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Volumn 261, Issue 1, 2014, Pages 84-101

Innate immune regulation by STAT-mediated transcriptional mechanisms

Author keywords

Cytokines; Dendritic cells; Macrophages; Neutrophils; STAT proteins

Indexed keywords

CHEMOKINE; CYTOKINE; GROWTH FACTOR; JANUS KINASE; PATTERN RECOGNITION RECEPTOR; PEPTIDE DERIVATIVE; PROTEIN TYROSINE KINASE; STAT PROTEIN;

EID: 84905979501     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12198     Document Type: Article
Times cited : (54)

References (254)
  • 1
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004;4:499-511.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 2
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007;25:821-852.
    • (2007) Annu Rev Immunol , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 3
    • 44449087304 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis
    • Panopoulos AD, Watowich SS. Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis. Cytokine 2008;42:277-288.
    • (2008) Cytokine , vol.42 , pp. 277-288
    • Panopoulos, A.D.1    Watowich, S.S.2
  • 4
    • 77958611660 scopus 로고    scopus 로고
    • Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors
    • Zhu J, Paul WE. Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev 2010;238:247-262.
    • (2010) Immunol Rev , vol.238 , pp. 247-262
    • Zhu, J.1    Paul, W.E.2
  • 5
    • 84859181084 scopus 로고    scopus 로고
    • Demand-adapted regulation of early hematopoiesis in infection and inflammation
    • Takizawa H, Boettcher S, Manz MG. Demand-adapted regulation of early hematopoiesis in infection and inflammation. Blood 2012;119:2991-3002.
    • (2012) Blood , vol.119 , pp. 2991-3002
    • Takizawa, H.1    Boettcher, S.2    Manz, M.G.3
  • 6
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 2002;415:389-395.
    • (2002) Nature , vol.415 , pp. 389-395
    • Zasloff, M.1
  • 7
    • 0141799911 scopus 로고    scopus 로고
    • Defensins: antimicrobial peptides of innate immunity
    • Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 2003;3:710-720.
    • (2003) Nat Rev Immunol , vol.3 , pp. 710-720
    • Ganz, T.1
  • 8
  • 9
    • 84869885308 scopus 로고    scopus 로고
    • Human airway epithelial cell innate immunity: relevance to asthma
    • Hirota JA, Knight DA. Human airway epithelial cell innate immunity: relevance to asthma. Curr Opin Immunol 2012;24:740-746.
    • (2012) Curr Opin Immunol , vol.24 , pp. 740-746
    • Hirota, J.A.1    Knight, D.A.2
  • 10
    • 84896851032 scopus 로고    scopus 로고
    • Intestinal epithelial cells: regulators of barrier function and immune homeostasis
    • Peterson LW, Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol 2014;14:141-153.
    • (2014) Nat Rev Immunol , vol.14 , pp. 141-153
    • Peterson, L.W.1    Artis, D.2
  • 11
    • 0025102756 scopus 로고
    • Haemopoietic receptors and helical cytokines
    • Bazan JF. Haemopoietic receptors and helical cytokines. Immunol Today 1990;11:350-354.
    • (1990) Immunol Today , vol.11 , pp. 350-354
    • Bazan, J.F.1
  • 12
    • 0025162844 scopus 로고
    • Structural design and molecular evolution of a cytokine receptor superfamily
    • Bazan JF. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 1990;87:6934-6938.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6934-6938
    • Bazan, J.F.1
  • 13
    • 0031036882 scopus 로고    scopus 로고
    • The structural and functional basis of cytokine receptor activation: lessons from the common beta subunit of the granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 receptors
    • Bagley CJ, Woodcock JM, Stomski FC, Lopez AF. The structural and functional basis of cytokine receptor activation: lessons from the common beta subunit of the granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 receptors. Blood 1997;89:1471-1482.
    • (1997) Blood , vol.89 , pp. 1471-1482
    • Bagley, C.J.1    Woodcock, J.M.2    Stomski, F.C.3    Lopez, A.F.4
  • 14
    • 0030890718 scopus 로고    scopus 로고
    • Gp130 and the interleukin-6 family of cytokines
    • Taga T, Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 1997;15:797-819.
    • (1997) Annu Rev Immunol , vol.15 , pp. 797-819
    • Taga, T.1    Kishimoto, T.2
  • 15
    • 0029962080 scopus 로고    scopus 로고
    • The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID
    • Sugamura K, et al. The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu Rev Immunol 1996;14:179-205.
    • (1996) Annu Rev Immunol , vol.14 , pp. 179-205
    • Sugamura, K.1
  • 17
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell JE, Jr. STATs and gene regulation. Science 1997;277:1630-1635.
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell Jr, J.E.1
  • 18
    • 0036731485 scopus 로고    scopus 로고
    • Stats: transcriptional control and biological impact
    • Levy DE, Darnell JE, Jr. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 2002;3:651-662.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell Jr, J.E.2
  • 19
    • 84859992161 scopus 로고    scopus 로고
    • The JAK-STAT pathway at twenty
    • Stark GR, Darnell JE, Jr. The JAK-STAT pathway at twenty. Immunity 2012;36:503-514.
    • (2012) Immunity , vol.36 , pp. 503-514
    • Stark, G.R.1    Darnell Jr, J.E.2
  • 21
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer 2003;3:650-665.
    • (2003) Nat Rev Cancer , vol.3 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 22
    • 84857618521 scopus 로고    scopus 로고
    • Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
    • Hume DA, MacDonald KP. Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood 2012;119:1810-1820.
    • (2012) Blood , vol.119 , pp. 1810-1820
    • Hume, D.A.1    MacDonald, K.P.2
  • 23
    • 0028826595 scopus 로고
    • Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts
    • Novak U, et al. Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts. Blood 1995;86:2948-2956.
    • (1995) Blood , vol.86 , pp. 2948-2956
    • Novak, U.1
  • 24
    • 0034649210 scopus 로고    scopus 로고
    • Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase
    • Zhang S, Broxmeyer HE. Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase. Biochem Biophys Res Commun 2000;277:195-199.
    • (2000) Biochem Biophys Res Commun , vol.277 , pp. 195-199
    • Zhang, S.1    Broxmeyer, H.E.2
  • 25
    • 78649375771 scopus 로고    scopus 로고
    • Neutrophils, from marrow to microbes
    • Borregaard N. Neutrophils, from marrow to microbes. Immunity 2010;33:657-670.
    • (2010) Immunity , vol.33 , pp. 657-670
    • Borregaard, N.1
  • 26
    • 0023928838 scopus 로고
    • Production of colony-stimulating factors (CSFs) during infection: separate determinations of macrophage-, granulocyte-, granulocyte-macrophage-, and multi-CSFs
    • Cheers C, Haigh AM, Kelso A, Metcalf D, Stanley ER, Young AM. Production of colony-stimulating factors (CSFs) during infection: separate determinations of macrophage-, granulocyte-, granulocyte-macrophage-, and multi-CSFs. Infect Immun 1988;56:247-251.
    • (1988) Infect Immun , vol.56 , pp. 247-251
    • Cheers, C.1    Haigh, A.M.2    Kelso, A.3    Metcalf, D.4    Stanley, E.R.5    Young, A.M.6
  • 27
    • 0024587417 scopus 로고
    • Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay
    • Watari K, et al. Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay. Blood 1989;73:117-122.
    • (1989) Blood , vol.73 , pp. 117-122
    • Watari, K.1
  • 28
    • 0025251126 scopus 로고
    • Levels of serum granulocyte colony-stimulating factor in patients with infections
    • Kawakami M, et al. Levels of serum granulocyte colony-stimulating factor in patients with infections. Blood 1990;76:1962-1964.
    • (1990) Blood , vol.76 , pp. 1962-1964
    • Kawakami, M.1
  • 29
    • 0028000668 scopus 로고
    • Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization
    • Lieschke GJ, et al. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood 1994;84:1737-1746.
    • (1994) Blood , vol.84 , pp. 1737-1746
    • Lieschke, G.J.1
  • 30
    • 0030292823 scopus 로고    scopus 로고
    • Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice
    • Liu F, Wu HY, Wesselschmidt R, Kornaga T, Link DC. Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice. Immunity 1996;5:491-501.
    • (1996) Immunity , vol.5 , pp. 491-501
    • Liu, F.1    Wu, H.Y.2    Wesselschmidt, R.3    Kornaga, T.4    Link, D.C.5
  • 31
    • 0033180176 scopus 로고    scopus 로고
    • A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation
    • Semerad CL, Poursine-Laurent J, Liu F, Link DC. A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation. Immunity 1999;11:153-161.
    • (1999) Immunity , vol.11 , pp. 153-161
    • Semerad, C.L.1    Poursine-Laurent, J.2    Liu, F.3    Link, D.C.4
  • 32
    • 0035102228 scopus 로고    scopus 로고
    • STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation
    • McLemore ML, et al. STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation. Immunity 2001;14:193-204.
    • (2001) Immunity , vol.14 , pp. 193-204
    • McLemore, M.L.1
  • 33
    • 0025830333 scopus 로고
    • Myeloid cell kinetics in mice treated with recombinant interleukin-3, granulocyte colony-stimulating factor (CSF), or granulocyte-macrophage CSF in vivo
    • Lord BI, Molineux G, Pojda Z, Souza LM, Mermod JJ, Dexter TM. Myeloid cell kinetics in mice treated with recombinant interleukin-3, granulocyte colony-stimulating factor (CSF), or granulocyte-macrophage CSF in vivo. Blood 1991;77:2154-2159.
    • (1991) Blood , vol.77 , pp. 2154-2159
    • Lord, B.I.1    Molineux, G.2    Pojda, Z.3    Souza, L.M.4    Mermod, J.J.5    Dexter, T.M.6
  • 34
    • 0036683377 scopus 로고    scopus 로고
    • Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation
    • Basu S, Hodgson G, Katz M, Dunn AR. Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation. Blood 2002;100:854-861.
    • (2002) Blood , vol.100 , pp. 854-861
    • Basu, S.1    Hodgson, G.2    Katz, M.3    Dunn, A.R.4
  • 35
    • 0036800086 scopus 로고    scopus 로고
    • G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood
    • Semerad CL, Liu F, Gregory AD, Stumpf K, Link DC. G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. Immunity 2002;17:413-423.
