-
1
-
-
20044374023
-
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
-
DOI 10.1002/hep.20701
-
Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41(6):1313-21. (Pubitemid 40770284)
-
(2005)
Hepatology
, vol.41
, Issue.6
, pp. 1313-1321
-
-
Kleiner, D.E.1
Brunt, E.M.2
Van Natta, M.3
Behling, C.4
Contos, M.J.5
Cummings, O.W.6
Ferrell, L.D.7
Liu, Y.-C.8
Torbenson, M.S.9
Unalp-Arida, A.10
Yeh, M.11
McCullough, A.J.12
Sanyal, A.J.13
-
2
-
-
0031947715
-
Steatohepatitis: A tale of two "hits"?
-
Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology. 1998;114(4):842-5.
-
(1998)
Gastroenterology
, vol.114
, Issue.4
, pp. 842-845
-
-
Day, C.P.1
James, O.F.2
-
3
-
-
78049522194
-
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
-
doi:10.1002/hep.24001
-
Tilg H, Moschen AR. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology. 2010;52(5):1836-46. doi:10.1002/hep.24001.
-
(2010)
Hepatology
, vol.52
, Issue.5
, pp. 1836-1846
-
-
Tilg, H.1
Moschen, A.R.2
-
4
-
-
66349115342
-
Adipocyte metabolism and obesity
-
doi:10.1194/jlr.R800057-JLR200
-
Attie AD, Scherer PE. Adipocyte metabolism and obesity. J Lipid Res. 2009;50(Suppl):S395-9. doi:10.1194/jlr.R800057-JLR200.
-
(2009)
J Lipid Res
, vol.50
, Issue.SUPPL.
-
-
Attie, A.D.1
Scherer, P.E.2
-
5
-
-
84865297442
-
The inflammation highway: Metabolism accelerates inflammatory traffic in obesity
-
doi:10.1111/j.1600-065X.2012.01151.x
-
Johnson AR, Milner JJ, Makowski L. The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev. 2012;249(1):218-38. doi:10.1111/j.1600-065X.2012.01151.x.
-
(2012)
Immunol Rev
, vol.249
, Issue.1
, pp. 218-238
-
-
Johnson, A.R.1
Milner, J.J.2
Makowski, L.3
-
6
-
-
84864090834
-
Mechanisms of simple hepatic steatosis: Not so simple after all
-
doi:10. 1016/j.cld.2012.05.005
-
Matherly SC, Puri P. Mechanisms of simple hepatic steatosis: not so simple after all. Clin Liver Dis. 2012;16(3):505-24. doi:10. 1016/j.cld.2012.05.005.
-
(2012)
Clin Liver Dis
, vol.16
, Issue.3
, pp. 505-524
-
-
Matherly, S.C.1
Puri, P.2
-
7
-
-
34848872799
-
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
-
DOI 10.1172/JCI31021
-
Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, Hofmann SM, et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest. 2007;117(9):2621-37. (Pubitemid 47494363)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.9
, pp. 2621-2637
-
-
Kim, J.-Y.1
Van De, W.E.2
Laplante, M.3
Azzara, A.4
Trujillo, M.E.5
Hofmann, S.M.6
Schraw, T.7
Durand, J.L.8
Li, H.9
Li, G.10
Jelicks, L.A.11
Mehler, M.F.12
Hui, D.Y.13
Deshaies, Y.14
Shulman, G.I.15
Schwartz, G.J.16
Scherer, P.E.17
-
8
-
-
34247604581
-
TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)
-
Endo M, Masaki T, Seike M, Yoshimatsu H. TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c). Exp Biol Med (Maywood). 2007;232(5):614-21. (Pubitemid 46683386)
-
(2007)
Experimental Biology and Medicine
, vol.232
, Issue.5
, pp. 614-621
-
-
Endo, M.1
Masaki, T.2
Seike, M.3
Yoshimatsu, H.4
-
9
-
-
51349151813
-
Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes
-
doi:10.1002/hep.22404
-
Clement S, Juge-Aubry C, Sgroi A, Conzelmann S, Pazienza V, Pittet-Cuenod B, et al. Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes. Hepatology. 2008;48(3):799-807. doi:10.1002/hep.22404.
-
(2008)
Hepatology
, vol.48
, Issue.3
, pp. 799-807
-
-
Clement, S.1
Juge-Aubry, C.2
Sgroi, A.3
Conzelmann, S.4
Pazienza, V.5
Pittet-Cuenod, B.6
-
10
-
-
33646035836
-
Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states
-
doi:10.1210/jc.2005-1709
-
Barrows BR, Parks EJ. Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states. J Clin Endocrinol Metab. 2006;91(4): 1446-52. doi:10.1210/jc.2005-1709.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, Issue.4
, pp. 1446-1452
-
-
Barrows, B.R.1
Parks, E.J.2
-
11
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
DOI 10.1172/JCI200523621
-
Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest. 2005;115(5):1343-51. doi:10.1172/JCI23621. (Pubitemid 40629054)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.5
, pp. 1343-1351
-
-
Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
Jessurun, J.4
Boldt, M.D.5
Parks, E.J.6
-
12
-
-
84894327806
-
Increased de novo Lipogenesis is a Distinct Characteristic of Individuals with Nonalcoholic Fatty Liver Disease
-
doi:10.1053/j.gastro.2013.11.049. Elegant human study demonstrating that hepatic steatosis in persons with NAFLD is largely due to enhanced hepatic DNL
-
.• Lambert JE. Ramos-Roman MA. Parks EJ. Increased de novo Lipogenesis is a Distinct Characteristic of Individuals with Nonalcoholic Fatty Liver Disease. Gastroenterology: Browning JD; 2013. doi:10.1053/j.gastro.2013. 11.049. Elegant human study demonstrating that hepatic steatosis in persons with NAFLD is largely due to enhanced hepatic DNL.
-
(2013)
Gastroenterology: Browning JD
-
-
Lambert, J.E.1
Ramos-Roman, M.A.2
Parks, E.J.3
-
13
-
-
0032905885
-
The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects
-
Chen X, Iqbal N, Boden G. The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects. J Clin Invest. 1999;103(3):365-72. doi:10.1172/JCI5479. (Pubitemid 29069986)
-
(1999)
Journal of Clinical Investigation
, vol.103
, Issue.3
, pp. 365-372
-
-
Chen, X.1
Iqbal, N.2
Boden, G.3
-
14
-
-
77649264504
-
Bifurcation of insulin signaling pathway in rat liver: MTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
-
doi:10.1073/pnas.0914798107
-
Li S, Brown MS, Goldstein JL. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A. 2010;107(8):3441-6. doi:10.1073/pnas.0914798107.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.8
, pp. 3441-3446
-
-
Li, S.1
Brown, M.S.2
Goldstein, J.L.3
-
15
-
-
0036251153
-
SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
-
DOI 10.1172/JCI200215593
-
Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 2002;109(9):1125-31. (Pubitemid 34496588)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.9
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
16
-
-
0142027805
-
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
-
DOI 10.1073/pnas.1534923100
-
Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, et al. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci U S A. 2003;100(21): 12027-32. doi:10.1073/pnas.1534923100. (Pubitemid 37271509)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.21
, pp. 12027-12032
-
-
Horton, J.D.1
Shah, N.A.2
Warrington, J.A.3
Anderson, N.N.4
Park, S.W.5
Brown, M.S.6
Goldstein, J.L.7
-
17
-
-
0033598749
-
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
-
Shimomura I, Bashmakov Y, Ikemoto S, Horton JD, Brown MS, Goldstein JL. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci U S A. 1999;96(24):13656-61.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.24
, pp. 13656-13661
-
-
Shimomura, I.1
Bashmakov, Y.2
Ikemoto, S.3
Horton, J.D.4
Brown, M.S.5
Goldstein, J.L.6
-
18
-
-
67651171781
-
Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance
-
Su Q, Tsai J, Xu E, Qiu W, Bereczki E, Santha M, et al. Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance. Hepatology. 2009;50(1):77-84.
-
(2009)
Hepatology
, vol.50
, Issue.1
, pp. 77-84
-
-
Su, Q.1
Tsai, J.2
Xu, E.3
Qiu, W.4
Bereczki, E.5
Santha, M.6
-
19
-
-
66449137379
-
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
-
doi:10.1172/JCI37007
-
Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest. 2009;119(5):1201-15. doi:10.1172/JCI37007.
