-
Jantzen PT, Connor KE, DiCarlo G, et al. Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. J Neurosci 2002; 22 (6): 2246-54
-
(2002)
J Neurosci
, vol.22
, Issue.6
, pp. 2246-2254
-
-
Jantzen, P.T.1
Connor, K.E.2
DiCarlo, G.3
-
105
-
-
0032568552
-
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
-
Simons M, Keller P, De Strooper B, et al. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci U S A 1998; 95 (11): 6460-4
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, Issue.11
, pp. 6460-6464
-
-
Simons, M.1
Keller, P.2
De Strooper, B.3
-
106
-
-
0035949755
-
Cholesterol and Alzheimer's disease: Is there a link?
-
Simons M, Keller P, Dichgans J, et al. Cholesterol and Alzheimer's disease: is there a link? Neurology 2001; 57 (6): 1089-93
-
(2001)
Neurology
, vol.57
, Issue.6
, pp. 1089-1093
-
-
Simons, M.1
Keller, P.2
Dichgans, J.3
-
107
-
-
0034638746
-
Statins and the risk of dementia
-
Jick H, Zornberg GL, Jick SS, et al. Statins and the risk of dementia. Lancet 2000; 356 (9242): 1627-31
-
(2000)
Lancet
, vol.356
, Issue.9242
, pp. 1627-1631
-
-
Jick, H.1
Zornberg, G.L.2
Jick, S.S.3
-
108
-
-
0035160066
-
A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease
-
Refolo LM, Pappolla MA, LaFrancois J, et al. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis 2001; 8 (5): 890-9
-
(2001)
Neurobiol Dis
, vol.8
, Issue.5
, pp. 890-899
-
-
Refolo, L.M.1
Pappolla, M.A.2
LaFrancois, J.3
-
109
-
-
0002639884
-
Dosing in phase II trial of Alzheimer's vaccine suspended
-
Senior K. Dosing in phase II trial of Alzheimer's vaccine suspended. Neurology 2002; 1: 3
-
(2002)
Neurology
, vol.1
, pp. 3
-
-
Senior, K.1
-
110
-
-
0036780877
-
Opinion: Amyloid-β immunotherapy for Alzheimer's disease: The end of the beginning
-
Schenk D. Opinion: Amyloid-β immunotherapy for Alzheimer's disease: the end of the beginning. Nat Rev Neurosci 2002; 3 (10): 824-8
-
(2002)
Nat Rev Neurosci
, vol.3
, Issue.10
, pp. 824-828
-
-
Schenk, D.1
-
112
-
-
0036853548
-
Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease
-
Nov
-
Hock C, Konietzko U, Papassotiropoulos A, et al. Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease. Nat Med 2002 Nov; 8 (11): 1270-5
-
(2002)
Nat Med
, vol.8
, Issue.11
, pp. 1270-1275
-
-
Hock, C.1
Konietzko, U.2
Papassotiropoulos, A.3
-
113
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
-
Apr
-
Nicoll JAR, Wilkinson D, Holmes C, et al. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 2003 Apr; 9 (4): 448-52
-
(2003)
Nat Med
, vol.9
, Issue.4
, pp. 448-452
-
-
Nicoll, J.A.R.1
Wilkinson, D.2
Holmes, C.3
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