    • (2002) Immunity , vol.17 , pp. 413-423
    • Semerad, C.L.1    Liu, F.2    Gregory, A.D.3    Stumpf, K.4    Link, D.C.5
  • 36
    • 38049098574 scopus 로고    scopus 로고
    • The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation
    • Wengner AM, Pitchford SC, Furze RC, Rankin SM. The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood 2008;111:42-49.
    • (2008) Blood , vol.111 , pp. 42-49
    • Wengner, A.M.1    Pitchford, S.C.2    Furze, R.C.3    Rankin, S.M.4
  • 37
    • 0025203281 scopus 로고
    • In vivo effects of human recombinant interleukin 6 on hemopoietic stem and progenitor cells and circulating blood cells in normal mice
    • Pojda Z, Tsuboi A. In vivo effects of human recombinant interleukin 6 on hemopoietic stem and progenitor cells and circulating blood cells in normal mice. Exp Hematol 1990;18:1034-1037.
    • (1990) Exp Hematol , vol.18 , pp. 1034-1037
    • Pojda, Z.1    Tsuboi, A.2
  • 38
    • 0030794861 scopus 로고    scopus 로고
    • Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation
    • Liu F, Poursine-Laurent J, Wu HY, Link DC. Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation. Blood 1997;90:2583-2590.
    • (1997) Blood , vol.90 , pp. 2583-2590
    • Liu, F.1    Poursine-Laurent, J.2    Wu, H.Y.3    Link, D.C.4
  • 39
    • 0030838839 scopus 로고    scopus 로고
    • Mice lacking both granulocyte colony-stimulating factor (CSF) and granulocyte-macrophage CSF have impaired reproductive capacity, perturbed neonatal granulopoiesis, lung disease, amyloidosis, and reduced long-term survival
    • Seymour JF, Lieschke GJ, Grail D, Quilici C, Hodgson G, Dunn AR. Mice lacking both granulocyte colony-stimulating factor (CSF) and granulocyte-macrophage CSF have impaired reproductive capacity, perturbed neonatal granulopoiesis, lung disease, amyloidosis, and reduced long-term survival. Blood 1997;90:3037-3049.
    • (1997) Blood , vol.90 , pp. 3037-3049
    • Seymour, J.F.1    Lieschke, G.J.2    Grail, D.3    Quilici, C.4    Hodgson, G.5    Dunn, A.R.6
  • 40
    • 0026072411 scopus 로고
    • The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor
    • Molineux G, Migdalska A, Szmitkowski M, Zsebo K, Dexter TM. The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor. Blood 1991;78:961-966.
    • (1991) Blood , vol.78 , pp. 961-966
    • Molineux, G.1    Migdalska, A.2    Szmitkowski, M.3    Zsebo, K.4    Dexter, T.M.5
  • 41
    • 0030948721 scopus 로고    scopus 로고
    • Flt-3 ligand synergizes with granulocyte colony-stimulating factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential
    • Molineux G, McCrea C, Yan XQ, Kerzic P, McNiece I. Flt-3 ligand synergizes with granulocyte colony-stimulating factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential. Blood 1997;89:3998-4004.
    • (1997) Blood , vol.89 , pp. 3998-4004
    • Molineux, G.1    McCrea, C.2    Yan, X.Q.3    Kerzic, P.4    McNiece, I.5
  • 42
    • 0028101326 scopus 로고
    • Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor
    • Tian SS, Lamb P, Seidel HM, Stein RB, Rosen J. Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor. Blood 1994;84:1760-1764.
    • (1994) Blood , vol.84 , pp. 1760-1764
    • Tian, S.S.1    Lamb, P.2    Seidel, H.M.3    Stein, R.B.4    Rosen, J.5
  • 43
    • 0029856943 scopus 로고    scopus 로고
    • Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes
    • Tian SS, Tapley P, Sincich C, Stein RB, Rosen J, Lamb P. Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes. Blood 1996;88:4435-4444.
    • (1996) Blood , vol.88 , pp. 4435-4444
    • Tian, S.S.1    Tapley, P.2    Sincich, C.3    Stein, R.B.4    Rosen, J.5    Lamb, P.6
  • 44
    • 0032534679 scopus 로고    scopus 로고
    • Stimulation of Stat5 by granulocyte colony-stimulating factor (G-CSF) is modulated by two distinct cytoplasmic regions of the G-CSF receptor
    • Dong F, et al. Stimulation of Stat5 by granulocyte colony-stimulating factor (G-CSF) is modulated by two distinct cytoplasmic regions of the G-CSF receptor. J Immunol 1998;161:6503-6509.
    • (1998) J Immunol , vol.161 , pp. 6503-6509
    • Dong, F.1
  • 45
    • 0030851722 scopus 로고    scopus 로고
    • Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells
    • Shimozaki K, Nakajima K, Hirano T, Nagata S. Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells. J Biol Chem 1997;272:25184-25189.
    • (1997) J Biol Chem , vol.272 , pp. 25184-25189
    • Shimozaki, K.1    Nakajima, K.2    Hirano, T.3    Nagata, S.4
  • 46
    • 0037166320 scopus 로고    scopus 로고
    • Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1
    • Panopoulos AD, Bartos D, Zhang L, Watowich SS. Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1. J Biol Chem 2002;277:19001-19007.
    • (2002) J Biol Chem , vol.277 , pp. 19001-19007
    • Panopoulos, A.D.1    Bartos, D.2    Zhang, L.3    Watowich, S.S.4
  • 47
    • 13844320172 scopus 로고    scopus 로고
    • Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells
    • Wang L, Arcasoy MO, Watowich SS, Forget BG. Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells. Exp Hematol 2005;33:308-317.
    • (2005) Exp Hematol , vol.33 , pp. 308-317
    • Wang, L.1    Arcasoy, M.O.2    Watowich, S.S.3    Forget, B.G.4
  • 48
    • 0036338213 scopus 로고    scopus 로고
    • STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation
    • Lee CK, et al. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity 2002;17:63-72.
    • (2002) Immunity , vol.17 , pp. 63-72
    • Lee, C.K.1
  • 49
    • 0037452789 scopus 로고    scopus 로고
    • STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity
    • Welte T, et al. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci USA 2003;100:1879-1884.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1879-1884
    • Welte, T.1
  • 50
    • 13744263866 scopus 로고    scopus 로고
    • Roles of Stat3 and ERK in G-CSF signaling
    • Kamezaki K, et al. Roles of Stat3 and ERK in G-CSF signaling. Stem Cells 2005;23:252-263.
    • (2005) Stem Cells , vol.23 , pp. 252-263
    • Kamezaki, K.1
  • 51
    • 33845239481 scopus 로고    scopus 로고
    • STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils
    • Panopoulos AD, et al. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood 2006;108:3682-3690.
    • (2006) Blood , vol.108 , pp. 3682-3690
    • Panopoulos, A.D.1
  • 53
    • 2542478996 scopus 로고    scopus 로고
    • The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response
    • Alexander WS, Hilton DJ. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol 2004;22:503-529.
    • (2004) Annu Rev Immunol , vol.22 , pp. 503-529
    • Alexander, W.S.1    Hilton, D.J.2
  • 54
    • 0033535958 scopus 로고    scopus 로고
    • Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter
    • Auernhammer CJ, Bousquet C, Melmed S. Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc Natl Acad Sci USA 1999;96:6964-6969.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6964-6969
    • Auernhammer, C.J.1    Bousquet, C.2    Melmed, S.3
  • 55
    • 33748209244 scopus 로고    scopus 로고
    • IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain
    • Zhang L, et al. IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain. Mol Cell Biochem 2006;288:179-189.
    • (2006) Mol Cell Biochem , vol.288 , pp. 179-189
    • Zhang, L.1
  • 56
    • 0036721716 scopus 로고    scopus 로고
    • Shaping gene expression in activated and resting primary macrophages by IL-10
    • Lang R, Patel D, Morris JJ, Rutschman RL, Murray PJ. Shaping gene expression in activated and resting primary macrophages by IL-10. J Immunol 2002;169:2253-2263.
    • (2002) J Immunol , vol.169 , pp. 2253-2263
    • Lang, R.1    Patel, D.2    Morris, J.J.3    Rutschman, R.L.4    Murray, P.J.5
  • 57
    • 10744223693 scopus 로고    scopus 로고
    • SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis
    • Croker BA, et al. SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 2004;20:153-165.
    • (2004) Immunity , vol.20 , pp. 153-165
    • Croker, B.A.1
  • 58
    • 85047689521 scopus 로고    scopus 로고
    • Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation
    • McLoughlin RM, et al. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest 2003;112:598-607.
    • (2003) J Clin Invest , vol.112 , pp. 598-607
    • McLoughlin, R.M.1
  • 59
    • 78751574200 scopus 로고    scopus 로고
    • Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation
    • Hakkim A, et al. Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. Nat Chem Biol 2011;7:75-77.
    • (2011) Nat Chem Biol , vol.7 , pp. 75-77
    • Hakkim, A.1
  • 60
    • 0031987330 scopus 로고    scopus 로고
    • Essential roles for granulocyte-macrophage colony-stimulating factor (GM-CSF) and G-CSF in the sustained hematopoietic response of Listeria monocytogenes-infected mice
    • Zhan Y, Lieschke GJ, Grail D, Dunn AR, Cheers C. Essential roles for granulocyte-macrophage colony-stimulating factor (GM-CSF) and G-CSF in the sustained hematopoietic response of Listeria monocytogenes-infected mice. Blood 1998;91:863-869.
    • (1998) Blood , vol.91 , pp. 863-869
    • Zhan, Y.1    Lieschke, G.J.2    Grail, D.3    Dunn, A.R.4    Cheers, C.5
  • 61
    • 77954335295 scopus 로고    scopus 로고
    • Hematopoietic growth factors: ESMO Clinical Practice Guidelines for the applications
    • Group EGW
    • Crawford J, Caserta C, Roila F, Group EGW. Hematopoietic growth factors: ESMO Clinical Practice Guidelines for the applications. Ann Oncol 2010;21 (Suppl):v248-v251.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL.
