Instructive cytokine signals in dendritic cell lineage commitment

Immunological Reviews

Volumn 234, Issue 1, 2010, Pages 32-44

  Schmid, Michael A ^a,b   Kingston, Dior ^a   Boddupalli, Sekhar ^a,b   Manz, Markus G ^a,b  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Common dendritic cells progenitor; Cytokines; Dendritic cells development; Fms like tyrosine kinase 3 ligand; Lineage instruction; Microenvironment

Indexed keywords

COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR RECEPTOR; CYTOKINE; CYTOKINE RECEPTOR; NITRIC OXIDE; STAT3 PROTEIN; TRANSCRIPTION FACTOR PU 1; TUMOR NECROSIS FACTOR ALPHA;

CELL LINEAGE; CELL MATURATION; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; INFLAMMATION; LYMPHOID CELL; MICROENVIRONMENT; MYELOID PROGENITOR CELL; NONHUMAN; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REVIEW; SIGNAL TRANSDUCTION; STEADY STATE; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CYTOKINES; DENDRITIC CELLS; HEMATOPOIETIC STEM CELLS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; SIGNAL TRANSDUCTION;

EID: 77349105277     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.0105-2896.2009.00877.x     Document Type: Review

References (101)

1. Traver D, et al. Development of CD8alpha-positive dendritic cells from a common myeloid progenitor. Science 2000 290 : 2152 2154.
2. Manz MG, Traver D, Miyamoto T, Weissman IL, Akashi K. Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood 2001 97 : 3333 3341.
3. O'Keeffe M, et al. Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus. J Exp Med 2002 196 : 1307 1319.
4. Liu K, Waskow C, Liu X, Yao K, Hoh J, Nussenzweig M. Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol 2007 8 : 578 583.
5. Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002 2 : 151 161.
6. Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 1973 137 : 1142 1162.
7. Liu YJ. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 2005 23 : 275 306.
8. Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat Immunol 2004 5 : 1219 1226.
9. Nakano H, Yanagita M, Gunn MD. Cd11c(+)b220(+)gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J Exp Med 2001 194 : 1171 1178.
10. Asselin-Paturel C, et al. Mouse type I IFNs-producing cells are immature APCs with plasmacytoid morphology. Nat Immunol 2001 2 : 1144 1150.
11. Schlecht G, Garcia S, Escriou N, Freitas AA, Leclerc C, Dadaglio G. Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation. Blood 2004 104 : 1808 1815.
12. Villadangos JA, Young L. Antigen-presentation properties of plasmacytoid dendritic cells. Immunity 2008 29 : 352 361.
13. Kondo M, et al. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol 2003 21 : 759 806.
14. Ebner S, et al. Production of IL-12 by human monocyte-derived dendritic cells is optimal when the stimulus is given at the onset of maturation, and is further enhanced by IL-4. J Immunol 2001 166 : 633 641.
15. Inaba K, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992 176 : 1693 1702.
16. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J Exp Med 1994 179 : 1109 1118.
17. Xu Y, Zhan Y, Lew AM, Naik SH, Kershaw MH. Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking. J Immunol 2007 179 : 7577 7584.
18. Brasel K, De Smedt T, Smith JL, Maliszewski CR. Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood 2000 96 : 3029 3039.
19. Gilliet M, et al. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J Exp Med 2002 195 : 953 958.
20. Vremec D, Lieschke GJ, Dunn AR, Robb L, Metcalf D, Shortman K. The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur J Immunol 1997 27 : 40 44.
21. Hamilton JA. GM-CSF in inflammation and autoimmunity. Trends Immunol 2002 23 : 403 408.
22. Naik SH, et al. Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol 2006 7 : 663 671.
23. Varol C, et al. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med 2007 204 : 171 180.
24. McKenna HJ. Role of hematopoietic growth factors/flt3 ligand in expansion and regulation of dendritic cells. Curr Opin Hematol 2001 8 : 149 154.
25. Waskow C, et al. The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol 2008 9 : 676 683.
26. Kingston D, Schmid MA, Onai N, Obata-Onai A, Baumjohann D, Manz MG. The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis. Blood 2009 114 : 835 843.
27. Brasel K, et al. Hematologic effects of flt3 ligand in vivo in mice. Blood 1996 88 : 2004 2012.
