Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals

Gastroenterology

Volumn 139, Issue 3, 2010, Pages

  Iozzo, Patricia ^a,b   Bucci, Marco ^a,b   Roivainen, Anne ^a   Någren, Kjell ^a   Järvisalo, Mikko J ^a   Kiss, Jan ^a   Guiducci, Letizia ^b   Fielding, Barbara ^c   Naum, Alexandru G ^a   Borra, Ronald ^a   Virtanen, Kirsi ^a   Savunen, Timo ^a   Salvadori, Piero A ^b   Ferrannini, Ele ^d   Knuuti, Juhani ^a   Nuutila, Pirjo ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF PISA   (Italy)

Author keywords

Insulin Resistance; Lipolysis; Liver Steatosis; Oxidative Stress

Indexed keywords

CARBON 11; FATTY ACID; INSULIN; PALMITIC ACID; TRIACYLGLYCEROL; CARBON; RADIOPHARMACEUTICAL AGENT;

ADIPOSE TISSUE; ADULT; ANIMAL EXPERIMENT; ARTERIAL BLOOD; ARTERY CATHETERIZATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; ESTERIFICATION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; HUMAN; HYPERINSULINEMIA; IMAGE QUALITY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPOLYSIS; LIVER; NONHUMAN; OBESITY; PORTAL VEIN BLOOD; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SWINE; ANIMAL; BLOOD; CASE CONTROL STUDY; DIAGNOSTIC USE; DISEASE MODEL; HYPERINSULINISM; INTRAABDOMINAL FAT; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATION REDUCTION REACTION; PATHOLOGY; PROSPECTIVE STUDY; SCINTISCANNING; UPREGULATION; VASCULARIZATION;

ANIMALS; CARBON RADIOISOTOPES; CASE-CONTROL STUDIES; DISEASE MODELS, ANIMAL; FASTING; FATTY ACIDS; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; LIPOLYSIS; LIVER; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; OBESITY; OXIDATION-REDUCTION; PALMITIC ACID; POSITRON-EMISSION TOMOGRAPHY; PROSPECTIVE STUDIES; RADIOPHARMACEUTICALS; SWINE; TRIGLYCERIDES; UP-REGULATION;

EID: 77956151046     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.05.039     Document Type: Article

References (39)