    • Crawford, J.1    Caserta, C.2    Roila, F.3
  • 62
    • 33745225494 scopus 로고    scopus 로고
    • C/EBPbeta is required for 'emergency' granulopoiesis
    • Hirai H, et al. C/EBPbeta is required for 'emergency' granulopoiesis. Immunol 2006;7:732-739.
    • (2006) Immunol , vol.7 , pp. 732-739
    • Hirai, H.1
  • 63
    • 0030854907 scopus 로고    scopus 로고
    • Transcription factors, normal myeloid development, and leukemia
    • Tenen DG, Hromas R, Licht JD, Zhang DE. Transcription factors, normal myeloid development, and leukemia. Blood 1997;90:489-519.
    • (1997) Blood , vol.90 , pp. 489-519
    • Tenen, D.G.1    Hromas, R.2    Licht, J.D.3    Zhang, D.E.4
  • 64
    • 0035005526 scopus 로고    scopus 로고
    • c-Myc is a critical target for c/EBPalpha in granulopoiesis
    • Johansen LM, et al. c-Myc is a critical target for c/EBPalpha in granulopoiesis. Mol Cell Biol 2001;21:3789-3806.
    • (2001) Mol Cell Biol , vol.21 , pp. 3789-3806
    • Johansen, L.M.1
  • 65
    • 0028136726 scopus 로고
    • Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
    • Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 1994;265:1573-1577.
    • (1994) Science , vol.265 , pp. 1573-1577
    • Scott, E.W.1    Simon, M.C.2    Anastasi, J.3    Singh, H.4
  • 66
    • 0242549003 scopus 로고    scopus 로고
    • Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
    • McKercher SR, et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J 1996;15:5647-5658.
    • (1996) EMBO J , vol.15 , pp. 5647-5658
    • McKercher, S.R.1
  • 67
    • 0037244284 scopus 로고    scopus 로고
    • Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation
    • Hock H, et al. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity 2003;18:109-120.
    • (2003) Immunity , vol.18 , pp. 109-120
    • Hock, H.1
  • 68
    • 77951434599 scopus 로고    scopus 로고
    • STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction
    • Nguyen-Jackson H, Panopoulos AD, Zhang H, Li HS, Watowich SS. STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction. Blood 2010;115:3354-3363.
    • (2010) Blood , vol.115 , pp. 3354-3363
    • Nguyen-Jackson, H.1    Panopoulos, A.D.2    Zhang, H.3    Li, H.S.4    Watowich, S.S.5
  • 69
    • 84870411737 scopus 로고    scopus 로고
    • G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils
    • Nguyen-Jackson HT, Li HS, Zhang H, Ohashi E, Watowich SS. G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils. J Leukoc Biol 2012;92:1215-1225.
    • (2012) J Leukoc Biol , vol.92 , pp. 1215-1225
    • Nguyen-Jackson, H.T.1    Li, H.S.2    Zhang, H.3    Ohashi, E.4    Watowich, S.S.5
  • 70
    • 0017684756 scopus 로고
    • Atopic dermatitis and impaired neutrophil chemotaxis in Job's syndrome
    • Paslin D, Norman ME. Atopic dermatitis and impaired neutrophil chemotaxis in Job's syndrome. Arch Dermatol 1977;113:801-805.
    • (1977) Arch Dermatol , vol.113 , pp. 801-805
    • Paslin, D.1    Norman, M.E.2
  • 71
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011;11:723-737.
    • (2011) Nat Rev Immunol , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 72
    • 80355146399 scopus 로고    scopus 로고
    • Transcriptional regulation of macrophage polarization: enabling diversity with identity
    • Lawrence T, Natoli G. Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol 2011;11:750-761.
    • (2011) Nat Rev Immunol , vol.11 , pp. 750-761
    • Lawrence, T.1    Natoli, G.2
  • 73
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux F, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010;330:841-845.
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1
  • 74
    • 33750478657 scopus 로고    scopus 로고
    • Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
    • Beers DR, et al. Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 2006;103:16021-16026.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16021-16026
    • Beers, D.R.1
  • 75
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 2007;10:1538-1543.
    • (2007) Nat Neurosci , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 76
    • 36448955070 scopus 로고    scopus 로고
    • Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
    • Mildner A, et al. Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosci 2007;10:1544-1553.
    • (2007) Nat Neurosci , vol.10 , pp. 1544-1553
    • Mildner, A.1
  • 77
    • 80355143546 scopus 로고    scopus 로고
    • Microglial cell origin and phenotypes in health and disease
    • Saijo K, Glass CK. Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 2011;11:775-787.
    • (2011) Nat Rev Immunol , vol.11 , pp. 775-787
    • Saijo, K.1    Glass, C.K.2
  • 78
    • 84859508307 scopus 로고    scopus 로고
    • A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    • Schulz C, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 2012;336:86-90.
    • (2012) Science , vol.336 , pp. 86-90
    • Schulz, C.1
  • 79
    • 84872765982 scopus 로고    scopus 로고
    • Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
    • Yona S, et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 2013;38:79-91.
    • (2013) Immunity , vol.38 , pp. 79-91
    • Yona, S.1
  • 80
    • 84876775203 scopus 로고    scopus 로고
    • Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
    • Hashimoto D, et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 2013;38:792-804.
    • (2013) Immunity , vol.38 , pp. 792-804
    • Hashimoto, D.1
  • 81
    • 84990557416 scopus 로고
    • Origin and kinetics of resident tissue macrophages. Parabiosis studies with radiolabelled leucocytes
    • Parwaresch MR, Wacker HH. Origin and kinetics of resident tissue macrophages. Parabiosis studies with radiolabelled leucocytes. Cell Tissue Kinet 1984;17:25-39.
    • (1984) Cell Tissue Kinet , vol.17 , pp. 25-39
    • Parwaresch, M.R.1    Wacker, H.H.2
  • 82
    • 0022482923 scopus 로고
    • Kinetics of Kupffer cells as shown by parabiosis and combined autoradiographic/immunohistochemical analysis
    • Wacker HH, Radzun HJ, Parwaresch MR. Kinetics of Kupffer cells as shown by parabiosis and combined autoradiographic/immunohistochemical analysis. Virchows Arch B Cell Pathol Incl Mol Pathol 1986;51:71-78.
    • (1986) Virchows Arch B Cell Pathol Incl Mol Pathol , vol.51 , pp. 71-78
    • Wacker, H.H.1    Radzun, H.J.2    Parwaresch, M.R.3
  • 83
    • 35748957798 scopus 로고    scopus 로고
    • Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages
    • Landsman L, Jung S. Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages. J Immunol 2007;179:3488-3494.
    • (2007) J Immunol , vol.179 , pp. 3488-3494
    • Landsman, L.1    Jung, S.2
  • 84
    • 80355146868 scopus 로고    scopus 로고
    • Monocyte recruitment during infection and inflammation
    • Shi C, Pamer EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol 2011;11:762-774.
    • (2011) Nat Rev Immunol , vol.11 , pp. 762-774
    • Shi, C.1    Pamer, E.G.2
  • 85
    • 84876349699 scopus 로고    scopus 로고
    • Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors
    • Bain CC, et al. Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors. Mucosal Immunol 2013;6:498-510.
    • (2013) Mucosal Immunol , vol.6 , pp. 498-510
    • Bain, C.C.1
  • 86
    • 79960411324 scopus 로고    scopus 로고
    • CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    • Qian BZ, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 2011;475:222-225.
    • (2011) Nature , vol.475 , pp. 222-225
    • Qian, B.Z.1
  • 88
    • 0036092801 scopus 로고    scopus 로고
    • Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
    • Dai XM, et al. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood 2002;99:111-120.
    • (2002) Blood , vol.99 , pp. 111-120
    • Dai, X.M.1
  • 89
    • 84863008117 scopus 로고    scopus 로고
    • GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells
    • Greter M, et al. GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity 2012;36:1031-1046.
    • (2012) Immunity , vol.36 , pp. 1031-1046
    • Greter, M.1
  • 90
    • 27644436741 scopus 로고    scopus 로고
    • Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580
    • Conway JG, et al. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci USA 2005;102:16078-16083.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16078-16083
    • Conway, J.G.1
  • 91
    • 33845581266 scopus 로고    scopus 로고
    • A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations
    • Irvine KM, Burns CJ, Wilks AF, Su S, Hume DA, Sweet MJ. A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. FASEB J 2006;20:1921-1923.
    • (2006) FASEB J , vol.20 , pp. 1921-1923
    • Irvine, K.M.1    Burns, C.J.2    Wilks, A.F.3    Su, S.4    Hume, D.A.5    Sweet, M.J.6
  • 92
    • 33845214085 scopus 로고    scopus 로고
    • A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model
    • Ohno H, et al. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther 2006;5:2634-2643.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2634-2643
    • Ohno, H.1
  • 93
    • 78149462163 scopus 로고    scopus 로고
    • An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation
    • MacDonald KP, et al. An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation. Blood 2010;116:3955-3963.
    • (2010) Blood , vol.116 , pp. 3955-3963
    • MacDonald, K.P.1
  • 94
    • 80053156515 scopus 로고    scopus 로고
    • Dendritic cell and macrophage heterogeneity in vivo
    • Hashimoto D, Miller J, Merad M. Dendritic cell and macrophage heterogeneity in vivo. Immunity 2011;35:323-335.
    • (2011) Immunity , vol.35 , pp. 323-335
    • Hashimoto, D.1    Miller, J.2    Merad, M.3
  • 95
    • 0025332897 scopus 로고
    • The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
    • Yoshida H, et al. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 1990;345:442-444.
    • (1990) Nature , vol.345 , pp. 442-444
    • Yoshida, H.1
  • 96
    • 84864152036 scopus 로고    scopus 로고
    • IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
    • Wang Y, et al. IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol 2012;13:753-760.
    • (2012) Nat Immunol , vol.13 , pp. 753-760
    • Wang, Y.1
  • 97
    • 79958715229 scopus 로고    scopus 로고
    • Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation
    • Jenkins SJ, et al. Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 2011;332:1284-1288.