-
(2009)
J Clin Invest
, vol.119
, Issue.5
, pp. 1201-1215
-
-
Kammoun, H.L.1
Chabanon, H.2
Hainault, I.3
Luquet, S.4
Magnan, C.5
Koike, T.6
-
20
-
-
79952303537
-
A dual sugar challenge test for lipogenic sensitivity to dietary fructose
-
doi:10.1210/jc.2010- 2007
-
Hudgins LC, Parker TS, Levine DM, Hellerstein MK. A dual sugar challenge test for lipogenic sensitivity to dietary fructose. J Clin Endocrinol Metab. 2011;96(3):861-8. doi:10.1210/jc.2010- 2007.
-
(2011)
J Clin Endocrinol Metab
, vol.96
, Issue.3
, pp. 861-868
-
-
Hudgins, L.C.1
Parker, T.S.2
Levine, D.M.3
Hellerstein, M.K.4
-
21
-
-
84878276815
-
Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans
-
doi:10.1002/oby. 20377
-
Lecoultre V, Egli L, Carrel G, Theytaz F, Kreis R, Schneiter P, et al. Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans. Obesity (Silver Spring). 2013;21(4):782-5. doi:10.1002/oby. 20377.
-
(2013)
Obesity (Silver Spring)
, vol.21
, Issue.4
, pp. 782-785
-
-
Lecoultre, V.1
Egli, L.2
Carrel, G.3
Theytaz, F.4
Kreis, R.5
Schneiter, P.6
-
22
-
-
44449096155
-
Dietary sugars stimulate fatty acid synthesis in adults
-
Parks EJ, Skokan LE, Timlin MT, Dingfelder CS. Dietary sugars stimulate fatty acid synthesis in adults. J Nutr. 2008;138(6):1039-46. (Pubitemid 351769126)
-
(2008)
Journal of Nutrition
, vol.138
, Issue.6
, pp. 1039-1046
-
-
Parks, E.J.1
Skokan, L.E.2
Timlin, M.T.3
Dingfelder, C.S.4
-
23
-
-
66449093225
-
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
-
Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest. 2009;119(5):1322-34.
-
(2009)
J Clin Invest
, vol.119
, Issue.5
, pp. 1322-1334
-
-
Stanhope, K.L.1
Schwarz, J.M.2
Keim, N.L.3
Griffen, S.C.4
Bremer, A.A.5
Graham, J.L.6
-
24
-
-
77952692915
-
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
-
doi:10.1002/hep.23535
-
Abdelmalek MF, Suzuki A, Guy C, Unalp-Arida A, Colvin R, Johnson RJ, et al. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology. 2010;51(6):1961-71. doi:10.1002/hep.23535.
-
(2010)
Hepatology
, vol.51
, Issue.6
, pp. 1961-1971
-
-
Abdelmalek, M.F.1
Suzuki, A.2
Guy, C.3
Unalp-Arida, A.4
Colvin, R.5
Johnson, R.J.6
-
25
-
-
43049170503
-
Fructose consumption as a risk factor for non-alcoholic fatty liver disease
-
doi:10.1016/j.jhep. 2008.02.011
-
Ouyang X, Cirillo P, Sautin Y, McCall S, Bruchette JL, Diehl AM, et al. Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol. 2008;48(6):993-9. doi:10.1016/j.jhep. 2008.02.011.
-
(2008)
J Hepatol
, vol.48
, Issue.6
, pp. 993-999
-
-
Ouyang, X.1
Cirillo, P.2
Sautin, Y.3
McCall, S.4
Bruchette, J.L.5
Diehl, A.M.6
-
26
-
-
0032814457
-
Regulation of gene expression by dietary fat
-
DOI 10.1146/annurev.nutr.19.1.63
-
Jump DB, Clarke SD. Regulation of gene expression by dietary fat. Annu Rev Nutr. 1999;19:63-90. (Pubitemid 29380597)
-
(1999)
Annual Review of Nutrition
, vol.19
, pp. 63-90
-
-
Jump, D.B.1
Clarke, S.D.2
-
27
-
-
19944430411
-
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
-
DOI 10.1016/j.cell.2004.11.043, PII S009286740401147X
-
Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, et al. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell. 2005;120(2):261-73. (Pubitemid 40174768)
-
(2005)
Cell
, vol.120
, Issue.2
, pp. 261-273
-
-
Lin, J.1
Yang, R.2
Tarr, P.T.3
Wu, P.-H.4
Handschin, C.5
Li, S.6
Yang, W.7
Pei, L.8
Uldry, M.9
Tontonoz, P.10
Newgard, C.B.11
Spiegelman, B.M.12
-
28
-
-
65249179010
-
Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction
-
doi:10.1053/j.gastro.2009.01.048
-
Kirk E, Reeds DN, Finck BN, Mayurranjan SM, Patterson BW, Klein S. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology. 2009;136(5):1552-60. doi:10.1053/j. gastro.2009.01.048.
-
(2009)
Gastroenterology
, vol.136
, Issue.5
, pp. 1552-1560
-
-
Kirk, E.1
Reeds, D.N.2
Finck, B.N.3
Mayurranjan, S.M.4
Patterson, B.W.5
Klein, S.6
-
29
-
-
33744948514
-
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
-
DOI 10.1074/jbc.M510660200
-
Malhi H, Bronk SF, Werneburg NW, Gores GJ. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem. 2006;281(17):12093-101. doi:10.1074/jbc.M510660200. (Pubitemid 43855473)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.17
, pp. 12093-12101
-
-
Malhi, H.1
Bronk, S.F.2
Werneburg, N.W.3
Gores, G.J.4
-
30
-
-
33644813043
-
JNK1 but not JNK2 promotes the development of steatohepatitis in mice
-
DOI 10.1002/hep.20999
-
Schattenberg JM, Singh R, Wang Y, Lefkowitch JH, Rigoli RM, Scherer PE, et al. JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology. 2006;43(1):163-72. doi: 10.1002/hep.20999. (Pubitemid 43733603)
-
(2006)
Hepatology
, vol.43
, Issue.1
, pp. 163-172
-
-
Schattenberg, J.M.1
Singh, R.2
Wang, Y.3
Lefkowitch, J.H.4
Rigoli, R.M.5
Scherer, P.E.6
Czaja, M.J.7
-
31
-
-
58949093454
-
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance
-
Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, Czaja MJ. Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology. 2009;49(1): 87-96.
-
(2009)
Hepatology
, vol.49
, Issue.1
, pp. 87-96
-
-
Singh, R.1
Wang, Y.2
Xiang, Y.3
Tanaka, K.E.4
Gaarde, W.A.5
Czaja, M.J.6
-
32
-
-
36349024819
-
A lipidomic analysis of nonalcoholic fatty liver disease
-
DOI 10.1002/hep.21763
-
Puri P, Baillie RA, Wiest MM, Mirshahi F, Choudhury J, Cheung O, et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology. 2007;46(4):1081-90. doi:10.1002/hep.21763. (Pubitemid 350144772)
-
(2007)
Hepatology
, vol.46
, Issue.4
, pp. 1081-1090
-
-
Puri, P.1
Baillie, R.A.2
Wiest, M.M.3
Mirshahi, F.4
Choudhury, J.5
Cheung, O.6
Sargeant, C.7
Contos, M.J.8
Sanyal, A.J.9
-
33
-
-
70350418854
-
JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis
-
Cazanave SC, Mott JL, Elmi NA, Bronk SF, Werneburg NW, Akazawa Y, et al. JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. J Biol Chem. 2009;284(39):26591- 602.
-
(2009)
J Biol Chem
, vol.284
, Issue.39
, pp. 26591-26602
-
-
Cazanave, S.C.1
Mott, J.L.2
Elmi, N.A.3
Bronk, S.F.4
Werneburg, N.W.5
Akazawa, Y.6
-
34
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
DOI 10.1126/science.287.5453.664
-
Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science. 2000;287(5453):664-6. (Pubitemid 30070916)
-
(2000)
Science
, vol.287
, Issue.5453
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
Zhang, Y.4
Chung, P.5
Harding, H.P.6
Ron, D.7
-
35
-
-
75749108288
-
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
-
doi:10.1016/j.cell.2010.01.001
-
Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, et al. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell. 2010;140(3):338-48. doi:10.1016/j.cell.2010.01. 001.
