Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

Nature Immunology

Volumn 10, Issue 5, 2009, Pages 488-495

  Bedoui, Sammy ^a   Whitney, Paul G ^a   Waithman, Jason ^a   Eidsmo, Liv ^a   Wakim, Linda ^a   Caminschi, Irina ^b   Allan, Rhys S ^a   Wojtasiak, Magdalena ^a   Shortman, Ken ^b   Carbone, Francis R ^a   Brooks, Andrew G ^a   Heath, William R ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; CD8ALPHA ANTIGEN; GLYCOPROTEIN P 15095; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MIGRATION; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CROSS PRESENTATION; DENDRITIC CELL; FLOW CYTOMETRY; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; KERATINOCYTE; LANGERHANS CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCAR FORMATION; SIGNAL TRANSDUCTION; SKIN INFECTION; T LYMPHOCYTE ACTIVATION; VIRUS REPLICATION; VIRUS TITRATION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, VIRAL; AUTOANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CROSS-PRIMING; DENDRITIC CELLS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HISTOCOMPATIBILITY ANTIGENS CLASS I; INTEGRIN ALPHA CHAINS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; SKIN;

EID: 65249099085     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1724     Document Type: Article

References (48)

1. Steinman, R.M. Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system. Nat. Med. 13, 1155-1159 (2007).
2. Villadangos, J.A. & Heath, W.R. Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: limitations of the Langerhans cells paradigm. Semin. Immunol. 17, 262-272 (2005).
3. Shortman, K. & Liu, Y. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2, 151-161 (2002).
4. Shortman, K. & Naik, S.H. Steady-state and inflammatory dendritic-cell development. Nat. Rev. Immunol. 7, 19-30 (2007).
5. Heath, W.R. et al. Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol. Rev. 199, 9-26 (2004).
6. Jakubzick, C. et al. Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. J. Exp. Med. 205, 2839-2850 (2008).
7. Wakim, L.M., Waithman, J., van Rooijen, N., Heath, W.R. & Carbone, F.R. Dendritic cell-induced memory T cell activation in nonlymphoid tissues. Science 319, 198-202 (2008).
8. + T cells and stimulate different aspects of cell-mediated immunity. Immunity 19, 47-57 (2003).
9. Allan, R.S. et al. Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. Immunity 25, 153-162 (2006).
10. Cella, M. et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 5, 919-923 (1999).
11. Diebold, S.S. et al. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature 424, 324-328 (2003).
12. + dendritic cells in vivo. J. Exp. Med. 196, 817-827 (2002).
13. Dudziak, D. et al. Differential antigen processing by dendritic cell subsets in vivo. Science 315, 107-111 (2007).
14. + dendritic cells in cross-presentation is not dictated by antigen capture. Proc. Natl. Acad. Sci. USA 103, 10729-10734 (2006).
15. + dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1. J. Immunol. 170, 4437-4440 (2003).
16. + dendritic cells but not by Langerhans cells. Science 301, 1925-1928 (2003).
17. + dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo. J. Immunol. 175, 196-200 (2005).
18. + dendritic cells are generally involved in priming CTL immunity to viruses. J. Immunol. 172, 1996-2000 (2004).
19. Belz, G.T. et al. Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus. Proc. Natl. Acad. Sci. USA 101, 8670-8675 (2004).
20. Wilson, N.S. et al. Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity. Nat. Immunol. 7, 165-172 (2006).
21. + T cell immunity in recombinant lentivector-mediated genetic immunization. Immunity 24, 643-656 (2006).
22. Bennett, C.L. et al. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J. Cell Biol. 169, 569-576 (2005).
23. Waithman, J. et al. Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells. J. Immunol. 179, 4535-4541 (2007).
24. Kaplan, D.H., Jenison, M.C., Saeland, S., Shlomchik, W.D. & Shlomchik, M.J. Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23, 611-620 (2005).
25. Kissenpfennig, A. et al. Dynamics and function of Langerhans cells in vivo dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22, 643-654 (2005).
26. + dendritic cells. J. Exp. Med. 204, 3147-3156 (2007).
27. + dendritic cells that develop and function independently of epidermal Langerhans cells. J. Exp. Med. 204, 3119-3131 (2007).
28. Ginhoux, F. et al. Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state. J. Exp. Med. 204, 3133-3146 (2007).
29. Simmons, A. & Nash, A.A. Zosteriform spread of herpes simplex virus as a model of recrudescence and its use to investigate the role of immune cells in prevention of recurrent disease. J. Virol. 52, 816-821 (1984).
30. + T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation. J. Immunol. 172, 392-397 (2004).
31. Azukizawa, H. et al. Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes. Eur. J. Immunol. 33, 1879-1888 (2003).
32. Zhao, X. et al. Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J. Exp. Med. 197, 153-162 (2003).
33. Lee, H.K. et al. Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection. J. Exp. Med. 206, 359-370 (2009).
34. Stoitzner, P. et al. Langerhans cells cross-present antigen derived from skin. Proc. Natl. Acad. Sci. USA 103, 7783-7788 (2006).
35. - dendritic cells cross-prime cytotoxic T cells in vivo. J. Exp. Med. 192 1685-1696 (2000).
36. 7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J. Immunol. 176, 2161-2172 (2006).
37. + dendritic cells in cytotoxic T cell immunity. Science 322, 1097-1100 (2008).
38. - but not plasmacytoid dendritic cells. J. Exp. Med. 205, 1621-1634 (2008).
39. + T cells. J. Immunol. 178, 6861-6866 (2007).
40. Jakubzick, C., Helft, J., Kaplan, T.J. & Randolph, G.J. Optimization of methods to study pulmonary dendritic cell migration reveals distinct capacities of DC subsets to acquire soluble versus particulate antigen. J. Immunol. Methods 337, 121-131 (2008).
41. Stock, A.T., Mueller, S.N., van Lint, A.L., Heath, W.R. & Carbone, F.R. Cutting edge: Prolonged antigen presentation after herpes simplex virus-1 skin infection. J. Immunol. 173, 2241-2244 (2004).
42. Salio, M., Cella, M., Suter, M. & Lanzavecchia, A. Inhibition of dendritic cell maturation by herpes simplex virus. Eur. J. Immunol. 29, 3245-3253 (1999).
43. Kruse, M. et al. Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity. J. Virol. 74, 7127-7136 (2000).
44. Jones, C.A. et al. Herpes simplex virus type 2 induces rapid cell death and functional impairment of murine dendritic cells in vitro. J. Virol. 77, 11139-11149 (2003).
45. Mueller, S.N., Heath, W., McLain, J.D., Carbone, F.R. & Jones, C.M. Characterization of two TCR transgenic mouse lines specific for herpes simplex virus. Immunol. Cell Biol. 80, 156-163 (2002).
46. Hogquist, K.A. et al. T cell receptor antagonist peptides induce positive selection. Cell 76, 17-27 (1994).
47. + T-cell attenuation of cutaneous herpes simplex virus infection reduces the average viral copy number of the ensuing latent infection. Immunol. Cell Biol. 86, 666-675 (2008).
48. + T cells. Nat. Immunol. 8, 1060-1066 (2007).