    • (2011) Science , vol.332 , pp. 1284-1288
    • Jenkins, S.J.1
  • 98
    • 0028333068 scopus 로고
    • Haematopoietic colony stimulating factors CSF-1 and GM-CSF increase phosphatidylinositol 3-kinase activity in murine bone marrow-derived macrophages
    • Yusoff P, Hamilton JA, Nolan RD, Phillips WA. Haematopoietic colony stimulating factors CSF-1 and GM-CSF increase phosphatidylinositol 3-kinase activity in murine bone marrow-derived macrophages. Growth Factors 1994;10:181-192.
    • (1994) Growth Factors , vol.10 , pp. 181-192
    • Yusoff, P.1    Hamilton, J.A.2    Nolan, R.D.3    Phillips, W.A.4
  • 99
    • 0028924793 scopus 로고
    • Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages
    • Buscher D, Hipskind RA, Krautwald S, Reimann T, Baccarini M. Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages. Mol Cell Biol 1995;15:466-475.
    • (1995) Mol Cell Biol , vol.15 , pp. 466-475
    • Buscher, D.1    Hipskind, R.A.2    Krautwald, S.3    Reimann, T.4    Baccarini, M.5
  • 100
    • 0030470274 scopus 로고    scopus 로고
    • Differences in the kinetics of activation of protein kinases and extracellular signal-related protein kinase 1 in colony-stimulating factor 1-stimulated and lipopolysaccharide-stimulated macrophages
    • Jaworowski A, Christy E, Yusoff P, Byrne R, Hamilton JA. Differences in the kinetics of activation of protein kinases and extracellular signal-related protein kinase 1 in colony-stimulating factor 1-stimulated and lipopolysaccharide-stimulated macrophages. Biochem J 1996;320:1011-1016.
    • (1996) Biochem J , vol.320 , pp. 1011-1016
    • Jaworowski, A.1    Christy, E.2    Yusoff, P.3    Byrne, R.4    Hamilton, J.A.5
  • 101
    • 22044432145 scopus 로고    scopus 로고
    • p85alpha subunit of class IA PI-3 kinase is crucial for macrophage growth and migration
    • Munugalavadla V, Borneo J, Ingram DA, Kapur R. p85alpha subunit of class IA PI-3 kinase is crucial for macrophage growth and migration. Blood 2005;106:103-109.
    • (2005) Blood , vol.106 , pp. 103-109
    • Munugalavadla, V.1    Borneo, J.2    Ingram, D.A.3    Kapur, R.4
  • 102
    • 0029550341 scopus 로고
    • PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation
    • Olson MC, et al. PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation. Immunity 1995;3:703-714.
    • (1995) Immunity , vol.3 , pp. 703-714
    • Olson, M.C.1
  • 103
    • 16044369709 scopus 로고    scopus 로고
    • Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene
    • Holtschke T, et al. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell 1996;87:307-317.
    • (1996) Cell , vol.87 , pp. 307-317
    • Holtschke, T.1
  • 104
    • 0032146794 scopus 로고    scopus 로고
    • PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors
    • Nerlov C, Graf T. PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Genes Dev 1998;12:2403-2412.
    • (1998) Genes Dev , vol.12 , pp. 2403-2412
    • Nerlov, C.1    Graf, T.2
  • 105
    • 0034717335 scopus 로고    scopus 로고
    • Regulation of B lymphocyte and macrophage development by graded expression of PU.1
    • DeKoter RP, Singh H. Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science 2000;288:1439-1441.
    • (2000) Science , vol.288 , pp. 1439-1441
    • DeKoter, R.P.1    Singh, H.2
  • 106
    • 0033680746 scopus 로고    scopus 로고
    • ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages
    • Tamura T, Nagamura-Inoue T, Shmeltzer Z, Kuwata T, Ozato K. ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity 2000;13:155-165.
    • (2000) Immunity , vol.13 , pp. 155-165
    • Tamura, T.1    Nagamura-Inoue, T.2    Shmeltzer, Z.3    Kuwata, T.4    Ozato, K.5
  • 107
    • 13244277736 scopus 로고    scopus 로고
    • Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
    • Nutt SL, Metcalf D, D'Amico A, Polli M, Wu L. Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. J Exp Med 2005;201:221-231.
    • (2005) J Exp Med , vol.201 , pp. 221-231
    • Nutt, S.L.1    Metcalf, D.2    D'Amico, A.3    Polli, M.4    Wu, L.5
  • 108
    • 70349748738 scopus 로고    scopus 로고
    • Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments
    • Qi CF, Li Z, Raffeld M, Wang H, Kovalchuk AL, Morse HC, 3rd. Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments. Immunol Res 2009;45:62-74.
    • (2009) Immunol Res , vol.45 , pp. 62-74
    • Qi, C.F.1    Li, Z.2    Raffeld, M.3    Wang, H.4    Kovalchuk, A.L.5    Morse, H.C.6
  • 109
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005;5:953-964.
    • (2005) Nat Rev Immunol , vol.5 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 110
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008;8:958-969.
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 111
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002;23:549-555.
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 112
    • 0017731240 scopus 로고
    • Cellular immunity and the parasite
    • Mackaness GB. Cellular immunity and the parasite. Adv Exp Med Biol 1977;93:65-73.
    • (1977) Adv Exp Med Biol , vol.93 , pp. 65-73
    • Mackaness, G.B.1
  • 113
    • 0023706894 scopus 로고
    • Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production
    • Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 1988;141:2407-2412.
    • (1988) J Immunol , vol.141 , pp. 2407-2412
    • Ding, A.H.1    Nathan, C.F.2    Stuehr, D.J.3
  • 114
    • 41549107522 scopus 로고    scopus 로고
    • Cytokine signaling modules in inflammatory responses
    • O'Shea JJ, Murray PJ. Cytokine signaling modules in inflammatory responses. Immunity 2008;28:477-487.
    • (2008) Immunity , vol.28 , pp. 477-487
    • O'Shea, J.J.1    Murray, P.J.2
  • 115
    • 0033152142 scopus 로고    scopus 로고
    • The chemokine system: redundancy for robust outputs
    • Mantovani A. The chemokine system: redundancy for robust outputs. Immunol Today 1999;20:254-257.
    • (1999) Immunol Today , vol.20 , pp. 254-257
    • Mantovani, A.1
  • 117
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell JE, Jr., Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994;264:1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 118
    • 0036222241 scopus 로고    scopus 로고
    • TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages
    • Toshchakov V, et al. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat Immunol 2002;3:392-398.
    • (2002) Nat Immunol , vol.3 , pp. 392-398
    • Toshchakov, V.1
  • 119
    • 18844457095 scopus 로고    scopus 로고
    • Mechanisms of type-I- and type-II-interferon-mediated signalling
    • Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 2005;5:375-386.
    • (2005) Nat Rev Immunol , vol.5 , pp. 375-386
    • Platanias, L.C.1
  • 120
    • 0031022516 scopus 로고    scopus 로고
    • An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide
    • Gao J, Morrison DC, Parmely TJ, Russell SW, Murphy WJ. An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide. J Biol Chem 1997;272:1226-1230.
    • (1997) J Biol Chem , vol.272 , pp. 1226-1230
    • Gao, J.1    Morrison, D.C.2    Parmely, T.J.3    Russell, S.W.4    Murphy, W.J.5
  • 121
    • 0035067108 scopus 로고    scopus 로고
    • Requirement for STAT1 in LPS-induced gene expression in macrophages
    • Ohmori Y, Hamilton TA. Requirement for STAT1 in LPS-induced gene expression in macrophages. J Leukoc Biol 2001;69:598-604.
    • (2001) J Leukoc Biol , vol.69 , pp. 598-604
    • Ohmori, Y.1    Hamilton, T.A.2
  • 122
    • 0026762988 scopus 로고
    • Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
    • Stein M, Keshav S, Harris N, Gordon S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 1992;176:287-292.
    • (1992) J Exp Med , vol.176 , pp. 287-292
    • Stein, M.1    Keshav, S.2    Harris, N.3    Gordon, S.4
  • 123
    • 0033082935 scopus 로고    scopus 로고
    • Other functions, other genes: alternative activation of antigen-presenting cells
    • Goerdt S, Orfanos CE. Other functions, other genes: alternative activation of antigen-presenting cells. Immunity 1999;10:137-142.
    • (1999) Immunity , vol.10 , pp. 137-142
    • Goerdt, S.1    Orfanos, C.E.2
  • 124
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003;3:23-35.
    • (2003) Nat Rev Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 125
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: an immunologic functional perspective
    • Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 2009;27:451-483.
    • (2009) Annu Rev Immunol , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 126
    • 0026751491 scopus 로고
    • IL-4 reciprocally regulates IL-1 and IL-1 receptor antagonist expression in human monocytes
    • Fenton MJ, Buras JA, Donnelly RP. IL-4 reciprocally regulates IL-1 and IL-1 receptor antagonist expression in human monocytes. J Immunol 1992;149:1283-1288.
    • (1992) J Immunol , vol.149 , pp. 1283-1288
    • Fenton, M.J.1    Buras, J.A.2    Donnelly, R.P.3
  • 127
    • 0030734165 scopus 로고    scopus 로고
    • Alternatively activated macrophages actively inhibit proliferation of peripheral blood lymphocytes and CD4+ T cells in vitro
    • Schebesch C, et al. Alternatively activated macrophages actively inhibit proliferation of peripheral blood lymphocytes and CD4+ T cells in vitro. Immunology 1997;92:478-486.
    • (1997) Immunology , vol.92 , pp. 478-486
    • Schebesch, C.1
  • 128
    • 0032102990 scopus 로고    scopus 로고
    • Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype
    • Munder M, Eichmann K, Modolell M. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol 1998;160:5347-5354.
    • (1998) J Immunol , vol.160 , pp. 5347-5354
    • Munder, M.1    Eichmann, K.2    Modolell, M.3
  • 129
    • 0032532054 scopus 로고    scopus 로고
    • Divergent effects of interleukin-4 and interferon-gamma on macrophage-derived chemokine production: an amplification circuit of polarized T helper 2 responses
    • Bonecchi R, et al. Divergent effects of interleukin-4 and interferon-gamma on macrophage-derived chemokine production: an amplification circuit of polarized T helper 2 responses. Blood 1998;92:2668-2671.