28. Maraskovsky E, et al. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med 1996 184 : 1953 1962.
29. Bjorck P. Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. Blood 2001 98 : 3520 3526.
30. Ginhoux F, et al. Langerhans cells arise from monocytes in vivo. Nat Immunol 2006 7 : 265 273.
31. Lin H, et al. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science 2008 320 : 807 811.
32. Sasmono RT, et al. A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 2003 101 : 1155 1163.
33. Macdonald KP, et al. The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. J Immunol 2005 175 : 1399 1405.
34. Fancke B, Suter M, Hochrein H, O'Keeffe M. M-CSF: a novel plasmacytoid and conventional dendritic cell poietin. Blood 2008 111 : 150 159.
35. Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000 404 : 193 197.
36. Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 1997 91 : 661 672.
37. Adolfsson J, et al. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 2005 121 : 295 306.
38. Shortman K, Caux C. Dendritic cell development: multiple pathways to nature's adjuvants. Stem Cells 1997 15 : 409 419.
39. Ardavin C. Thymic dendritic cells. Immunol Today 1997 18 : 350 361.
40. Wu L, Nichogiannopoulou A, Shortman K, Georgopoulos K. Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity 1997 7 : 483 492.
41. Wu L, D'Amico A, Winkel KD, Suter M, Lo D, Shortman K. RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells. Immunity 1998 9 : 839 847.
42. Guerriero A, Langmuir PB, Spain LM, Scott EW. PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood 2000 95 : 879 885.
43. Manz MG, et al. Dendritic cell development from common myeloid progenitors. Ann NY Acad Sci 2001 938 : 167 173.
44. Shigematsu H, et al. Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity 2004 21 : 43 53.
45. Merad M, Manz MG. Dendritic cell homeostasis. Blood 2009 113 : 3418 3427.
46. Wu L, D'Amico A, Hochrein H, O'Keeffe M, Shortman K, Lucas K. Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood 2001 98 : 3376 3382.
47. Karsunky H, Merad M, Mende I, Manz MG, Engleman EG, Weissman IL. Developmental origin of interferon-alpha-producing dendritic cells from hematopoietic precursors. Exp Hematol 2005 33 : 173 181.
48. Ishikawa F, et al. The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways. Blood 2007 110 : 3591 3660.
49. Ardavin C, Wu L, Li CL, Shortman K. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 1993 362 : 761 763.
50. Wu L, Li CL, Shortman K. Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny. J Exp Med 1996 184 : 903 911.
51. Litman GW, Cooper MD. Why study the evolution of immunity? Nat Immunol 2007 8 : 547 548.
52. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 252.
53. Jung S, et al. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 2002 17 : 211 220.
54. MartIn-Fontecha A, et al. Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J Exp Med 2003 198 : 615 621.
55. Shortman K, Naik SH. Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol 2007 7 : 19 30.
56. Ohnmacht C, et al. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med 2009 206 : 549 559.
57. Birnberg T, et al. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 2008 29 : 986 987.
58. Rolink AG, Schaniel C, Andersson J, Melchers F. Selection events operating at various stages in B cell development. Curr Opin Immunol 2001 13 : 202 207.
59. Goldrath AW, Bevan MJ. Selecting and maintaining a diverse T-cell repertoire. Nature 1999 402 : 255 262.
60. Mende I, Karsunky H, Weissman IL, Engleman EG, Merad M. Flk2+ myeloid progenitors are the main source of Langerhans cells. Blood 2006 107 : 1383 1390.
61. Proietto AI, Lahoud MH, Wu L. Distinct functional capacities of mouse thymic and splenic dendritic cell populations. Immunol Cell Biol 2008 86 : 700 708.
62. Kohara H, Omatsu Y, Sugiyama T, Noda M, Fujii N, Nagasawa T. Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling. Blood 2007 110 : 4153 4160.
63. McKenna HJ, et al. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood 2000 95 : 3489 3497.
64. Karsunky H, Merad M, Cozzio A, Weissman IL, Manz MG. Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med 2003 198 : 305 313.
65. D'Amico A, Wu L. The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3. J Exp Med 2003 198 : 293 303.
66. Onai N, Obata-Onai A, Schmid MA, Ohteki T, Jarrossay D, Manz MG. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol 2007 8 : 1207 1216.
