A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors

Journal of Experimental Medicine

Volumn 210, Issue 12, 2013, Pages 2515-2522

  Chen, Yi Ling ^a   Chen, Ting Ting ^a   Pai, Li Mei ^b   Wesoly, Joanna ^c   Bluyssen, Hans A R ^c   Lee, Chien Kuo ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c ADAM MICKIEWICZ UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; FLT3 LIGAND; INTERFERON; STAT2 PROTEIN; STAT3 PROTEIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DESTRUCTION; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FLOW CYTOMETRY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOID PROGENITOR CELL; MEASLES; MOUSE; MYELOID DENDRITIC CELL; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PSORIASIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; DENDRITIC CELLS; HEMATOPOIESIS; INTERFERON TYPE I; INTERFERON-ALPHA; LYMPHOID PROGENITOR CELLS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; RECEPTOR, INTERFERON ALPHA-BETA; SIGNAL TRANSDUCTION;

EID: 84888100092     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20130536     Document Type: Article

References (31)

1. Asselin-Paturel, C., G. Brizard, K. Chemin, A. Boonstra, A. O'Garra, A. Vicari, and G. Trinchieri. 2005. Type I interferon dependence of plasmacytoid dendritic cell activation and migration. J. Exp. Med. 201:1157-1167. http://dx.doi.org/10.1084/jem.20041930
2. Chen, L.S., P.C. Wei, T. Liu, C.H. Kao, L.M. Pai, and C.K. Lee. 2009. STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response. J. Biomed. Sci. 16:22. http://dx.doi .org/10.1186/1423-0127-16-22
3. Chicha, L., D. Jarrossay, and M.G. Manz. 2004. Clonal type I interferonproducing and dendritic cell precursors are contained in both human lymphoid and myeloid progenitor populations. J. Exp. Med. 200:1519-1524. http://dx.doi.org/10.1084/jem.20040809
4. D'Amico, A., and L. Wu. 2003. The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3. J. Exp. Med. 198:293-303. http://dx.doi.org/10.1084/jem.20030107
5. Dalod, M., T.P. Salazar-Mather, L. Malmgaard, C. Lewis, C. Asselin-Paturel, F. Brière, G. Trinchieri, and C.A. Biron. 2002. Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo. J. Exp. Med. 195:517-528. http://dx.doi.org/10.1084/jem.20011672
6. Essers, M.A., S. Offner, W.E. Blanco-Bose, Z. Waibler, U. Kalinke, M.A. Duchosal, and A. Trumpp. 2009. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature. 458:904-908. http://dx.doi.org/10.1038/nature07815
7. Gautier, G., M. Humbert, F. Deauvieau, M. Scuiller, J. Hiscott, E.E. Bates, G. Trinchieri, C. Caux, and P. Garrone. 2005. A type I interferon autocrine- paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J. Exp. Med. 201:1435-1446. http://dx.doi.org/10.1084/jem.20041964
8. Gilliet, M., W. Cao, and Y.J. Liu. 2008. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 8:594-606. http://dx.doi.org/10.1038/nri2358
9. Hahm, B., M.J. Trifilo, E.I. Zuniga, and M.B. Oldstone. 2005. Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. Immunity. 22:247-257. http://dx.doi.org/10.1016/j.immuni.2005.01.005
10. Honda, K., S. Sakaguchi, C. Nakajima, A. Watanabe, H. Yanai, M. Matsumoto, T. Ohteki, T. Kaisho, A. Takaoka, S. Akira, et al. 2003. Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc. Natl. Acad. Sci. USA. 100:10872-10877. http://dx.doi.org/10.1073/pnas.1934678100
11. Karsunky, H., M. Merad, A. Cozzio, I.L. Weissman, and M.G. Manz. 2003. Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J. Exp. Med. 198:305-313. http://dx.doi.org/10.1084/jem.20030323
12. Kondo, M., I.L. Weissman, and K. Akashi. 1997. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 91:661-672. http://dx.doi.org/10.1016/S0092-8674(00)80453-5
13. Levy, D.E., I.J. Marié, and J.E. Durbin. 2011. Induction and function of type I and III interferon in response to viral infection. Curr Opin Virol. 1:476-486. http://dx.doi.org/10.1016/j.coviro.2011.11.001
