Transcription Factor E2-2 Is an Essential and Specific Regulator of Plasmacytoid Dendritic Cell Development

Cell

Volumn 135, Issue 1, 2008, Pages 37-48

  Cisse, Babacar ^a   Caton, Michele L ^a   Lehner, Manfred ^b   Maeda, Takahiro ^c   Scheu, Stefanie ^d,e   Locksley, Richard ^d   Holmberg, Dan ^f   Zweier, Christiane ^b   den Hollander, Nicolette S ^g   Kant, Sarina G ^g   Holter, Wolfgang ^b   Rauch, Anita ^b   Zhuang, Yuan ^h   Reizis, Boris ^a  

^a NewYork Presbyterian Hospital   (United States)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^c NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e HEINRICH HEINE UNIVERSITY   (Germany)

^f UMEÅ UNIVERSITY   (Sweden)

^g LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^h DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CELLIMMUNO; HUMDISEASE

Indexed keywords

DNA; INTERFERON; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 7; NUCLEIC ACID; PROTEIN TCF4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2 2; TRANSCRIPTION FACTOR SPIB; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LINEAGE; CELL MATURATION; CELL TYPE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; EMBRYO; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION PROFILING; GENETIC DISORDER; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PITT HOPKINS SYNDROME; PLASMACYTOID DENDRITIC CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD;

MURINAE; MUS;

EID: 52949106528     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2008.09.016     Document Type: Article

References (44)

1. Amiel J., Rio M., de Pontual L., Redon R., Malan V., Boddaert N., Plouin P., Carter N.P., Lyonnet S., Munnich A., et al. Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction. Am. J. Hum. Genet. 80 (2007) 988-993
2. Asselin-Paturel C., and Trinchieri G. Production of type I interferons: Plasmacytoid dendritic cells and beyond. J. Exp. Med. 202 (2005) 461-465
3. Bain G., Gruenwald S., and Murre C. E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins. Mol. Cell. Biol. 13 (1993) 3522-3529
4. Banchereau J., and Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 25 (2006) 383-392
5. Barchet W., Cella M., Odermatt B., Asselin-Paturel C., Colonna M., and Kalinke U. Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo. J. Exp. Med. 195 (2002) 507-516
6. Barchet W., Cella M., and Colonna M. Plasmacytoid dendritic cells-virus experts of innate immunity. Semin. Immunol. 17 (2005) 253-261
7. Bergqvist I., Eriksson M., Saarikettu J., Eriksson B., Corneliussen B., Grundstrom T., and Holmberg D. The basic helix-loop-helix transcription factor E2-2 is involved in T lymphocyte development. Eur. J. Immunol. 30 (2000) 2857-2863
8. Cao W., and Liu Y.J. Innate immune functions of plasmacytoid dendritic cells. Curr. Opin. Immunol. 19 (2007) 24-30
9. Caton M.L., Smith-Raska M.R., and Reizis B. Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J. Exp. Med. 204 (2007) 1653-1664
10. Dias S., Mansson R., Gurbuxani S., Sigvardsson M., and Kee B.L. E2A proteins promote development of lymphoid-primed multipotent progenitors. Immunity 29 (2008) 217-227
11. Esashi E., Wang Y.H., Perng O., Qin X.F., Liu Y.J., and Watowich S.S. The signal tTransducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity 28 (2008) 509-520
12. Flora A., Garcia J.J., Thaller C., and Zoghbi H.Y. The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors. Proc. Natl. Acad. Sci. USA 104 (2007) 15382-15387
13. Gilliet M., Cao W., and Liu Y.J. Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 8 (2008) 594-606
14. Hacker C., Kirsch R.D., Ju X.S., Hieronymus T., Gust T.C., Kuhl C., Jorgas T., Kurz S.M., Rose-John S., Yokota Y., et al. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat. Immunol. 4 (2003) 380-386
15. Harman B.C., Miller J.P., Nikbakht N., Gerstein R., and Allman D. Mouse plasmacytoid dendritic cells derive exclusively from estrogen-resistant myeloid progenitors. Blood 108 (2006) 878-885
16. Honda K., Ohba Y., Yanai H., Negishi H., Mizutani T., Takaoka A., Taya C., and Taniguchi T. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434 (2005) 1035-1040
17. Jones M.E., and Zhuang Y. Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. Immunity 27 (2007) 860-870
18. Kumagai Y., Takeuchi O., Kato H., Kumar H., Matsui K., Morii E., Aozasa K., Kawai T., and Akira S. Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. Immunity 27 (2007) 240-252
19. Lande R., Gregorio J., Facchinetti V., Chatterjee B., Wang Y.H., Homey B., Cao W., Wang Y.H., Su B., Nestle F.O., et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449 (2007) 564-569
20. Laouar Y., Welte T., Fu X.Y., and Flavell R.A. STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity 19 (2003) 903-912
21. Lazorchak A., Jones M.E., and Zhuang Y. New insights into E-protein function in lymphocyte development. Trends Immunol. 26 (2005) 334-338
22. Maeda T., Murata K., Fukushima T., Sugahara K., Tsuruda K., Anami M., Onimaru Y., Tsukasaki K., Tomonaga M., Moriuchi R., et al. A novel plasmacytoid dendritic cell line, CAL-1, established from a patient with blastic natural killer cell lymphoma. Int. J. Hematol. 81 (2005) 148-154
23. Meyers J.H., Justement J.S., Hallahan C.W., Blair E.T., Sun Y.A., O'Shea M.A., Roby G., Kottilil S., Moir S., Kovacs C.M., et al. Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cells. PLoS ONE 2 (2007) e458
24. Murre C. Helix-loop-helix proteins and lymphocyte development. Nat. Immunol. 6 (2005) 1079-1086
25. Naik S.H., Sathe P., Park H.Y., Metcalf D., Proietto A.I., Dakic A., Carotta S., O'Keeffe M., Bahlo M., Papenfuss A., et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat. Immunol. 8 (2007) 1217-1226
26. Nutt S.L., and Kee B.L. The transcriptional regulation of B cell lineage commitment. Immunity 26 (2007) 715-725
27. O'Keeffe M., Hochrein H., Vremec D., Caminschi I., Miller J.L., Anders E.M., Wu L., Lahoud M.H., Henri S., Scott B., et al. Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus. J. Exp. Med. 196 (2002) 1307-1319
28. Onai N., Obata-Onai A., Tussiwand R., Lanzavecchia A., and Manz M.G. Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development. J. Exp. Med. 203 (2006) 227-238
29. Onai N., Obata-Onai A., Schmid M.A., Ohteki T., Jarrossay D., and Manz M.G. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat. Immunol. 8 (2007) 1207-1216
30. Pelayo R., Hirose J., Huang J., Garrett K.P., Delogu A., Busslinger M., and Kincade P.W. Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow. Blood 105 (2005) 4407-4415
31. Quong M.W., Harris D.P., Swain S.L., and Murre C. E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination. EMBO J. 18 (1999) 6307-6318
32. Quong M.W., Martensson A., Langerak A.W., Rivera R.R., Nemazee D., and Murre C. Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A. J. Exp. Med. 199 (2004) 1101-1112
33. Reizis B., and Leder P. The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes. J. Exp. Med. 194 (2001) 979-990
34. Robbins S.H., Walzer T., Dembele D., Thibault C., Defays A., Bessou G., Xu H., Vivier E., Sellars M., Pierre P., et al. Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol. 9 (2008) R17
35. Schiavoni G., Mattei F., Sestili P., Borghi P., Venditti M., Morse III H.C., Belardelli F., and Gabriele L. ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells. J. Exp. Med. 196 (2002) 1415-1425
36. Schotte R., Nagasawa M., Weijer K., Spits H., and Blom B. The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. J. Exp. Med. 200 (2004) 1503-1509
37. Shigematsu H., Reizis B., Iwasaki H., Mizuno S., Hu D., Traver D., Leder P., Sakaguchi N., and Akashi K. Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity 21 (2004) 43-53
38. Singh H., Medina K.L., and Pongubala J.M. Contingent gene regulatory networks and B cell fate specification. Proc. Natl. Acad. Sci. USA 102 (2005) 4949-4953
39. Spits H., Couwenberg F., Bakker A.Q., Weijer K., and Uittenbogaart C.H. Id2 and Id3 inhibit development of CD34(+) stem cells into predendritic cell (pre-DC)2 but not into pre-DC1. Evidence for a lymphoid origin of pre-DC2. J. Exp. Med. 192 (2000) 1775-1784
40. Tsujimura H., Tamura T., and Ozato K. Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells. J. Immunol. 170 (2003) 1131-1135
41. Wikstrom I., Forssell J., Goncalves M., Colucci F., and Holmberg D. E2-2 regulates the expansion of pro-B cells and follicular versus marginal zone decisions. J. Immunol. 177 (2006) 6723-6729
42. Wu L., and Liu Y.J. Development of dendritic-cell lineages. Immunity 26 (2007) 741-750
43. Zhuang Y., Cheng P., and Weintraub H. B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol. Cell. Biol. 16 (1996) 2898-2905
44. Zweier C., Peippo M.M., Hoyer J., Sousa S., Bottani A., Clayton-Smith J., Reardon W., Saraiva J., Cabral A., Gohring I., et al. Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome). Am. J. Hum. Genet. 80 (2007) 994-1001