    • (1998) Blood , vol.92 , pp. 2668-2671
    • Bonecchi, R.1
  • 130
    • 15844404509 scopus 로고    scopus 로고
    • Essential role of Stat6 in IL-4 signalling
    • Takeda K, et al. Essential role of Stat6 in IL-4 signalling. Nature 1996;380:627-630.
    • (1996) Nature , vol.380 , pp. 627-630
    • Takeda, K.1
  • 131
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • Sica A, Bronte V. Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest 2007;117:1155-1166.
    • (2007) J Clin Invest , vol.117 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 132
    • 77956639386 scopus 로고    scopus 로고
    • Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling
    • Qualls JE, et al. Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling. Sci Signal 2010;3:ra62.
    • (2010) Sci Signal , vol.3
    • Qualls, J.E.1
  • 133
    • 56349093356 scopus 로고    scopus 로고
    • Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
    • El Kasmi KC, et al. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol 2008;9:1399-1406.
    • (2008) Nat Immunol , vol.9 , pp. 1399-1406
    • El Kasmi, K.C.1
  • 134
    • 0033104946 scopus 로고    scopus 로고
    • Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1
    • Ito S, et al. Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1. Blood 1999;93:1456-1463.
    • (1999) Blood , vol.93 , pp. 1456-1463
    • Ito, S.1
  • 135
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda K, et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999;10:39-49.
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1
  • 136
    • 0036625960 scopus 로고    scopus 로고
    • The role of STATs in apoptosis
    • Battle TE, Frank DA. The role of STATs in apoptosis. Curr Mol Med 2002;2:381-392.
    • (2002) Curr Mol Med , vol.2 , pp. 381-392
    • Battle, T.E.1    Frank, D.A.2
  • 137
    • 0036797750 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB
    • Yu Z, Zhang W, Kone BC. Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB. Biochem J 2002;367:97-105.
    • (2002) Biochem J , vol.367 , pp. 97-105
    • Yu, Z.1    Zhang, W.2    Kone, B.C.3
  • 138
    • 0345826123 scopus 로고    scopus 로고
    • Interleukin 1 activates STAT3/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism
    • Yoshida Y, et al. Interleukin 1 activates STAT3/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism. J Biol Chem 2004;279:1768-1776.
    • (2004) J Biol Chem , vol.279 , pp. 1768-1776
    • Yoshida, Y.1
  • 139
    • 63249092765 scopus 로고    scopus 로고
    • Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
    • Lee H, et al. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 2009;15:283-293.
    • (2009) Cancer Cell , vol.15 , pp. 283-293
    • Lee, H.1
  • 140
    • 79951671510 scopus 로고    scopus 로고
    • IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
    • Krausgruber T, et al. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol 2011;12:231-238.
    • (2011) Nat Immunol , vol.12 , pp. 231-238
    • Krausgruber, T.1
  • 141
    • 77956954197 scopus 로고    scopus 로고
    • The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
    • Satoh T, et al. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol 2010;11:936-944.
    • (2010) Nat Immunol , vol.11 , pp. 936-944
    • Satoh, T.1
  • 142
    • 34247124840 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation
    • Fleetwood AJ, Lawrence T, Hamilton JA, Cook AD. Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation. J Immunol 2007;178:5245-5252.
    • (2007) J Immunol , vol.178 , pp. 5245-5252
    • Fleetwood, A.J.1    Lawrence, T.2    Hamilton, J.A.3    Cook, A.D.4
  • 143
    • 46249090513 scopus 로고    scopus 로고
    • Colony-stimulating factors in inflammation and autoimmunity
    • Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol 2008;8:533-544.
    • (2008) Nat Rev Immunol , vol.8 , pp. 533-544
    • Hamilton, J.A.1
  • 144
    • 0036521607 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation
    • Lehtonen A, Matikainen S, Miettinen M, Julkunen I. Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation. J Leukoc Biol 2002;71:511-519.
    • (2002) J Leukoc Biol , vol.71 , pp. 511-519
    • Lehtonen, A.1    Matikainen, S.2    Miettinen, M.3    Julkunen, I.4
  • 145
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: balance, tolerance, and diversity
    • Mantovani A, Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 2010;22:231-237.
    • (2010) Curr Opin Immunol , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 146
    • 84868030361 scopus 로고    scopus 로고
    • Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer
    • Quatromoni JG, Eruslanov E. Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer. Am J Transl Res 2012;4:376-389.
    • (2012) Am J Transl Res , vol.4 , pp. 376-389
    • Quatromoni, J.G.1    Eruslanov, E.2
  • 147
    • 43249130187 scopus 로고    scopus 로고
    • Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity
    • Movahedi K, et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood 2008;111:4233-4244.
    • (2008) Blood , vol.111 , pp. 4233-4244
    • Movahedi, K.1
  • 148
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloid-derived suppressor cells in tumor-bearing mice
    • Youn JI, Nagaraj S, Collazo M, Gabrilovich DI. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol 2008;181:5791-5802.
    • (2008) J Immunol , vol.181 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 149
    • 82755192210 scopus 로고    scopus 로고
    • A critical role for macrophages in promotion of urethane-induced lung carcinogenesis
    • Zaynagetdinov R, et al. A critical role for macrophages in promotion of urethane-induced lung carcinogenesis. J Immunol 2011;187:5703-5711.
    • (2011) J Immunol , vol.187 , pp. 5703-5711
    • Zaynagetdinov, R.1
  • 150
    • 66349099293 scopus 로고    scopus 로고
    • Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated
    • Torroella-Kouri M, et al. Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated. Cancer Res 2009;69:4800-4809.
    • (2009) Cancer Res , vol.69 , pp. 4800-4809
    • Torroella-Kouri, M.1
  • 151
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Kortylewski M, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005;11:1314-1321.
    • (2005) Nat Med , vol.11 , pp. 1314-1321
    • Kortylewski, M.1
  • 152
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007;7:41-51.
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 153
    • 84875866083 scopus 로고    scopus 로고
    • STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients
    • Vasquez-Dunddel D, et al. STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients. J Clin Invest 2013;123:1580-1589.
    • (2013) J Clin Invest , vol.123 , pp. 1580-1589
    • Vasquez-Dunddel, D.1
  • 154
    • 53349099219 scopus 로고    scopus 로고
    • Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    • Cheng P, et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 2008;205:2235-2249.
    • (2008) J Exp Med , vol.205 , pp. 2235-2249
    • Cheng, P.1
  • 155
    • 66949145484 scopus 로고    scopus 로고
    • Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells
    • Corzo CA, et al. Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J Immunol 2009;182:5693-5701.
    • (2009) J Immunol , vol.182 , pp. 5693-5701
    • Corzo, C.A.1
  • 156
    • 84894274842 scopus 로고    scopus 로고
    • Tumor-induced STAT3 signaling in myeloid cells impairs dendritic cell generation by decreasing PKCbetaII abundance
    • Farren MR, et al. Tumor-induced STAT3 signaling in myeloid cells impairs dendritic cell generation by decreasing PKCbetaII abundance. Sci Signal 2014;7:ra16.
    • (2014) Sci Signal , vol.7
    • Farren, M.R.1
  • 157
    • 0032560475 scopus 로고    scopus 로고
    • Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice
    • Kaplan DH, et al. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci USA 1998;95:7556-7561.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7556-7561
    • Kaplan, D.H.1
  • 158
    • 33344460032 scopus 로고    scopus 로고
    • A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation)
    • Biswas SK, et al. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation). Blood 2006;107:2112-2122.
    • (2006) Blood , vol.107 , pp. 2112-2122
    • Biswas, S.K.1
  • 159
    • 17044366637 scopus 로고    scopus 로고
    • STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion
    • Kusmartsev S, Gabrilovich DI. STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion. J Immunol 2005;174:4880-4891.
    • (2005) J Immunol , vol.174 , pp. 4880-4891
    • Kusmartsev, S.1    Gabrilovich, D.I.2
  • 160
    • 33646250439 scopus 로고    scopus 로고
    • Stat1 deficiency in the host enhances interleukin-12-mediated tumor regression
    • Torrero MN, Xia X, Henk W, Yu S, Li S. Stat1 deficiency in the host enhances interleukin-12-mediated tumor regression. Cancer Res 2006;66:4461-4467.
    • (2006) Cancer Res , vol.66 , pp. 4461-4467
    • Torrero, M.N.1    Xia, X.2    Henk, W.3    Yu, S.4    Li, S.5
  • 161
    • 33745025705 scopus 로고    scopus 로고
    • IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice
    • Hanada T, et al. IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med 2006;203:1391-1397.
    • (2006) J Exp Med , vol.203 , pp. 1391-1397
    • Hanada, T.1
  • 162
    • 65249089638 scopus 로고    scopus 로고
    • In vivo analysis of dendritic cell development and homeostasis
    • Liu K, et al. In vivo analysis of dendritic cell development and homeostasis. Science 2009;324:392-397.
    • (2009) Science , vol.324 , pp. 392-397
    • Liu, K.1
  • 163
    • 84880838451 scopus 로고    scopus 로고
    • Origin of monocytes and macrophages in a committed progenitor
    • Hettinger J, et al. Origin of monocytes and macrophages in a committed progenitor. Nat Immunol 2013;14:821-830.
    • (2013) Nat Immunol , vol.14 , pp. 821-830
    • Hettinger, J.1
  • 164
    • 0015619335 scopus 로고
    • Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution
    • Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 1973;137:1142-1162.
    • (1973) J Exp Med , vol.137 , pp. 1142-1162
    • Steinman, R.M.1    Cohn, Z.A.2
  • 165
    • 0015949926 scopus 로고
    • Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro
    • Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. J Exp Med 1974;139:380-397.
    • (1974) J Exp Med , vol.139 , pp. 380-397
    • Steinman, R.M.1    Cohn, Z.A.2
  • 166
    • 65349134226 scopus 로고    scopus 로고
    • Dendritic cell homeostasis
    • Merad M, Manz MG. Dendritic cell homeostasis. Blood 2009;113:3418-3427.
