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Volumn 11, Issue 11, 2011, Pages 723-737

Protective and pathogenic functions of macrophage subsets

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD163 ANTIGEN; CHEMOKINE RECEPTOR CX3CR1; CHLORDANE; CXCL13 CHEMOKINE; GALECTIN 3; GAMMA INTERFERON; GLYCOPROTEIN P 15095; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 13; INTERLEUKIN 23P19; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR ALPHA; INTERLEUKIN 6; LYMPHOCYTE ANTIGEN; MANNOSE RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; RANTES; STAT1 PROTEIN; STAT3 PROTEIN; STAT6 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNINDEXED DRUG;

EID: 80355131976     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri3073     Document Type: Review
Times cited : (3948)

References (176)
  • 1
    • 76249095169 scopus 로고    scopus 로고
    • Development of monocytes, macrophages, and dendritic cells
    • Geissmann, F. et al. Development of monocytes, macrophages, and dendritic cells. Science 327, 656-661 (2010).
    • (2010) Science , vol.327 , pp. 656-661
    • Geissmann, F.1
  • 2
    • 0015324633 scopus 로고
    • Phagocytosis of immune complexes by macrophages. Different roles of the macrophage receptor sites for complement (C3) and for immunoglobulin (IgG)
    • Mantovani, B., Rabinovitch, M. & Nussenzweig, V. Phagocytosis of immune complexes by macrophages. Different roles of the macrophage receptor sites for complement (C3) and for immunoglobulin (IgG). J. Exp. Med. 135, 780-792 (1972).
    • (1972) J. Exp. Med. , vol.135 , pp. 780-792
    • Mantovani, B.1    Rabinovitch, M.2    Nussenzweig, V.3
  • 3
    • 38049123476 scopus 로고    scopus 로고
    • Clearance of apoptotic cells by phagocytes
    • Erwig, L. P. & Henson, P. M. Clearance of apoptotic cells by phagocytes. Cell Death Differ. 15, 243-250 (2008).
    • (2008) Cell Death Differ. , vol.15 , pp. 243-250
    • Erwig, L.P.1    Henson, P.M.2
  • 4
    • 79952123931 scopus 로고    scopus 로고
    • Microbial manipulation of receptor crosstalk in innate immunity
    • Hajishengallis, G. & Lambris, J. D. Microbial manipulation of receptor crosstalk in innate immunity. Nature Rev. Immunol. 11, 187-200 (2011).
    • (2011) Nature Rev. Immunol. , vol.11 , pp. 187-200
    • Hajishengallis, G.1    Lambris, J.D.2
  • 5
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • Gordon, S. & Taylor, P. R. Monocyte and macrophage heterogeneity. Nature Rev. Immunol. 5, 953-964 (2005).
    • (2005) Nature Rev. Immunol. , vol.5 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 6
    • 79956358140 scopus 로고    scopus 로고
    • Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen
    • McGaha, T. L., Chen, Y., Ravishankar, B., van Rooijen, N. & Karlsson, M. C. Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen. Blood 117, 5403-5412 (2011).
    • (2011) Blood , vol.117 , pp. 5403-5412
    • McGaha, T.L.1    Chen, Y.2    Ravishankar, B.3    Van Rooijen, N.4    Karlsson, M.C.5
  • 7
    • 77953920853 scopus 로고    scopus 로고
    • Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus
    • Iannacone, M. et al. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature 465, 1079-1083 (2010).
    • (2010) Nature , vol.465 , pp. 1079-1083
    • Iannacone, M.1
  • 8
    • 35948935059 scopus 로고    scopus 로고
    • Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
    • Junt, T. et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 450, 110-114 (2007).
    • (2007) Nature , vol.450 , pp. 110-114
    • Junt, T.1
  • 10
    • 77957020717 scopus 로고    scopus 로고
    • Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors
    • Cros, J. et al. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity 33, 375-386 (2010).
    • (2010) Immunity , vol.33 , pp. 375-386
    • Cros, J.1
  • 11
    • 0030926583 scopus 로고    scopus 로고
    • Selective suppression of interleukin-12 induction after macrophage receptor ligation
    • Sutterwala, F. S., Noel, G. J., Clynes, R. & Mosser, D. M. Selective suppression of interleukin-12 induction after macrophage receptor ligation. J. Exp. Med. 185, 1977-1985 (1997).
    • (1997) J. Exp. Med. , vol.185 , pp. 1977-1985
    • Sutterwala, F.S.1    Noel, G.J.2    Clynes, R.3    Mosser, D.M.4
  • 12
    • 0032490575 scopus 로고    scopus 로고
    • Reversal of proinflammatory responses by ligating the macrophage Fcγ receptor type i
    • Sutterwala, F. S., Noel, G. J., Salgame, P. & Mosser, D. M. Reversal of proinflammatory responses by ligating the macrophage Fcγ receptor type I. J. Exp. Med. 188, 217-222 (1998).
    • (1998) J. Exp. Med. , vol.188 , pp. 217-222
    • Sutterwala, F.S.1    Noel, G.J.2    Salgame, P.3    Mosser, D.M.4
  • 13
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser, D. M. & Edwards, J. P. Exploring the full spectrum of macrophage activation. Nature Rev. Immunol. 8, 958-969 (2008).
    • (2008) Nature Rev. Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 14
    • 79953678939 scopus 로고    scopus 로고
    • Obstacles and opportunities for understanding macrophage polarization
    • Murray, P. J. & Wynn, T. A. Obstacles and opportunities for understanding macrophage polarization. J. Leukoc. Biol. 89, 557-563 (2011).
    • (2011) J. Leukoc. Biol. , vol.89 , pp. 557-563
    • Murray, P.J.1    Wynn, T.A.2
  • 15
    • 45149134605 scopus 로고    scopus 로고
    • "re-educating" tumor-associated macrophages by targeting NF-κB
    • Hagemann, T. et al. "Re-educating" tumor-associated macrophages by targeting NF-κB. J. Exp. Med. 205, 1261-1268 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 1261-1268
    • Hagemann, T.1
  • 16
    • 0035865047 scopus 로고    scopus 로고
    • Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production
    • Rutschman, R. et al. Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production. J. Immunol. 166, 2173-2177 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 2173-2177
    • Rutschman, R.1
  • 17
    • 77957940963 scopus 로고    scopus 로고
    • Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice
    • Kawanishi, N., Yano, H., Yokogawa, Y. & Suzuki, K. Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice. Exerc. Immunol. Rev. 16, 105-118 (2010).