67. Naik SH, et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol 2007 8 : 1217 1226.
68. Fogg DK, et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 2006 311 : 83 87.
69. Liu K, et al. In vivo analysis of dendritic cell development and homeostasis. Science 2009 324 : 392 397.
70. Varol C, et al. Intestinal lamina propria dendritic cell subsets have diffe rent origin and functions. Immunity 2009 31 : 502 512.
71. Bogunovic M, et al. Origin of the lamina propria dendritic cell network. Immunity 2009 31 : 513 525.
72. Karsunky H, Inlay MA, Serwold T, Bhattacharya D, Weissman IL. Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages. Blood 2008 111 : 5562 5570.
73. Metcalf D. Lineage commitment and maturation in hematopoietic cells: the case for extrinsic regulation. Blood 1998 92 : 345 347.
74. Rieger MA, Hoppe PS, Smejkal BM, Eitelhuber AC, Schroeder T. Hematopoietic cytokines can instruct lineage choice. Science 2009 325 : 217 218.
75. Onai N, Obata-Onai A, Tussiwand R, Lanzavecchia A, Manz MG. Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development. J Exp Med 2006 203 : 227 238.
76. Onai N, Obata-Onai A, Schmid MA, Manz MG. Flt3 in regulation of type-I interferon producing and dendritic cell development. Ann NY Acad Sci 2007 1106 : 253 261.
77. McClanahan T, et al. Biochemical and genetic characterization of multiple splice variants of the Flt3 ligand. Blood 1996 88 : 3371 3382.
78. Lyman SD, Jacobsen SE. c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood 1998 91 : 1101 1134.
79. Solanilla A, et al. Expression of Flt3-ligand by the endothelial cell. Leukemia 2000 14 : 153 162.
80. Sitnicka E, Bryder D, Theilgaard-Monch K, Buza-Vidas N, Adolfsson J, Jacobsen SE. Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool. Immunity 2002 17 : 463 472.
81. Lyman SD, et al. Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. Cell 1993 75 : 1157 1167.
82. Hannum C, et al. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature 1994 368 : 643 648.
83. Kenins L, Gill JW, Boyd RL, Hollander GA, Wodnar-Filipowicz A. Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation. J Exp Med 2008 205 : 523 531.
84. Chklovskaia E. Reconstitution of dendritic and natural killer-cell subsets after allogeneic stem cell transplantation: effects of endogenous Flt3 ligand. Blood 2004 103 : 3860 3868.
85. Tussiwand R, Onai N, Mazzucchelli L, Manz MG. Inhibition of natural type I IFNs-producing and dendritic cell development by a small molecule receptor tyrosine kinase inhibitor with Flt3 affinity. J Immunol 2005 175 : 3674 3680.
86. Whartenby KA, et al. Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease. Proc Natl Acad Sci USA 2005 102 : 16741 16746.
87. Darrasse-Jeze G, et al. Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med 2009 206 : 1853 1862.
88. Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2007 8 : 191 197.
89. Swee LK, Bosco N, Malissen B, Ceredig R, Rolink A. Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment. Blood 2009 113 : 6277 6287.
90. Manz MG. Flt3L, DCs, and NTregs: team contra GVHD? Blood 2009 113 : 6267 6268.
91. Sarrazin S, et al. MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells. Cell 2009 138 : 300 313.
92. Laiosa CV, Stadtfeld M, Graf T. Determinants of lymphoid-myeloid lineage diversification. Annu Rev Immunol 2006 24 : 705 738.
93. Esashi E, Wang YH, Perng O, Qin XF, Liu YJ, Watowich SS. The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity 2008 28 : 509 520.
94. Onai N, Manz MG. The STATs on dendritic cell development. Immunity 2008 28 : 490 492.
95. Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature 2007 449 : 419 426.
96. Manz MG, Miyamoto T, Akashi K, Weissman IL. Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci USA 2002 99 : 11872 11877.
97. Galy A, Travis M, Cen D, Chen B. Human, T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity 1995 3 : 459 473.
98. Chicha L, Jarrossay D, Manz MG. Clonal type I interferon-producing and dendritic cell precursors are contained in both human lymphoid and myeloid progenitor populations. J Exp Med 2004 200 : 1519 1524.
99. Traggiai E, et al. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 2004 304 : 104 107.
100. Manz MG. Human-hemato-lymphoid-system mice: opportunities and challenges. Immunity 2007 26 : 537 541.
101. Legrand N, et al. Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe 2009 6 : 5 9.