ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8α+ dendritic cells

Journal of Experimental Medicine

Volumn 196, Issue 11, 2002, Pages 1415-1425

  Schiavoni, Giovanna ^a   Mattei, Fabrizio ^a   Sestili, Paola ^a   Borghi, Paola ^a   Venditti, Massimo ^a   Morse III, Herbert C ^b   Belardelli, Filippo ^a   Gabriele, Lucia ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Dendritic cell subsets; Differentiation; Interferon; Maturation; Transcription factor

Indexed keywords

B7 ANTIGEN; CD11 ANTIGEN; CD40 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; CELL ADHESION MOLECULE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; CYTOKINE; INTERFERON; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 4; ISOPROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; POLYSACCHARIDE; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL ISOLATION; CELL LEVEL; CELL LINEAGE; CELL MATURATION; CELL STIMULATION; CELL SUBPOPULATION; CONTROLLED STUDY; DENDRITIC CELL; DISEASE PREDISPOSITION; IMMUNE RESPONSE; IMMUNOSTIMULATION; INTERFERON PRODUCTION; LYMPH NODE; LYMPHOID ORGAN; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; TH1 CELL; THYMUS; VIRUS INFECTION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD11A; ANTIGENS, CD40; ANTIGENS, CD8; ANTIGENS, CD80; ANTIGENS, CD86; CYTOKINES; DENDRITIC CELLS; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON REGULATORY FACTORS; INTERFERON TYPE I; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; RECEPTORS, CHEMOKINE; REPRESSOR PROTEINS;

EID: 0037011021     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021263     Document Type: Article

References (58)