    • (2010) Exerc. Immunol. Rev. , vol.16 , pp. 105-118
    • Kawanishi, N.1    Yano, H.2    Yokogawa, Y.3    Suzuki, K.4
  • 18
    • 64849097221 scopus 로고    scopus 로고
    • Alternatively activated macrophages elicited by helminth infection can be reprogrammed to enable microbial killing
    • Mylonas, K. J., Nair, M. G., Prieto-Lafuente, L., Paape, D. & Allen, J. E. Alternatively activated macrophages elicited by helminth infection can be reprogrammed to enable microbial killing. J. Immunol. 182, 3084-3094 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 3084-3094
    • Mylonas, K.J.1    Nair, M.G.2    Prieto-Lafuente, L.3    Paape, D.4    Allen, J.E.5
  • 19
    • 21244443731 scopus 로고    scopus 로고
    • Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences
    • Stout, R. D. et al. Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J. Immunol. 175, 342-349 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 342-349
    • Stout, R.D.1
  • 20
    • 4344706372 scopus 로고    scopus 로고
    • Functional plasticity of macrophages: Reversible adaptation to changing microenvironments
    • Stout, R. D. & Suttles, J. Functional plasticity of macrophages: reversible adaptation to changing microenvironments. J. Leukoc. Biol. 76, 509-513 (2004).
    • (2004) J. Leukoc. Biol. , vol.76 , pp. 509-513
    • Stout, R.D.1    Suttles, J.2
  • 21
    • 70049098536 scopus 로고    scopus 로고
    • Regulatory T cells reinforce intestinal homeostasis
    • Barnes, M. J. & Powrie, F. Regulatory T cells reinforce intestinal homeostasis. Immunity 31, 401-411 (2009).
    • (2009) Immunity , vol.31 , pp. 401-411
    • Barnes, M.J.1    Powrie, F.2
  • 22
    • 70049099836 scopus 로고    scopus 로고
    • Intestinal lamina propria dendritic cell subsets have different origin and functions
    • Varol, C. et al. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31, 502-512 (2009).
    • (2009) Immunity , vol.31 , pp. 502-512
    • Varol, C.1
  • 23
    • 79959271087 scopus 로고    scopus 로고
    • Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • Maloy, K. J. & Powrie, F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474, 298-306 (2011).
    • (2011) Nature , vol.474 , pp. 298-306
    • Maloy, K.J.1    Powrie, F.2
  • 24
    • 79958715229 scopus 로고    scopus 로고
    • Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation
    • Jenkins, S. J. et al. Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 332, 1284-1288 (2011).
    • (2011) Science , vol.332 , pp. 1284-1288
    • Jenkins, S.J.1
  • 25
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: Sensing and reacting to damage
    • Chen, G. Y. & Nunez, G. Sterile inflammation: sensing and reacting to damage. Nature Rev. Immunol. 10, 826-837 (2010).
    • (2010) Nature Rev. Immunol. , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nunez, G.2
  • 26
    • 79952126441 scopus 로고    scopus 로고
    • Tissue-based class control: The other side of tolerance
    • Matzinger, P. & Kamala, T. Tissue-based class control: the other side of tolerance. Nature Rev. Immunol. 11, 221-230 (2011).
    • (2011) Nature Rev. Immunol. , vol.11 , pp. 221-230
    • Matzinger, P.1    Kamala, T.2
  • 27
    • 79956314385 scopus 로고    scopus 로고
    • Host defense pathways: Role of redundancy and compensation in infectious disease phenotypes
    • Nish, S. & Medzhitov, R. Host defense pathways: role of redundancy and compensation in infectious disease phenotypes. Immunity 34, 629-636 (2011).
    • (2011) Immunity , vol.34 , pp. 629-636
    • Nish, S.1    Medzhitov, R.2
  • 28
    • 36749069393 scopus 로고    scopus 로고
    • Interferons at age 50: Past, current and future impact on biomedicine
    • Borden, E. C. et al. Interferons at age 50: past, current and future impact on biomedicine. Nature Rev. Drug Discov. 6, 975-990 (2007).
    • (2007) Nature Rev. Drug Discov. , vol.6 , pp. 975-990
    • Borden, E.C.1
  • 29
    • 79956303498 scopus 로고    scopus 로고
    • Regulation of the antimicrobial response by NLR proteins
    • Elinav, E., Strowig, T., Henao-Mejia, J. & Flavell, R. A. Regulation of the antimicrobial response by NLR proteins. Immunity 34, 665-679 (2011).
    • (2011) Immunity , vol.34 , pp. 665-679
    • Elinav, E.1    Strowig, T.2    Henao-Mejia, J.3    Flavell, R.A.4
  • 30
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • Kawai, T. & Akira, S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34, 637-650 (2011).
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 31
    • 79956292569 scopus 로고    scopus 로고
    • Myeloid C-type lectin receptors in pathogen recognition and host defense
    • Osorio, F. & Reis, E. S. C. Myeloid C-type lectin receptors in pathogen recognition and host defense. Immunity 34, 651-664 (2011).
    • (2011) Immunity , vol.34 , pp. 651-664
    • Osorio, F.1    Reis, E.S.C.2
  • 32
    • 77950365906 scopus 로고    scopus 로고
    • Nonresolving inflammation
    • Nathan, C. & Ding, A. Nonresolving inflammation. Cell 140, 871-882 (2010).
    • (2010) Cell , vol.140 , pp. 871-882
    • Nathan, C.1    Ding, A.2
  • 33
    • 42649108339 scopus 로고    scopus 로고
    • Monocyte-mediated defense against microbial pathogens
    • Serbina, N. V., Jia, T., Hohl, T. M. & Pamer, E. G. Monocyte-mediated defense against microbial pathogens. Annu. Rev. Immunol. 26, 421-452 (2008).
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 421-452
    • Serbina, N.V.1    Jia, T.2    Hohl, T.M.3    Pamer, E.G.4
  • 34
    • 51249105349 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in inflammatory bowel disease: A new immunoregulatory pathway
    • Haile, L. A. et al. Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway. Gastroenterology 135, 871-881 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 871-881
    • Haile, L.A.1
  • 36
    • 77954977151 scopus 로고    scopus 로고
    • Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice
    • Garcia, M. R. et al. Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice. J. Clin. Invest. 120, 2486-2496 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 2486-2496
    • Garcia, M.R.1
  • 37
    • 34250359119 scopus 로고    scopus 로고
    • MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis
    • Delano, M. J. et al. MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis. J. Exp. Med. 204, 1463-1474 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1463-1474
    • Delano, M.J.1
  • 38
    • 0036800086 scopus 로고    scopus 로고
    • G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood
    • Semerad, C. L., Liu, F., Gregory, A. D., Stumpf, K. & Link, D. C. G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. Immunity 17, 413-423 (2002).
    • (2002) Immunity , vol.17 , pp. 413-423
    • Semerad, C.L.1    Liu, F.2    Gregory, A.D.3    Stumpf, K.4    Link, D.C.5
  • 39
    • 0033180176 scopus 로고    scopus 로고
    • A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation
    • Semerad, C. L., Poursine-Laurent, J., Liu, F. & Link, D. C. A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation. Immunity 11, 153-161 (1999).
    • (1999) Immunity , vol.11 , pp. 153-161
    • Semerad, C.L.1    Poursine-Laurent, J.2    Liu, F.3    Link, D.C.4
  • 40
    • 80051959957 scopus 로고    scopus 로고
    • The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C-monocytes
    • Hanna, R. N. et al. The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C-monocytes. Nature Immunol. 12, 778-785 (2011).
    • (2011) Nature Immunol. , vol.12 , pp. 778-785
    • Hanna, R.N.1
  • 41
    • 68149119072 scopus 로고    scopus 로고
    • Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    • Swirski, F. K. et al. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science 325, 612-616 (2009).
    • (2009) Science , vol.325 , pp. 612-616
    • Swirski, F.K.1
  • 42
    • 65249145291 scopus 로고    scopus 로고
    • TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection
    • Aldridge, J. R. Jr et al. TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc. Natl Acad. Sci. USA 106, 5306-5311 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 5306-5311
    • Aldridge Jr., J.R.1
  • 43
    • 77955661668 scopus 로고    scopus 로고
    • Monocytes mediate mucosal immunity to Toxoplasma gondii
    • Dunay, I. R. & Sibley, L. D. Monocytes mediate mucosal immunity to Toxoplasma gondii. Curr. Opin. Immunol. 22, 461-466 (2010).
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 461-466
    • Dunay, I.R.1    Sibley, L.D.2
  • 44
    • 70149107112 scopus 로고    scopus 로고
    • Distinct responses of human monocyte subsets to Aspergillus fumigatus conidia
    • Serbina, N. V. et al. Distinct responses of human monocyte subsets to Aspergillus fumigatus conidia. J. Immunol. 183, 2678-2687 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 2678-2687
    • Serbina, N.V.1
  • 45
    • 33645902493 scopus 로고    scopus 로고
    • Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
    • Serbina, N. V. & Pamer, E. G. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nature Immunol. 7, 311-317 (2006).
    • (2006) Nature Immunol. , vol.7 , pp. 311-317
    • Serbina, N.V.1    Pamer, E.G.2
  • 46
    • 79956319462 scopus 로고    scopus 로고
    • The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes
    • Kim, Y. G. et al. The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. Immunity 34, 769-780 (2011).
    • (2011) Immunity , vol.34 , pp. 769-780
    • Kim, Y.G.1
  • 47
    • 77950386333 scopus 로고    scopus 로고
    • Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines
    • Zhang, S., Kim, C. C., Batra, S., McKerrow, J. H. & Loke, P. Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines. PLoS Negl. Trop. Dis. 4, e648 (2010).
    • (2010) PLoS Negl. Trop. Dis. , vol.4
    • Zhang, S.1    Kim, C.C.2    Batra, S.3    McKerrow, J.H.4    Loke, P.5
  • 48
    • 79958265461 scopus 로고    scopus 로고
    • Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection
    • Goncalves, R., Zhang, X., Cohen, H., Debrabant, A. & Mosser, D. M. Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection. J. Exp. Med. 208, 1253-1265 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1253-1265
    • Goncalves, R.1    Zhang, X.2    Cohen, H.3    Debrabant, A.4    Mosser, D.M.5
  • 49
    • 79954591540 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating Toll-like receptor ligands
    • Shi, C. et al. Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating Toll-like receptor ligands. Immunity 34, 590-601 (2011).
    • (2011) Immunity , vol.34 , pp. 590-601
    • Shi, C.1
  • 50
    • 79960411324 scopus 로고    scopus 로고
    • CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    • Qian, B. Z. et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475, 222-225 (2011).
    • (2011) Nature , vol.475 , pp. 222-225
    • Qian, B.Z.1
  • 51
    • 77958124602 scopus 로고    scopus 로고
    • Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2 IFN-γ and MyD88 signaling
    • Bosschaerts, T. et al. Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-γ and MyD88 signaling. PLoS Pathog. 6, e1001045 (2010).
    • (2010) PLoS Pathog. , vol.6
    • Bosschaerts, T.1
  • 52
    • 79956068261 scopus 로고    scopus 로고
    • Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation
    • Hashimoto, D. et al. Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J. Exp. Med. 208, 1069-1082 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1069-1082
    • Hashimoto, D.1
  • 53
    • 70049098070 scopus 로고    scopus 로고
    • Origin of the lamina propria dendritic cell network
    • Bogunovic, M. et al. Origin of the lamina propria dendritic cell network. Immunity 31, 513-525 (2009).
    • (2009) Immunity , vol.31 , pp. 513-525
    • Bogunovic, M.1
  • 54
    • 34548764423 scopus 로고    scopus 로고
    • Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
    • Denning, T. L., Wang, Y. C., Patel, S. R., Williams, I. R. & Pulendran, B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nature Immunol. 8, 1086-1094 (2007).
    • (2007) Nature Immunol. , vol.8 , pp. 1086-1094
    • Denning, T.L.1    Wang, Y.C.2    Patel, S.R.3    Williams, I.R.4    Pulendran, B.5
  • 55
    • 80052671020 scopus 로고    scopus 로고
    • Plasticity of Ly-6Chi myeloid cells in T cell regulation
    • Zhu, B. et al. Plasticity of Ly-6Chi myeloid cells in T cell regulation. J. Immunol. 187, 2418-2432 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 2418-2432
    • Zhu, B.1
  • 56
    • 70449393651 scopus 로고    scopus 로고
    • MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages
    • Aziz, A., Soucie, E., Sarrazin, S. & Sieweke, M. H. MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages. Science 326, 867-871 (2009).
    • (2009) Science , vol.326 , pp. 867-871
    • Aziz, A.1    Soucie, E.2    Sarrazin, S.3    Sieweke, M.H.4
  • 57
    • 66349084135 scopus 로고    scopus 로고
    • Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis
    • Pesce, J. T. et al. Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog. 5, e1000371 (2009).