1. M. Charlton Nonalcoholic fatty liver disease: a review of current understanding and future impact Clin Gastroenterol Hepatol 2 2004 1048 1058
2. S. Petta, C. Muratore, and A. Craxi Non-alcoholic fatty liver disease pathogenesis: the present and the future Dig Liver Dis 41 2009 615 625
3. M. Brownlee Biochemistry and molecular cell biology of diabetic complications Nature 414 2001 813 820
4. A. Kotronen, A. Seppala-Lindroos, and R. Bergholm Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome Diabetologia 51 2008 130 138
5. K. Yamaguchi, L. Yang, and S. McCall Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis Hepatology 45 2007 1366 1374
6. S.S. Choi, and A.M. Diehl Hepatic triglyceride synthesis and nonalcoholic fatty liver disease Curr Opin Lipidol 19 2008 295 300
7. B. Fromenty, M.A. Robin, and A. Igoudjil The ins and outs of mitochondrial dysfunction in NASH Diabetes Metab 30 2004 121 138
8. S. Yang, H. Zhu, and Y. Li Mitochondrial adaptations to obesity-related oxidant stress Arch Biochem Biophys 378 2000 259 268
9. S. Nakamura, T. Takamura, and N. Matsuzawa-Nagata Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria J Biol Chem 284 2009 14809 14818
10. S. Nielsen, Z. Guo, and C.M. Johnson Splanchnic lipolysis in human obesity J Clin Invest 113 2004 1582 1588
11. J. Knuuti, T.O. Takala, and K. Nagren Myocardial fatty acid oxidation in patients with impaired glucose tolerance Diabetologia 44 2001 184 187
12. T. Arai, S. Wakabayashi, and M.A. Channing Incorporation of [1-carbon-11]palmitate in monkey brain using PET J Nucl Med 36 1995 2261 2267
13. S.R. Bergmann, C.J. Weinheimer, and J. Markham Quantitation of myocardial fatty acid metabolism using PET J Nucl Med 37 1996 1723 1730
14. S. Klein, V.R. Young, and G.L. Blackburn Palmitate and glycerol kinetics during brief starvation in normal weight young adult and elderly subjects J Clin Invest 78 1986 928 933
15. P. Iozzo, M.J. Jarvisalo, and J. Kiss Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs Gastroenterology 132 2007 531 542
16. S. Rigazio, H.R. Lehto, and H. Tuunanen The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans Am J Physiol Endocrinol Metab 295 2008 E413 E419
17. H. Akaike [Data analysis by statistical models] No To Hattatsu 24 1992 127 133
18. A. Natali, G. Buzzigoli, and S. Taddei Effects of insulin on hemodynamics and metabolism in human forearm Diabetes 39 1990 490 500
19. A.J. Sanyal, C. Campbell-Sargent, and F. Mirshahi Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities Gastroenterology 120 2001 1183 1192
20. G.F. Lewis, K.D. Uffelman, and L.W. Szeto Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans J Clin Invest 95 1995 158 166
21. R. Malmstrom, C.J. Packard, and M. Caslake Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects Diabetes 47 1998 779 787
22. P.N. Durrington, R.S. Newton, and D.B. Weinstein Effects of insulin and glucose on very low density lipoprotein triglyceride secretion by cultured rat hepatocytes J Clin Invest 70 1982 63 73
23. P. Iozzo, A.K. Turpeinen, and T. Takala Defective liver disposal of free fatty acids in patients with impaired glucose tolerance J Clin Endocrinol Metab 89 2004 3496 3502
24. L.J. Brady, P.S. Brady, and D.R. Romsos Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) mice Biochem J 231 1985 439 444
25. G.A. Cook, and M.S. Gamble Regulation of carnitine palmitoyltransferase by insulin results in decreased activity and decreased apparent Ki values for malonyl-CoA J Biol Chem 262 1987 2050 2055
26. C.P. Day, and O.F. James Steatohepatitis: a tale of two "hits"? Gastroenterology 114 1998 842 845
27. N. Matsuzawa-Nagata, T. Takamura, and H. Ando Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity Metabolism 57 2008 1071 1077
28. A. Kotronen, L. Juurinen, and M. Tiikkainen Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes Gastroenterology 135 2008 122 130
29. A.S. Bickerton, R. Roberts, and B.A. Fielding Adipose tissue fatty acid metabolism in insulin-resistant men Diabetologia 51 2008 1466 1474
30. R.J. Havel, J.P. Kane, and E.O. Balasse Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans J Clin Invest 49 1970 2017 2035
31. M.J. Muller Hepatic energy and substrate metabolism: a possible metabolic basis for early nutritional support in cirrhotic patients Nutrition 14 1998 30 38
32. P. Iozzo, M.J. Jarvisalo, and J. Kiss Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs Gastroenterology 132 2007 531 542
33. H.C. Padgett, G.D. Robinson, and J.R. Barrio [1-(11)C]palmitic acid: improved radiopharmaceutical preparation Int J Appl Radiat Isot 33 1982 1471 1472
34. L. Guiducci, M. Jarvisalo, and J. Kiss [11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia Nucl Med Biol 33 2006 521 528
35. P. Iozzo, A.K. Turpeinen, and T. Takala Defective liver disposal of free fatty acids in patients with impaired glucose tolerance J Clin Endocrinol Metab 89 2004 3496 3502
36. J. Knuuti, T.O. Takala, and K. Nagren Myocardial fatty acid oxidation in patients with impaired glucose tolerance Diabetologia 44 2001 184 187
37. S. Rigazio, H.R. Lehto, and H. Tuunanen The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans Am J Physiol Endocrinol Metab 295 2008 E413 E419
38. H.W. de Jong, L.J. Rijzewijk, and M. Lubberink Kinetic models for analysing myocardial [(11)C]palmitate data Eur J Nucl Med Mol Imaging 36 2009 966 978
39. S.R. Bergmann, C.J. Weinheimer, and J. Markham Quantitation of myocardial fatty acid metabolism using PET J Nucl Med 37 1996 1723 1730