The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis

Blood

Volumn 114, Issue 4, 2009, Pages 835-843

  Kingston, Dior ^a   Schmid, Michael A ^a   Onai, Nobuyuki ^a,b,c   Obata Onai, Aya ^a,b,c   Baumjohann, Dirk ^a   Manz, Markus G ^a  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b AKITA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR RECEPTOR; CYTOKINE RECEPTOR; FLT3 LIGAND; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; IMMUNOGLOBULIN G; CD135 ANTIGEN; FLT3 LIGAND PROTEIN; FLT3 PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FLT3 LIGAND DEFICIENCY; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR DEFICIENCY; HOMEOSTASIS; IMMUNE RESPONSE; IMMUNIZATION; LYMPH NODE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SPLEEN CELL; STEM CELL; T LYMPHOCYTE; ANIMAL; ANTIBODY SPECIFICITY; BONE MARROW CELL; C57BL MOUSE; CELL PROLIFERATION; FEMALE; GENE EXPRESSION; GENETICS; INNATE IMMUNITY; MALE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; BONE MARROW CELLS; CELL PROLIFERATION; DENDRITIC CELLS; FEMALE; FMS-LIKE TYROSINE KINASE 3; GENE EXPRESSION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HOMEOSTASIS; IMMUNITY, INNATE; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SPECIFICITY; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; STEM CELLS;

EID: 68249155389     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-02-206318     Document Type: Article

References (44)

1. Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol. 2002;2002:151-161. (Pubitemid 37336516)
2. Valladeau J, Saeland S. Cutaneous dendritic cells. Semin Immunol. 2005;17:273-283.
3. Merad M, Manz MG. Dendritic cell homeostasis. Blood. 2009;113:3418-3427.
4. Inaba K, Inaba M, Romani N, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/ macrophage colony-stimulating factor. J Exp Med. 1992;176:1693-1702.
5. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med. 1994;179:1109-1118. (Pubitemid 24091769)
6. Esashi E, Wang YH, Perng O, Qin XF, Liu YJ, Watowich SS. The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity. 2008;28:509-520.
7. Gilliet M, Boonstra A, Paturel C, et al. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J Exp Med. 2002;195:953-958. (Pubitemid 34286765)
8. Onai N, Manz MG. The STATs on dendritic cell development. Immunity. 2008;28:490-492.
9. Burnham K, Robb L, Scott CL, O'Keeffe M, Shortman K. Effect of granulocyte-macrophage colony-stimulating factor on the generation of epidermal Langerhans cells. J Interferon Cytokine Res. 2000;20:1071-1076. (Pubitemid 32015246)
10. Vremec D, Lieschke GJ, Dunn AR, Robb L, Metcalf D, Shortman K. The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur J Immunol. 1997;27:40-44. (Pubitemid 27046056)
11. Naik SH, Metcalf D, van Nieuwenhuijze A, et al. Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol. 2006;7:663-671. (Pubitemid 43797348)
12. Varol C, Landsman L, Fogg DK, et al. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med. 2007;204:171-180. (Pubitemid 46148767)
13. Xu Y, Zhan Y, Lew AM, Naik SH, Kershaw MH. Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking. J Immunol. 2007; 179:7577-7584.
14. Brasel K, De Smedt T, Smith JL, Maliszewski CR. Generation of murine dendritic cells from flt3- ligand-supplemented bone marrow cultures. Blood. 2000;96:3029-3039. (Pubitemid 30815210)
15. McKenna HJ, Stocking KL, Miller RE, et al. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood. 2000;95: 3489-3497.
16. Tussiwand R, Onai N, Mazzucchelli L, Manz MG. Inhibition of natural type I IFN-producing and dendritic cell development by a small molecule receptor tyrosine kinase inhibitor with Flt3 affinity. J Immunol. 2005;175:3674-3680. (Pubitemid 41292027)
17. Maraskovsky E, Brasel K, Teepe M, et al. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med. 1996;184:1953-1962. (Pubitemid 26404485)
18. Karsunky H, Merad M, Cozzio A, Weissman IL, Manz MG. Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloidcommitted progenitors to Flt3+ dendritic cells in vivo. J Exp Med. 2003;198:305-313. (Pubitemid 36987855)
19. Manfra DJ, Chen SC, Jensen KK, Fine JS, Wiekowski MT, Lira SA. Conditional expression of murine Flt3 ligand leads to expansion of multiple dendritic cell subsets in peripheral blood and tissues of transgenic mice. J Immunol. 2003;170: 2843-2852.
20. Bjorck P. Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor- treated mice. Blood. 2001;98:3520-3526.
21. D'Amico A, Wu L. The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3. J Exp Med. 2003;198:293-303. (Pubitemid 36987854)
22. Onai N, Obata-Onai A, Tussiwand R, Lanzavecchia A, Manz MG. Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development. J Exp Med. 2006;203:227-238. (Pubitemid 43139660)
23. Waskow C, Liu K, Darrasse-Jeze G, et al. The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol. 2008;9:676-683. (Pubitemid 351712638)
24. Fogg DK, Sibon C, Miled C, et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science. 2006;311:83-87. (Pubitemid 43063063)
25. Auffray C, Fogg DK, Narni-Mancinelli E, et al. CX3CR1+ CD115+ CD135+ common macrophage/ DC precursors and the role of CX3CR1 in their response to inflammation. J Exp Med. 2009; 206:595-606.
26. Liu K, Victora GD, Schwickert TA, et al. In vivo analysis of dendritic cell development and homeostasis. Science. 2009;324:392-397.
27. Onai N, Obata-Onai A, Schmid MA, Ohteki T, Jarrossay D, Manz MG. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol. 2007;8:1207-1216. (Pubitemid 350011759)
28. Naik SH, Sathe P, Park HY, et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol. 2007;8:1217-1226. (Pubitemid 350011760)
29. Dranoff G, Crawford AD, Sadelain M, et al. Involvement of granulocyte-macrophage colonystimulating factor in pulmonary homeostasis. Science. 1994;264:713-716. (Pubitemid 24185882)
30. Ginhoux F, Tacke F, Angeli V, et al. Langerhans cells arise from monocytes in vivo. Nat Immunol. 2006;7:265-273.
31. Ruedl C, Koebel P, Bachmann M, Hess M, Karjalainen K. Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes. J Immunol. 2000;165:4910-4916. (Pubitemid 30809415)
32. Sunderkotter C, Nikolic T, Dillon MJ, et al. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol. 2004;172:4410-4417. (Pubitemid 38375256)
33. Macdonald KP, Rowe V, Bofinger HM, et al. The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. J Immunol. 2005;175:1399-1405. (Pubitemid 41023039)
34. Fancke B, Suter M, Hochrein H, O'Keeffe M. M-CSF: a novel plasmacytoid and conventional dendritic cell poietin. Blood. 2008;111:150-159.
35. Mackarehtschian K, Hardin JD, Moore KA, Boast S, Goff SP, Lemischka IR. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity. 1995;3:147-161.
36. Jakubzick C, Bogunovic M, Bonito AJ, Kuan EL, Merad M, Randolph GJ. Lymph-migrating, tissuederived dendritic cells are minor constituents within steady-state lymph nodes. J Exp Med. 2008;205:2839-2850.
37. Bursch LS, Wang L, Igyarto B, et al. Identification of a novel population of Langerin+ dendritic cells. J Exp Med. 2007;204:3147-3156.
38. Ginhoux F, Collin MP, Bogunovic M, et al. Bloodderived dermal langerin+ dendritic cells survey the skin in the steady state. J Exp Med. 2007; 204:3133-3146.
39. Poulin LF, Henri S, de Bovis B, Devilard E, Kissenpfennig A, Malissen B. The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med. 2007;204:3119-3131.
40. Jung S, Unutmaz D, Wong P, et al. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cellassociated antigens. Immunity. 2002;17:211-220. (Pubitemid 35245963)
41. MartIn-Fontecha A, Sebastiani S, Hopken UE, et al. Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J Exp Med. 2003;198:615-621. (Pubitemid 37040395)
42. Robbins SH, Walzer T, Dembele D, et al. Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol. 2008;9:R17. (Pubitemid 351911930)
43. Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008;8:533-544.
44. Lyman SD, Jacobsen SE. c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood. 1998;91:1101-1134.