    • (2009) PLoS Pathog. , vol.5
    • Pesce, J.T.1
  • 58
    • 0037625155 scopus 로고    scopus 로고
    • TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    • Serbina, N. V., Salazar-Mather, T. P., Biron, C. A., Kuziel, W. A. & Pamer, E. G. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 19, 59-70 (2003).
    • (2003) Immunity , vol.19 , pp. 59-70
    • Serbina, N.V.1    Salazar-Mather, T.P.2    Biron, C.A.3    Kuziel, W.A.4    Pamer, E.G.5
  • 59
    • 79952135247 scopus 로고    scopus 로고
    • An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice
    • Sindrilaru, A. et al. An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J. Clin. Invest. 121, 985-997 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 985-997
    • Sindrilaru, A.1
  • 60
    • 55849103960 scopus 로고    scopus 로고
    • Macrophage diversity in renal injury and repair
    • Ricardo, S. D., van Goor, H. & Eddy, A. A. Macrophage diversity in renal injury and repair. J. Clin. Invest. 118, 3522-3530 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 3522-3530
    • Ricardo, S.D.1    Van Goor, H.2    Eddy, A.A.3
  • 61
    • 77954961992 scopus 로고    scopus 로고
    • Macrophages: Master regulators of inflammation and fibrosis
    • Wynn, T. A. & Barron, L. Macrophages: master regulators of inflammation and fibrosis. Semin. Liver Dis. 30, 245-257 (2010).
    • (2010) Semin. Liver Dis. , vol.30 , pp. 245-257
    • Wynn, T.A.1    Barron, L.2
  • 62
    • 3543107212 scopus 로고    scopus 로고
    • Fibrotic disease and the TH1/TH2 paradigm
    • Wynn, T. A. Fibrotic disease and the TH1/TH2 paradigm. Nature Rev. Immunol. 4, 583-594 (2004).
    • (2004) Nature Rev. Immunol. , vol.4 , pp. 583-594
    • Wynn, T.A.1
  • 64
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
    • Biswas, S. K. & Mantovani, A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nature Immunol. 11, 889-896 (2010).
    • (2010) Nature Immunol. , vol.11 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 65
    • 34248997759 scopus 로고    scopus 로고
    • Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
    • Arnold, L. et al. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J. Exp. Med. 204, 1057-1069 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1057-1069
    • Arnold, L.1
  • 66
    • 79955565441 scopus 로고    scopus 로고
    • Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages
    • Barron, L. & Wynn, T. A. Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages. Am. J. Physiol. Gastrointest. Liver Physiol. 300, G723-G728 (2011).
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.300
    • Barron, L.1    Wynn, T.A.2
  • 67
    • 0022471924 scopus 로고
    • Transforming growth factor type β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
    • Roberts, A. B. et al. Transforming growth factor type β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl Acad. Sci. USA 83, 4167-4171 (1986).
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 4167-4171
    • Roberts, A.B.1
  • 69
    • 0022404365 scopus 로고
    • A significant part of macrophage-derived growth factor consists of at least two forms of PDGF
    • Shimokado, K. et al. A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. Cell 43, 277-286 (1985).
    • (1985) Cell , vol.43 , pp. 277-286
    • Shimokado, K.1
  • 70
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn, T. A. Cellular and molecular mechanisms of fibrosis. J. Pathol. 214, 199-210 (2008).
    • (2008) J. Pathol. , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 71
    • 72849117761 scopus 로고    scopus 로고
    • Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages
    • Atabai, K. et al. Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J. Clin. Invest. 119, 3713-3722 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 3713-3722
    • Atabai, K.1
  • 72
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel, T. J. et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature Med. 10, 942-949 (2004).
    • (2004) Nature Med. , vol.10 , pp. 942-949
    • Curiel, T.J.1
  • 73
    • 0032908743 scopus 로고    scopus 로고
    • Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine
    • Imai, T. et al. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int. Immunol. 11, 81-88 (1999).
    • (1999) Int. Immunol. , vol.11 , pp. 81-88
    • Imai, T.1
  • 74
    • 0037899249 scopus 로고    scopus 로고
    • The myofibroblast in wound healing and fibrocontractive diseases
    • Gabbiani, G. The myofibroblast in wound healing and fibrocontractive diseases. J. Pathol. 200, 500-503 (2003).
    • (2003) J. Pathol. , vol.200 , pp. 500-503
    • Gabbiani, G.1
  • 75
    • 0025763807 scopus 로고
    • IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
    • Fiorentino, D. F. et al. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 146, 3444-3451 (1991).
    • (1991) J. Immunol. , vol.146 , pp. 3444-3451
    • Fiorentino, D.F.1
  • 76
    • 49649093608 scopus 로고    scopus 로고
    • Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFβ-1
    • Savage, N. D. et al. Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFβ-1. J. Immunol. 181, 2220-2226 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 2220-2226
    • Savage, N.D.1
  • 77
    • 77953446979 scopus 로고    scopus 로고
    • Arginase i suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis
    • Herbert, D. R. et al. Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. J. Immunol. 184, 6438-6446 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 6438-6446
    • Herbert, D.R.1
  • 78
    • 66749141911 scopus 로고    scopus 로고
    • Chitinases and chitinase-like proteins: Potential therapeutic targets for the treatment of T-helper type 2 allergies
    • Sutherland, T. E., Maizels, R. M. & Allen, J. E. Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies. Clin. Exp. Allergy 39, 943-955 (2009).
    • (2009) Clin. Exp. Allergy , vol.39 , pp. 943-955
    • Sutherland, T.E.1    Maizels, R.M.2    Allen, J.E.3
  • 79
    • 66349089268 scopus 로고    scopus 로고
    • Retnla (Relmα/Fizz1) suppresses helminth-induced Th2-type immunity
    • Pesce, J. T. et al. Retnla (Relmα/Fizz1) suppresses helminth-induced Th2-type immunity. PLoS Pathog. 5, e1000393 (2009).
    • (2009) PLoS Pathog. , vol.5
    • Pesce, J.T.1
  • 80
    • 34247626970 scopus 로고    scopus 로고
    • Chitin induces accumulation in tissue of innate immune cells associated with allergy
    • Reese, T. A. et al. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 447, 92-96 (2007).
