Transcriptional profiling identifies Id2 function in dendritic cell development

Nature Immunology

Volumn 4, Issue 4, 2003, Pages 380-386

  Hacker, Christine ^a   Kirsch, Ralf D ^a   Ju, Xin Sheng ^a   Hieronymus, Thomas ^a   Gust, Tatjana C ^a   Kuhl, Christiane ^a,d   Jorgas, Thorsten ^a   Kurz, Steffen M ^a   Rose John, Stefan ^b   Yokota, Yoshifumi ^c   Zenke, Martin ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c UNIVERSITY OF FUKUI   (Japan)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; HELIX LOOP HELIX PROTEIN; INHIBITOR OF DIFFERENTIATION 2; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CELL FUNCTION; CELL LINEAGE; CELL LOSS; CELL MATURATION; CELL SUBPOPULATION; CONTROLLED STUDY; DECISION MAKING; DENDRITIC CELL; GENE EXPRESSION; GENE FUNCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; LANGERHANS CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN CELL; STEM CELL; UPREGULATION;

B-LYMPHOCYTES; CELL DIFFERENTIATION; DENDRITIC CELLS; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 2; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; RECEPTORS, INTERLEUKIN-4; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 0037386339     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni903     Document Type: Article

References (52)

1. Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245-252 (1998).
2. Banchereau, J. et al. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18, 767-811 (2000).
3. Lanzavecchia, A. & Sallusto, F. Regulation of T cell immunity by dendritic cells. Cell 106, 263-266 (2001).
4. Ardavin, C. et al. Origin and differentiation of dendritic cells. Trends Immunol. 22, 691-700 (2001)
5. Liu, Y.J., Kanzler, H., Soumelis, V. & Gilliet, M. Dendritic cell lineage, plasticity and cross-regulation. Nat. Immunol. 2, 585-589 (2001).
6. Shortman, K. & Liu, Y.J. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2, 151-161 (2002).
7. + dendritic cells from a common myeloid progenitor. Science 290, 2152-2154 (2000).
8. Manz, M.G. Traver, D., Miyamoto, T., Weissman, I.L. & Akashi, K. Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood 97, 3333-3334 (2001).
9. Wu, L. et al. Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood 98, 3376-3382 (2001).
10. Grouard, G. et al. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J. Exp. Med. 185, 1101-1111 (1997).
11. Asselin-Paturel, C. et al. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat. Immunol. 2, 1144-1150 (2001).
12. + cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 194, 1171-1178 (2001).
13. Martinez del Hoyo, G. et al. Characterisation of a common precursor population for dendritic cells. Nature 415, 1043-1047 (2002).
14. Norton, J.D., Deed, R.W., Craggs, G. & Sablitzky, F. Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol. 8, 58-65 (1998).
15. Massari, M.E. & Murre, C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell. Biol. 20, 429-440 (2000).
16. Yokota, Y. Id and development. Oncogene 20, 8290-8298 (2001).
17. Yokota, Y. et al. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature 397, 702-706 (1999).
18. Mori, S., Nishikawa, S.I. & Yokota, Y. Lactation defect in mice lacking the helix-loop-helix inhibitor Id2. EMBO J. 19, 5772-5781 (2000).
19. Ikawa, T., Fujimoto, S., Kawamoto, H., Katsura, Y. & Yokota, Y. Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2. Proc. Natl. Acad. Sci. USA 98, 5164-5169 (2001).
20. + cells. Immunity 17, 31-40 (2002).
21. Boehmelt, G. et al. Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-RelER. Cell 80, 341-352 (1995).
22. Ju, X.-J. & Zenke, M. Differentiation of human antigen presenting dendritic cells from CD34+ hematopoietic stem cells in vitro. in Methods in Molecular Medicine. Cytokines and Colony Assays (ed. Körholz, D.) 399-407 (Humana Press, Totowa, NJ, 2003).
23. Granucci, F. et al. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat, Immunol. 2, 882-888 (2001).
24. Eisen, M.B., Spellman, P.T., Brown, P.O. & Botstein, D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95, 14863-14868 (1998).
25. Soumelis, V. et al. Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP. Nat. Immunol. 3, 673-680 (2002).
26. Tamayo, P. et al. Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc. Natl. Acad. Sci. USA 96, 2907-2912 (1999).
27. Boudjelal, M. et al. Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells, Genes Dev. 11, 2052-2065 (1997).
28. Vremec, D., Pooley, J., Hochrein, H., Wu, L. & Shortman, K. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J. Immunol. 164, 2978-2986 (2000).
29. Hochrein, H. et al. Differential production of IL-12, IFN-α, and IFN-γ by mouse dendritic cell subsets. J. Immunol. 166, 5448-5455 (2001).
30. Borkowski, T.A., Letterio, J.J., Farr, A.G. & Udey, M.C. A role for endogenous transforming growth factor β1 in Langerhans cell biology: the skin of transforming growth factor β1 null mice is devoid of epidermal Langerhans cells. J. Exp. Med. 184, 2417-2422 (1996).
31. Strobl, H. & Knapp, W. TGF-β1 regulation of dendritic cells. Microbes Infect. 1, 1283-1290 (1999).
32. Kee, B.L., Rivera, R.R. & Murre, C. Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-β. Nat. Immunol. 2, 242-247 (2001).
33. Sugai, M. et al. Essential role of Id2 in negative regulation of IgE class switching. Nat. Immunol. 4, 25-30 (2003).
34. Wong, J. et al. Characterization of a basic helix-loop-helix protein, ABF-1: nuclear localization, transcriptional properties, and interaction with Id2. DNA Cell Biol. 20, 465-471 (2001).
35. Galy A., Travis, M., Cen, D. & Chen, B. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity 3, 459-473 (1995).
36. Kondo, M., Weissman, I.L. & Akashi, K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91, 661-672 (1997).
37. Miyamoto, T. et al. Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev. Cell 3, 137-147 (2002).
38. Becker-Herman, S., Lantner, F. & Shachar, I. Id2 negatively regulates B cell differentiation in the spleen. J. Immunol. 168, 5507-5513 (2002).
39. + stem cells into predendritic cell (pre-DC)2 but not into pre-DC1, Evidence for a lymphoid origin of pre-DC2. J. Exp. Med. 192, 1775-1784 (2000).
40. Yoshida, H. et al. Different cytokines induce surface lymphotoxin-αβ on IL-7 receptor-α cells that differentially engender lymph nodes and Peyer's patches. Immunity 17, 823-833 (2002).
41. Burkly, L. et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373, 531-536 (1995).
42. Weih, F. et al. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κ B/Rel family. Cell 80, 331-340 (1995).
43. + dendritic cells. Immunity 9, 839-847 (1998).
44. + dendritic cells. J. Exp. Med. 196, 1415-1425 (2002).
45. Fischer, M. et al. I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat. Biotechnol. 15, 142-145 (1997).
46. Diebold, S.S. et al. Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection. Hum. Gene Ther. 10, 775-786 (1999).
47. Inaba, K. et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176, 1693-1702 (1992).
48. Manickasingham, S. & Reis e Sousa, C. Microbial and T cell-derived stimuli regulate antigen presentation by dendritic cells in vivo. J. Immunol. 165, 5027-5034 (2000).
49. Madruga, J., Koritschoner, N.P., Diebold, S.S., Kurz, S.M. & Zenke, M. Polarised expression pattern of focal contact proteins in highly motile antigen presenting dendritic cells. J. Cell Sci. 112, 1685-1696 (1999).
50. Kurz, S.M. et al. The impact of c-met/scatter factor receptor on dendritic cell migration. Eur. J. Immunol. 32, 1832-1838 (2002).
51. Valladeau, J. et al. Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. J. Immunol. 168, 782-792 (2002).
52. Hinz, M. et al. Nuclear factor κB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity. J. Exp. Med. 196, 605-617 (2002).