    • (2009) Blood , vol.113 , pp. 3418-3427
    • Merad, M.1    Manz, M.G.2
  • 167
    • 0037141105 scopus 로고    scopus 로고
    • The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo
    • Iyoda T, et al. The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J Exp Med 2002;195:1289-1302.
    • (2002) J Exp Med , vol.195 , pp. 1289-1302
    • Iyoda, T.1
  • 168
    • 56449097442 scopus 로고    scopus 로고
    • Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity
    • Hildner K, et al. Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 2008;322:1097-1100.
    • (2008) Science , vol.322 , pp. 1097-1100
    • Hildner, K.1
  • 169
    • 65249099085 scopus 로고    scopus 로고
    • Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
    • Bedoui S, et al. Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat Immunol 2009;10:488-495.
    • (2009) Nat Immunol , vol.10 , pp. 488-495
    • Bedoui, S.1
  • 170
    • 76149133088 scopus 로고    scopus 로고
    • CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells
    • Henri S, et al. CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med 2010;207:189-206.
    • (2010) J Exp Med , vol.207 , pp. 189-206
    • Henri, S.1
  • 171
    • 80355136945 scopus 로고    scopus 로고
    • Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells
    • Fuertes MB, et al. Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells. J Exp Med 2011;208:2005-2016.
    • (2011) J Exp Med , vol.208 , pp. 2005-2016
    • Fuertes, M.B.1
  • 172
    • 84864517178 scopus 로고    scopus 로고
    • Cross-dressed CD8alpha+/CD103+ dendritic cells prime CD8+ T cells following vaccination
    • Li L, et al. Cross-dressed CD8alpha+/CD103+ dendritic cells prime CD8+ T cells following vaccination. Proc Natl Acad Sci USA 2012;109:12716-12721.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 12716-12721
    • Li, L.1
  • 173
    • 84868628564 scopus 로고    scopus 로고
    • Cross-presenting CD103+ dendritic cells are protected from influenza virus infection
    • Helft J, et al. Cross-presenting CD103+ dendritic cells are protected from influenza virus infection. J Clin Invest 2012;122:4037-4047.
    • (2012) J Clin Invest , vol.122 , pp. 4037-4047
    • Helft, J.1
  • 174
    • 17644372733 scopus 로고    scopus 로고
    • IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    • Liu YJ. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 2005;23:275-306.
    • (2005) Annu Rev Immunol , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 175
    • 84857426963 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells control T-cell response to chronic viral infection
    • Cervantes-Barragan L, et al. Plasmacytoid dendritic cells control T-cell response to chronic viral infection. Proc Natl Acad Sci USA 2012;109:3012-3017.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 3012-3017
    • Cervantes-Barragan, L.1
  • 176
    • 0034679566 scopus 로고    scopus 로고
    • Natural interferon alpha/beta-producing cells link innate and adaptive immunity
    • Kadowaki N, Antonenko S, Lau JY, Liu YJ. Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med 2000;192:219-226.
    • (2000) J Exp Med , vol.192 , pp. 219-226
    • Kadowaki, N.1    Antonenko, S.2    Lau, J.Y.3    Liu, Y.J.4
  • 177
    • 80053620170 scopus 로고    scopus 로고
    • Cell-intrinsic role for IFN-alpha-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response
    • Li HS, et al. Cell-intrinsic role for IFN-alpha-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response. Blood 2011;118:3879-3889.
    • (2011) Blood , vol.118 , pp. 3879-3889
    • Li, H.S.1
  • 178
    • 51349158548 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells mediate oral tolerance
    • Goubier A, et al. Plasmacytoid dendritic cells mediate oral tolerance. Immunity 2008;29:464-475.
    • (2008) Immunity , vol.29 , pp. 464-475
    • Goubier, A.1
  • 179
    • 78650409670 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons
    • Gregorio J, et al. Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med 2010;207:2921-2930.
    • (2010) J Exp Med , vol.207 , pp. 2921-2930
    • Gregorio, J.1
  • 180
    • 84867503094 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells promote immunosuppression in ovarian cancer via ICOS costimulation of Foxp3(+) T-regulatory cells
    • Conrad C, et al. Plasmacytoid dendritic cells promote immunosuppression in ovarian cancer via ICOS costimulation of Foxp3(+) T-regulatory cells. Cancer Res 2012;72:5240-5249.
    • (2012) Cancer Res , vol.72 , pp. 5240-5249
    • Conrad, C.1
  • 181
    • 84865973889 scopus 로고    scopus 로고
    • Nucleic acid-containing amyloid fibrils potently induce type I interferon and stimulate systemic autoimmunity
    • Di Domizio J, et al. Nucleic acid-containing amyloid fibrils potently induce type I interferon and stimulate systemic autoimmunity. Proc Natl Acad Sci USA 2012;109:14550-14555.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 14550-14555
    • Di Domizio, J.1
  • 182
    • 84865418665 scopus 로고    scopus 로고
    • Deciphering the transcriptional network of the dendritic cell lineage
    • Miller JC, et al. Deciphering the transcriptional network of the dendritic cell lineage. Nat Immunol 2012;13:888-899.
    • (2012) Nat Immunol , vol.13 , pp. 888-899
    • Miller, J.C.1
  • 183
    • 84874028143 scopus 로고    scopus 로고
    • Reply to: "Can DCs be distinguished from macrophages by molecular signatures?"
    • Randolph G, Merad M. Reply to: "Can DCs be distinguished from macrophages by molecular signatures?". Nat Immunol 2013;14:189-190.
    • (2013) Nat Immunol , vol.14 , pp. 189-190
    • Randolph, G.1    Merad, M.2
  • 184
    • 0030456368 scopus 로고    scopus 로고
    • A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells
    • Borkowski TA, Letterio JJ, Farr AG, Udey MC. A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells. J Exp Med 1996;184:2417-2422.
    • (1996) J Exp Med , vol.184 , pp. 2417-2422
    • Borkowski, T.A.1    Letterio, J.J.2    Farr, A.G.3    Udey, M.C.4
  • 185
    • 77952239111 scopus 로고    scopus 로고
    • Ontogeny and homeostasis of Langerhans cells
    • Ginhoux F, Merad M. Ontogeny and homeostasis of Langerhans cells. Immunol Cell Biol 2010;88:387-392.
    • (2010) Immunol Cell Biol , vol.88 , pp. 387-392
    • Ginhoux, F.1    Merad, M.2
  • 186
    • 0036906526 scopus 로고    scopus 로고
    • Langerhans cells renew in the skin throughout life under steady-state conditions
    • Merad M, et al. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol 2002;3:1135-1141.
    • (2002) Nat Immunol , vol.3 , pp. 1135-1141
    • Merad, M.1
  • 187
    • 2442658900 scopus 로고    scopus 로고
    • Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
    • Merad M, et al. Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med 2004;10:510-517.
    • (2004) Nat Med , vol.10 , pp. 510-517
    • Merad, M.1
  • 188
    • 56749152272 scopus 로고    scopus 로고
    • Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    • Merad M, Ginhoux F, Collin M. Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat Rev Immunol 2008;8:935-947.
    • (2008) Nat Rev Immunol , vol.8 , pp. 935-947
    • Merad, M.1    Ginhoux, F.2    Collin, M.3
  • 189
    • 84884214656 scopus 로고    scopus 로고
    • Multicolor fate mapping of Langerhans cell homeostasis
    • Ghigo C, et al. Multicolor fate mapping of Langerhans cell homeostasis. J Exp Med 2013;210:1657-1664.
    • (2013) J Exp Med , vol.210 , pp. 1657-1664
    • Ghigo, C.1
  • 190
    • 0041660895 scopus 로고    scopus 로고
    • The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3
    • D'Amico A, Wu L. The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3. J Exp Med 2003;198:293-303.
    • (2003) J Exp Med , vol.198 , pp. 293-303
    • D'Amico, A.1    Wu, L.2
  • 191
    • 0035761466 scopus 로고    scopus 로고
    • Development of thymic and splenic dendritic cell populations from different hemopoietic precursors
    • Wu L, D'Amico A, Hochrein H, O'Keeffe M, Shortman K, Lucas K. Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood 2001;98:3376-3382.
    • (2001) Blood , vol.98 , pp. 3376-3382
    • Wu, L.1    D'Amico, A.2    Hochrein, H.3    O'Keeffe, M.4    Shortman, K.5    Lucas, K.6
  • 192
    • 77949956058 scopus 로고    scopus 로고
    • Fate mapping reveals separate origins of T cells and myeloid lineages in the thymus
    • Schlenner SM, et al. Fate mapping reveals separate origins of T cells and myeloid lineages in the thymus. Immunity 2010;32:426-436.
    • (2010) Immunity , vol.32 , pp. 426-436
    • Schlenner, S.M.1
  • 193
    • 84872093721 scopus 로고    scopus 로고
    • Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells
    • Sathe P, Vremec D, Wu L, Corcoran L, Shortman K. Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells. Blood 2013;121:11-19.
    • (2013) Blood , vol.121 , pp. 11-19
    • Sathe, P.1    Vremec, D.2    Wu, L.3    Corcoran, L.4    Shortman, K.5
  • 194
    • 30344444770 scopus 로고    scopus 로고
    • A clonogenic bone marrow progenitor specific for macrophages and dendritic cells
    • Fogg DK, et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 2006;311:83-87.
    • (2006) Science , vol.311 , pp. 83-87
    • Fogg, D.K.1
  • 195
    • 77349124883 scopus 로고    scopus 로고
    • Origin and development of dendritic cells
    • Liu K, Nussenzweig MC. Origin and development of dendritic cells. Immunol Rev 2010;234:45-54.
    • (2010) Immunol Rev , vol.234 , pp. 45-54
    • Liu, K.1    Nussenzweig, M.C.2
  • 196
    • 77349105277 scopus 로고    scopus 로고
    • Instructive cytokine signals in dendritic cell lineage commitment
    • Schmid MA, Kingston D, Boddupalli S, Manz MG. Instructive cytokine signals in dendritic cell lineage commitment. Immunol Rev 2010;234:32-44.
    • (2010) Immunol Rev , vol.234 , pp. 32-44
    • Schmid, M.A.1    Kingston, D.2    Boddupalli, S.3    Manz, M.G.4
  • 197
    • 35549000134 scopus 로고    scopus 로고
    • Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo
    • Naik SH, et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol 2007;8:1217-1226.
    • (2007) Nat Immunol , vol.8 , pp. 1217-1226
    • Naik, S.H.1
  • 198
    • 35548970740 scopus 로고    scopus 로고
    • Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow
    • Onai N, Obata-Onai A, Schmid MA, Ohteki T, Jarrossay D, Manz MG. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol 2007;8:1207-1216.
    • (2007) Nat Immunol , vol.8 , pp. 1207-1216
    • Onai, N.1    Obata-Onai, A.2    Schmid, M.A.3    Ohteki, T.4    Jarrossay, D.5    Manz, M.G.6
  • 199
    • 10344240415 scopus 로고    scopus 로고
    • Biochemical and genetic characterization of multiple splice variants of the Flt3 ligand
    • McClanahan T, et al. Biochemical and genetic characterization of multiple splice variants of the Flt3 ligand. Blood 1996;88:3371-3382.
    • (1996) Blood , vol.88 , pp. 3371-3382
    • McClanahan, T.1
  • 200
    • 0033963624 scopus 로고    scopus 로고
    • Expression of Flt3-ligand by the endothelial cell
    • Solanilla A, et al. Expression of Flt3-ligand by the endothelial cell. Leukemia 2000;14:153-162.
    • (2000) Leukemia , vol.14 , pp. 153-162
    • Solanilla, A.1
  • 201
    • 0036797682 scopus 로고    scopus 로고
    • Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool
    • Sitnicka E, Bryder D, Theilgaard-Monch K, Buza-Vidas N, Adolfsson J, Jacobsen SE. Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool. Immunity 2002;17:463-472.
    • (2002) Immunity , vol.17 , pp. 463-472
    • Sitnicka, E.1    Bryder, D.2    Theilgaard-Monch, K.3    Buza-Vidas, N.4    Adolfsson, J.5    Jacobsen, S.E.6
  • 202
    • 84875528275 scopus 로고    scopus 로고
    • The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
    • Merad M, Sathe P, Helft J, Miller J, Mortha A. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol 2013;31:563-604.
    • (2013) Annu Rev Immunol , vol.31 , pp. 563-604
    • Merad, M.1    Sathe, P.2    Helft, J.3    Miller, J.4    Mortha, A.5
  • 203
    • 0034210658 scopus 로고    scopus 로고
    • Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
    • McKenna HJ, et al. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood 2000;95:3489-3497.
    • (2000) Blood , vol.95 , pp. 3489-3497
    • McKenna, H.J.1
  • 204
    • 44049097818 scopus 로고    scopus 로고
    • The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
    • Waskow C, et al. The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol 2008;9:676-683.
    • (2008) Nat Immunol , vol.9 , pp. 676-683
    • Waskow, C.1
  • 205
    • 68249155389 scopus 로고    scopus 로고
    • The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis
    • Kingston D, Schmid MA, Onai N, Obata-Onai A, Baumjohann D, Manz MG. The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis. Blood 2009;114:835-843.
    • (2009) Blood , vol.114 , pp. 835-843
    • Kingston, D.1    Schmid, M.A.2    Onai, N.3    Obata-Onai, A.4    Baumjohann, D.5    Manz, M.G.6
  • 206
    • 0029661945 scopus 로고    scopus 로고
    • Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified
    • Maraskovsky E, et al. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med 1996;184:1953-1962.
    • (1996) J Exp Med , vol.184 , pp. 1953-1962
    • Maraskovsky, E.1
  • 207
    • 0034254472 scopus 로고    scopus 로고
    • In vivo generation of human dendritic cell subsets by Flt3 ligand
    • Maraskovsky E, et al. In vivo generation of human dendritic cell subsets by Flt3 ligand. Blood 2000;96:878-884.
    • (2000) Blood , vol.96 , pp. 878-884
    • Maraskovsky, E.1
  • 208
    • 0035902607 scopus 로고    scopus 로고
    • Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy
    • Fong L, et al. Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy. Proc Natl Acad Sci USA 2001;98:8809-8814.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8809-8814
    • Fong, L.1
  • 209
    • 0037443489 scopus 로고    scopus 로고
    • Conditional expression of murine Flt3 ligand leads to expansion of multiple dendritic cell subsets in peripheral blood and tissues of transgenic mice
    • Manfra DJ, Chen SC, Jensen KK, Fine JS, Wiekowski MT, Lira SA. Conditional expression of murine Flt3 ligand leads to expansion of multiple dendritic cell subsets in peripheral blood and tissues of transgenic mice. J Immunol 2003;170:2843-2852.
    • (2003) J Immunol , vol.170 , pp. 2843-2852
    • Manfra, D.J.1    Chen, S.C.2    Jensen, K.K.3    Fine, J.S.4    Wiekowski, M.T.5    Lira, S.A.6
  • 210
    • 84869802361 scopus 로고    scopus 로고
    • The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development
    • Li HS, et al. The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. Blood 2012;120:4363-4373.
    • (2012) Blood , vol.120 , pp. 4363-4373
    • Li, H.S.1
  • 211
    • 84897374531 scopus 로고    scopus 로고
    • In vivo evidence for an instructive role of fms-like tyrosine kinase-3 (FLT3) ligand in hematopoietic development
    • Tsapogas P, et al. In vivo evidence for an instructive role of fms-like tyrosine kinase-3 (FLT3) ligand in hematopoietic development. Haematologica 2014;99:638-646.
    • (2014) Haematologica , vol.99 , pp. 638-646
    • Tsapogas, P.1
  • 212
    • 0031712344 scopus 로고    scopus 로고
    • In vitro propagated dendritic cells from patients with human-papilloma virus-associated preneoplastic lesions of the uterine cervix: use of Flt3 ligand
    • Hubert P, et al. In vitro propagated dendritic cells from patients with human-papilloma virus-associated preneoplastic lesions of the uterine cervix: use of Flt3 ligand. Cancer Immunol Immunother 1998;47:81-89.
    • (1998) Cancer Immunol Immunother , vol.47 , pp. 81-89
    • Hubert, P.1
  • 213
    • 0034684655 scopus 로고    scopus 로고
    • Generation of interferon alpha-producing predendritic cell (Pre-DC)2 from human CD34(+) hematopoietic stem cells
    • Blom B, Ho S, Antonenko S, Liu YJ. Generation of interferon alpha-producing predendritic cell (Pre-DC)2 from human CD34(+) hematopoietic stem cells. J Exp Med 2000;192:1785-1796.
    • (2000) J Exp Med , vol.192 , pp. 1785-1796
    • Blom, B.1    Ho, S.2    Antonenko, S.3    Liu, Y.J.4
  • 214
    • 0036534871 scopus 로고    scopus 로고
    • The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor
    • Gilliet M, et al. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J Exp Med 2002;195:953-958.
    • (2002) J Exp Med , vol.195 , pp. 953-958
    • Gilliet, M.1
  • 215
    • 0036679853 scopus 로고    scopus 로고
    • GM-CSF in inflammation and autoimmunity
    • Hamilton JA. GM-CSF in inflammation and autoimmunity. Trends Immunol 2002;23:403-408.
    • (2002) Trends Immunol , vol.23 , pp. 403-408
    • Hamilton, J.A.1
  • 216
    • 0026481133 scopus 로고
    • Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
    • Inaba K, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992;176:1693-1702.
    • (1992) J Exp Med , vol.176 , pp. 1693-1702
    • Inaba, K.1
  • 217
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    • Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994;179:1109-1118.
    • (1994) J Exp Med , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 218
    • 10144260007 scopus 로고    scopus 로고
    • CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha
    • Caux C, et al. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J Exp Med 1996;184:695-706.
    • (1996) J Exp Med , vol.184 , pp. 695-706
    • Caux, C.1
  • 219
    • 41549151507 scopus 로고    scopus 로고
    • The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8
    • Esashi E, Wang YH, Perng O, Qin XF, Liu YJ, Watowich SS. The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity 2008;28:509-520.
    • (2008) Immunity , vol.28 , pp. 509-520
    • Esashi, E.1    Wang, Y.H.2    Perng, O.3    Qin, X.F.4    Liu, Y.J.5    Watowich, S.S.6
  • 220
    • 0031013082 scopus 로고    scopus 로고
    • The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs
    • Vremec D, Lieschke GJ, Dunn AR, Robb L, Metcalf D, Shortman K. The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur J Immunol 1997;27:40-44.
    • (1997) Eur J Immunol , vol.27 , pp. 40-44
    • Vremec, D.1    Lieschke, G.J.2    Dunn, A.R.3    Robb, L.4    Metcalf, D.5    Shortman, K.6
  • 221
    • 0034234607 scopus 로고    scopus 로고
    • Polyethylene glycol-modified GM-CSF expands CD11b(high)CD11c(high) but notCD11b(low)CD11c(high) murine dendritic cells in vivo: a comparative analysis with Flt3 ligand
    • Daro E, et al. Polyethylene glycol-modified GM-CSF expands CD11b(high)CD11c(high) but notCD11b(low)CD11c(high) murine dendritic cells in vivo: a comparative analysis with Flt3 ligand. J Immunol 2000;165:49-58.
    • (2000) J Immunol , vol.165 , pp. 49-58
    • Daro, E.1
  • 222
    • 0037085754 scopus 로고    scopus 로고
    • Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice
    • O'Keeffe M, et al. Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice. Blood 2002;99:2122-2130.
    • (2002) Blood , vol.99 , pp. 2122-2130
    • O'Keeffe, M.1
  • 223
    • 77952310536 scopus 로고    scopus 로고
    • GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization
    • King IL, Kroenke MA, Segal BM. GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization. J Exp Med 2010;207:953-961.