-
(2010)
Cell
, vol.140
, Issue.3
, pp. 338-348
-
-
Nakamura, T.1
Furuhashi, M.2
Li, P.3
Cao, H.4
Tuncman, G.5
Sonenberg, N.6
-
36
-
-
83555162619
-
Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes
-
doi:10.1016/j.jhep. 2011.03.019
-
Sharma M, Urano F, Jaeschke A. Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes. J Hepatol. 2012;56(1):192-8. doi:10.1016/j.jhep. 2011.03.019.
-
(2012)
J Hepatol
, vol.56
, Issue.1
, pp. 192-198
-
-
Sharma, M.1
Urano, F.2
Jaeschke, A.3
-
37
-
-
80053554640
-
Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation
-
doi:10.1016/j.cell.2011.08.034
-
Holzer RG, Park EJ, Li N, Tran H, Chen M, Choi C, et al. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell. 2011;147(1):173- 84. doi:10.1016/j.cell.2011.08.034.
-
(2011)
Cell
, vol.147
, Issue.1
, pp. 173-184
-
-
Holzer, R.G.1
Park, E.J.2
Li, N.3
Tran, H.4
Chen, M.5
Choi, C.6
-
38
-
-
84855989829
-
Inflammasomes in health and disease
-
doi:10.1038/ nature10759
-
Strowig T, Henao-Mejia J, Elinav E, Flavell R. Inflammasomes in health and disease. Nature. 2012;481(7381):278-86. doi:10.1038/ nature10759.
-
(2012)
Nature
, vol.481
, Issue.7381
, pp. 278-286
-
-
Strowig, T.1
Henao-Mejia, J.2
Elinav, E.3
Flavell, R.4
-
39
-
-
79959573042
-
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells
-
doi:10.1002/hep.24341
-
Csak T, Ganz M, Pespisa J, Kodys K, Dolganiuc A, Szabo G. Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Hepatology. 2011;54(1):133-44. doi:10.1002/hep.24341.
-
(2011)
Hepatology
, vol.54
, Issue.1
, pp. 133-144
-
-
Csak, T.1
Ganz, M.2
Pespisa, J.3
Kodys, K.4
Dolganiuc, A.5
Szabo, G.6
-
40
-
-
84896709837
-
NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation and fibrosis
-
doi:10.1002/hep.26592
-
Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, et al. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation and fibrosis. Hepatology. 2013. doi:10.1002/hep.26592.
-
(2013)
Hepatology
-
-
Wree, A.1
Eguchi, A.2
McGeough, M.D.3
Pena, C.A.4
Johnson, C.D.5
Canbay, A.6
-
41
-
-
84864883030
-
Caspase-1: Is IL-1 just the tip of the ICEberg?
-
doi:10.1038/ cddis.2012.86
-
Denes A, Lopez-Castejon G, Brough D. Caspase-1: is IL-1 just the tip of the ICEberg? Cell Death Dis. 2012;3:e338. doi:10.1038/ cddis.2012.86.
-
(2012)
Cell Death Dis
, Issue.3
-
-
Denes, A.1
Lopez-Castejon, G.2
Brough, D.3
-
42
-
-
84873573078
-
Caspase-1 as a central regulator of high fat diet-induced nonalcoholic steatohepatitis
-
doi:10. 1371/journal.pone.0056100
-
Dixon LJ, Flask CA, Papouchado BG, Feldstein AE, Nagy LE. Caspase-1 as a central regulator of high fat diet-induced nonalcoholic steatohepatitis. PLoS One. 2013;8(2):e56100. doi:10. 1371/journal.pone.0056100.
-
(2013)
PLoS One
, vol.8
, Issue.2
-
-
Dixon, L.J.1
Flask, C.A.2
Papouchado, B.G.3
Feldstein, A.E.4
Nagy, L.E.5
-
43
-
-
38049186666
-
Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes
-
Han MS, Park SY, Shinzawa K, Kim S, Chung KW, Lee JH, et al. Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. J Lipid Res. 2008;49(1):84-97.
-
(2008)
J Lipid Res
, vol.49
, Issue.1
, pp. 84-97
-
-
Han, M.S.1
Park, S.Y.2
Shinzawa, K.3
Kim, S.4
Chung, K.W.5
Lee, J.H.6
-
44
-
-
83755177737
-
Mechanisms of lysophosphatidylcholineinduced hepatocyte lipoapoptosis
-
doi:10.1152/ajpgi.00301. 2011
-
Kakisaka K, Cazanave SC, Fingas CD, Guicciardi ME, Bronk SF, Werneburg NW, et al. Mechanisms of lysophosphatidylcholineinduced hepatocyte lipoapoptosis. Am J Physiol Gastrointest Liver Physiol. 2012;302(1):G77- 84. doi:10.1152/ajpgi.00301. 2011.
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.302
, Issue.1
-
-
Kakisaka, K.1
Cazanave, S.C.2
Fingas, C.D.3
Guicciardi, M.E.4
Bronk, S.F.5
Werneburg, N.W.6
-
45
-
-
84864292975
-
Role of ceramides in nonalcoholic fatty liver disease
-
doi:10.1016/j.tem.2012. 04.005
-
Pagadala M, Kasumov T, McCullough AJ, Zein NN, Kirwan JP. Role of ceramides in nonalcoholic fatty liver disease. Trends Endocrinol Metab. 2012;23(8):365-71. doi:10.1016/j.tem.2012. 04.005.
-
(2012)
Trends Endocrinol Metab
, vol.23
, Issue.8
, pp. 365-371
-
-
Pagadala, M.1
Kasumov, T.2
McCullough, A.J.3
Zein, N.N.4
Kirwan, J.P.5
-
46
-
-
33747626511
-
Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis
-
DOI 10.1016/j.cmet.2006.07.006, PII S1550413106002658
-
Mari M, Caballero F, Colell A, Morales A, Caballeria J, Fernandez A, et al. Mitochondrial free cholesterol loading sensitizes to TNF-and Fas-mediated steatohepatitis. Cell Metab. 2006;4(3):185-98. doi:10.1016/j.cmet.2006.07.006. (Pubitemid 44307975)
-
(2006)
Cell Metabolism
, vol.4
, Issue.3
, pp. 185-198
-
-
Mari, M.1
Caballero, F.2
Colell, A.3
Morales, A.4
Caballeria, J.5
Fernandez, A.6
Enrich, C.7
Fernandez-Checa, J.C.8
Garcia-Ruiz, C.9
-
47
-
-
0031784544
-
Tumor necrosis factor-alpha in sera of obese patients: Fall with weight loss
-
doi:10.1210/jcem.83.8.5026
-
Dandona P, Weinstock R, Thusu K, Abdel-Rahman E, Aljada A, Wadden T. Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. J Clin Endocrinol Metab. 1998;83(8):2907- 10. doi:10.1210/jcem.83.8.5026.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, Issue.8
, pp. 2907-2910
-
-
Dandona, P.1
Weinstock, R.2
Thusu, K.3
Abdel-Rahman, E.4
Aljada, A.5
Wadden, T.6
-
48
-
-
15644362064
-
Serum levels of tumor necrosis factor-alpha are increased in obese patients with noninsulin-dependent diabetes mellitus
-
doi:10.1210/jcem.83.3. 4618
-
Katsuki A, Sumida Y, Murashima S, Murata K, Takarada Y, Ito K, et al. Serum levels of tumor necrosis factor-alpha are increased in obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1998;83(3):859-62. doi:10.1210/jcem.83.3. 4618.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, Issue.3
, pp. 859-862
-
-
Katsuki, A.1
Sumida, Y.2
Murashima, S.3
Murata, K.4
Takarada, Y.5
Ito, K.6
-
49
-
-
84860469242
-
Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease
-
doi:10.1016/j.cmet. 2012.04.004
-
Min HK, Kapoor A, Fuchs M, Mirshahi F, Zhou H, Maher J, et al. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metab. 2012;15(5):665-74. doi:10.1016/j.cmet. 2012.04.004.