1. Nguyen, H., J. Hiscott, and P.M. Pitha. 1997. The growing family of interferon regulatory factors. Cytokine Growth Factor Rev. 8:293-312.
2. Nagamura-Inoue, T., T. Tamura, and K. Ozato. 2001. Transcription factors that regulate growth and differentiation of myeloid cells. Int. Rev. Immunol. 20:83-105.
3. Tamura, T., and K. Ozato. 2002. ICSBP/IRF-8: Its regulatory roles in the development of myeloid cells. J. Interferon Cytokine Res. 22:145-152.
4. Scheller, M., J. Foerster, C.M. Heyworth, J.F. Waring, J. Lohler, G.L. Gilmore, R.K. Shadduck, T.M. Dexter, and I. Horak. 1999. Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein. Blood. 94: 3764-3771.
5. Giese, N.A., L. Gabriele, T.M. Doherty, D.M. Klinman, L. Tadesse-Heath, C. Contursi, S.L. Epstein, and H.C. Morse III. 1997. Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression. J. Exp. Med. 186:1535-1546.
6. Friedman, A.D. 2002. Transcriptional regulation of granulocyte and monocyte development. Oncogene. 21:3377-3390.
7. Holtschke, T., J. Lohler, Y. Kanno, T. Fehr, N. Giese, F. Rosenbauer, J. Lou, K.P. Knobeloch, L. Gabriele, J.F. Waring, et al. 1996. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell. 87:307-317.
8. Gabriele, L., J. Phung, J. Fukumoto, D. Segal, I.M. Wang, P. Giannakakou, N.A. Giese, K. Ozato, and H.C. Morse III. 1999. Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein. J. Exp. Med. 190:411-421.
9. Tamura, T., T. Nagamura-Inoue, Z. Shmeltzer, T. Kuwata, and K. Ozato. 2000. ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity. 13:155-165.
10. Banchereau, J., F. Briere, C. Caux, J. Davoust, S. Lebeque, Y.-J. Liu, B. Pulendran, and K. Palucka. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18:767-811.
11. Underhill, D.M., and A. Ozinsky. 2002. Toll-like receptors: Key mediators of microbe detection. Curr. Opin. Immunol. 14: 103-110.
12. Reis e Sousa, C. 2001. Dendritic cells as sensors of infection. Immunity. 14:495-498.
13. Belardelli, F., and I. Gresser. 1996. The neglected role of type I interferon in the T cell-response: Implications for its clinical use. Immunol. Today. 17:369-372.
14. Belardelli, F., and M. Ferrantini. 2002. Cytokines as a link between innate and adaptive antitumor immunity. Trends Immunol. 23:201-208.
15. Le Bon, A., and D.F. Tough. 2002. Links between innate and adaptive immunity via type I interferon. Curr. Opin. Immunol. 14:432-436.
16. Montoya, M., G. Schiavoni, F. Mattei, I. Gresser, F. Belardelli, P. Borrow, and D.F. Tough. 2002. Type I interferons produced by dendritic cells promote their phenotypic and functional activation. Blood. 99:3263-3271.
17. Santini, S.M., C. Lapenta, M. Logozzi, S. Parlato, M. Spada, T. Di Pucchio, and F. Belardelli. 2000. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL. J. Exp. Med. 191:1777-1788.
18. Liu, Y.J. 2001. Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell. 106:259-262.
19. Shortman, K., and Y.-J. Liu. 2002. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2:151-161.
20. Cella, M., D. Jarrossay, F. Facchetti, O. Alebardi, H. Nakajima, A. Lanzavecchia, and M. Colonna. 1999. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 5:919-923.
21. Siegal, F.P., N. Kadowaki, M. Shodell, P.A. Fitzgerald-Bocarsly, K. Shah, S. Ho, S. Antonenko, and Y.-J. Liu. 1999. The nature of the principal type 1 interferon-producing cells in human blood. Science. 284:1835-1837.
22. Bjorck, P. 2001. Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. Blood. 98: 3520-3526.
23. Asselin-Paturel, C., A. Boonstra, M. Dalod, I. Durand, N. Yessaad, C. Dezutter-Dambuyant, A. Vicari, A. O'Garra, C. Biron, F. Briere, and G. Trinchieri. 2001. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat. Immunol. 2:1144-1150.
24. + cells in mouse lymph nodes and spleens display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 194: 1171-1178.
25. Kadowaki, N., S. Antonenko, J.Y.-N. Lau, and Y.-J. Liu. 2000. Natural interferon α/β-producing cells link innate and adaptive immunity. J. Exp. Med. 192:219-225.
26. Cella, M., F. Facchetti, A. Lanzavecchia, and M. Colonna. 2000. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent Th1 polarization. Nat. Immunol. 1:305-310.
27. Vremec, D., M. Zorbas, R. Scollay, D.J. Saunders, C.F. Ardavin, L. Wu, and K. Shortman. 1992. The surface phenotype of dendritic cells purified from mouse thymus and spleen: Investigation of the CD8 expression by a subpopulation of dendritic cells. J. Exp. Med. 176:47-58.
28. Anjuère, F., P. Martín, I. Ferrero, M. López Fraga, G. Martínez del Hoyo, N. Wright, and C. Ardavín. 1999. Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse. Blood. 93:590-598.
29. O'Keeffe, M., H. Hochrein, D. Vremec, J. Pooley, R. Evans, S. Woulfe, and K. Shortman. 2002. Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colonystimulating factor on dendritic cell subsets in mice. Blood. 99: 2122-2130.
30. Moser, M., and K.M. Murphy. 2000. Dendritic cell regulation of Th1-Th2 development. Nat. Immunol. 1: 199-205.
