Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans

Obesity

Volumn 21, Issue 4, 2013, Pages 782-785

  Lecoultre, V ^a   Egli, L ^a   Carrel, G ^a   Theytaz, F ^a   Kreis, R ^b   Schneiter, P ^a   Boss, A ^b   Zwygart, K ^b   Le K A ^a   Bortolotti, M ^a   Boesch, C ^b   Tappy, L ^a,c  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSE; GLUCOSE; LIPID; SATURATED FATTY ACID;

ADULT; ARTICLE; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INSULIN RESISTANCE; INSULIN SENSITIVITY; LOW FAT DIET; MALE; NONALCOHOLIC FATTY LIVER; NORMAL HUMAN; OVERNUTRITION; PROTON NUCLEAR MAGNETIC RESONANCE;

BLOOD GLUCOSE; BODY MASS INDEX; DIET; ENERGY INTAKE; FASTING; FATTY ACIDS; FRUCTOSE; GLUCOSE; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; MALE; YOUNG ADULT;

EID: 84878276815     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20377     Document Type: Article

References (14)

1. Lustig RH, Schmidt LA, Brindis CD,. Public health: the toxic truth about sugar. Nature 2012; 482: 27-29.
2. Bizeau ME, Pagliassotti MJ,. Hepatic adaptations to sucrose and fructose. Metabol Clin Exp 2005; 54: 1189-1201.
3. Le KA, Ith M, Kreis R, et al. Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am J Clin Nutr 2009; 89: 1760-1765.
4. Faeh D, Minehira K, Schwarz J, Periasami R, Seongus P, Tappy L,. Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy males. Diabetes 2005; 54: 1907-1913.
5. Silbernagel G, Machann J, Unmuth S, et al. Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial. Br J Nutr 2011; 106: 79-86.
6. Stanhope KL, Schwarz JM, Keim NL, et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009; 119: 1322-1334.
7. Mitrakou A, Kelley D, Mokan M, et al. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 1992; 326: 22-29.
8. Le KA, Faeh D, Stettler R, et al. A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans. Am J Clin Nutr 2006; 84: 1374-1379.
9. Thorburn AW, Crapo PA, Griver K, Wallace P, Henry RR,. Long-term effects of dietary fructose on carbohydrate metabolism in non-insulin-dependent diabetes mellitus. Metab Clin Exp 1990; 39: 58-63.
10. Ngo Sock ET, Le KA, Ith M, Kreis R, Boesch C, Tappy L,. Effects of a short-term overfeeding with fructose or glucose in healthy young males. Br J Nutr 2010; 103: 939-943.
11. Theytaz F, Noguchi Y, Egli L, et al. Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans. Am J Clin Nutr 2012; 96: 1008-1016.
12. Belfort R, Harrison SA, Brown K, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006; 355: 2297-2307.
13. Vos MB, Kimmons JE, Gillespie C, Welsh J, Blanck HM,. Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey. Medscape J Med 2008; 10: 160.
14. Kirk E, Reeds DN, Finck BN, Mayurranjan SM, Patterson BW, Klein S,. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology 2009; 136: 1552-1560.