-
(2012)
Cell Metab
, vol.15
, Issue.5
, pp. 665-674
-
-
Min, H.K.1
Kapoor, A.2
Fuchs, M.3
Mirshahi, F.4
Zhou, H.5
Maher, J.6
-
50
-
-
84884984539
-
Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease
-
doi:10.1002/ hep.26226
-
Begriche K, Massart J, Robin MA, Bonnet F, Fromenty B. Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease. Hepatology. 2013;58(4):1497-507. doi:10.1002/ hep.26226.
-
(2013)
Hepatology
, vol.58
, Issue.4
, pp. 1497-1507
-
-
Begriche, K.1
Massart, J.2
Robin, M.A.3
Bonnet, F.4
Fromenty, B.5
-
51
-
-
82955239838
-
Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
-
doi:10.1016/j.cmet.2011.11.004
-
Sunny NE, Parks EJ, Browning JD, Burgess SC. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab. 2011;14(6):804- 10. doi:10.1016/j.cmet.2011.11.004.
-
(2011)
Cell Metab
, vol.14
, Issue.6
, pp. 804-810
-
-
Sunny, N.E.1
Parks, E.J.2
Browning, J.D.3
Burgess, S.C.4
-
52
-
-
77956151046
-
Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals
-
doi:10.1053/j.gastro.2010. 05.039
-
Iozzo P, Bucci M, Roivainen A, Nagren K, Jarvisalo MJ, Kiss J, et al. Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals. Gastroenterology. 2010;139(3):e1-6. doi:10.1053/j.gastro.2010. 05.039.
-
(2010)
Gastroenterology
, vol.139
, Issue.3
-
-
Iozzo, P.1
Bucci, M.2
Roivainen, A.3
Nagren, K.4
Jarvisalo, M.J.5
Kiss, J.6
-
53
-
-
84879550625
-
Increased hepatic de novo lipogenesis and mitochondrial efficiency in a model of obesity induced by diets rich in fructose
-
doi:10.1007/ s00394-012-0356-y
-
Crescenzo R, Bianco F, Falcone I, Coppola P, Liverini G, Iossa S. Increased hepatic de novo lipogenesis and mitochondrial efficiency in a model of obesity induced by diets rich in fructose. Eur J Nutr. 2013;52(2):537 - 45. doi:10.1007/ s00394-012-0356-y.
-
(2013)
Eur J Nutr
, vol.52
, Issue.2
, pp. 537-545
-
-
Crescenzo, R.1
Bianco, F.2
Falcone, I.3
Coppola, P.4
Liverini, G.5
Iossa, S.6
-
54
-
-
0034659814
-
Mitochondrial adaptations to obesity-related oxidant stress
-
doi:10.1006/abbi.2000. 1829
-
Yang S, Zhu H, Li Y, Lin H, Gabrielson K, Trush MA, et al. Mitochondrial adaptations to obesity-related oxidant stress. Arch Biochem Biophys. 2000;378(2):259-68. doi:10.1006/abbi.2000. 1829.
-
(2000)
Arch Biochem Biophys
, vol.378
, Issue.2
, pp. 259-268
-
-
Yang, S.1
Zhu, H.2
Li, Y.3
Lin, H.4
Gabrielson, K.5
Trush, M.A.6
-
55
-
-
32844458032
-
Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it
-
doi:10.1016/j.mito. 2005.10.004
-
Begriche K, Igoudjil A, Pessayre D, Fromenty B. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion. 2006;6(1):1-28. doi:10.1016/j.mito. 2005.10.004.
-
(2006)
Mitochondrion
, vol.6
, Issue.1
, pp. 1-28
-
-
Begriche, K.1
Igoudjil, A.2
Pessayre, D.3
Fromenty, B.4
-
56
-
-
18144444592
-
Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis
-
DOI 10.1053/jhep.2003.50398
-
Perez-Carreras M, Del Hoyo P, Martin MA, Rubio JC, Martin A, Castellano G, et al. Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology. 2003;38(4):999-1007. doi:10.1053/jhep.2003.50398. (Pubitemid 37221683)
-
(2003)
Hepatology
, vol.38
, Issue.4
, pp. 999-1007
-
-
Perez-Carreras, M.1
Del, H.P.2
Martin, M.A.3
Rubio, J.C.4
Martin, A.5
Castellano, G.6
Colina, F.7
Arenas, J.8
Solis-Herruzo, J.A.9
-
57
-
-
84655169624
-
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
-
doi:10.1016/j.freeradbiomed.2011.10. 003
-
Rolo AP, Teodoro JS, Palmeira CM. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic Biol Med. 2012;52(1):59-69. doi:10.1016/j.freeradbiomed.2011.10. 003.
-
(2012)
Free Radic Biol Med
, vol.52
, Issue.1
, pp. 59-69
-
-
Rolo, A.P.1
Teodoro, J.S.2
Palmeira, C.M.3
-
58
-
-
38349125024
-
A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet
-
Baumgardner JN, Shankar K, Hennings L, Badger TM, Ronis MJ. A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet. Am J Physiol Gastrointest Liver Physiol. 2008;294(1):G27- 38.
-
(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.294
, Issue.1
-
-
Baumgardner, J.N.1
Shankar, K.2
Hennings, L.3
Badger, T.M.4
Ronis, M.J.5
-
59
-
-
0037369729
-
Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis
-
DOI 10.1053/jhep.2003.50095
-
Chalasani N, Gorski JC, Asghar MS, Asghar A, Foresman B, Hall SD, et al. Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis. Hepatology. 2003;37(3):544-50. doi:10.1053/jhep.2003.50095. (Pubitemid 36258775)
-
(2003)
Hepatology
, vol.37
, Issue.3
, pp. 544-550
-
-
Chalasani, N.1
Christopher, G.J.2
Asghar, M.S.3
Asghar, A.4
Foresman, B.5
Hall, S.D.6
Crabb, D.W.7
-
60
-
-
80054859494
-
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role
-
doi:10.1016/j. clinre.2011.04.015
-
Aubert J, Begriche K, Knockaert L, Robin MA, Fromenty B. Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role. Clin Res Hepatol Gastroenterol. 2011;35(10):630-7. doi:10.1016/j. clinre.2011.04.015.
-
(2011)
Clin Res Hepatol Gastroenterol
, vol.35
, Issue.10
, pp. 630-637
-
-
Aubert, J.1
Begriche, K.2
Knockaert, L.3
Robin, M.A.4
Fromenty, B.5
-
61
-
-
84865504141
-
Sterile inflammation in the liver
-
doi:10.1053/j.gastro. 2012.09.008
-
Kubes P, Mehal WZ. Sterile inflammation in the liver. Gastroenterology. 2012;143(5):1158-72. doi:10.1053/j.gastro. 2012.09.008.
-
(2012)
Gastroenterology
, vol.143
, Issue.5
, pp. 1158-1172
-
-
Kubes, P.1
Mehal, W.Z.2
-
62
-
-
79955038882
-
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
-
doi:10. 1038/ni.2022
-
Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol. 2011;12(5):408-15. doi:10. 1038/ni.2022.
-
(2011)
Nat Immunol
, vol.12
, Issue.5
, pp. 408-415
-
-
Wen, H.1
Gris, D.2
Lei, Y.3
Jha, S.4
Zhang, L.5
Huang, M.T.6
-
63
-
-
34347399563
-
Metabolic endotoxemia initiates obesity and insulin resistance
-
DOI 10.2337/db06-1491
-
Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761-72. doi:10.2337/db06-1491. (Pubitemid 47025442)
-
(2007)
Diabetes
, vol.56
, Issue.7
, pp. 1761-1772
-
-
Cani, P.D.1
Amar, J.2
Iglesias, M.A.3
Poggi, M.4
Knauf, C.5
Bastelica, D.6
Neyrinck, A.M.7
Fava, F.8
Tuohy, K.M.9
Chabo, C.10
Waget, A.11
Delmee, E.12
Cousin, B.13
Sulpice, T.14
Chamontin, B.15
Ferrieres, J.16
Tanti, J.-F.17
Gibson, G.R.18
Casteilla, L.19
Delzenne, N.M.20
Alessi, M.C.21
Burcelin, R.22
more..
-
64
-
-
32044438279
-
Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: The role of toll-like receptors 2 and 4
-
Szabo G, Velayudham A, Romics Jr L, Mandrekar P. Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4. Alcohol Clin Exp Res. 2005;29(11 Suppl):140S-5.