14. Li, H.S., A. Gelbard, G.J. Martinez, E. Esashi, H. Zhang, H. Nguyen-Jackson, Y.J. Liu, W.W. Overwijk, and S.S. Watowich. 2011. Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response. Blood. 118:3879-3889. http://dx.doi.org/10.1182/blood-2011-04-349761
15. Li, H.S., C.Y. Yang, K.C. Nallaparaju, H. Zhang, Y.J. Liu, A.W. Goldrath, and S.S. Watowich. 2012. The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. Blood. 120:4363-4373. http://dx.doi.org/10.1182/blood-2012-07-441311
16. Liu, Y.J. 2005. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 23:275-306. http://dx.doi.org/10.1146/annurev.immunol.23.021704.115633
17. Liu, K., G.D. Victora, T.A. Schwickert, P. Guermonprez, M.M. Meredith, K. Yao, F.F. Chu, G.J. Randolph, A.Y. Rudensky, and M. Nussenzweig. 2009. In vivo analysis of dendritic cell development and homeostasis. Science. 324:392-397. http://dx.doi.org/10.1126/science.1171243
18. Longman, R.S., D. Braun, S. Pellegrini, C.M. Rice, R.B. Darnell, and M.L. Albert. 2007. Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation. Blood. 109:1113-1122. http://dx.doi.org/10.1182/blood-2006-05-023465
19. McKenna, H.J., K.L. Stocking, R.E. Miller, K. Brasel, T. De Smedt, E. Maraskovsky, C.R. Maliszewski, D.H. Lynch, J. Smith, B. Pulendran, et al. 2000. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood. 95:3489-3497.
20. Merad, M. 2010. PU.1 takes control of the dendritic cell lineage. Immunity. 32:583-585. http://dx.doi.org/10.1016/j.immuni.2010.05.006
21. Naik, S.H., A.I. Proietto, N.S. Wilson, A. Dakic, P. Schnorrer, M. Fuchsberger, M.H. Lahoud, M. O'Keeffe, Q.X. Shao, W.F. Chen, et al. 2005. Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J. Immunol. 174:6592-6597.
22. Naik, S.H., P. Sathe, H.Y. Park, D. Metcalf, A.I. Proietto, A. Dakic, S. Carotta, M. O'Keeffe, M. Bahlo, A. Papenfuss, et al. 2007. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat. Immunol. 8:1217-1226. http://dx.doi.org/10.1038/ni1522
23. Onai, N., A. Obata-Onai, R. Tussiwand, A. Lanzavecchia, and M.G. Manz. 2006. Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development. J. Exp. Med. 203:227-238. http://dx.doi.org/10.1084/jem.20051645
24. Onai, N., A. Obata-Onai, M.A. Schmid, T. Ohteki, D. Jarrossay, and M.G. Manz. 2007. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat. Immunol. 8:1207-1216. http://dx.doi.org/10.1038/ni1518
25. Sathe, P., D. Vremec, L. Wu, L. Corcoran, and K. Shortman. 2013. Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells. Blood. 121:11-19. http://dx.doi.org/10 .1182/blood-2012-02-413336
26. Schmid, M.A., D. Kingston, S. Boddupalli, and M.G. Manz. 2010. Instructive cytokine signals in dendritic cell lineage commitment. Immunol. Rev. 234:32-44. http://dx.doi.org/10.1111/j.0105-2896.2009.00877.x
27. Shigematsu, H., B. Reizis, H. Iwasaki, S. Mizuno, D. Hu, D. Traver, P. Leder, N. Sakaguchi, and K. Akashi. 2004. Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity. 21:43-53. http://dx.doi.org/10.1016/j.immuni.2004.06.011
28. Stirewalt, D.L., and J.P. Radich. 2003. The role of FLT3 in haematopoietic malignancies. Nat. Rev. Cancer. 3:650-665. http://dx.doi.org/10 .1038/nrc1169
29. Swiecki, M., Y. Wang, W. Vermi, S. Gilfillan, R.D. Schreiber, and M. Colonna. 2011. Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo. J. Exp. Med. 208:2367-2374. http://dx.doi .org/10.1084/jem.20110654
30. Waskow, C., K. Liu, G. Darrasse-Jèze, P. Guermonprez, F. Ginhoux, M. Merad, T. Shengelia, K. Yao, and M. Nussenzweig. 2008. The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat. Immunol. 9:676-683. http://dx.doi.org/10.1038/ni.1615
31. Whitlock, C.A., G.F. Tidmarsh, C. Muller-Sieburg, and I.L. Weissman. 1987. Bone marrow stromal cell lines with lymphopoietic activity express high levels of a pre-B neoplasia-associated molecule. Cell. 48:1009-1021. http://dx.doi.org/10.1016/0092-8674(87)90709-4