The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor

Journal of Experimental Medicine

Volumn 195, Issue 7, 2002, Pages 953-958

  Gilliet, Michel ^a   Boonstra, Andre ^a   Paturel, Carine ^a   Antonenko, Svetlana ^a   Xu, Xiu Ling ^a   Trinchieri, Giorgio ^a   O'Garra, Anne ^a   Liu, Yong Jun ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antiviral immune response; Innate immunity; IPC; Pre DC2; T lymphocyte

Indexed keywords

ALPHA INTERFERON; FLT3 LIGAND; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; BONE MARROW CULTURE; CELL MATURATION; CPG ISLAND; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; HERPES SIMPLEX VIRUS; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STEM CELL;

ANIMALS; ANTIGENS, DIFFERENTIATION; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; FEMALE; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOPOIESIS; HUMANS; KINETICS; MACROPHAGE-1 ANTIGEN; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; SPECIES SPECIFICITY; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036534871     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020045     Document Type: Article

References (30)

1. The nature of the principal type 1 interferon-producing cells in human blood
2. Plasmacytoid dendritic cells activated by influenza virus and CD40-ligand drive a potent TH1 polarization
3. + cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells
4. The major type I interferon producing cells in mice are immature antigen-presenting cells exhibiting plasmacytoid morphology
5. Isolation and characterization of murine plasmacytoid dendritic cells
6. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature
7. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand
8. Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin
9. BDCA-2, BDCA-3, and BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood
10. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
11. Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor
12. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells
13. Flt3-ligand and granulocyte colony-stimulating factor mobilize distinct human dendritic cell subsets in vivo
14. + hematopoietic stem
15. Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures
16. Burnet oration: Dendritic cells: Multiple subtypes, multiple origins, multiple functions
17. Dendritic cell regulation of TH-1-TH-2 development
18. Modulating the immune response with dendritic cells and their growth factors
19. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
20. + dendritic cells
21. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
22. Dendritic cells and the control of immunity
23. Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2
24. Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients
25. Decreased interferon-alpha production in HIV-infected patients correlates with numerical and functional deficiencies in circulating Type 2 dendritic cell precursors
26. - plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load
27. Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors
28. Generation of human CD8 T regulatory cells by CD40-ligand activated plasmacytoid dendritic cells
29. Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus
30. A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus