PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

Genes and Development

Volumn 12, Issue 15, 1998, Pages 2403-2412

  Nerlov, Claus ^a   Graf, Thomas ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Differentiation; Eosinophil; GATA 1; Transcription factor

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL LINEAGE; DOWN REGULATION; EOSINOPHIL; HEMATOPOIETIC STEM CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; MAMMALIA;

EID: 0032146794     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.15.2403     Document Type: Article

References (41)

1. Baron, M.H. and S.M. Farrington. 1994. Positive regulators of the lineage-specific transcription factor GATA-1 in differentiating erythroid cells. Mol. Cell. Biol. 14: 3108-3114.
2. Brune, K. and J.K. Spitznagel. 1973. Peroxidaseless chicken leukocytes: Isolation and characterization of antibacterial granules. J. Infect. Dis. 127: 84-94.
3. Cairns, L.A., S. Crotta, M. Minuzzo, E. Moroni, F. Granucci, S. Nicolis, R. Schiro, L. Pozzi, B. Giglioni, P. Riccardi-Castagnoli, and S. Ottolenghi. 1994. Immortalization of multipotent growth-factor dependent hematopoietic progenitors from mice transgenic for GATA-1 driven SV40 tsA58 gene. EMBO J. 13: 4577-4586.
4. Chen, H.-M., D. Ray-Gallet, P. Zhang, C.J. Hetherington, D.A. Gonzalez, D.-E. Zhang, F. Moreau-Gachelin, and D.G. Tenen. 1995. PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene 11: 1549-1560.
5. Chomczynski, P. and N. Sacchi. 1987. Single step isolation of RNA by acid guanidinium isothiocyanate method. Anal. Biochem. 162: 156-159.
6. Dugaiczyk, A. 1983. Cloning and sequencing of a deoxyribonucleic acid copy of glyceraldehyde-3-phosphate dehydrogenase messenger ribonucleic acid isolated from chicken muscle. Biochemistry 22: 1605-1613.
7. Eilers, M., D. Picard, K.R. Yamamoto, and J.M. Bishop. 1989. Chimeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature 340: 66-68.
8. Evan, G.I., G.K. Lewis, G. Ramsay, and J.M. Bishop. 1985. Isolation of monoclonal antibodies specific for the human c-myc oncogene product. Mol. Cell. Biol. 5: 3610-3616.
9. Ewert, D.L., M.S. Munchus, C.L. Chen, and M.D. Cooper. 1984. Analysis of structural properties and cellular distribution of avian Ia antigen by using monoclonal antibody to monomorphic determinants. J. Immunol. 132: 2524-2530.
10. Frampton, J., K.M. McNagny, M. Sieweke, A. Philip, G. Smith, and T. Graf. 1995. v-Myb DNA binding is required to block thrombocytic differentiation of Myb-Ets-transformed multipotent hematopoietic progenitors. EMBO J. 14: 2866-2875.
11. Frampton, J., T. Ramqvist, and T. Graf. 1996. v-Myb of E26 leukemia virus up-regulates bcl-2 and suppresses apoptosis in myeloid cells. Genes & Dev. 10: 2720-2731.
12. Graf, T., K.M. McNagny, G. Brady, and J. Frampton. 1992. Chicken "erythroid" cells transformed by the Gag-Myb-Ets encoding E26 leukemia virus are multipotent. Cell 70: 201-213.
13. Hagemeier, C., A. Cook, and T. Kouzarides. 1993. The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro. Nucleic Acids Res. 21: 4998-5004.
14. Henkel, G. and M.A. Brown. 1994. PU.1 and GATA: Components of a mast cell-specific interleukin 4 intronic enhancer. Proc. Natl. Acad. Sci. 91: 7737-7741.
15. Katz, S., E. Kowenz-Leutz, C. Müller, K. Meese, S.A. Ness, and A. Leutz. 1993. The NF-M transcription factor is related to C/EBPβ and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells. EMBO J. 12: 1321-1332.
16. Klemsz, M.J. and R.A. Maki. 1996. Activation of transcription by PU.1 requires both acidic and glutamine residues. Mol. Cell. Biol. 16: 390-397.
17. Klemsz, M.J., S.R. McKersher, A. Celada, C. Van Beveren, and R.A. Maki. 1990. The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61: 113-124.
18. Kornfeld, S., H. Beug, G. Doederlein, and T. Graf. 1983. Detection of avian hematopoietic cell surface antigens with monoclonal antibodies to myeloid cells. Exp. Cell Res. 143: 383-394.
19. Kraut, N., J. Frampton, K.M. McNagny, and T. Graf. 1994. A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by Myb-Ets. Genes & Dev. 8: 33-44.