-
(2005)
Alcohol Clin Exp Res
, vol.29
, Issue.11 SUPPL.
-
-
Szabo, G.1
Velayudham, A.2
Romics Jr., L.3
Mandrekar, P.4
-
65
-
-
34548272744
-
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
-
doi:10.1016/j.jhep. 2007.04.019
-
Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, Wallace M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol. 2007;47(4):571-9. doi:10.1016/j.jhep. 2007.04.019.
-
(2007)
J Hepatol
, vol.47
, Issue.4
, pp. 571-579
-
-
Rivera, C.A.1
Adegboyega, P.2
Van Rooijen, N.3
Tagalicud, A.4
Allman, M.5
Wallace, M.6
-
66
-
-
77953891627
-
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice
-
doi:10.1053/j.gastro.2010.03.052
-
Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010;139(1):323- 34 e7. doi:10.1053/j.gastro.2010.03. 052.
-
(2010)
Gastroenterology
, vol.139
, Issue.1
-
-
Miura, K.1
Kodama, Y.2
Inokuchi, S.3
Schnabl, B.4
Aoyama, T.5
Ohnishi, H.6
-
67
-
-
84873289589
-
Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice
-
doi:10.1002/hep.26081. Study demonstrating that simultaneous exposure of Kupffer cells to TLR2 ligands and palmitate activates the inflammasome in these cells and contributes to NASH pathogenesis
-
• Miura K, Yang L, van Rooijen N, Brenner DA, Ohnishi H, Seki E. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology. 2013;57(2):577-89. doi:10.1002/hep.26081. Study demonstrating that simultaneous exposure of Kupffer cells to TLR2 ligands and palmitate activates the inflammasome in these cells and contributes to NASH pathogenesis.
-
(2013)
Hepatology
, vol.57
, Issue.2
, pp. 577-589
-
-
Miura, K.1
Yang, L.2
Van Rooijen, N.3
Brenner, D.A.4
Ohnishi, H.5
Seki, E.6
-
68
-
-
67649227049
-
Contribution of TIR domaincontaining adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice
-
doi:10.1016/j.jhep.2009.03.027
-
Imamura M, Tsutsui H, Yasuda K, Uchiyama R, Yumikura- Futatsugi S, Mitani K, et al. Contribution of TIR domaincontaining adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice. J Hepatol. 2009;51(2):333-41. doi:10.1016/j.jhep.2009.03.027.
-
(2009)
J Hepatol
, vol.51
, Issue.2
, pp. 333-341
-
-
Imamura, M.1
Tsutsui, H.2
Yasuda, K.3
Uchiyama, R.4
Yumikura- Futatsugi, S.5
Mitani, K.6
-
69
-
-
75449101395
-
Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity
-
doi:10.1002/hep.23337
-
Stienstra R, Saudale F, Duval C, Keshtkar S, Groener JE, van Rooijen N, et al. Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. Hepatology. 2010;51(2):511-22. doi:10.1002/hep.23337.
-
(2010)
Hepatology
, vol.51
, Issue.2
, pp. 511-522
-
-
Stienstra, R.1
Saudale, F.2
Duval, C.3
Keshtkar, S.4
Groener, J.E.5
Van Rooijen, N.6
-
70
-
-
79251600358
-
Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice
-
doi:10.1053/j.gastro.2010.08.020
-
Petrasek J, Dolganiuc A, Csak T, Kurt-Jones EA, Szabo G. Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice. Gastroenterology. 2011;140(2):697-708 e4. doi:10.1053/j.gastro.2010.08.020.
-
(2011)
Gastroenterology
, vol.140
, Issue.2
-
-
Petrasek, J.1
Dolganiuc, A.2
Csak, T.3
Kurt-Jones, E.A.4
Szabo, G.5
-
71
-
-
84862669638
-
Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
-
doi:10.1016/j.jhep.2012.02.028
-
Leroux A, Ferrere G, Godie V, Cailleux F, Renoud ML, Gaudin F, et al. Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. J Hepatol. 2012;57(1):141-9. doi:10.1016/j.jhep.2012.02.028.
-
(2012)
J Hepatol
, vol.57
, Issue.1
, pp. 141-149
-
-
Leroux, A.1
Ferrere, G.2
Godie, V.3
Cailleux, F.4
Renoud, M.L.5
Gaudin, F.6
-
72
-
-
82655181355
-
Kupffer cell depletion prevents but has no therapeutic effect onmetabolic and inflammatory changes induced by a high-fat diet
-
doi:10.1096/fj.11-189472
-
Lanthier N, Molendi-Coste O, Cani PD, van Rooijen N, Horsmans Y, Leclercq IA. Kupffer cell depletion prevents but has no therapeutic effect onmetabolic and inflammatory changes induced by a high-fat diet. FASEB J. 2011;25(12):4301-11. doi:10.1096/fj.11-189472.
-
(2011)
FASEB J
, vol.25
, Issue.12
, pp. 4301-4311
-
-
Lanthier, N.1
Molendi-Coste, O.2
Cani, P.D.3
Van Rooijen, N.4
Horsmans, Y.5
Leclercq, I.A.6
-
73
-
-
84870042853
-
Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-alpha production
-
doi:10.1074/jbc.M112.417014
-
Tosello-Trampont AC, Landes SG, Nguyen V, Novobrantseva TI, Hahn YS. Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-alpha production. J Biol Chem. 2012;287(48):40161-72. doi:10.1074/jbc.M112.417014.
-
(2012)
J Biol Chem
, vol.287
, Issue.48
, pp. 40161-40172
-
-
Tosello-Trampont, A.C.1
Landes, S.G.2
Nguyen, V.3
Novobrantseva, T.I.4
Hahn, Y.S.5
-
74
-
-
84872158743
-
Contrasting responses of Kupffer cells and inflammatory mononuclear phagocytes to biliary obstruction in a mouse model of cholestatic liver injury
-
doi:10.1111/liv.12048
-
Duwaerts CC, Gehring S, Cheng CW, van Rooijen N, Gregory SH. Contrasting responses of Kupffer cells and inflammatory mononuclear phagocytes to biliary obstruction in a mouse model of cholestatic liver injury. Liver Int. 2013;33(2):255-65. doi:10.1111/liv.12048.
-
(2013)
Liver Int
, vol.33
, Issue.2
, pp. 255-265
-
-
Duwaerts, C.C.1
Gehring, S.2
Cheng, C.W.3
Van Rooijen, N.4
Gregory, S.H.5
-
75
-
-
84857883847
-
Macrophage plasticity and polarization: In vivo veritas
-
doi:10.1172/ JCI59643
-
Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 2012;122(3):787-95. doi:10.1172/ JCI59643.
-
(2012)
J Clin Invest
, vol.122
, Issue.3
, pp. 787-795
-
-
Sica, A.1
Mantovani, A.2
-
76
-
-
84860243402
-
Bias in macrophage activation pattern influences nonalcoholic steatohepatitis (NASH) in mice
-
doi:10.1042/CS20110366
-
Maina V, Sutti S, Locatelli I, Vidali M, Mombello C, Bozzola C, et al. Bias in macrophage activation pattern influences nonalcoholic steatohepatitis (NASH) in mice. Clin Sci (Lond). 2012;122(11):545-53. doi:10.1042/CS20110366.
-
(2012)
Clin Sci (Lond)
, vol.122
, Issue.11
, pp. 545-553
-
-
Maina, V.1
Sutti, S.2
Locatelli, I.3
Vidali, M.4
Mombello, C.5
Bozzola, C.6
-
77
-
-
84894798789
-
M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease
-
doi:10.1002/hep.26607
-
Wan J, Benkdane M, Teixeira-Clerc F, Bonnafous S, Louvet A, Lafdil F, et al. M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease. Hepatology. 2013. doi:10.1002/hep.26607.
-
(2013)
Hepatology
-
-
Wan, J.1
Benkdane, M.2
Teixeira-Clerc, F.3
Bonnafous, S.4
Louvet, A.5
Lafdil, F.6
-
78
-
-
44349161098
-
Alternative M2 Activation of Kupffer Cells by PPARdelta Ameliorates Obesity-Induced Insulin Resistance
-
DOI 10.1016/j.cmet.2008.04.003, PII S1550413108001137
-
Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, Vats D, Morel CR, Goforth MH, et al. Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab. 2008;7(6):496-507. doi:10.1016/j.cmet.2008.04.003. (Pubitemid 351729205)
-
(2008)
Cell Metabolism
, vol.7
, Issue.6
, pp. 496-507
-
-
Odegaard, J.I.1
Ricardo-Gonzalez, R.R.2
Red, E.A.3
Vats, D.4
Morel, C.R.5
Goforth, M.H.6
Subramanian, V.7
Mukundan, L.8
Ferrante, A.W.9
Chawla, A.10
-
79
-
-
79953863868
-
Molecular mechanism for adiponectin-dependent M2 macrophage polarization: Link between the metabolic and innate immune activity of full-length adiponectin
-
doi:10.1074/jbc.M110.204644
-
Mandal P, Pratt BT, Barnes M, McMullen MR, Nagy LE. Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin. J Biol Chem. 2011;286(15):13460-9. doi:10.1074/jbc.M110.204644.
-
(2011)
J Biol Chem
, vol.286
, Issue.15
, pp. 13460-13469
-
-
Mandal, P.1
Pratt, B.T.2
Barnes, M.3
McMullen, M.R.4
Nagy, L.E.5
-
80
-
-
80053314254
-
Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice
-
doi:10.1002/hep.24524
-
Louvet A, Teixeira-Clerc F, Chobert MN, Deveaux V, Pavoine C, Zimmer A, et al. Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology. 2011;54(4):1217-26. doi:10.1002/hep.24524.
-
(2011)
Hepatology
, vol.54
, Issue.4
, pp. 1217-1226
-
-
Louvet, A.1
Teixeira-Clerc, F.2
Chobert, M.N.3
Deveaux, V.4
Pavoine, C.5
Zimmer, A.6
-
81
-
-
67349172516
-
Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways
-
doi:10.1016/j.jhep.2009.03.024
-
Jiang JX, Mikami K, Venugopal S, Li Y, Torok NJ. Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways. J Hepatol. 2009;51(1):139-48. doi:10.1016/j.jhep.2009.03.024.
-
(2009)
J Hepatol
, vol.51
, Issue.1
, pp. 139-148
-
-
Jiang, J.X.1
Mikami, K.2
Venugopal, S.3
Li, Y.4
Torok, N.J.5
-
82
-
-
72949123737
-
Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis
-
doi:10.1002/hep.23167
-
Witek RP, Stone WC, Karaca FG, Syn WK, Pereira TA, Agboola KM, et al. Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. Hepatology. 2009;50(5):1421-30. doi:10.1002/hep.23167.
-
(2009)
Hepatology
, vol.50
, Issue.5
, pp. 1421-1430
-
-
Witek, R.P.1
Stone, W.C.2
Karaca, F.G.3
Syn, W.K.4
Pereira, T.A.5
Agboola, K.M.6
-
83
-
-
77955852465
-
Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis
-
doi:10.1016/j.jhep.2010.03.016
-
Anstee QM, Concas D, Kudo H, Levene A, Pollard J, Charlton P, et al. Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis. J Hepatol. 2010;53(3):542-50. doi:10.1016/j.jhep.2010.03.016.
-
(2010)
J Hepatol
, vol.53
, Issue.3
, pp. 542-550
-
-
Anstee, Q.M.1
Concas, D.2
Kudo, H.3
Levene, A.4
Pollard, J.5
Charlton, P.6
-
84
-
-
84884984479
-
Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
-
doi:10.1002/hep.26429
-
Pradere JP, Kluwe J, De Minicis S, Jiao JJ, Gwak GY, Dapito DH, et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology. 2013;58(4):1461-73. doi:10.1002/hep.26429.
-
(2013)
Hepatology
, vol.58
, Issue.4
, pp. 1461-1473
-
-
Pradere, J.P.1
Kluwe, J.2
De Minicis, S.3
Jiao, J.J.4
Gwak, G.Y.5
Dapito, D.H.6
-
85
-
-
35948958955
-
TLR4 enhances TGF-beta signaling and hepatic fibrosis
-
DOI 10.1038/nm1663, PII NM1663
-
Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007;13(11):1324-32. (Pubitemid 350073596)
-
(2007)
Nature Medicine
, vol.13
, Issue.11
, pp. 1324-1332
-
-
Seki, E.1
De Minicis, S.2
Osterreicher, C.H.3
Kluwe, J.4
Osawa, Y.5
Brenner, D.A.6
Schwabe, R.F.7
-
86
-
-
33144463511
-
Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice
-
DOI 10.1136/gut.2005.071118
-
Tomita K, Tamiya G, Ando S, Ohsumi K, Chiyo T, Mizutani A, et al. Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of nonalcoholic steatohepatitis in mice. Gut. 2006;55(3):415-24. doi: 10.1136/gut.2005.071118. (Pubitemid 43268283)
-
(2006)
Gut
, vol.55
, Issue.3
, pp. 415-424
-
-
Tomita, K.1
Tamiya, G.2
Ando, S.3
Ohsumi, K.4
Chiyo, T.5
Mizutani, A.6
Kitamura, N.7
Toda, K.8
Kaneko, T.9
Horie, Y.10
Han, J.-Y.11
Kato, S.12
Shimoda, M.13
Oike, Y.14
Tomizawa, M.15
Makino, S.16
Ohkura, T.17
Saito, H.18
Kumagai, N.19
Nagata, H.20
Ishii, H.21
Hibi, T.22
more..
-
87
-
-
79954523464
-
Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice
-
doi:10.1152/ajpgi.00163.2009
-
Csak T, Velayudham A, Hritz I, Petrasek J, Levin I, Lippai D, et al. Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. 2011;300(3): G433-41. doi:10.1152/ajpgi. 00163.2009.
-
(2011)
Am J Physiol Gastrointest Liver Physiol
, vol.300
, Issue.3
-
-
Csak, T.1
Velayudham, A.2
Hritz, I.3
Petrasek, J.4
Levin, I.5
Lippai, D.6
-
88
-
-
84861872575
-
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2
-
doi:10.1152/ajpgi.00365.2011
-
Miura K, Yang L, van Rooijen N, Ohnishi H, Seki E. Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol. 2012;302(11):G1310-21. doi:10.1152/ajpgi.00365.2011.
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.302
, Issue.11
-
-
Miura, K.1
Yang, L.2
Van Rooijen, N.3
Ohnishi, H.4
Seki, E.5
-
89
-
-
0036204924
-
Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice
-
DOI 10.1053/jhep.2002.32029
-
Saxena NK, Ikeda K, Rockey DC, Friedman SL, Anania FA. Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology. 2002;35(4):762-71. doi:10.1053/jhep.2002. 32029. (Pubitemid 34258369)
-
(2002)
Hepatology
, vol.35
, Issue.4
, pp. 762-771
-
-
Saxena, N.K.1
Ikeda, K.2
Rockey, D.C.3
Friedman, S.L.4
Anania, F.A.5
-
90
-
-
33745834319
-
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
-
DOI 10.1172/JCI29126
-
Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006;116(7): 1784-92. doi:10.1172/JCI29126. (Pubitemid 44033298)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.7
, pp. 1784-1792
-
-
Kadowaki, T.1
Yamauchi, T.2
Kubota, N.3
Hara, K.4
Ueki, K.5
Tobe, K.6
-
91
-
-
19544378172
-
The roles of leptin and adiponectin: A novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology
-
Ding X, Saxena NK, Lin S, Xu A, Srinivasan S, Anania FA. The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Pathol. 2005;166(6):1655-69. doi:10.1016/S0002-9440(10)62476-5. (Pubitemid 40734389)
-
(2005)
American Journal of Pathology
, vol.166
, Issue.6
, pp. 1655-1669
-
-
Ding, X.1
Saxena, N.K.2
Lin, S.3
Xu, A.4
Srinivasan, S.5
Anania, F.A.6
-
92
-
-
80052448815
-
Modulation of liver fibrosis by adipokines
-
doi:10.1159/000329799
-
Marra F, Navari N, Vivoli E, Galastri S, Provenzano A. Modulation of liver fibrosis by adipokines. Dig Dis. 2011;29(4): 371-6. doi:10.1159/000329799.
