Flt3 ligand induces tyrosine phosphorylation of Gab1 and Gab2 and their association with Shp-2, Grb2, and PI3 kinase

Biochemical and Biophysical Research Communications

Volumn 277, Issue 1, 2000, Pages 195-199

  Zhang, Shuli ^a,b   Broxmeyer, Hal E ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WALTHER CANCER INSTITUTE   (United States)

Author keywords

Flt3; Gab; Hematopoietic cells; Signal transduction; Tyrosine phosphorylation

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; ENZYME ACTIVATION; GENE OVEREXPRESSION; HEMATOPOIESIS; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALIA;

EID: 0034649210     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3662     Document Type: Article

References (24)

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2. Cloning of the human homologue of the murine flt3 ligand: A growth factor for early hematopoietic progenitor cells
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4. Flt3 ligand stimulates/costimulates the growth of myeloid stem/progenitor cells
5. Hematopoietic receptors of class III receptor-type tyrosine kinases
6. Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells
7. Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase
8. Analysis of the mitogenic pathway of the FLT3 receptor and characterization in its C terminal region of a specific binding site for the PI3' kinase
9. p85 Subunit of Pi3 kinase does not bind to human Flt3 receptor, but associates with Shp2, Ship, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells
10. Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells
11. The CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cells
12. FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates
13. A Grb2-associated docking protein in EGF- and insulin-receptor signalling
14. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
15. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors
16. Engagement of Gab1 and Gab2 in erythropoietin signaling
17. Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors
18. Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase
19. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1
20. Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation
21. Effects of FLT3 ligand on human leukemia cells. I. Proliferative response of myeloid leukemia cells
22. Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics
23. Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts
24. Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor