Flt-3 ligand synergizes with granulocyte colony-stimulating factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential

Blood

Volumn 89, Issue 11, 1997, Pages 3998-4004

  Molineux, Graham ^a   McCrea, Clay ^a   Yan, Xiao Qiang ^a   Kerzic, Patrick ^a   McNiece, Ian ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; GRANULOCYTE COLONY STIMULATING FACTOR; STEM CELL FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL MOTILITY; CELL PROLIFERATION; DENDRITIC CELL; ENZYME ACTIVITY; GRAFT FAILURE; HEMATOPOIESIS; LIGAND BINDING; MALE; MAST CELL; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

EID: 0030948721     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.11.3998     Document Type: Article

References (27)

1. Lyman SD, James L, Vanden-Bos T, de Vries P, Brasel K, Gliniak B, Hollingsworth LT, Picha KS, McKenna HJ, Splett RR: Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells. Cell 75:1157, 1993
2. Rosnet O, Marchetto S, deLapeyriere O, Birnbaum D: Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/ CSF1R family. Oncogene 6:1641, 1991
3. Matthews W, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR: A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 65:1143, 1991
4. Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J: Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature 368:643, 1994
5. Lyman SD, James L, Johnson L, Brasel K, de Vries P, Escobar SS, Downey H, Splett RR, Beckmann MP, McKenna HJ: Cloning of the human homologue of the murine flt3 ligand: A growth factor for early hematopoietic progenitor cells. Blood 83:2795, 1994
6. de Vries P, Brasel KA, McKenna HJ, Beckmann MP, Gliniak BC, Williams DE, Lyman SD: The effects of soluble flt3 ligand on murine pluripotent hematopoietic stem cells. Exp Hematol 22:724, 1994
7. Broxmeyer HE, Lu L, Cooper S, Li ZH, McKenna HJ, Williams DE, Beckmann MP, Lyman SD: The stimulating/co-stimulating effects of flt 3-ligand on immature subsets of myeloid stem/ progenitor cells. Exp Hematol 22:725, 1994
8. McKenna HJ, Lyman SD, de Vries P, Brasel KA, Beckmann MP, Williams DE: The biological effects of flt3 ligand on CD34 positive progenitor cells isolated from human bone marrow and cord blood. Exp Hematol 22:763, 1994
9. McNiece IK, Langley KE, Zsebo KM: Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages. Exp Hematol 19:226, 1991
10. Westwood NB, Chung R, Emmerson AJ, Pearson TC: The in vitro effects of stem cell factor, interleukin 3 and granulocyte-macrophage colony stimulating factor on haemopoietic progenitor cells from premature infants. Br J Haematol 86:468, 1994
11. Piacibello W, Fubini L, Sanavio F, Brizzi MF, Severino A, Garetto L, Stacchini A, Pegoraro L, Aglietta M, Lyman ST: Effect of flt3/flk2 ligand on myeloid leukemia cell growth: Heterogeneity in response and synergy with other hematopoietic growth factors. Exp Hematol 23:850, 1995
12. Brasel K, Rousseau AM, de Vries P, Lyman SD: Recombinant flt3 ligand enhances hematopoiesis in myeloid and B-lymphoid long-term bone marrow cultures. Exp Hematol 22:736, 1995
13. Fletcher FA, Juan T, Lacey D, Yan X-Q, Hartley C, McElroy T, Sun Y, Hill D, Hawley R, McNiece I: Chronic over-expression of murine flt3/flk2 ligand in mice results in increased circulating white blood cell levels and abnormal lymphoreticular cell infiltrates associated with splenic fibrosis. Blood 86:21a, 1995 (suppl 1, abstr)
14. Molineux G, Migdalska A, Szmitkowski M, Zsebo K, Dexter TM: The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor. Blood 78:961. 1991
15. McNiece IK, Briddell RA, Hartley CA, Smith KA, Andrews RG: Stem cell factor enhances in vivo effects of granulocyte colony stimulating factor for stimulating mobilization of peripheral blood progenitor cells. Stem Cells 2:36, 1993 (suppl)
16. Briddell RA, Hartley CA, Smith KA, McNiece IK: Recombinant rat stem cell factor synergizes with recombinant human granulocyte colony-stimulating factor in vivo in mice to mobilize peripheral blood progenitor cells that have enhanced repopulating potential. Blood 82:1720, 1993
17. Bodine DM, Seidel NE, Zsebo KM, Orlic D: In vivo administration of stem cell factor to mice increases the absolute number of pluripotent hematopoietic stem cells. Blood 82:445, 1993
18. Glaspy J, McNiece I, LeMaistre F, Menchaca D, Briddell RA, Lill M, Jones R, Tami J, Morstyn G, Brown S, Shpall EJ: Effects of stem cell factor (rhSCF) and filgrastim (rhG-CSF) on the mobilization of peripheral blood progenitor cells (PBPC) and hematological recovery post transplant: Preliminary phase I/II study results. Br J Haematol 87:156, 1994
19. Briddell RA, Glaspy J, Shpall EJ, LeMaistre F, Menchaca D, McNiece I: Recombinant human stem cell factor (rhSCF) and filgrastim (rhG-CSF) synergize to mobilize myeloid, erythroid and megakaryocyte progenitors in patients with breast cancer. Br J Haematol 87:92, 1994
20. Ashihara E, Shimazaki C, Sudo Y, Araki S, Yamagata N, Goto H, Inaba T, Fujita N, Lyman SD, Nakagawa M: Flt-3 ligand (FL) mobilizes stem/progenitor cells into blood in mice. Exp Hematol 23:801, 1995
21. Brasel K, McKenna HJ, Charrier K, Morrissey P, Williams DE, Lyman SD: Mobilization of peripheral blood progenitor cells with flt-3 ligand. Blood 86:463a, 1995 (suppl 1, abstr)
22. Brasel K, McKenna HJ, Morrissey PJ, Charrier K, Morris AE, Lee CC, Williams DE, Lyman SD: Hematological effects of flt3 ligand in vivo in mice. Blood 88:2004, 1996
23. Papayannopoulou T, Nakamoto B, Lyman S: Mobilization of lymphoid/myeloid hemopoietic progenitors in primates treated with flt3/flk2-ligand. Blood 86:423a, 1995 (suppl 1, abstr)
24. Brasel K, McKenna HJ, Charrier K, Morrissey P, Williams DE, Lyman SD: Synergistic effects in vivo of flt3 ligand with GM-CSF or G-CSF in mobilization of colony forming cells in mice. Blood 86:499a, 1995 (suppl 1, abstr)
25. Shimazaki C, Sudo Y, Kikuta T, Hirai H, Sumikuma T, Yamagata N, Goto H, Inaba T, Fujita N, Nakagawa M: Flt-3 ligand synergistically enhances the in vivo response to G-CSF for mobilizing hematopoietic stem/progenitor cells into blood in mice. Blood 86:111a, 1995 (suppl 1, abstr)
26. Yan XQ, Hartley C, McElroy P, Chang A, McCrea C, McNiece I: Peripheral blood progenitor cells mobilized by recombinant human granulocyte colony-stimulating factor plus recombinant rat stem cell factor contain long-term engrafting cells capable of cellular proliferation for more than two years as shown by serial transplantation in mice. Blood 85:2303, 1995
27. + cells in pheresis harvests from patients mobilized by growth factors predict engraftment post transplantation. Blood 84:348, 1994