-
(2011)
Dig Dis
, vol.29
, Issue.4
, pp. 371-376
-
-
Marra, F.1
Navari, N.2
Vivoli, E.3
Galastri, S.4
Provenzano, A.5
-
93
-
-
65249188812
-
Heritability of nonalcoholic fatty liver disease
-
doi:10.1053/j.gastro. 2009.01.050
-
Schwimmer JB, Celedon MA, Lavine JE, Salem R, Campbell N, Schork NJ, et al. Heritability of nonalcoholic fatty liver disease. Gastroenterology. 2009;136(5):1585-92. doi:10.1053/j.gastro. 2009.01.050.
-
(2009)
Gastroenterology
, vol.136
, Issue.5
, pp. 1585-1592
-
-
Schwimmer, J.B.1
Celedon, M.A.2
Lavine, J.E.3
Salem, R.4
Campbell, N.5
Schork, N.J.6
-
94
-
-
67650496665
-
Correlates and heritability of nonalcoholic fatty liver disease in a minority cohort
-
doi:10.1038/oby.2009.4
-
Wagenknecht LE, Scherzinger AL, Stamm ER, Hanley AJ, Norris JM, Chen YD, et al. Correlates and heritability of nonalcoholic fatty liver disease in a minority cohort. Obesity (Silver Spring). 2009;17(6):1240-6. doi:10.1038/oby.2009.4.
-
(2009)
Obesity (Silver Spring)
, vol.17
, Issue.6
, pp. 1240-1246
-
-
Wagenknecht, L.E.1
Scherzinger, A.L.2
Stamm, E.R.3
Hanley, A.J.4
Norris, J.M.5
Chen, Y.D.6
-
95
-
-
56749096610
-
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
-
doi:10.1038/ng.257
-
Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2008;40(12):1461-5. doi:10.1038/ng.257.
-
(2008)
Nat Genet
, vol.40
, Issue.12
, pp. 1461-1465
-
-
Romeo, S.1
Kozlitina, J.2
Xing, C.3
Pertsemlidis, A.4
Cox, D.5
Pennacchio, L.A.6
-
96
-
-
79953745343
-
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
-
doi:10.1371/journal.pgen.1001324
-
Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet. 2011;7(3): e1001324. doi:10.1371/journal.pgen.1001324.
-
(2011)
PLoS Genet
, vol.7
, Issue.3
-
-
Speliotes, E.K.1
Yerges-Armstrong, L.M.2
Wu, J.3
Hernaez, R.4
Kim, L.J.5
Palmer, C.D.6
-
97
-
-
79957462315
-
Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
-
doi:10.1002/hep.24283
-
Sookoian S, Pirola CJ. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology. 2011;53(6):1883-94. doi:10.1002/hep.24283.
-
(2011)
Hepatology
, vol.53
, Issue.6
, pp. 1883-1894
-
-
Sookoian, S.1
Pirola, C.J.2
-
98
-
-
84860465005
-
Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase
-
doi:10.1016/j.cmet.2012.04.008
-
Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, et al. Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab. 2012;15(5):691-702. doi:10.1016/j.cmet.2012.04.008.
-
(2012)
Cell Metab
, vol.15
, Issue.5
, pp. 691-702
-
-
Kumari, M.1
Schoiswohl, G.2
Chitraju, C.3
Paar, M.4
Cornaciu, I.5
Rangrez, A.Y.6
-
99
-
-
80054806707
-
Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease
-
doi:10.1074/jbc.M111.290114
-
Huang Y, Cohen JC, Hobbs HH. Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease. J Biol Chem. 2011;286(43):37085-93. doi:10.1074/jbc.M111.290114.
-
(2011)
J Biol Chem
, vol.286
, Issue.43
, pp. 37085-37093
-
-
Huang, Y.1
Cohen, J.C.2
Hobbs, H.H.3
-
100
-
-
84868609657
-
Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis
-
doi:10.1172/JCI65179
-
Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, et al. Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. J Clin Invest. 2012;122(11):4130-44. doi:10.1172/JCI65179.
-
(2012)
J Clin Invest
, vol.122
, Issue.11
, pp. 4130-4144
-
-
Li, J.Z.1
Huang, Y.2
Karaman, R.3
Ivanova, P.T.4
Brown, H.A.5
Roddy, T.6
-
101
-
-
77950607738
-
Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
-
doi:10.1002/hep.23622
-
Valenti L, Al-Serri A, Daly AK, Galmozzi E, Rametta R, Dongiovanni P, et al. Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. Hepatology. 2010;51(4):1209-17. doi:10.1002/hep.23622.
-
(2010)
Hepatology
, vol.51
, Issue.4
, pp. 1209-1217
-
-
Valenti, L.1
Al-Serri, A.2
Daly, A.K.3
Galmozzi, E.4
Rametta, R.5
Dongiovanni, P.6
-
102
-
-
79959562237
-
Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: Non-invasive elastography-based study in chronic liver disease
-
doi:10.1016/j.jhep.2010.10.042
-
Krawczyk M, Grunhage F, Zimmer V, Lammert F. Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: non-invasive elastography-based study in chronic liver disease. J Hepatol. 2011;55(2):299-306. doi:10.1016/j.jhep. 2010.10.042.
-
(2011)
J Hepatol
, vol.55
, Issue.2
, pp. 299-306
-
-
Krawczyk, M.1
Grunhage, F.2
Zimmer, V.3
Lammert, F.4
-
103
-
-
84868304332
-
PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals
-
doi:10.1016/j.dld.2012.05.006
-
Burza MA, Pirazzi C, Maglio C, Sjoholm K, Mancina RM, Svensson PA, et al. PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals. Dig Liver Dis. 2012;44(12):1037-41. doi:10.1016/j.dld.2012.05.006.
-
(2012)
Dig Liver Dis
, vol.44
, Issue.12
, pp. 1037-1041
-
-
Burza, M.A.1
Pirazzi, C.2
Maglio, C.3
Sjoholm, K.4
Mancina, R.M.5
Svensson, P.A.6
-
104
-
-
84882825411
-
Association between variants in or near PNPLA3, GCKR, and PPP1R3B with ultrasound-defined steatosis based on data from the third national health and nutrition examination survey
-
doi:10.1016/j.cgh.2013.02.011
-
Hernaez R, McLean J, Lazo M, Brancati FL, Hirschhorn JN, Borecki IB, et al. Association between variants in or near PNPLA3, GCKR, and PPP1R3B with ultrasound-defined steatosis based on data from the third national health and nutrition examination survey. Clin Gastroenterol Hepatol. 2013;11(9): 1183-90 e2. doi:10.1016/j.cgh.2013.02.011.
-
(2013)
Clin Gastroenterol Hepatol
, vol.11
, Issue.9
-
-
Hernaez, R.1
McLean, J.2
Lazo, M.3
Brancati, F.L.4
Hirschhorn, J.N.5
Borecki, I.B.6
-
105
-
-
84880198084
-
Genetic predisposition in NAFLD and NASH: Impact on severity of liver disease and response to treatment
-
Dongiovanni P, Anstee QM, Valenti L. Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment. Curr Pharm Des. 2013;19(29):5219-38.
-
(2013)
Curr Pharm des
, vol.19
, Issue.29
, pp. 5219-5238
-
-
Dongiovanni, P.1
Anstee, Q.M.2
Valenti, L.3
-
106
-
-
8144226856
-
The gut microbiota as an environmental factor that regulates fat storage
-
DOI 10.1073/pnas.0407076101
-
Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004;101(44):15718-23. doi:10.1073/pnas.0407076101. (Pubitemid 39473554)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.44
, pp. 15718-15723
-
-
Backhed, F.1
Ding, H.2
Wang, T.3
Hooper, L.V.4
Gou, Y.K.5
Nagy, A.6
Semenkovich, C.F.7
Gordon, J.I.8
-
107
-
-
33846542071
-
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
-
DOI 10.1073/pnas.0605374104
-
Backhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A. 2007;104(3):979-84. doi:10.1073/pnas.0605374104. (Pubitemid 46154722)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.3
, pp. 979-984
-
-
Backhed, F.1
Manchester, J.K.2
Semenkovich, C.F.3
Gordon, J.I.4
-
108
-
-
20544444045
-
Microbiology: Diversity of the human intestinal microbial flora
-
DOI 10.1126/science.1110591
-
Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, et al. Diversity of the human intestinal microbial flora. Science. 2005;308(5728):1635-8. doi:10.1126/science.1110591. (Pubitemid 40807514)
-
(2005)
Science
, vol.308
, Issue.5728
, pp. 1635-1638
-
-
Eckburg, P.B.1
Bik, E.M.2
Bernstein, C.N.3
Purdom, E.4
Dethlefsen, L.5
Sargent, M.6
Gill, S.R.7
Nelson, K.E.8
Relman, D.A.9
-
109
-
-
80053618114
-
Linking long-term dietary patterns with gut microbial enterotypes
-
doi:10.1126/science. 1208344
-
Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334(6052):105-8. doi:10.1126/science. 1208344.