31. McLellan, A.D., M. Kapp, A. Eggert, C. Linden, U. Bommhardt, E.B. Brocker, U. Kammerer, and E. Kampgen. 2002. Anatomic location and T-cell stimulatory functions of mouse dendritic cell subsets defined by CD4 and CD8 expression. Blood. 99:2084-2093.
32. Tovey, M.G., J. Begon-Lours, and I. Gresser. 1974. A method for the large scale production of potent interferon preparations. Proc. Soc. Exp. Biol. Med. 146:809-815.
33. Vremec, D., J. Pooley, H. Hochrein, L. Wu, and K. Shortman. 2000. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J. Immunol. 164:2978-2986.
34. Merad, M., L. Fong, J. Bogenberger, and E.G. Engleman. 2000. Differentiation of myeloid dendritic cells into CD8a-positive dendritic cells in vivo. Blood. 96:1865-1872.
35. Wu, L., A. D'Amico, H. Hochrein, M. O'Keeffe, K. Shortman, and K. Lucas. 2001. Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood. 98:3376-3382.
36. Del Hoyo, G.M., P. Martin, C.F. Arias, A.R. Marin, and C. Ardavin. 2002. CD8α(+) dendritic cells originate from the CD8α(-) dendritic cell subset by a maturation process involving CD8α, DEC-205, and CD24 up-regulation. Blood. 99:999-1004.
37. Kamath, A.T., J. Pooley, M.A. O'Keeffe, D. Vremec, Y. Zhan, A.M. Lew, A. D'Amico, L. Wu, D.F. Tough, and K. Shortman. 2000. The development, maturation, and turnover rate of mouse spleen dendritic cell populations. J. Immunol. 165:6762-6770.
38. Gallucci, S., M. Lolkema, and P. Matzinger. 1999. Natural adjuvants: Endogenous activators of dendritic cells. Nat. Med. 5:1249-1255.
39. De Smedt, T., E. Butz, J. Smith, R. Maldonado-Lopez, B. Pajak, M. Moser, and C. Maliszewski. 2001. CD8α(-) and CD8α(+) subsets of dendritic cells undergo phenotypic and functional maturation in vitro and in vivo. J. Leukoc. Biol. 69: 951-958.
40. Chow, J.C., D.W. Young, D.T. Golenbock, W.J. Christ, and F. Gusovsky. 1999. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J. Biol. Chem. 274:10689-10692.
41. Alexopoulou, L., A.C. Holt, R. Medzhitov, and R.A. Flavell. 2001. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 413:732-738.
42. Yoshie, O. 2000. Role of chemokines in trafficking of lymphocytes and dendritic cells. Int. J. Hematol. 72:399-407.
43. Caux, C., S. Ait-Yahia, K. Chemin, O. de Bouteiller, M.C. Dieu-Nosjean, B. Homey, C. Massacrier, B. Vanbervliet, A. Zlotnik, and A. Vicari. 2000. Dendritic cell biology and regulation of dendritic cell trafficking by chemokines. Springer Semin. Immunopathol. 22:345-369.
44. Saeki, H., A.M. Moore, M.J. Brown, and S.T. Hwang. 1999. Cutting edge: Secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J. Immunol. 162:2472-2475.
45. Maldonado-Lopez, R., C. Maliszewski, J. Urbain, and M. Moser. 2001. Cytokines regulate the capacity of CD8α(+) and CD8α(-) dendritic cells to prime Th1/Th2 cells in vivo. J. Immunol. 167:4345-4350.
46. Maldonado-Lopez, R., and M. Moser. 2001. Dendritic cell subsets and the regulation of Th1/Th2 responses. Semin. Immunol. 13:275-282.
47. Barchet, W., M. Cella, B. Odermatt, C. Asselin-Paturel, M. Colonna, and U. Kalinke. 2002. Virus-induced interferon α production by a dendritic cell subset in the absence of feedback signaling in vivo. J. Exp. Med. 195:507-516.
48. Shortman, K. 2000. Burnet oration: Dendritic cells: Multiple subtypes, multiple origins, multiple functions. Immunol. Cell Biol. 78:161-165.
49. + dendritic cells. Immunity. 9:839-847.
50. Traver, D., K. Akashi, M. Manz, M. Merad, T. Miyamoto, E.G. Engleman, and I.L. Weissman. 2000. Development of CD8α-positive dendritic cells from a common myeloid progenitor. Science. 290:2152-2154.
51. Del Hoyo, G.M., P. Martin, H.H. Vargas, S. Ruix, C.F. Arias, and C. Ardavin. 2002. Characterization of a common precursor population for dendritic cells. Nature. 415:1043-1047.
52. Wu, C.Y., H. Maeda, C. Contursi, K. Ozato, and R.A. Seder. 1999. Differential requirement of IFN consensus sequence binding protein for the production of IL-12 and induction of Th1-type cells in response to IFN-gamma. J. Immunol. 162:807-812.
53. + dendritic cells. Blood. 10.1182/blood-2002-04-1088.
54. Ardavin, C., G. Martinez del Hoyo, P. Martin, F. Anjuere, C.F. Arias, A.R. Marin, S. Ruiz, V. Parrillas, and H. Hernandez. 2001. Origin and differentiation of dendritic cells. Trends Immunol. 22:691-700.
55. Vanbervliet, B., B. Homey, I. Durand, C. Massacrier, S. Ait-Yahia, O. de Bouteiller, A. Vicari, and C. Caux. 2002. Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: Possible role at inflamed epithelial surfaces. Eur. J. Immunol. 32:231-242.
56. Kucharzik, T., J.T. Hudsafon, III, R.L. Waikel, W.D. Martin, and I.R. Williams. 2002. CCR6 expression distinguishes mouse myeloid and lymphoid dendritic cell subsets: Demonstration using a CCR6 EGFP knock-in mouse. Eur. J. Immunol. 32:104-112.
57. Mattei, F., G. Schiavoni, F. Belardelli, and D.F. Tough. 2001. IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation. J. Immunol. 167:1179-1187.
58. Hochrein, H., K. Shortman, D. Vremec, B. Scott, P. Hertzog, and M. O'Keeffe. 2001. Differential production of IL-12, IFN-α, and IFN-gamma by mouse dendritic cell subsets. J. Immunol. 166:5448-5455.