Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain

Neurobiology of Aging

Volumn 18, Issue 1, 1997, Pages 111-120

  Jope, Richard S ^a,b   Song, Ling ^a   Powers, Richard E ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Alzheimer's disease; cholinergic; G protein; muscarinic stimulation; phosphatidylinositol; phosphoinositide hydrolysis

Indexed keywords

ACETYLCHOLINE; CHOLINE ACETYLTRANSFERASE; CHOLINERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE INHIBITOR; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL; PROTEIN G;

ALZHEIMER DISEASE; ARTICLE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; HYDROLYSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AGED; ALZHEIMER DISEASE; BRAIN; BRAIN CHEMISTRY; CHOLINE O-ACETYLTRANSFERASE; CHOLINERGIC AGONISTS; CHOLINESTERASE INHIBITORS; FEMALE; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; HYDROLYSIS; MALE; PARASYMPATHETIC NERVOUS SYSTEM; PHOSPHATIDYLINOSITOLS; SIGNAL TRANSDUCTION;

EID: 0031051353     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(96)00205-9     Document Type: Article

References (29)

1. Alder, J. T.; Chessell, I. P.; Bowen, D. M. A neurochemical approach for studying response to acetylcholine in Alzheimer s disease. Neurochem. Res. 20:769-771; 1995.
2. Behl, C.; Davis, J. B.; Lesley, R.; Schubert, D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77:817-827; 1994.
3. Claro, E.; Garcia, A.; Picatoste, F. Carbachol and histamine stimulation of guanine-nucleotide-dependent phosphoinositide hydrolysis in rat brain cortical membranes. Biochem. J. 261:29-35; 1989.
4. Cowburn, R. F.; Wiehager, B.; Sundstrom, E. β-Amyloid peptides enhance binding of the calcium mobilising second messengers, inositol (l,4,5)trisphosphate and inositol (l,3,4,5)tetrakisphosphate to their receptor sites in rat cortical membranes. Neurosci. Lett. 191:31-34; 1995.
5. Crews, F. T.; Kurian, P.; Freund, G. Cholinergic and serotonergic stimulation of phosphoinositide hydrolysis is decreased in Alzheimer's disease. Life Sci. 25/26:1993-2002; 1994.
6. Crews, F. T. Amyloid β protein disruption of cholinergic and growth factor phospholipase C signals could underlie cognitive and neurode-generative aspects of Alzheimer s disease. Neurobiol. Aging 15:S95-S96; 1994.
7. 3H]-PIP2 hydrolysis in Alzheimer's disease. Life Sci. 53: 439-444; 1993.
8. Fisher, S. K.; Heacock, A. M; Agranoff, B. W. Inositol lipids and signal transduction in the nervous system: An update. J. Neurochem. 58:18-38; 1992.
9. 1 muscarinic receptors in Alzheimer s disease: Implications for the failure of cholinergic replacement therapies. Ann. Neurol. 29:256-262; 1991.
10. Fonnum, F. A rapid radiochemical method for determination of choline acetyltransferase. J. Neurochem. 24:407-409; 1975.
11. Fowler, C. J.; Cowburn, R. F.; O'Neil, C. Brain signal transduction disturbances in neurodegenerative disorders. Cell. Signal. 4:1-9; 1992.
12. Greenwood, A. F.; Powers, R. E.; Jope, R. S. Phosphoinositide hydrolysis, Gβ, phospholipase C, and protein kinase C in post mortem human brain: Effects of post mortem interval, subject age, and Alzheimer's disease. Neuroscience 69:125-138; 1995.
13. Gurwitz, D.; Haring, R.; Heldman, E.; Fraser, C. M.; Manor, D.; Fisher, A. Discrete activation of transduction pathways associated with acetylcholine m1 receptor by several muscarinic ligands. Eur. J. Pharmacol. 267:21-31; 1994.
14. Hensley, K.; Carney, J. M.; Mattson, M. P.; Aksenova, M.; Harris, M.; Wu, J. F.; Floyd, R. A.; Butterfield, D. A. A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease. Proc. Natl. Acad. Sci. USA 91:3270-3274; 1994.
15. Jope, R. S. Cholinergic muscarinic receptor signaling by the phosphoinositide signal transduction system in Alzheimer disease. Alzheimer's Dis. Rev. 1:2-14; 1996.
16. Jope, R. S.; Song, L.; Powers, R. Agonist-induced, GTP-dependent phosphoinositide hydrolysis in postmortem human brain membranes. J. Neurochem. 62:180-186; 1994.
17. Jope, R. S.; Song, L.; Li, X.; Powers, R. Impaired phosphoinositide hydrolysis in Alzheimer's disease brain. Neurobiol. Aging 15:221-226; 1994.
18. 3H]PtdIns hydrolysis in postmortem human brain membranes is mediated by the G-proteins Gq/11 and phospholipase C-β. Biochem. J. 304:655-659; 1994.
19. Katzman, R. Alzheimer's disease. N. Engl. J. Med. 314:964-973; 1986.
20. Nitsch, R. M.; Growdon, J. H. Role of neurotransmission in the regulation of amyloid β-protein precursor processing. Biochem. Pharmacol. 47:1275-1284; 1994.
21. Nordberg, A. Neuroreceptor changes in Alzheimer disease. Cerebrovasc. Brain Metab. Rev. 4:303-328; 1992.
22. Smith, C. J.; Perry, E. K.; Perry, R. H.; Fairbairn, A. F.; Birdsall, N. J. M. Guanine nucleotide modulation of muscarinic cholinergic receptor binding in postmortem human brain - A preliminary study in Alzheimer's disease. Neurosci. Lett. 82:227-232; 1987.
23. Song, L.; Jope, R. S. Chronic lithium treatment impairs phosphatidylinositol hydrolysis in membranes from rat brain regions. J. Neurochem. 58:2200-2206; 1992.
24. Stokes, C. E.; Hawthorne, J. N. Reduced phosphoinositide concentrations in anterior temporal cortex of Alzheimer-diseased brains. J. Neurochem. 48:1018-1021; 1987.
25. Wallace, M. A. Effects of Alzheimer's disease-related β amyloid protein fragments on enzymes metabolizing phosphoinositides in brain. Biochim. Biophys. Acta 1227:183-187; 1994.
26. Wallace, M. A.; Claro, E. A novel role for dopamine: Inhibition of muscarinic cholinergic-stimulated phosphoinositide hydrolysis in rat brain cortical membranes. Neurosci. Lett. 110:155-161; 1990.
27. Wallace, M. A.; Claro, E. Transmembrane signaling through phospholipase C in human conical membranes. Neurochem. Res. 18:139-145; 1993.
28. Wang, H.-Y.; Friedman, E. Receptor-mediated activation of G proteins is reduced in postmortem brains from Alzheimer s disease patients. Neurosci. Lett. 173:37-39; 1994.
29. Warpman, U.; Alafuzoff, L; Nordberg, A. Coupling of muscarinic receptors to GTP-binding proteins in postmortem human brain Alterations in Alzheimer's disease. Neurosci. Lett. 150:39-43; 1993.