20. Kulessa, H., J. Frampton, and T. Graf. 1995. GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts. Genes & Dev. 9: 1250-1262.
21. Leutz, A., H. Beug, and T. Graf. 1984. Purification and characterization of cMGF, a novel chicken myelomonocytic growth factor. EMBO J. 3: 3191-3197.
22. Leutz, A., K. Damm, E. Sterneck, E. Kowenz, S. Ness, R. Frank, H. Gausepohl, Y.-C.E. Pan, J. Smart, M. Hayman, and T. Graf. 1989. Molecular cloning of the chicken myelomonocytic growth factor (cMGF) reveals relationship to interleukin 6 and granulocyte colony stimulating factor. EMBO J. 8: 175-181.
23. Lillie, J.W. and M.R. Green. 1989. Transcription activation by the adenovirus E1a protein. Nature 338: 39-44.
24. Mandi, Y., R. Pusztai, K. Baranji, G. Seprenyi, B. Tarodi, M. Bakay, and I. Beladi. 1987. The role of interferon in the adenovirus-induced augmentation of granulocyte-mediated cytotoxicity in chicken. Immunobiology 174: 210-220.
25. McKercher, S.R., B.E. Torbett, K.L. Anderson, G.W. Henkel, D.J. Vestal, H. Baribault, M. Klemsz, A.J. Feeney, G.E. Wu, C.J. Paige, and R.A. Maki. 1996. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15: 5647-5658.
26. McNagny, K.M., F. Lim, S. Grieser, and T. Graf. 1992. Cell surface proteins of chicken hematopoietic progenitors, thrombocytes and eosinophils detected by novel monoclonal antibodies. Leukemia 6: 975-984.
27. McNagny, K.M., F. Rossi, G. Smith, and T. Graf. 1996. The eosinophil-specific cell surface antegen, EOS47, is a chicken homologue of the oncofetal antigen melanotransferrin. Blood 87: 1343-1352.
28. McNagny, K.M., I. Pettersson, F. Rossi, I. Flamme, A. Shevchenko, M. Mann, and T. Graf. 1997. Thrombomucin, a novel cell surface antigen that defines thrombocytes and multipotent hematopoietic progenitors. J. Cell Biol. 138: 1395-1407.
29. McNagny, K.M., M. Sieweke, G. Döderlein, T. Graf, and C. Nerlov. 1998. Regulation of eosinophil-specific gene expression by a c/EBP-Ets complex and GATA-1. EMBO J. 17: 3669-3680.
30. Nerlov, C., K.M. McNagny, G. Döderlein, E. Kowenz-Leutz, and T. Graf. 1998. Distinct C/EBP functions are required for eosinophil lineage commitment and maturation. Genes & Dev. (this issue).
31. Ness, S.A. and J.D. Engel. 1995. Vintage reds and whites: Combinatorial transcription factor utilization in hematopoietic differentiation. Curr. Opin. Genet. Dev. 4: 718-724.
32. Orlic, D., S. Anderson, L.G. Biesecker, B.P. Sorrentino, and D.M. Bodine. 1995. Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7. Proc. Natl. Acad. Sci. 92: 4601-4605.
33. Rao, G., N. Rekthman, G. Cheng, T. Krasikov, and A.I. Skoultchi. 1997. Deregulated expression of the PU.1 transcription factor blocks murine erythroleukemia cell terminal differentiation. Oncogene 14: 123-131.
34. Ray, D., S. Culine, A. Tavitian, and F. Moreau-Gachelin. 1990. The human homologue of the putative proto-oncogene Spi1: Characterization and expression in tumors. Oncogene 5: 663-668.
35. Rossi, F., K.M. McNagny, C. Logie, A.F. Stewart, and T. Graf. 1996a. Excision of Ets by an inducible site-specific recombinase causes differentiation of differentiation of Myb-Ets-transformed hematopoietic progenitors. Curr. Biol. 6: 866-872.
36. Rossi, F., K.M. McNagny, G. Smith, J. Frampton, and T. Graf. 1996b. Lineage commitment of transformed haematopoietic progenitors is determined by the level of PKC activity. EMBO J. 15: 1984-1901.
37. Scott, E.W., M.C. Simon, J. Anastasi, and H. Singh. 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265: 1573-1577.
38. Scott, E.W., R.C. Fisher, M.C. Olson, E.W. Kehrli, M.C. Simon, and H. Singh. 1997. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity 6: 437-447.
39. Sieweke, M.H., H. Tekotte, J. Frampton, and T. Graf. 1996. MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation. Cell 85: 49-60.
40. Tenen, D.G., R. Hromas, J.D. Licht, and D.-E. Zhang. 1997. Transcription factors, normal myeloid development, and leukemia. Blood 90: 489-519.
41. Yamamoto, M., L.J. Ko, M.W. Leonard, H. Beug, S.H. Orkin, and J.D. Engel. 1990. Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes & Dev. 4: 1650-1662.