Adipocyte metabolism and obesity

Journal of Lipid Research

Volumn 50, Issue SUPPL., 2009, Pages

  Attie, Alan D ^a   Scherer, Philipp E ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Adiponectin; Inflammation; Leptin

Indexed keywords

ADIPOCYTE; ENDOPLASMIC RETICULUM; IMMUNOLOGY; INFLAMMATION; METABOLISM; OBESITY; PHYSIOLOGICAL STRESS; PROTEIN FOLDING; REVIEW;

ADIPOCYTES; ENDOPLASMIC RETICULUM; INFLAMMATION; OBESITY; PROTEIN FOLDING; STRESS, PHYSIOLOGICAL;

EID: 66349115342     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.R800057-JLR200     Document Type: Review

References (35)

1. de Luca, C., and J. M. Olefsky. 2008. Inflammation and insulin resistance. FEBS Lett. 582: 97-105. (Pubitemid 50010731)
2. She, P., C. Van Horn, T. Reid, S. M. Hutson, R. N. Cooney, and C. J. Lynch. 2007. Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. Am. J. Physiol. Endocrinol. Metab. 293: E1552-E1563. (Pubitemid 350255104)
3. Krebs, M., A. Brehm, M. Krssak, C. Anderwald, E. Bernroider, P. Nowotny, E. Roth, V. Chandramouli, B. R. Landau, W. Waldhausl, et al. 2003. Direct and indirect effects of amino acids on hepatic glucose metabolism in humans. Diabetologia. 46: 917-925. (Pubitemid 36961314)
4. Krebs, M., M. Krssak, E. Bernroider, C. Anderwald, A. Brehm, M. Meyerspeer, P. Nowotny, E. Roth, W. Waldhausl, and M. Roden. 2002. Mechanism of amino acid-induced skeletal muscle insulin resistance in humans. Diabetes. 51: 599-605. (Pubitemid 34760165)
5. Tremblay, F., M. Krebs, L. Dombrowski, A. Brehm, E. Bernroider, E. Roth, P. Nowotny, W. Waldhausl, A. Marette, and M. Roden. 2005. Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes. 54: 2674-2684. (Pubitemid 41233590)
6. Blasiole, D. A., R. A. Davis, and A. D. Attie. 2007. The physiological and molecular regulation of lipoprotein assembly and secretion. Mol. Biosyst. 3: 608-619. (Pubitemid 47258227)
7. Browning, J. D., L. S. Szczepaniak, R. Dobbins, P. Nuremberg, J. D. Horton, J. C. Cohen, S. M. Grundy, and H. H. Hobbs. 2004. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 40: 1387-1395. (Pubitemid 39657013)
8. Romeo, S., J. Kozlitina, C. Xing, A. Pertsemlidis, D. Cox, L. A. Pennacchio, E. Boerwinkle, J. C. Cohen, and H. H. Hobbs. 2008. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 40: 1461-1465.
9. Nadler, S. T., J. P. Stoehr, K. L. Schueler, G. Tanimoto, B. S. Yandell, and A. D. Attie. 2000. The expression of adipogenic genes is decreased in obesity and diabetes mellitus. Proc. Natl. Acad. Sci. USA. 97: 11371-11376.
10. Soukas, A., P. Cohen, N. D. Socci, and J. M. Friedman. 2000. Leptinspecific patterns of gene expression in white adipose tissue. Genes Dev. 14: 963-980. (Pubitemid 30253005)
11. Reitman, M. L. 2002. Metabolic lessons from genetically lean mice. Annu. Rev. Nutr. 22: 459-482. (Pubitemid 35221469)
12. Makowski, L., K. C. Brittingham, J. M. Reynolds, J. Suttles, and G. S. Hotamisligil. 2005. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J. Biol. Chem. 280: 12888-12895.
13. Kim, J. Y., E. van de Wall, M. Laplante, A. Azzara, M. E. Trujillo, S. M. Hofmann, T. Schraw, J. L. Durand, H. Li, G. Li, et al. 2007. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J. Clin. Invest. 117: 2621-2637. (Pubitemid 47494363)
14. Horowitz, J. F., and S. Klein. 2000. Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women. Am. J. Physiol. Endocrinol. Metab. 278: E1144-E1152. (Pubitemid 30439153)
15. Monetti, M., M. C. Levin, M. J. Watt, M. P. Sajan, S. Marmor, B. K. Hubbard, R. D. Stevens, J. R. Bain, C. B. Newgard, R. V. Farese, Sr., et al. 2007. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 6: 69-78. (Pubitemid 46995777)
16. Chibalin, A. V., Y. Leng, E. Vieira, A. Krook, M. Bjornholm, Y. C. Long, O. Kotova, Z. Zhong, F. Sakane, T. Steiler, et al. 2008. Down-regulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell. 132: 375-386. (Pubitemid 351191998)