-
(2011)
Science
, vol.334
, Issue.6052
, pp. 105-108
-
-
Wu, G.D.1
Chen, J.2
Hoffmann, C.3
Bittinger, K.4
Chen, Y.Y.5
Keilbaugh, S.A.6
-
110
-
-
33845901507
-
Microbial ecology: Human gut microbes associated with obesity
-
DOI 10.1038/4441022a, PII 4441022A
-
Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444(7122):1022-3. doi:10.1038/4441022a. (Pubitemid 46018512)
-
(2006)
Nature
, vol.444
, Issue.7122
, pp. 1022-1023
-
-
Ley, R.E.1
Turnbaugh, P.J.2
Klein, S.3
Gordon, J.I.4
-
111
-
-
70350110294
-
High-fat diet determines the composition of the murine gut microbiome independently of obesity
-
doi:10.1053/j. gastro.2009.08.042
-
Hildebrandt MA, Hoffmann C, Sherrill-Mix SA, Keilbaugh SA, Hamady M, Chen YY, et al. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology. 2009;137(5):1716-24 e1-2. doi:10.1053/j. gastro.2009.08.042.
-
(2009)
Gastroenterology
, vol.137
, Issue.5
-
-
Hildebrandt, M.A.1
Hoffmann, C.2
Sherrill-Mix, S.A.3
Keilbaugh, S.A.4
Hamady, M.5
Chen, Y.Y.6
-
112
-
-
23344442120
-
Obesity alters gut microbial ecology
-
doi:10.1073/pnas. 0504978102
-
Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A. 2005;102(31):11070 - 5. doi:10.1073/pnas. 0504978102.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, Issue.31
, pp. 11070-11075
-
-
Ley, R.E.1
Backhed, F.2
Turnbaugh, P.3
Lozupone, C.A.4
Knight, R.D.5
Gordon, J.I.6
-
113
-
-
58749112734
-
A core gut microbiome in obese and lean twins
-
doi:10.1038/nature07540
-
Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, et al. A core gut microbiome in obese and lean twins. Nature. 2009;457(7228):480-4. doi:10.1038/nature07540.
-
(2009)
Nature
, vol.457
, Issue.7228
, pp. 480-484
-
-
Turnbaugh, P.J.1
Hamady, M.2
Yatsunenko, T.3
Cantarel, B.L.4
Duncan, A.5
Ley, R.E.6
-
114
-
-
48249125862
-
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
-
doi:10. 2337/db07-1403
-
Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008;57(6):1470-81. doi:10. 2337/db07-1403.
-
(2008)
Diabetes
, vol.57
, Issue.6
, pp. 1470-1481
-
-
Cani, P.D.1
Bibiloni, R.2
Knauf, C.3
Waget, A.4
Neyrinck, A.M.5
Delzenne, N.M.6
-
115
-
-
84899490742
-
IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice
-
doi: 10.1002/hep.26746. Novel animal study implicating certain types of gut bacteria in the pathogenesis of NASH via induction of IL-17
-
• Harley IT, Stankiewicz TE, Giles DA, Softic S, Flick LM, Cappelletti M, et al. IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice. Hepatology. 2013. doi: 10.1002/hep.26746. Novel animal study implicating certain types of gut bacteria in the pathogenesis of NASH via induction of IL-17.
-
(2013)
Hepatology
-
-
Harley, I.T.1
Stankiewicz, T.E.2
Giles, D.A.3
Softic, S.4
Flick, L.M.5
Cappelletti, M.6
-
116
-
-
0034320252
-
Increased gastrointestinal ethanol production in obese mice: Implications for fatty liver disease pathogenesis
-
Cope K, Risby T, Diehl AM. Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis. Gastroenterology. 2000;119(5):1340-7.
-
(2000)
Gastroenterology
, vol.119
, Issue.5
, pp. 1340-1347
-
-
Cope, K.1
Risby, T.2
Diehl, A.M.3
-
117
-
-
68949148889
-
Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
-
doi:10.1002/hep.22848
-
Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, Ricci R, et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology. 2009;49(6): 1877-87. doi:10.1002/hep.22848.
-
(2009)
Hepatology
, vol.49
, Issue.6
, pp. 1877-1887
-
-
Miele, L.1
Valenza, V.2
La Torre, G.3
Montalto, M.4
Cammarota, G.5
Ricci, R.6
-
118
-
-
84864193026
-
Nutrition, intestinal permeability, and blood ethanol levels are altered in patients with nonalcoholic fatty liver disease (NAFLD)
-
doi:10.1007/s10620-012-2112-9
-
Volynets V, Kuper MA, Strahl S, Maier IB, Spruss A, Wagnerberger S, et al. Nutrition, intestinal permeability, and blood ethanol levels are altered in patients with nonalcoholic fatty liver disease (NAFLD). DigDis Sci. 2012;57(7):1932-41. doi:10.1007/s10620-012-2112-9.
-
(2012)
DigDis Sci
, vol.57
, Issue.7
, pp. 1932-1941
-
-
Volynets, V.1
Kuper, M.A.2
Strahl, S.3
Maier, I.B.4
Spruss, A.5
Wagnerberger, S.6
-
119
-
-
84873296091
-
Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH
-
doi:10.1002/hep.26093
-
Zhu L, Baker SS, Gill C, Liu W, Alkhouri R, Baker RD, et al. Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH. Hepatology. 2013;57(2):601 - 9. doi:10.1002/hep.26093.
-
(2013)
Hepatology
, vol.57
, Issue.2
, pp. 601-609
-
-
Zhu, L.1
Baker, S.S.2
Gill, C.3
Liu, W.4
Alkhouri, R.5
Baker, R.D.6
-
120
-
-
84879604697
-
Intestinal microbiota in patients with nonalcoholic fatty liver disease
-
doi:10.1002/hep.26319
-
Mouzaki M, Comelli EM, Arendt BM, Bonengel J, Fung SK, Fischer SE, et al. Intestinal microbiota in patients with nonalcoholic fatty liver disease. Hepatology. 2013;58(1):120-7. doi:10.1002/hep.26319.
-
(2013)
Hepatology
, vol.58
, Issue.1
, pp. 120-127
-
-
Mouzaki, M.1
Comelli, E.M.2
Arendt, B.M.3
Bonengel, J.4
Fung, S.K.5
Fischer, S.E.6
-
121
-
-
79960299110
-
Probiotics as an emerging therapeutic strategy to treat NAFLD: Focus on molecular and biochemical mechanisms
-
doi:10.1016/j.jnutbio.2010.10.002
-
Iacono A, Raso GM, Canani RB, Calignano A, Meli R. Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms. J Nutr Biochem. 2011;22(8):699-711. doi:10.1016/j.jnutbio.2010.10. 002.
-
(2011)
J Nutr Biochem
, vol.22
, Issue.8
, pp. 699-711
-
-
Iacono, A.1
Raso, G.M.2
Canani, R.B.3
Calignano, A.4
Meli, R.5
-
122
-
-
84889634755
-
Systematic review with meta-analysis: Non-alcoholic steatohepatitis - A case for personalised treatment based on pathogenic targets
-
doi:10.1111/apt.12543
-
Younossi ZM, Reyes MJ, Mishra A, Mehta R, Henry L. Systematic review with meta-analysis: non-alcoholic steatohepatitis - a case for personalised treatment based on pathogenic targets. Aliment Pharmacol Ther. 2014;39(1):3-14. doi:10.1111/apt.12543.
-
(2014)
Aliment Pharmacol Ther
, vol.39
, Issue.1
, pp. 3-14
-
-
Younossi, Z.M.1
Reyes, M.J.2
Mishra, A.3
Mehta, R.4
Henry, L.5
|