    • (2007) Nature , vol.447 , pp. 92-96
    • Reese, T.A.1
  • 81
    • 78651473243 scopus 로고    scopus 로고
    • Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages
    • London, A. et al. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J. Exp. Med. 208, 23-39 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 23-39
    • London, A.1
  • 82
    • 79751496064 scopus 로고    scopus 로고
    • Alternative macrophage activation and metabolism
    • Odegaard, J. I. & Chawla, A. Alternative macrophage activation and metabolism. Annu. Rev. Pathol. 6, 275-297 (2011).
    • (2011) Annu. Rev. Pathol. , vol.6 , pp. 275-297
    • Odegaard, J.I.1    Chawla, A.2
  • 83
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng, C. N., Bodzin, J. L. & Saltiel, A. R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117, 175-184 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 84
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
    • Odegaard, J. I. et al. Macrophage-specific PPARγ controls alternative activation and improves insulin resistance. Nature 447, 1116-1120 (2007).
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1
  • 85
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar, B. et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nature Med. 17, 179-188 (2011).
    • (2011) Nature Med. , vol.17 , pp. 179-188
    • Vandanmagsar, B.1
  • 86
    • 80355133234 scopus 로고    scopus 로고
    • Macrophage-mediated inflammation in metabolic disease
    • 10 Oct doi:10.1038/nri3071
    • Chawla, A. et al. Macrophage-mediated inflammation in metabolic disease. Nature Rev. Immunol. 10 Oct 2011 (doi:10.1038/nri3071).
    • (2011) Nature Rev. Immunol.
    • Chawla, A.1
  • 87
    • 0027492915 scopus 로고
    • Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10
    • de Waal Malefyt, R. et al. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10. J. Immunol. 151, 6370-6381 (1993).
    • (1993) J. Immunol. , vol.151 , pp. 6370-6381
    • De Waal Malefyt, R.1
  • 88
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon, S. Alternative activation of macrophages. Nature Rev. Immunol. 3, 23-35 (2003).
    • (2003) Nature Rev. Immunol. , vol.3 , pp. 23-35
    • Gordon, S.1
  • 89
    • 33746806604 scopus 로고    scopus 로고
    • Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
    • Anthony, R. M. et al. Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nature Med. 12, 955-960 (2006).
    • (2006) Nature Med. , vol.12 , pp. 955-960
    • Anthony, R.M.1
  • 90
    • 79251580630 scopus 로고    scopus 로고
    • Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype
    • Bhatia, S. et al. Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype. PLoS ONE 6, e15943 (2011).
    • (2011) PLoS ONE , vol.6
    • Bhatia, S.1
  • 91
    • 33846809273 scopus 로고    scopus 로고
    • IL-10-producing monocytes differentiate to alternatively activated macrophages and are increased in atopic patients
    • Prasse, A. et al. IL-10-producing monocytes differentiate to alternatively activated macrophages and are increased in atopic patients. J. Allergy Clin. Immunol. 119, 464-471 (2007).
    • (2007) J. Allergy Clin. Immunol. , vol.119 , pp. 464-471
    • Prasse, A.1
  • 92
    • 44949257271 scopus 로고    scopus 로고
    • Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
    • Kim, E. Y. et al. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nature Med. 14, 633-640 (2008).
    • (2008) Nature Med. , vol.14 , pp. 633-640
    • Kim, E.Y.1
  • 93
    • 77956909334 scopus 로고    scopus 로고
    • Rhinovirus infection of allergen-sensitized and-challenged mice induces eotaxin release from functionally polarized macrophages
    • Nagarkar, D. R. et al. Rhinovirus infection of allergen-sensitized and-challenged mice induces eotaxin release from functionally polarized macrophages. J. Immunol. 185, 2525-2535 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 2525-2535
    • Nagarkar, D.R.1
  • 95
    • 75549085516 scopus 로고    scopus 로고
    • IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
    • Kurowska-Stolarska, M. et al. IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J. Immunol. 183, 6469-6477 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 6469-6477
    • Kurowska-Stolarska, M.1
  • 96
    • 17144367365 scopus 로고    scopus 로고
    • In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma
    • van Rijt, L. S. et al. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J. Exp. Med. 201, 981-991 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 981-991
    • Van Rijt, L.S.1
  • 97
    • 77951447568 scopus 로고    scopus 로고
    • Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-TLR4-and IFN-β-dependent
    • Shirey, K. A. et al. Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4-, and IFN-β-dependent. Mucosal Immunol. 3, 291-300 (2010).
    • (2010) Mucosal Immunol. , vol.3 , pp. 291-300
    • Shirey, K.A.1
  • 98
    • 65549084867 scopus 로고    scopus 로고
    • Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung
    • Nair, M. G. et al. Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung. J. Exp. Med. 206, 937-952 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 937-952
    • Nair, M.G.1
  • 99
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • Sica, A. & Bronte, V. Altered macrophage differentiation and immune dysfunction in tumor development. J. Clin. Invest. 117, 1155-1166 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 100
    • 76349088502 scopus 로고    scopus 로고
    • FcRγ activation regulates inflammation-associated squamous carcinogenesis
    • Andreu, P. et al. FcRγ activation regulates inflammation-associated squamous carcinogenesis. Cancer Cell 17, 121-134 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 121-134
    • Andreu, P.1
  • 101
    • 19344365408 scopus 로고    scopus 로고
    • De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
    • de Visser, K. E., Korets, L. V. & Coussens, L. M. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7, 411-423 (2005).
    • (2005) Cancer Cell , vol.7 , pp. 411-423
    • De Visser, K.E.1    Korets, L.V.2    Coussens, L.M.3
  • 102
    • 42649125222 scopus 로고    scopus 로고
    • Macrophages and cancer
    • Nardin, A. & Abastado, J. P. Macrophages and cancer. Front. Biosci. 13, 3494-3505 (2008).
    • (2008) Front. Biosci. , vol.13 , pp. 3494-3505
    • Nardin, A.1    Abastado, J.P.2
  • 103
    • 78651237168 scopus 로고    scopus 로고
    • Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells
    • Yang, X. D. et al. Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells. Nature Med. 17, 87-95 (2011).
    • (2011) Nature Med. , vol.17 , pp. 87-95
    • Yang, X.D.1
  • 104
    • 46949110502 scopus 로고    scopus 로고
    • Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages
    • Sierra, J. R. et al. Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages. J. Exp. Med. 205, 1673-1685 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 1673-1685
    • Sierra, J.R.1
  • 105
    • 33645853780 scopus 로고    scopus 로고
    • B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
    • Kryczek, I. et al. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J. Exp. Med. 203, 871-881 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 871-881
    • Kryczek, I.1
  • 106
    • 77955295091 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
    • Imtiyaz, H. Z. et al. Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation. J. Clin. Invest. 120, 2699-2714 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 2699-2714
    • Imtiyaz, H.Z.1
  • 107
    • 77949345555 scopus 로고    scopus 로고
    • Tumor-associated macrophages and survival in classic Hodgkin's lymphoma
    • Steidl, C. et al. Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. N. Engl. J. Med. 362, 875-885 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 875-885
    • Steidl, C.1
  • 108
    • 77952389941 scopus 로고    scopus 로고
    • Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment
    • Ahn, G. O. et al. Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment. Proc. Natl Acad. Sci. USA 107, 8363-8368 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 8363-8368
    • Ahn, G.O.1
  • 109
    • 67651160649 scopus 로고    scopus 로고
    • CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • DeNardo, D. G. et al. CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16, 91-102 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 91-102
    • Denardo, D.G.1
  • 110
    • 0034569025 scopus 로고    scopus 로고
    • NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway
    • Terabe, M. et al. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nature Immunol. 1, 515-520 (2000).
    • (2000) Nature Immunol. , vol.1 , pp. 515-520
    • Terabe, M.1
  • 111
    • 76149146398 scopus 로고    scopus 로고
    • IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
    • Gocheva, V. et al. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev. 24, 241-255 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 241-255
    • Gocheva, V.1
  • 112
    • 29244474606 scopus 로고    scopus 로고
    • Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis
    • Sinha, P., Clements, V. K. & Ostrand-Rosenberg, S. Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis. Cancer Res. 65, 11743-11751 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 11743-11751
    • Sinha, P.1    Clements, V.K.2    Ostrand-Rosenberg, S.3
  • 113
    • 79959680070 scopus 로고    scopus 로고
    • Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth
    • 13 Jun doi:10.1084/jem.20100730
    • Zorro Manrique, S. et al. Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth. J. Exp. Med. 13 Jun 2011 (doi:10.1084/jem.20100730).
    • (2011) J. Exp. Med.
    • Zorro Manrique, S.1
  • 114
    • 67449088117 scopus 로고    scopus 로고
    • Interferon-γ reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages
    • Duluc, D. et al. Interferon-γ reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int. J. Cancer 125, 367-373 (2009).
    • (2009) Int. J. Cancer , vol.125 , pp. 367-373
    • Duluc, D.1
  • 115
    • 45149087674 scopus 로고    scopus 로고
    • An antiinflammatory role for IKKβ through the inhibition of "classical" macrophage activation
    • Fong, C. H. et al. An antiinflammatory role for IKKβ through the inhibition of "classical" macrophage activation. J. Exp. Med. 205, 1269-1276 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 1269-1276
    • Fong, C.H.1
  • 116
    • 66349083007 scopus 로고    scopus 로고
    • Vα24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages
    • Song, L. et al. Vα24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages. J. Clin. Invest. 119, 1524-1536 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 1524-1536
    • Song, L.1
  • 117
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 118
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro-and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    • Murphy, C. A. et al. Divergent pro-and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198, 1951-1957 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1951-1957
    • Murphy, C.A.1
  • 119
    • 69449105914 scopus 로고    scopus 로고
    • Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
    • Smith, A. M. et al. Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J. Exp. Med. 206, 1883-1897 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1883-1897
    • Smith, A.M.1
  • 120
    • 33750465224 scopus 로고    scopus 로고
    • Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
    • Kawane, K. et al. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 443, 998-1002 (2006).
    • (2006) Nature , vol.443 , pp. 998-1002
    • Kawane, K.1
  • 121
    • 77953644572 scopus 로고    scopus 로고
    • An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation
    • Platt, A. M., Bain, C. C., Bordon, Y., Sester, D. P. & Mowat, A. M. An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation. J. Immunol. 184, 6843-6854 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 6843-6854
    • Platt, A.M.1    Bain, C.C.2    Bordon, Y.3    Sester, D.P.4    Mowat, A.M.5
  • 122
    • 68149183243 scopus 로고    scopus 로고
    • Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability
    • Kamada, N. et al. Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability. J. Immunol. 183, 1724-1731 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 1724-1731
    • Kamada, N.1
  • 123
    • 45749107055 scopus 로고    scopus 로고
    • Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis
    • Kamada, N. et al. Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis. J. Clin. Invest. 118, 2269-2280 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 2269-2280
    • Kamada, N.1
  • 124
    • 78650807608 scopus 로고    scopus 로고
    • Intestinal macrophages and response to microbial encroachment
    • Smith, P. D. et al. Intestinal macrophages and response to microbial encroachment. Mucosal Immunol. 4, 31-42 (2011).
    • (2011) Mucosal Immunol. , vol.4 , pp. 31-42
    • Smith, P.D.1
  • 125
    • 70350464351 scopus 로고    scopus 로고
    • Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    • Murai, M. et al. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nature Immunol. 10, 1178-1184 (2009).
    • (2009) Nature Immunol. , vol.10 , pp. 1178-1184
    • Murai, M.1
  • 126
    • 34948814168 scopus 로고    scopus 로고
    • Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species
    • Gelderman, K. A. et al. Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species. J. Clin. Invest. 117, 3020-3028 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 3020-3028
    • Gelderman, K.A.1
  • 128
    • 0035911254 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis
    • Huang, D. R., Wang, J., Kivisakk, P., Rollins, B. J. & Ransohoff, R. M. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193, 713-726 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 713-726
    • Huang, D.R.1    Wang, J.2    Kivisakk, P.3    Rollins, B.J.4    Ransohoff, R.M.5
  • 129
    • 79956116032 scopus 로고    scopus 로고
    • RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    • Codarri, L. et al. RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nature Immunol. 12, 560-567 (2011).
    • (2011) Nature Immunol. , vol.12 , pp. 560-567
    • Codarri, L.1
  • 130
    • 79956152607 scopus 로고    scopus 로고
    • The encephalitogenicity of TH17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF
    • El-Behi, M. et al. The encephalitogenicity of TH17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF. Nature Immunol. 12, 568-575 (2011).
    • (2011) Nature Immunol. , vol.12 , pp. 568-575
    • El-Behi, M.1
  • 131
    • 78651247933 scopus 로고    scopus 로고
    • MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway
    • Ponomarev, E. D., Veremeyko, T., Barteneva, N., Krichevsky, A. M. & Weiner, H. L. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway. Nature Med. 17, 64-70 (2011).
    • (2011) Nature Med. , vol.17 , pp. 64-70
    • Ponomarev, E.D.1    Veremeyko, T.2    Barteneva, N.3    Krichevsky, A.M.4    Weiner, H.L.5
  • 132
    • 0035123658 scopus 로고    scopus 로고
    • The role of macrophages in immune-mediated damage to the peripheral nervous system
    • Kiefer, R., Kieseier, B. C., Stoll, G. & Hartung, H. P. The role of macrophages in immune-mediated damage to the peripheral nervous system. Prog. Neurobiol. 64, 109-127 (2001).
    • (2001) Prog. Neurobiol. , vol.64 , pp. 109-127
    • Kiefer, R.1    Kieseier, B.C.2    Stoll, G.3    Hartung, H.P.4
  • 133
    • 17744388105 scopus 로고    scopus 로고
    • Down-regulation of the macrophage lineage through interaction with OX2 (CD200)
    • Hoek, R. M. et al. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290, 1768-1771 (2000).
    • (2000) Science , vol.290 , pp. 1768-1771
    • Hoek, R.M.1
  • 134
    • 68049143269 scopus 로고    scopus 로고
    • Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
    • Shechter, R. et al. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med. 6, e1000113 (2009).
    • (2009) PLoS Med. , vol.6
    • Shechter, R.1
  • 135
    • 76449107634 scopus 로고    scopus 로고
    • Monocytes in atherosclerosis: Subsets and functions
    • Woollard, K. J. & Geissmann, F. Monocytes in atherosclerosis: subsets and functions. Nature Rev. Cardiol. 7, 77-86 (2010).
    • (2010) Nature Rev. Cardiol. , vol.7 , pp. 77-86
    • Woollard, K.J.1    Geissmann, F.2
  • 136
    • 0030974188 scopus 로고    scopus 로고
    • IFN-γ potentiates atherosclerosis in ApoE knock-out mice
    • Gupta, S. et al. IFN-γ potentiates atherosclerosis in ApoE knock-out mice. J. Clin. Invest. 99, 2752-2761 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 2752-2761
    • Gupta, S.1
  • 137
    • 0036852744 scopus 로고    scopus 로고
    • The macrophage foam cell as a target for therapeutic intervention
    • Li, A. C. & Glass, C. K. The macrophage foam cell as a target for therapeutic intervention. Nature Med. 8, 1235-1242 (2002).
    • (2002) Nature Med. , vol.8 , pp. 1235-1242
    • Li, A.C.1    Glass, C.K.2
  • 138
    • 0034833822 scopus 로고    scopus 로고
    • CD36: A class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism
    • Febbraio, M., Hajjar, D. P. & Silverstein, R. L. CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. J. Clin. Invest. 108, 785-791 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 785-791
    • Febbraio, M.1    Hajjar, D.P.2    Silverstein, R.L.3
  • 139
    • 0030046797 scopus 로고    scopus 로고
    • Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
    • Acton, S. et al. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 271, 518-520 (1996).
    • (1996) Science , vol.271 , pp. 518-520
    • Acton, S.1
  • 140
    • 0030895048 scopus 로고    scopus 로고
    • A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
    • Suzuki, H. et al. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386, 292-296 (1997).
    • (1997) Nature , vol.386 , pp. 292-296
    • Suzuki, H.1
  • 141
    • 0037205317 scopus 로고    scopus 로고
    • Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient mice by altering lymphocyte and macrophage phenotypes
    • Pinderski, L. J. et al. Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient mice by altering lymphocyte and macrophage phenotypes. Circ. Res. 90, 1064-1071 (2002).
    • (2002) Circ. Res. , vol.90 , pp. 1064-1071
    • Pinderski, L.J.1
  • 142
    • 0029079926 scopus 로고
    • Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein e
    • Smith, J. D. et al. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc. Natl Acad. Sci. USA 92, 8264-8268 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 8264-8268
    • Smith, J.D.1
  • 143
    • 34147185633 scopus 로고    scopus 로고
    • Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques
    • Stoneman, V. et al. Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques. Circ. Res. 100, 884-893 (2007).
    • (2007) Circ. Res. , vol.100 , pp. 884-893
    • Stoneman, V.1
  • 144
    • 61749103652 scopus 로고    scopus 로고
    • CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima
    • Park, Y. M., Febbraio, M. & Silverstein, R. L. CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. J. Clin. Invest. 119, 136-145 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 136-145
    • Park, Y.M.1    Febbraio, M.2    Silverstein, R.L.3
  • 145
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J. & Glass, C. K. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391, 79-82 (1998).
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 146
    • 71549152580 scopus 로고    scopus 로고
    • Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
    • Erbay, E. et al. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nature Med. 15, 1383-1391 (2009).
    • (2009) Nature Med. , vol.15 , pp. 1383-1391
    • Erbay, E.1
  • 147
    • 0025314453 scopus 로고
    • Upregulation of platelet-derived growth factor-A and-B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis
    • Nagaoka, I., Trapnell, B. C. & Crystal, R. G. Upregulation of platelet-derived growth factor-A and-B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis. J. Clin. Invest. 85, 2023-2027 (1990).
    • (1990) J. Clin. Invest. , vol.85 , pp. 2023-2027
    • Nagaoka, I.1    Trapnell, B.C.2    Crystal, R.G.3
  • 148
    • 0025174844 scopus 로고
    • Regulation of insulin-like growth factor i gene expression in the human macrophage-like cell line U937
    • Nagaoka, I., Trapnell, B. C. & Crystal, R. G. Regulation of insulin-like growth factor I gene expression in the human macrophage-like cell line U937. J. Clin. Invest. 85, 448-455 (1990).
    • (1990) J. Clin. Invest. , vol.85 , pp. 448-455
    • Nagaoka, I.1    Trapnell, B.C.2    Crystal, R.G.3
  • 149
    • 0026010305 scopus 로고
    • Transforming growth factor β1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis
    • Broekelmann, T. J., Limper, A. H., Colby, T. V. & McDonald, J. A. Transforming growth factor β1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc. Natl Acad. Sci. USA 88, 6642-6646 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 6642-6646
    • Broekelmann, T.J.1    Limper, A.H.2    Colby, T.V.3    McDonald, J.A.4
  • 150
    • 0034967219 scopus 로고    scopus 로고
    • Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis
    • Kolb, M., Margetts, P. J., Anthony, D. C., Pitossi, F. & Gauldie, J. Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis. J. Clin. Invest. 107, 1529-1536 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 1529-1536
    • Kolb, M.1    Margetts, P.J.2    Anthony, D.C.3    Pitossi, F.4    Gauldie, J.5
  • 151
    • 36849056773 scopus 로고    scopus 로고
    • IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice
    • Gasse, P. et al. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J. Clin. Invest. 117, 3786-3799 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 3786-3799
    • Gasse, P.1
  • 152
    • 77949516122 scopus 로고    scopus 로고
    • Bleomycin and IL-1β-mediated pulmonary fibrosis is IL-17A dependent
    • Wilson, M. S. et al. Bleomycin and IL-1β-mediated pulmonary fibrosis is IL-17A dependent. J. Exp. Med. 207, 535-552 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 535-552
    • Wilson, M.S.1
  • 154
    • 0035903306 scopus 로고    scopus 로고
    • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor β1
    • Lee, C. G. et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor β1. J. Exp. Med. 194, 809-821 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 809-821
    • Lee, C.G.1
  • 155
    • 13744255589 scopus 로고    scopus 로고
    • Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    • Duffield, J. S. et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J. Clin. Invest. 115, 56-65 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 56-65
    • Duffield, J.S.1
  • 156
    • 34948871629 scopus 로고    scopus 로고
    • IL-13Rα2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice
    • Wilson, M. S. et al. IL-13Rα2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. J. Clin. Invest. 117, 2941-2951 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 2941-2951
    • Wilson, M.S.1
  • 157
    • 65949106130 scopus 로고    scopus 로고
    • Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
    • Aouadi, M. et al. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature 458, 1180-1184 (2009).
    • (2009) Nature , vol.458 , pp. 1180-1184
    • Aouadi, M.1
  • 158
    • 79951671510 scopus 로고    scopus 로고
    • IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
    • Krausgruber, T. et al. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nature Immunol. 12, 231-238 (2011).
    • (2011) Nature Immunol. , vol.12 , pp. 231-238
    • Krausgruber, T.1
  • 159
    • 62149128961 scopus 로고    scopus 로고
    • Death and resurrection of the human IRGM gene
    • Bekpen, C. et al. Death and resurrection of the human IRGM gene. PLoS Genet. 5, e1000403 (2009).
    • (2009) PLoS Genet. , vol.5
    • Bekpen, C.1
  • 161
    • 77951256153 scopus 로고    scopus 로고
    • Autophagy in infection
    • Deretic, V. Autophagy in infection. Curr. Opin. Cell Biol. 22, 252-262 (2010).
    • (2010) Curr. Opin. Cell Biol. , vol.22 , pp. 252-262
    • Deretic, V.1
  • 162
    • 0042541930 scopus 로고    scopus 로고
    • Species differences in macrophage NO production are important
    • Bogdan, C. Species differences in macrophage NO production are important. Nature Immunol. 3, 102 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 102
    • Bogdan, C.1
  • 163
  • 164
    • 33745605778 scopus 로고    scopus 로고
    • Role of iNOS in human host defense
    • author reply 1874-1875 2006
    • Nathan, C. Role of iNOS in human host defense. Science 312, 1874-1875; author reply 1874-1875 (2006).
    • Science , vol.312 , pp. 1874-1875
    • Nathan, C.1
  • 165
    • 77955634800 scopus 로고    scopus 로고
    • Activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine
    • Manicassamy, S. et al. Activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 329, 849-853 (2010).
    • (2010) Science , vol.329 , pp. 849-853
    • Manicassamy, S.1
  • 166
    • 79960668955 scopus 로고    scopus 로고
    • Comment on "activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine"
    • author reply 405
    • Murphy, K. M. Comment on "Activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine". Science 333, 405; author reply 405 (2011).
    • (2011) Science , vol.333 , pp. 405
    • Murphy, K.M.1
  • 167
    • 79960513242 scopus 로고    scopus 로고
    • Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory t cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization
    • Denning, T. L. et al. Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory t cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization. J. Immunol. 187, 733-747 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 733-747
    • Denning, T.L.1
  • 168
    • 58749083404 scopus 로고    scopus 로고
    • Macrophages as APC and the dendritic cell myth
    • Hume, D. A. Macrophages as APC and the dendritic cell myth. J. Immunol. 181, 5829-5835 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 5829-5835
    • Hume, D.A.1
  • 169
    • 78751704362 scopus 로고    scopus 로고
    • CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens
    • Asano, K. et al. CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens. Immunity 34, 85-95 (2011).
    • (2011) Immunity , vol.34 , pp. 85-95
    • Asano, K.1
  • 170
    • 35348865583 scopus 로고    scopus 로고
    • EMR1, the human homolog of F4/80, is an eosinophil-specific receptor
    • Hamann, J. et al. EMR1, the human homolog of F4/80, is an eosinophil-specific receptor. Eur. J. Immunol. 37, 2797-2802 (2007).
    • (2007) Eur. J. Immunol. , vol.37 , pp. 2797-2802
    • Hamann, J.1
  • 171
    • 79960021457 scopus 로고    scopus 로고
    • Kruppel-like factor 4 regulates macrophage polarization
    • Liao, X. et al. Kruppel-like factor 4 regulates macrophage polarization. J. Clin. Invest. 121, 2736-2749 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2736-2749
    • Liao, X.1
  • 172
    • 56349093356 scopus 로고    scopus 로고
    • Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
    • El Kasmi, K. C. et al. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nature Immunol. 9, 1399-1406 (2008).
    • (2008) Nature Immunol. , vol.9 , pp. 1399-1406
    • El Kasmi, K.C.1
  • 173
    • 77956639386 scopus 로고    scopus 로고
    • Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling
    • Qualls, J. E. et al. Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling. Sci. Signal. 3, ra62 (2010).
    • (2010) Sci. Signal. , vol.3
    • Qualls, J.E.1
  • 174
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva, M. & O'Garra, A. The regulation of IL-10 production by immune cells. Nature Rev. Immunol. 10, 170-181 (2010).
    • (2010) Nature Rev. Immunol. , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 175
    • 56149111288 scopus 로고    scopus 로고
    • Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism
    • Shirey, K. A., Cole, L. E., Keegan, A. D. & Vogel, S. N. Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism. J. Immunol. 181, 4159-4167 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 4159-4167
    • Shirey, K.A.1    Cole, L.E.2    Keegan, A.D.3    Vogel, S.N.4
  • 176
    • 79953815551 scopus 로고    scopus 로고
    • Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    • Wu, D. et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332, 243-247 (2011).
    • (2011) Science , vol.332 , pp. 243-247
    • Wu, D.1


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