17. Kim, J. K., J. J. Fillmore, M. J. Sunshine, B. Albrecht, T. Higashimori, D. W. Kim, Z. X. Liu, T. J. Soos, G. W. Cline, W. R. O'Brien, et al. 2004. PKC-theta knockout mice are protected from fat-induced insulin resistance. J. Clin. Invest. 114: 823-827. (Pubitemid 39578741)
18. Hotamisligil, G. S., P. Peraldi, A. Budavari, R. Ellis, M. F. White, and B. M. Spiegelman. 1996. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science. 271: 665-668. (Pubitemid 26052915)
19. Summers, S. A., L. A. Garza, H. Zhou, and M. J. Birnbaum. 1998. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol. Cell. Biol. 18: 5457-5464. (Pubitemid 28388128)
20. Stratford, S., K. L. Hoehn, F. Liu, and S. A. Summers. 2004. Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J. Biol. Chem. 279: 36608-36615. (Pubitemid 39129005)
21. Wang, M. Y., L. Orci, M. Ravazzola, and R. H. Unger. 2005. Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity. Proc. Natl. Acad. Sci. USA. 102: 18011-18016. (Pubitemid 41798493)
22. Tran, T. T., Y. Yamamoto, S. Gesta, and C. R. Kahn. 2008. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab. 7: 410-420. (Pubitemid 351598027)
23. Weisberg, S. P., D. McCann, M. Desai, M. Rosenbaum, R. L. Leibel, and A. W. Ferrante, Jr. 2003. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112: 1796-1808. (Pubitemid 38063703)
24. Kanda, H., S. Tateya, Y. Tamori, K. Kotani, K. Hiasa, R. Kitazawa, S. Kitazawa, H. Miyachi, S. Maeda, K. Egashira, et al. 2006. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 116: 1494-1505.
25. Lumeng, C. N., J. L. Bodzin, and A. R. Saltiel. 2007. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117: 175-184. (Pubitemid 46048464)
26. Koza, R. A., L. Nikonova, J. Hogan, J. S. Rim, T. Mendoza, C. Faulk, J. Skaf, and L. P. Kozak. 2006. Changes in gene expression fore-shadow diet-induced obesity in genetically identical mice. PLoS Genet. 2: e81.
27. Hosogai, N., A. Fukuhara, K. Oshima, Y. Miyata, S. Tanaka, K. Segawa, S. Furukawa, Y. Tochino, R. Komuro, M. Matsuda, et al. 2007. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 56: 901-911. (Pubitemid 46525054)
28. Ye, J., Z. Gao, J. Yin, and Q. He. 2007. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am. J. Physiol. Endocrinol. Metab. 293: E1118-E1128. (Pubitemid 47535846)
29. Higgins, D. F., K. Kimura, M. Iwano, and V. H. Haase. 2008. Hypoxia-inducible factor signaling in the development of tissue fibrosis. Cell Cycle. 7: 1128-1132. (Pubitemid 351749261)
30. Gregor, M. F., and G. S. Hotamisligil. 2007. Thematic review series: adipocyte biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J. Lipid Res. 48: 1905-1914. (Pubitemid 47360610)
31. Sharma, J. K., K. D. Swapan, A. K. Mondal, O. G. Hackney, W. S. Chu, P. L. Kern, N. Rasouli, H. J. Spencer, A. Yao-Borengasser, and S. C. Elbein. 2008. Endoplasmic reticulum stress markers are associated with obesity in non-diabetic subjects. J. Clin. Endocrinol. Metab. 93: 4532-4541. (Pubitemid 352789557)
32. Kaser, A., A.H. Lee, A. Franke, J.N. Glickman, S. Zeissig, H. Tilg,E.E. Nieuwenhuis, D. E. Higgins, S. Schreiber, L. H. Glimcher, et al. 2008. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 134: 743-756.
33. Wilson-Fritch, L., S. Nicoloro, M. Chouinard, M. A. Lazar, P. C. Chui, J. Leszyk, J. Straubhaar, M. P. Czech, and S. Corvera. 2004. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J. Clin. Invest. 114: 1281-1289. (Pubitemid 40385299)
34. Shi, X., A. Burkart, S. M. Nicoloro, M. P. Czech, J. Straubhaar, and S. Corvera. 2008. Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells. J. Biol. Chem. 283: 30658-30667.
35. Lin, Y., A. H. Berg, P. Iyengar, T. K. Lam, A. Giacca, T. P. Combs,M.W. Rajala, X. Du, B. Rollman, W. Li, et al. 2005. The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J. Biol. Chem. 280: 4617-4626. (Pubitemid 40288630)