    • (2010) J Exp Med , vol.207 , pp. 953-961
    • King, I.L.1    Kroenke, M.A.2    Segal, B.M.3
  • 224
    • 34347401419 scopus 로고    scopus 로고
    • Activation mechanisms of STAT5 by oncogenic Flt3-ITD
    • Choudhary C, et al. Activation mechanisms of STAT5 by oncogenic Flt3-ITD. Blood 2007;110:370-374.
    • (2007) Blood , vol.110 , pp. 370-374
    • Choudhary, C.1
  • 225
    • 0030935260 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
    • Takeda K, et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci USA 1997;94:3801-3804.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3801-3804
    • Takeda, K.1
  • 226
    • 0347480225 scopus 로고    scopus 로고
    • STAT3 is required for Flt3L-dependent dendritic cell differentiation
    • Laouar Y, Welte T, Fu XY, Flavell RA. STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity 2003;19:903-912.
    • (2003) Immunity , vol.19 , pp. 903-912
    • Laouar, Y.1    Welte, T.2    Fu, X.Y.3    Flavell, R.A.4
  • 227
    • 77951886963 scopus 로고    scopus 로고
    • Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function
    • Melillo JA, et al. Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function. J Immunol 2010;184:2638-2645.
    • (2010) J Immunol , vol.184 , pp. 2638-2645
    • Melillo, J.A.1
  • 228
    • 61349152914 scopus 로고    scopus 로고
    • E and ID proteins branch out
    • Kee BL. E and ID proteins branch out. Nat Rev Immunol 2009;9:175-184.
    • (2009) Nat Rev Immunol , vol.9 , pp. 175-184
    • Kee, B.L.1
  • 229
    • 52949106528 scopus 로고    scopus 로고
    • Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development
    • Cisse B, et al. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 2008;135:37-48.
    • (2008) Cell , vol.135 , pp. 37-48
    • Cisse, B.1
  • 230
    • 78650178058 scopus 로고    scopus 로고
    • Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells
    • Ghosh HS, Cisse B, Bunin A, Lewis KL, Reizis B. Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells. Immunity 2010;33:905-916.
    • (2010) Immunity , vol.33 , pp. 905-916
    • Ghosh, H.S.1    Cisse, B.2    Bunin, A.3    Lewis, K.L.4    Reizis, B.5
  • 232
    • 4444268818 scopus 로고    scopus 로고
    • Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
    • Cui Y, et al. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol 2004;24:8037-8047.
    • (2004) Mol Cell Biol , vol.24 , pp. 8037-8047
    • Cui, Y.1
  • 233
    • 32244444750 scopus 로고    scopus 로고
    • Stat5a/b are essential for normal lymphoid development and differentiation
    • Yao Z, et al. Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci USA 2006;103:1000-1005.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1000-1005
    • Yao, Z.1
  • 234
    • 84865509868 scopus 로고    scopus 로고
    • A STATus report on dendritic cell development
    • Li H, Watowich S. A STATus report on dendritic cell development. J Leukoc Biol 2012;92:445-459.
    • (2012) J Leukoc Biol , vol.92 , pp. 445-459
    • Li, H.1    Watowich, S.2
  • 235
    • 84905993712 scopus 로고    scopus 로고
    • Diversification of dendritic cell subsets: emerging roles for STAT proteins
    • Li HS, Watowich SS. Diversification of dendritic cell subsets: emerging roles for STAT proteins. JakSTAT 2013;2:e25112.
    • (2013) JakSTAT , vol.2
    • Li, H.S.1    Watowich, S.S.2
  • 236
    • 3142562354 scopus 로고    scopus 로고
    • Id2 is a primary partner for the E2-2 basic helix-loop-helix transcription factor in the human placenta
    • Liu YP, Burleigh D, Durning M, Hudson L, Chiu IM, Golos TG. Id2 is a primary partner for the E2-2 basic helix-loop-helix transcription factor in the human placenta. Mol Cell Endocrinol 2004;222:83-91.
    • (2004) Mol Cell Endocrinol , vol.222 , pp. 83-91
    • Liu, Y.P.1    Burleigh, D.2    Durning, M.3    Hudson, L.4    Chiu, I.M.5    Golos, T.G.6
  • 237
    • 73949101833 scopus 로고    scopus 로고
    • The origin and development of nonlymphoid tissue CD103+ DCs
    • Ginhoux F, et al. The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med 2009;206:3115-3130.
    • (2009) J Exp Med , vol.206 , pp. 3115-3130
    • Ginhoux, F.1
  • 238
    • 0037386339 scopus 로고    scopus 로고
    • Transcriptional profiling identifies Id2 function in dendritic cell development
    • Hacker C, et al. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol 2003;4:380-386.
    • (2003) Nat Immunol , vol.4 , pp. 380-386
    • Hacker, C.1
  • 239
    • 14044270784 scopus 로고    scopus 로고
    • IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity
    • Tamura T, et al. IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol 2005;174:2573-2581.
    • (2005) J Immunol , vol.174 , pp. 2573-2581
    • Tamura, T.1
  • 240
    • 0037011021 scopus 로고    scopus 로고
    • ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells
    • Schiavoni G, et al. ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells. J Exp Med 2002;196:1415-1425.
    • (2002) J Exp Med , vol.196 , pp. 1415-1425
    • Schiavoni, G.1
  • 241
    • 41349119601 scopus 로고    scopus 로고
    • The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse
    • Tailor P, Tamura T, Morse HC, 3rd, Ozato K. The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse. Blood 2008;111:1942-1945.
    • (2008) Blood , vol.111 , pp. 1942-1945
    • Tailor, P.1    Tamura, T.2    Morse, H.C.3    Ozato, K.4
  • 242
    • 79960219807 scopus 로고    scopus 로고
    • IRF8 mutations and human dendritic-cell immunodeficiency
    • Hambleton S, et al. IRF8 mutations and human dendritic-cell immunodeficiency. N Engl J Med 2011;365:127-138.
    • (2011) N Engl J Med , vol.365 , pp. 127-138
    • Hambleton, S.1
  • 243
    • 77349083495 scopus 로고    scopus 로고
    • Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells
    • Edelson BT, et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J Exp Med 2010;207:823-836.
    • (2010) J Exp Med , vol.207 , pp. 823-836
    • Edelson, B.T.1
  • 244
    • 84875421490 scopus 로고    scopus 로고
    • The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses
    • Bell BD, et al. The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol 2013;14:364-371.
    • (2013) Nat Immunol , vol.14 , pp. 364-371
    • Bell, B.D.1
  • 245
    • 0036855470 scopus 로고    scopus 로고
    • CpG-DNA-induced IFN-alpha production involves p38 MAPK-dependent STAT1 phosphorylation in human plasmacytoid dendritic cell precursors
    • Takauji R, et al. CpG-DNA-induced IFN-alpha production involves p38 MAPK-dependent STAT1 phosphorylation in human plasmacytoid dendritic cell precursors. J Leukoc Biol 2002;72:1011-1019.
    • (2002) J Leukoc Biol , vol.72 , pp. 1011-1019
    • Takauji, R.1
  • 246
    • 21444443078 scopus 로고    scopus 로고
    • Tissue-specific positive feedback requirements for production of type I interferon following virus infection
    • Prakash A, Smith E, Lee CK, Levy DE. Tissue-specific positive feedback requirements for production of type I interferon following virus infection. Biol Chem 2005;280:18651-18657.
    • (2005) Biol Chem , vol.280 , pp. 18651-18657
    • Prakash, A.1    Smith, E.2    Lee, C.K.3    Levy, D.E.4
  • 247
    • 34249781695 scopus 로고    scopus 로고
    • STAT1 expression in dendritic cells, but not T cells, is required for immunity to Leishmania major
    • Johnson LM, Scott P. STAT1 expression in dendritic cells, but not T cells, is required for immunity to Leishmania major. J Immunol 2007;178:7259-7266.
    • (2007) J Immunol , vol.178 , pp. 7259-7266
    • Johnson, L.M.1    Scott, P.2
  • 248
    • 70149123505 scopus 로고    scopus 로고
    • Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL
    • Pilz A, et al. Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol 2009;183:2286-2293.
    • (2009) J Immunol , vol.183 , pp. 2286-2293
    • Pilz, A.1
  • 249
    • 80355147292 scopus 로고    scopus 로고
    • Type I interferon is selectively required by dendritic cells for immune rejection of tumors
    • Diamond MS, et al. Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med 2011;208:1989-2003.
    • (2011) J Exp Med , vol.208 , pp. 1989-2003
    • Diamond, M.S.1
  • 250
    • 84864047369 scopus 로고    scopus 로고
    • Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection
    • Kernbauer E, et al. Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. PLoS Pathog 2012;8:e1002763.
    • (2012) PLoS Pathog , vol.8
    • Kernbauer, E.1
  • 251
    • 66149115277 scopus 로고    scopus 로고
    • IFNalpha activates dormant haematopoietic stem cells in vivo
    • Essers MA, et al. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 2009;458:904-908.
    • (2009) Nature , vol.458 , pp. 904-908
    • Essers, M.A.1
  • 252
    • 77953462161 scopus 로고    scopus 로고
    • Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection
    • Baldridge MT, King KY, Boles NC, Weksberg DC, Goodell MA. Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature 2010;465:793-797.
    • (2010) Nature , vol.465 , pp. 793-797
    • Baldridge, M.T.1    King, K.Y.2    Boles, N.C.3    Weksberg, D.C.4    Goodell, M.A.5
  • 253
    • 84888100092 scopus 로고    scopus 로고
    • A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors
    • Chen YL, Chen TT, Pai LM, Wesoly J, Bluyssen HA, Lee CK. A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors. J Exp Med 2013;210:2515-2522.
    • (2013) J Exp Med , vol.210 , pp. 2515-2522
    • Chen, Y.L.1    Chen, T.T.2    Pai, L.M.3    Wesoly, J.4    Bluyssen, H.A.5    Lee, C.K.6
  • 254
    • 13844296660 scopus 로고    scopus 로고
    • Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling
    • Hahm B, Trifilo MJ, Zuniga EI, Oldstone MB. Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. Immunity 2005;22:247-257.
    • (2005) Immunity , vol.22 , pp. 247-257
    • Hahm, B.1    Trifilo, M.J.2    Zuniga, E.I.3    Oldstone, M.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.